CD44 variant isoforms associate with tetraspanins and EpCAM.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Experimental Cell Research

• Publication date

  2004-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.YEXCR.2004.02.023PMID 15212938
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cadherins and Catenins: Role in Signal Transduction and Tumor Progression

  2004cited by this paper
• On the Role of Cell Surface Carbohydrates and their Binding Proteins (lectins) in Tumor Metastasis

  2004cited by this paper
• The association of the tetraspanin D6.1A with the α6β4 integrin supports cell motility and liver metastasis formation

  2003cited by this paper
• CD44v7 interferes with activation‐induced cell death by up‐regulation of anti‐apoptotic gene expression

  2003cited by this paper
• The association of the tetraspanin D6.1A with the alpha6beta4 integrin supports cell motility and liver metastasis formation.

  2003cited by this paper
• CD44: From adhesion molecules to signalling regulators

  2003cited by this paper
• CD44 in Cancer Progression: Adhesion, Migration and Growth Regulation

  2003cited by this paper
• Regulation of the SHP-2 Tyrosine Phosphatase by a Novel Cholesterol- and Cell Confluence-dependent Mechanism* 210

  2003cited by this paper
• CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling.

  2002cited by this paper
• Hyaluronan Binding Properties of a CD44 Chimera Containing the Link Module of TSG-6*

  2002cited by this paper
• INAUGURAL ARTICLE by a Recently Elected Academy Member:The glycosynapse

  2002cited by this paper
• The hyaluronan receptor, CD44.

  2002cited by this paper
• Reciprocal raft–receptor interactions and the assembly of adhesion complexes

  2002cited by this paper
• CD44 in Cancer

  2002cited by this paper
• Soluble osteopontin inhibits apoptosis of adherent endothelial cells deprived of growth factors *

  2002cited by this paper
• The glycosynapse.

  2002cited by this paper
• Hyaluronan Promotes Signaling Interaction between CD44 and the Transforming Growth Factor β Receptor I in Metastatic Breast Tumor Cells*

  2002cited by this paper
• CD44 is required for two consecutive steps in HGF/c-Met signaling.

  2002cited by this paper
• Tetraspanin CD9 Is a “Proteolipid,” and Its Interaction with α3 Integrin in Microdomain Is Promoted by GM3 Ganglioside, Leading to Inhibition of Laminin-5-dependent Cell Motility*

  2002cited by this paper
• The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44.

  2001cited by this paper
• A CD44 survival pathway triggers chemoresistance via lyn kinase and phosphoinositide 3-kinase/Akt in colon carcinoma cells.

  2001cited by this paper
• Oligomeric State of the Colon Carcinoma-associated Glycoprotein GA733-2 (Ep-CAM/EGP40) and Its Role in GA733-mediated Homotypic Cell-Cell Adhesion*

  2001cited by this paper
• N-terminal protein acylation confers localization to cholesterol, sphingolipid-enriched membranes but not to lipid rafts/caveolae.

  2001cited by this paper
• Stromal cells can contribute oncogenic signals.

  2001cited by this paper
• Overexpression of tetraspanin CO-029 in hepatocellular carcinoma.

  2001cited by this paper
• KAI1, A prostate metastasis suppressor: Prediction of solvated structure and interactions with binding partners; integrins, cadherins, and cell‐surface receptor proteins †

  2001cited by this paper
• Epidermal Growth Factor-Like Repeats Mediate Lateral and Reciprocal Interactions of Ep-CAM Molecules in Homophilic Adhesions

  2001cited by this paper
• Complexes of tetraspanins with integrins: more than meets the eye.

  2001cited by this paper
• Osp/Claudin-11 Forms a Complex with a Novel Member of the Tetraspanin Super Family and β1 Integrin and Regulates Proliferation and Migration of Oligodendrocytes

  2001cited by this paper
• ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse.

  2001cited by this paper
• Annexins: Key Regulators of Haemostasis, Thrombosis, and Apoptosis

  2001cited by this paper
• Transmembrane-4 Superfamily Proteins Associate with Activated Protein Kinase C (PKC) and Link PKC to Specific β1 Integrins*

  2001cited by this paper
• Cell adhesion in tumor invasion and metastasis: loss of the glue is not enough.

  2001cited by this paper
• Evaluation of Prototype Transmembrane 4 Superfamily Protein Complexes and Their Relation to Lipid Rafts*

  2001cited by this paper
• CD44 Is the Physiological Trigger of Fas Up-Regulation on Rheumatoid Synovial Cells1

  2001cited by this paper
• Up‐regulation of the tumour‐associated marker CD44V6 in experimental kidney disease

  2000cited by this paper
• CD44 supports T cell proliferation and apoptosis by apposition of protein kinases

  2000cited by this paper
• Domain analysis of the tetraspanins: studies of CD9/CD63 chimeric molecules on subcellular localization and upregulation activity for diphtheria toxin binding.

  2000cited by this paper
• Ep-CAM overexpression in breast cancer as a predictor of survival.

  2000cited by this paper
• Ga733/EpCAM as a Target for Passive and Active Specific Immunotherapy in Patients with Colorectal Carcinoma

  2000cited by this paper
• Interaction between CD44 and the repeat domain of ankyrin promotes hyaluronic acid‐mediated ovarian tumor cell migration

  2000cited by this paper
• Signaling through sphingolipid microdomains of the plasma membrane: The concept of signaling platform

  2000cited by this paper
• Expression of CD44 Variants in Lung Cancer and Its Relationship to Hyaluronan Binding

  2000cited by this paper
• Lipid-dependent Targeting of G Proteins into Rafts*

  2000cited by this paper
• Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1.

  2000cited by this paper
• Tumor progression and metastasis.

  2000cited by this paper
• Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity.

  2000cited by this paper
• CD44 variant isoforms on blood leukocytes in chronic inflammatory bowel disease and other systemic autoimmune diseases.

  1999cited by this paper
• Acyl and alkyl chain length of GPI‐anchors is critical for raft association in vitro

  1999cited by this paper
• CD44 signaling through p56lck involves lateral association with CD4 in human CD4+ T cells.

  1999cited by this paper
• CD44 involvement in experimental collagen-induced arthritis (CIA).

  1999cited by this paper
• CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis.

  1999cited by this paper
• Are selectins involved in metastasis?

  1999cited by this paper
• Analysis of Cd44-Containing Lipid Rafts

  1999cited by this paper
• Metastasis-association of the rat ortholog of the human epithelial glycoprotein antigen EGP314

  1999cited by this paper
• Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis.

  1999cited by this paper
• CD44 stimulation induces integrin-mediated adhesion of colon cancer cell lines to endothelial cells by up-regulation of integrins and c-Met and activation of integrins.

  1999cited by this paper
• The biology of the 17–1A antigen (Ep-CAM)

  1999cited by this paper
• Functions of lipid rafts in biological membranes.

  1998cited by this paper
• CD19 Is Linked to the Integrin-associated Tetraspans CD9, CD81, and CD82*

  1998cited by this paper
• Association Between the Rat Homologue of CO-029, a Metastasis-associated Tetraspanin Molecule and Consumption Coagulopathy

  1998cited by this paper
• Cloning and functional characterization of a new phosphatidyl-inositol anchored molecule of a metastasizing rat pancreatic tumor

  1998cited by this paper
• Ezrin/Radixin/Moesin (ERM) Proteins Bind to a Positively Charged Amino Acid Cluster in the Juxta-Membrane Cytoplasmic Domain of CD44, CD43, and ICAM-2

  1998cited by this paper
• Lipids, lipid domains and lipid-protein interactions in endocytic membrane traffic.

  1998cited by this paper
• CD44 variant isoform expression in a variety of skin-associated autoimmune diseases.

  1998cited by this paper
• How tumor cells make use of CD44.

  1998cited by this paper
• Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44

  1998cited by this paper
• A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth.

  1998cited by this paper
• A high throughput screening for rarely transcribed differentially expressed genes

  1997cited by this paper
• Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains.

  1997cited by this paper
• The tetraspanin superfamily: molecular facilitators

  1997cited by this paper
• Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway

  1996cited by this paper
• Hyaluronate-independent metastatic behavior of CD44 variant-expressing pancreatic carcinoma cells.

  1996cited by this paper
• Accelerated immune response in transgenic mice expressing rat CD44v4-v7 on T cells.

  1996cited by this paper
• Developmentally regulated expression of metastasis-associated antigens in the rat.

  1996cited by this paper
• Expression of multiple CD44 isoforms in the apical ectodermal ridge of the embryonic mouse limb

  1996cited by this paper
• Functional significance of CD9 association with beta 1 integrins in human epidermal keratinocytes.

  1996cited by this paper
• CD44 in malignant disorders.

  1996cited by this paper
• In vitro culture of human peripheral blood monocytes induces hyaluronan binding and up-regulates monocyte variant CD44 isoform expression.

  1996cited by this paper
• A Splice Variant of CD44 Expressed in the Rat Apical Ectodermal Ridge Contributes to Limb Outgrowth

  1996cited by this paper
• CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor

  1995cited by this paper
• Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule

  1994cited by this paper
• Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function

  1994cited by this paper
• Expression of CD44 splice variants during lymphocyte activation and tumor progression.

  1994cited by this paper
• ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons

  1994cited by this paper
• In vivo and in vitro reactivity of rat spleen cells against regressor and progressor colon‐cancer cell variants

  1993cited by this paper
• CD44 and its interaction with extracellular matrix.

  1993cited by this paper
• Restricted expression of the hyaluronan receptor, CD44, during postimplantation mouse embryogenesis suggests key roles in tissue formation and patterning.

  1993cited by this paper
• Participation in normal immune responses of a metastasis-inducing splice variant of CD44.

  1992cited by this paper
• Establishment and characterization of monoclonal antibodies against an octahedral gallium chelate suitable for immunoscintigraphy with PET.

  1992cited by this paper
• CD44: the hyaluronan receptor.

  1992cited by this paper
• A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells.

  1991cited by this paper
• Formation of hemidesmosomes in vitro by a transformed rat bladder cell line

  1991cited by this paper
• CD44 is the principal cell surface receptor for hyaluronate.

  1990cited by this paper
• Antigenic differences between metastatic and nonmetastatic BSp73 rat tumor variants characterized by monoclonal antibodies.

  1989cited by this paper
• Clonal analysis of diversity in the BSp73 rat tumor.

  1985cited by this paper
• Characterization of BSp73, a spontaneous rat tumor and its in vivo selected variants showing different metastasizing capacities.

  1983cited by this paper

• Landscape of cancer associated EpCAM mutations: molecular modeling, predictive insights and impact on patient survival

  2025cites this paper
• Expression of CD44 and Its Spliced Variants: Innate and Inducible Roles in Nervous Tissue Cells and Their Environment

  2025cites this paper
• Sensitive Profiling of Mouse Liver Membrane Proteome Dysregulation Following a High‐Fat and Alcohol Diet Treatment

  2024cites this paper
• Profiling the organ membrane proteome dysregulation in the context of liver disease

  2024cites this paper
• Regulation of the Function and Expression of EpCAM

  2024cites this paper
• Fibrolamellar Carcinomas-Growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharides.

  2023cites this paper
• Patch grafting of organoids of stem/progenitors into solid organs can correct genetic-based disease states.

  2022cites this paper
• Proteomic alteration of endometrial tissues during secretion in polycystic ovary syndrome may affect endometrial receptivity

  2022cites this paper
• Oncogenic tetraspanins: Implications for metastasis, drug resistance, cancer stem cell maintenance and diagnosis of leading cancers in females

  2022cites this paper
• Molecular pathology underlying the robustness of cancer stem cells

  2021influential citation
• Changes in Proteomics of Endometrial Tissue During Secretion of Polycystic Ovary Syndrome May Affect Endometrial Receptivity

  2021cites this paper
• EpCAM-claudin-tetraspanin-modulated ovarian cancer progression and drug resistance

  2020cites this paper
• Protein Kinase C regulates the complex between cell membrane molecules in ovarian cancer

  2020cites this paper
• EpCAM as Modulator of Tissue Plasticity

  2020cites this paper
• EpCAM cellular functions in adhesion and migration, and potential impact on invasion: A critical review.

  2020cites this paper
• Tetraspanin CD9: A Key Regulator of Cell Adhesion in the Immune System

  2018cites this paper
• Hyaluronan coating improves liver engraftment of transplanted human biliary tree stem/progenitor cells

  2017cites this paper
• Cholangiocytes: Cell transplantation.

  2017cites this paper
• Long intergenic non-protein-coding RNA 1567 (LINC01567) acts as a “sponge” against microRNA-93 in regulating the proliferation and tumorigenesis of human colon cancer stem cells

  2017cites this paper
• EpCAM as a novel therapeutic target for hepatocellular carcinoma

  2017cites this paper
• Proteomic insights into extracellular vesicle biology – defining exosomes and shed microvesicles

  2017cites this paper
• Molecular Mechanisms of Human Papillomavirus Induced Skin Carcinogenesis

  2017cites this paper
• The fibronectin/α3β1 integrin axis serves as molecular basis for keratinocyte invasion induced by βHPV

  2016cites this paper
• Differential Tetraspanin Expression in Monocyte Subsets May Regulate the Formation of Multinucleated Giant Cells

  2016influential citation
• Membranous co-expression of EpCAM and CD 44 s predicts poor prognosis in pancreatic cancer patients

  2016influential citation
• Mechanism of HPV8-E7 mediated keratinocyte invasion

  2016cites this paper
• Expression of epithelial cell adhesion molecule (EpCAM) in oral squamous cell carcinoma

  2016cites this paper
• Identification des régulateurs de l’expression transcriptionnelle de TSPAN8 impliqués dans l’invasion précoce du mélanome cutané

  2016cites this paper
• The cytosolic tail of the tumor marker protein Trop2 - a structural switch triggered by phosphorylation

  2015cites this paper
• Circulating tumor cells isolation: the "post-EpCAM era".

  2015cites this paper
• Generation of Multicellular Tumor Spheroids with Microwell-Based Agarose Scaffolds for Drug Testing

  2015cites this paper
• Lineage-dependent effects of aryl hydrocarbon receptor agonists contribute to liver tumorigenesis

  2015cites this paper
• Coexpression of EpCAM, CD44 Variant Isoforms and Claudin-7 in Anaplastic Thyroid Carcinoma

  2014cites this paper
• Studies of stem cell and adhesion proteins in breast cancer

  2014cites this paper
• The diagnostic, predictive, and prognostic role of serum epithelial cell adhesion molecule (EpCAM) and vascular cell adhesion molecule-1 (VCAM-1) levels in breast cancer

  2014cites this paper
• EpCAM is decreased but is still present in uterine epithelial cells during early pregnancy in the rat: potential mechanism for maintenance of mucosal integrity during implantation

  2014cites this paper
• EpCAM and the biology of hepatic stem/progenitor cells

  2014cites this paper
• Tetraspanins

  2013cites this paper
• The Role of Tetraspanins in Cell Migration and Intercellular Adhesion

  2013cites this paper
• EpCAM‐associated claudin‐7 supports lymphatic spread and drug resistance in rat pancreatic cancer

  2013cites this paper
• The epithelial cell adhesion molecule (EpCAM) regulates cell motility and cell-cell adhesion by inhibiting PKC signaling

  2013influential citation
• EpCAM: structure and function in health and disease.

  2013cites this paper
• EpCAM expression is an indicator of recurrence in basal-like breast cancer

  2012cites this paper
• Expression and role of epithelial cell adhesion molecule in dysplastic nodule and hepatocellular carcinoma.

  2012cites this paper
• Cultivation and identification of colon cancer stem cell-derived spheres from the Colo205 cell line

  2012cites this paper
• Cancer spheres from gastric cancer patients provide an ideal model system for cancer stem cell research

  2011cites this paper
• Functional polymorphisms in CD166/ALCAM gene associated with increased risk for breast cancer in a Chinese population

  2011cites this paper
• Epithelial Cell Adhesion Molecule (EpCAM) Complex Proteins Promote Transcription Factor-mediated Pluripotency Reprogramming*

  2011cites this paper
• Selection and analysis of anti‐cancer antibodies for cancer therapy obtained from antibody phage library

  2011cites this paper
• A non-synonymous polymorphism Thr115Met in the EpCAM gene is associated with an increased risk of breast cancer in Chinese population

  2011cites this paper
• Eradizierung von Krebsstammzellen mittels eines EpCAM/CD3-bispezifischen Antikörpers

  2011cites this paper
• Ep-CAM RNA expression predicts metastasis-free survival in three cohorts of untreated node-negative breast cancer

  2011cites this paper
• The tumor-associated EpCAM regulates morphogenetic movements through intracellular signaling

  2010cites this paper
• Characterization of Epithelial Cell Adhesion Molecule as a Surface Marker on Undifferentiated Human Embryonic Stem Cells

  2010cites this paper
• Epithelial cell adhesion molecule (EpCAM) is overexpressed in breast cancer metastases

  2010cites this paper
• RETRACTED ARTICLE: EpCAM: A Potential Antimetastatic Target for Gastric Cancer

  2010cites this paper
• The stem cell code in oral epithelial tumorigenesis: 'the cancer stem cell shift hypothesis'.

  2010cites this paper
• Tetraspanins and Cancer Metastasis

  2010cites this paper
• Etude multicentrique de nouveaux marqueurs tumoraux moléculaires dans les épanchements péritonéaux et le sang : analyse par PCR quantitative en temps réel

  2010cites this paper
• Aspects of the mode of action of bispecific T cell engager (BiTE) antibodies

  2009cites this paper
• Trop2: a possible therapeutic target for late stage epithelial carcinomas.

  2009cites this paper
• CD44v6 dependence of premetastatic niche preparation by exosomes.

  2009cites this paper
• CD44 Variant Isoforms Promote Metastasis Formation by a Tumor Cell-Matrix Cross-talk That Supports Adhesion and Apoptosis Resistance

  2009cites this paper
• Atypical E-cadherin expression in cell clusters overlying focally disrupted mammary myoepithelial cell layers: implications for tumor cell motility and invasion.

  2009cites this paper
• Epithelial cell-cell junctions and plasma membrane domains.

  2009cites this paper
• Abnormal Placental Development and Early Embryonic Lethality in EpCAM-Null Mice

  2009cites this paper
• Claudin-7 Regulates EpCAM-Mediated Functions in Tumor Progression

  2009cites this paper
• The Epithelial Cell Adhesion Molecule EpCAM Is Required for Epithelial Morphogenesis and Integrity during Zebrafish Epiboly and Skin Development

  2009cites this paper
• Therapeutic window of MuS110, a single-chain antibody construct bispecific for murine EpCAM and murine CD3.

  2008cites this paper
• The tumor antigen EpCAM: tetraspanins and the tight junction protein claudin-7, new partners, new functions.

  2008influential citation
• Expression and Prognostic Significance of EpCAM

  2008cites this paper
• CD44 and EpCAM: cancer-initiating cell markers.

  2008cites this paper
• Therapeutic Window of MuS 110 , a Single-Chain Antibody Construct Bispecific for Murine EpCAM and Murine CD 3

  2007cites this paper
• Construct Bispecific for Murine EpCAM and Murine CD 3 Therapeutic Window of MuS 110 , a Single-Chain Antibody

  2007cites this paper
• Epithelial cell adhesion molecule: more than a carcinoma marker and adhesion molecule.

  2007cites this paper
• A Complex of EpCAM, Claudin-7, CD44 Variant Isoforms, and Tetraspanins Promotes Colorectal Cancer Progression

  2007influential citation
• CD81 et microdomaines enrichis en tétraspanines : rôle dans l'infection des hépatocytes par Plasmodium.

  2006cites this paper
• Isoform-specific Loss of CD44 Interferes with Different Aspects of the Metastatic Process

  2006cites this paper
• THESE DE DOCTORAT DE L'UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)

  2006cites this paper
• A subset of cell clusters with malignant features in morphologically normal-appearing and hyperplastic tissues.

  2006cites this paper
• A subset of prostate basal cells lacks the expression of corresponding phenotypic markers.

  2006cites this paper
• Transcript and proteome analysis reveals reduced expression of calgranulins in head and neck squamous cell carcinoma.

  2005cites this paper
• The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7.

  2005cites this paper
• Metabolic Activation-related CD147-CD98 Complex*S

  2005cites this paper
• A subset of in situ breast tumor cell clusters lacks expression of proliferation and progression related markers but shows signs of stromal and vascular invasion.

  2005cites this paper
• The tetraspanin D6.1A and its molecular partners on rat carcinoma cells.

  2005cites this paper
• CD44 in Cancer Progression: Adhesion, Migration and Growth Regulation

  2003cites this paper
• Jcb: Article

  year unknowncites this paper
• Profiling the organ membrane proteome dysregulation in the context of liver disease

  year unknowncites this paper