N-terminal protein acylation confers localization to cholesterol, sphingolipid-enriched membranes but not to lipid rafts/caveolae.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Molecular Biology of the Cell

• Publication date

  2001-11-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1091/MBC.12.11.3601PMID 11694592PMCID PMC60279
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Synthesis of mitochondrial DNA in permeabilised human cultured cells.

  2001influential reference
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  2000cited by this paper
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• Ligand-induced internalization of neurotensin in transfected COS-7 cells: differential intracellular trafficking of ligand and receptor.

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• Selective Accumulation of Raft-Associated Membrane Protein Lat in T Cell Receptor Signaling Assemblies

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• Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi.

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• Plasma Membrane Microdomains Act as Concentration Platforms to Facilitate Intoxication by Aerolysin

  1999influential reference
• Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

  1999influential reference
• Critical Role for Cholesterol in Lyn-mediated Tyrosine Phosphorylation of FcεRI and Their Association with Detergent-resistant Membranes

  1999cited by this paper
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  1999cited by this paper
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  1999influential reference
• Glycosphingolipid Domains on Cell Plasma Membrane

  1999cited by this paper
• Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles.

  1999cited by this paper
• Clathrin, adaptors and eps15 in endosomes containing activated epidermal growth factor receptors.

  1999cited by this paper
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  1999cited by this paper
• Functionally different GPI proteins are organized in different domains on the neuronal surface

  1999cited by this paper
• Membrane microdomains and caveolae.

  1999influential reference
• Polarized Distribution of Endogenous Rac1 and RhoA at the Cell Surface*

  1999cited by this paper
• Role of Lipid Modifications in Targeting Proteins to Detergent-resistant Membrane Rafts

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• Phagosomal Maturation, Acidification, and Inhibition of Bacterial Growth in Nonphagocytic Cells Transfected with FcγRIIA Receptors*

  1999cited by this paper
• Epidermal growth factor receptor activation is localized within low-buoyant density, non-caveolar membrane domains.

  1999cited by this paper
• Functional roles for fatty acylated amino-terminal domains in subcellular localization.

  1999influential reference
• Detergent-insoluble glycosphingolipid/cholesterol-rich membrane domains, lipid rafts and caveolae (review).

  1999cited by this paper
• Immunoisolation of Caveolae with High Affinity Antibody Binding to the Oligomeric Caveolin Cage

  1999cited by this paper
• Palmitoylation of GAP-43 by the ER-Golgi intermediate compartment and Golgi apparatus.

  1999cited by this paper
• Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins.

  1999influential reference
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  1999cited by this paper
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  1999cited by this paper
• Acute cholesterol depletion inhibits clathrin-coated pit budding.

  1999influential reference
• Quantitative analysis of phospholipids in functionally important membrane domains from RBL-2H3 mast cells using tandem high-resolution mass spectrometry.

  1999cited by this paper
• Amphitropic proteins: regulation by reversible membrane interactions (review).

  1999cited by this paper
• The Dually Acylated NH2-terminal Domain of Gi1α Is Sufficient to Target a Green Fluorescent Protein Reporter to Caveolin-enriched Plasma Membrane Domains

  1999cited by this paper
• GPI-anchored proteins are organized in submicron domains at the cell surface

  1998cited by this paper
• Cholesterol‐dependent retention of GPI‐anchored proteins in endosomes

  1998cited by this paper
• Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane.

  1998influential reference
• Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog.

  1998influential reference
• Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components

  1998influential reference
• Cholesterol and Sphingolipid Enhance the Triton X-100 Insolubility of Glycosylphosphatidylinositol-anchored Proteins by Promoting the Formation of Detergent-insoluble Ordered Membrane Domains*

  1998cited by this paper
• Association of GAP-43 with Detergent-resistant Membranes Requires Two Palmitoylated Cysteine Residues*

  1998influential reference
• Functions of lipid rafts in biological membranes.

  1998influential reference
• The caveolae membrane system.

  1998cited by this paper
• Polyunsaturated Fatty Acids Inhibit T Cell Signal Transduction by Modification of Detergent-insoluble Membrane Domains

  1998cited by this paper
• Filipin-dependent Inhibition of Cholera Toxin: Evidence for Toxin Internalization and Activation through Caveolae-like Domains

  1998influential reference
• Signalling functions of protein palmitoylation.

  1998cited by this paper
• Cellubrevin-targeted Fluorescence Uncovers Heterogeneity in the Recycling Endosomes*

  1998cited by this paper
• Characterization of a Cytosolic Heat-shock Protein-Caveolin Chaperone Complex

  1998cited by this paper
• Structure and Origin of Ordered Lipid Domains in Biological Membranes

  1998influential reference
• Separation of “Glycosphingolipid Signaling Domain” from Caveolin-containing Membrane Fraction in Mouse Melanoma B16 Cells and Its Role in Cell Adhesion Coupled with Signaling*

  1998influential reference
• Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association.

  1997cited by this paper
• Analysis of the N-terminal binding domain of Go alpha.

  1997cited by this paper
• Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains.

  1997cited by this paper
• Association of Engrailed homeoproteins with vesicles presenting caveolae-like properties.

  1997influential reference
• Regulation of caveolin and caveolae by cholesterol in MDCK cells.

  1997cited by this paper
• Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content.

  1997cited by this paper
• Pathophysiologic implications of membrane phospholipid asymmetry in blood cells.

  1997cited by this paper
• Functional rafts in cell membranes

  1997cited by this paper
• Rapid Plasma Membrane Anchoring of Newly Synthesized p59  fyn: Selective Requirement for NH2-Terminal Myristoylation and Palmitoylation at Cysteine-3

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• Targeting of a G alpha subunit (Gi1 alpha) and c-Src tyrosine kinase to caveolae membranes: clarifying the role of N-myristoylation.

  1997influential reference
• The 2.0 Å crystal structure of a heterotrimeric G protein

  1996cited by this paper
• Intracellular Distribution of Arf Proteins in Mammalian Cells

  1996cited by this paper
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  1995cited by this paper
• Characterization of proteins in detergent-resistant membrane complexes from Madin-Darby canine kidney epithelial cells.

  1995influential reference
• GFP in mammalian cells.

  1995cited by this paper
• Digging into caveolae

  1995cited by this paper
• VIP21/caveolin is a cholesterol-binding protein.

  1995cited by this paper
• Doubly-lipid-modified protein sequence motifs exhibit long-lived anchorage to lipid bilayer membranes.

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  1994influential reference
• Intracellular sorting of neuromodulin (GAP-43) mutants modified in the membrane targeting domain

  1994cited by this paper
• Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface.

  1992cited by this paper
• Progesterone blocks cholesterol translocation from lysosomes.

  1992influential reference
• Static and dynamic lipid asymmetry in cell membranes.

  1991cited by this paper
• Isolation and characterization of Chinese hamster ovary cell mutants defective in intracellular low density lipoprotein-cholesterol trafficking

  1990influential reference
• Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme.

  1989cited by this paper
• Filipin as a flow microfluorometry probe for cellular cholesterol.

  1984cited by this paper
• Structural heterogeneity of endocytic membranes in macrophages as revealed by the cholesterol probe, filipin.

  1981cited by this paper
• The biosynthesis of phosphatidylserines by acylation of 1-acyl-sn-glycero-3-phosphoserine in rat liver.

  1980cited by this paper

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  2019cites this paper
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  2016cites this paper
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  2013cites this paper
• Identification and subcellular localization of TcHIP, a putative Golgi zDHHC palmitoyl transferase of Trypanosoma cruzi.

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  2006cites this paper
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  2006cites this paper
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  2005cites this paper
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  2004cites this paper