Cellular and molecular mechanisms underlying bone marrow and liver fibrosis: a review.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  European Cytokine Network

• Publication date

  2008-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1684/ecn.2008.0127PMID 18632420
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Allogeneic Hematopoietic Stem Cell Transplantation for Myelofibrosis.

  2009cited by this paper
• Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.

  2008cited by this paper
• JAK2 inhibitor therapy in myeloproliferative disorders: rationale, preclinical studies and ongoing clinical trials

  2008cited by this paper
• Adenoviral-mediated TGF-beta1 inhibition in a mouse model of myelofibrosis inhibit bone marrow fibrosis development.

  2007cited by this paper
• Bone marrow–derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice

  2007cited by this paper
• Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice.

  2007cited by this paper
• Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice.

  2007cited by this paper
• Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice

  2007cited by this paper
• TLR4 enhances TGF-beta signaling and hepatic fibrosis.

  2007cited by this paper
• Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice.

  2007cited by this paper
• Treatment strategy for liver fibrosis through recruitment and differentiation of bone marrow stem/progenitor cells

  2007cited by this paper
• Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases.

  2007cited by this paper
• The Role of the Hyaluronan Receptor CD44 in Mesenchymal Stem Cell Migration in the Extracellular Matrix

  2006cited by this paper
• Myelofibrosis in chronic myeloproliferative disorders--dynamics and clinical impact.

  2006cited by this paper
• Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model.

  2006cited by this paper
• Aberrant collagenase expression in chronic idiopathic myelofibrosis is related to the stage of disease but not to the JAK2 mutation status.

  2006cited by this paper
• JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.

  2006cited by this paper
• The role of circulating fibrocytes in fibrosis

  2006cited by this paper
• Monocyte/Macrophage Dysfunctions Do Not Impair the Promotion of Myelofibrosis by High Levels of Thrombopoietin1

  2006cited by this paper
• European consensus on grading bone marrow fibrosis and assessment of cellularity.

  2005cited by this paper
• Liver fibrosis.

  2005cited by this paper
• Pathogenesis of myelofibrosis with myeloid metaplasia.

  2005cited by this paper
• Aberrant expression of platelet-derived growth factor (PDGF) and PDGF receptor-alpha is associated with advanced bone marrow fibrosis in idiopathic myelofibrosis.

  2005cited by this paper
• Anti-TGF-beta strategies for the treatment of chronic liver disease.

  2005cited by this paper
• Production of Pro- and Anti-fibrotic Agents by Rat Kupffer Cells; The Effect of Octreotide

  2005cited by this paper
• A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-beta1 in the development of myelofibrosis.

  2005cited by this paper
• Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats

  2005cited by this paper
• Hepatic fibrosis: molecular mechanisms and drug targets.

  2005cited by this paper
• Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.

  2005cited by this paper
• Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats.

  2005cited by this paper
• A gain-of-function mutation of JAK2 in myeloproliferative disorders.

  2005cited by this paper
• Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.

  2005cited by this paper
• Role for the nuclear factor kappaB pathway in transforming growth factor-beta1 production in idiopathic myelofibrosis: possible relationship with FK506 binding protein 51 overexpression.

  2005cited by this paper
• A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.

  2005cited by this paper
• Developmental biology of fibroblasts and neoplastic disease.

  2005cited by this paper
• Importance of Plasma Matrix Metalloproteinases (MMP) and Tissue Inhibitors of Metalloproteinase (TIMP) in development of fibrosis in agnogenic myeloid metaplasia

  2005cited by this paper
• Activated hepatic stellate cells express keratinocyte growth factor in chronic liver disease.

  2004cited by this paper
• TGF-beta1 induces bone marrow reticulin fibrosis in hairy cell leukemia.

  2004cited by this paper
• Liver fibrosis

  2004cited by this paper
• Fibrotic disease and the T(H)1/T(H)2 paradigm.

  2004cited by this paper
• IL-13 Activates a Mechanism of Tissue Fibrosis That Is Completely TGF-β Independent

  2004cited by this paper
• Stellate cells: A moving target in hepatic fibrogenesis

  2004cited by this paper
• Allogeneic hematopoietic stem cell transplantation for myelofibrosis.

  2003cited by this paper
• Does cytogenetic mosaicism in CD34+CD38low cells reflect the persistence of normal primitive hematopoietic progenitors in myeloid metaplasia with myelofibrosis?

  2003cited by this paper
• Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation.

  2002cited by this paper
• Development of myelofibrosis in mice genetically impaired for GATA-1 expression (GATA-1(low) mice).

  2002cited by this paper
• Prominent role of TGF-beta 1 in thrombopoietin-induced myelofibrosis in mice.

  2002cited by this paper
• Hepatic fibrosis--role of hepatic stellate cell activation.

  2002cited by this paper
• Plasma matrix metalloproteinase and tissue inhibitor of metalloproteinase in patients with agnogenic myeloid metaplasia or idiopathic primary myelofibrosis

  2002cited by this paper
• Expression of Hepatocyte Growth Factor mRNA in Rat Liver Cirrhosis Induced by N-nitrosodimethylamine as Evidenced by In Situ RT-PCR

  2002cited by this paper
• Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells.

  2001cited by this paper
• Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats.

  2001cited by this paper
• Elevated vascular endothelial growth factor (VEGF) serum levels in idiopathic myelofibrosis

  2001cited by this paper
• Studies of murine schistosomiasis reveal interleukin‐13 blockade as a treatment for established and progressive liver fibrosis

  2001cited by this paper
• Extracellular Matrix Degradation and the Role of Hepatic Stellate Cells

  2001cited by this paper
• Schistosome Infection of Transgenic Mice Defines Distinct and Contrasting Pathogenic Roles for IL-4 and IL-13: IL-13 Is a Profibrotic Agent1

  2000cited by this paper
• Inhibition of transforming growth factor β prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine‐treated rats

  2000cited by this paper
• Evaluation and clinical correlations of bone marrow angiogenesis in myelofibrosis with myeloid metaplasia.

  2000cited by this paper
• Myelofibrosis: pathogenesis of myelofibrosis with myeloid metaplasia

  2000cited by this paper
• NF-kappa B as a central mediator in the induction of TGF-beta in monocytes from patients with idiopathic myelofibrosis: an inflammatory response beyond the realm of homeostasis.

  2000cited by this paper
• Pathologic interaction between megakaryocytes and polymorphonuclear leukocytes in myelofibrosis.

  2000cited by this paper
• The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo.

  1999cited by this paper
• In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis.

  1999cited by this paper
• Myelofibrosis: pathogenesis of myelofibrosis with myeloid metaplasia. French INSERM Research Network on Myelofibrosis with Myeloid Metaplasia.

  1999cited by this paper
• Basic fibroblast growth factor is expressed by CD19/CD11c-positive cells in hairy cell leukemia.

  1999cited by this paper
• Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat.

  1999cited by this paper
• The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.

  1999cited by this paper
• An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response.

  1999cited by this paper
• Thrombospondin-1 is a major activator of TGF-beta1 in vivo.

  1998cited by this paper
• Adenovector-mediated expression of human thrombopoietin cDNA in immune-compromised mice: insights into the pathophysiology of osteomyelofibrosis.

  1998cited by this paper
• Transforming growth factor-β gene expression in normal and fibrotic rat liver

  1997cited by this paper
• Elevated levels of basic fibroblast growth factor in megakaryocytes and platelets from patients with idiopathic myelofibrosis

  1997cited by this paper
• Idiopathic myelofibrosis: pathogenesis, natural history and management.

  1997cited by this paper
• Tissue inhibitors of metalloproteinases in liver fibrosis.

  1997cited by this paper
• High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice.

  1997cited by this paper
• Transforming growth factor-beta gene expression in normal and fibrotic rat liver.

  1997cited by this paper
• Investigation of calmodulin and basic fibroblast growth factor (bFGF) in idiopathic myelofibrosis: evidence for a role of extracellular calmodulin in fibroblast proliferation

  1996cited by this paper
• Differential expression of transforming growth factor-beta, basic fibroblast growth factor, and their receptors in CD34+ hematopoietic progenitor cells from patients with myelofibrosis and myeloid metaplasia.

  1996cited by this paper
• CD44 and hyaluronan binding by human myeloid cells.

  1996cited by this paper
• A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation.

  1996cited by this paper
• An algorithm for the grading of activity in chronic hepatitis C

  1996cited by this paper
• TGF-beta and megakaryocytes in the pathogenesis of myelofibrosis in myeloproliferative disorders.

  1995cited by this paper
• Transforming growth factor beta in tissue fibrosis.

  1994cited by this paper
• Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair

  1994cited by this paper
• Transforming growth factor‐β and megakaryocytes in the pathogenesis of idiopathic myelofibrosis

  1994cited by this paper
• Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.

  1994cited by this paper
• Monocyte adhesion in patients with bone marrow fibrosis is required for the production of fibrogenic cytokines. Potential role for interleukin-1 and TGF-beta.

  1994cited by this paper
• Autoregulation by Eicosanoids of Human Kupffer Cell Secretory Products A Study of Interleukin‐1, Interleukin‐6, Tumor Necrosis Factor-α, Transforming Growth Factor-β, and Nitric Oxide

  1994cited by this paper
• Increased Release of Platelet-Derived Growth Factor from Platelets in Chronic Liver Disease

  1994cited by this paper
• Increased release of platelet-derived growth factor from platelets in chronic liver disease

  1994influential reference
• Reduced responsiveness of bone marrow megakaryocyte progenitors to platelet‐derived transforming growth factor β1, produced in normal amount, in patients with essential thrombocythaemia

  1993cited by this paper
• Idiopathic myelofibrosis. Clinical aspects and studies on extracellular matrix metabolism.

  1993cited by this paper
• Cellular and molecular aspects of hepatic fibrosis

  1993cited by this paper
• Characterization of an acute micromegakaryocytic leukaemia: evidence for the pathogenesis of myelofibrosis

  1993cited by this paper
• Enhanced hematopoietic growth factor production in an experimental myeloproliferative syndrome.

  1992cited by this paper
• Cytogenetic studies of bone marrow fibroblasts cultured from patients with myelofibrosis and myeloid metaplasia

  1992cited by this paper
• Increased intraplatelet levels of platelet‐derived growth factor and transforming growth factor‐β in patients with myelofibrosis with myeloid metaplasia

  1991cited by this paper
• Retinoic acid and transforming growth factor beta differentially inhibit platelet-derived-growth-factor-induced Ito-cell activation.

  1991cited by this paper
• The production of transforming growth factor-beta in acute megakaryoblastic leukemia and its possible implications in myelofibrosis

  1990cited by this paper
• The production of transforming growth factor-beta in acute megakaryoblastic leukemia and its possible implications in myelofibrosis.

  1990cited by this paper

• Fibrotic Disease: from Signaling Pathways and Biomarkers to Molecular Imaging

  2025cites this paper
• Fibrosis and bone marrow: understanding causation and pathobiology

  2023cites this paper
• New insights into fibrosis from the ECM degradation perspective: the macrophage-MMP-ECM interaction

  2022cites this paper
• Circulating Nestin-GFP+ Cells Participate in the Pathogenesis of Paracoccidioides brasiliensis in the Lungs

  2021cites this paper
• Exosomes Secreted from Amniotic Membrane Contribute to Its Anti-Fibrotic Activity

  2021cites this paper
• Transforming growth factor β‐mediated micromechanics modulates disease progression in primary myelofibrosis

  2020cites this paper
• MicroRNA‐326 attenuates hepatic stellate cell activation and liver fibrosis by inhibiting TLR4 signaling

  2020cites this paper
• Valeriana jatamansi: An herbaceous plant with multiple medicinal uses

  2019cites this paper
• Long-Term Evaluation of Imatinib´s Effect on Bone Marrow Fibrosis in Patients with Chronic Myeloid Leukemia

  2019cites this paper
• Distinguishing autoimmune myelofibrosis from primary myelofibrosis.

  2018cites this paper
• Long-term effects of ruxolitinib versus best available therapy on bone marrow fibrosis in patients with myelofibrosis

  2018cites this paper
• Hematopoietic Cell Transplants: Concepts, Controversies, and Future Directions

  2017cites this paper
• The role of the extracellular matrix in primary myelofibrosis

  2017cites this paper
• Identity of Gli 1 + cells in the bone marrow Running title : Gli 1 + cells in the bone marrow

  2017cites this paper
• Identity of Gli1+ cells in the bone marrow.

  2017cites this paper
• Lessons learned from bone marrow failure in systemic lupus erythematosus: Case reports and review of the literature.

  2017cites this paper
• Bone marrow fibrosis with fibrocytic and immunoregulatory responses induced by β-catenin activation in osteoprogenitors.

  2016cites this paper
• Overcoming treatment challenges in myelofibrosis and polycythemia vera: the role of ruxolitinib

  2016cites this paper
• Growth differentiation factor 15 contributes to cancer-associated fibroblasts-mediated chemo-protection of AML cells

  2016cites this paper
• Increased Expression of TGF-β1 in Correlation with Liver Fibrosis during Echinococcus granulosus Infection in Mice

  2016cites this paper
• The diagnosis and management of the haematologic manifestations of lupus.

  2016cites this paper
• PDGFB hypomethylation is a favourable prognostic biomarker in primary myelofibrosis.

  2015cites this paper
• Managing Patients With Myelofibrosis in the Era of Janus Kinase Inhibitors

  2015cites this paper
• Current Challenges in Stem Cell Transplantation in Myelofibrosis

  2015cites this paper
• Assessment of Liver and Spleen Stiffness in Patients With Myelofibrosis Using FibroScan and Shear Wave Elastography

  2015cites this paper
• Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis

  2015cites this paper
• Cytokine Regulation of Microenvironmental Cells in Myeloproliferative Neoplasms

  2015cites this paper
• Bone marrow mononuclear cell transplantation improves mitochondrial bioenergetics in the liver of cholestatic rats.

  2015cites this paper
• Impact of bone marrow pathology on the clinical management of Philadelphia chromosome-negative myeloproliferative neoplasms.

  2015cites this paper
• Improvement of bone marrow fibrosis with ruxolitinib: will this finding change our perception of the drug?

  2015cites this paper
• Anti-fibrotic effects of the Masson pine pollen aqueous extract on hepatic fibrosis rat model.

  2015cites this paper
• Abnormal erythropoiesis and the pathophysiology of chronic anemia.

  2014cites this paper
• The Hepatocyte Growth Factor (HGF)/Met Axis: A Neglected Target in the Treatment of Chronic Myeloproliferative Neoplasms?

  2014cites this paper
• Bone marrow fibrosis as a feature of systemic lupus erythematosus: a case report and literature review

  2014cites this paper
• Myelofibrosis-associated complications: pathogenesis, clinical manifestations, and effects on outcomes

  2014cites this paper
• An Immune Dysregulation in MPN

  2014cites this paper
• Dynamic of bone marrow fibrosis regression predicts survival after allogeneic stem cell transplantation for myelofibrosis.

  2014cites this paper
• Antioxidant, anti-inflammatory and hepatoprotective effects of silymarin on hepatic dysfunction induced by sodium nitrite.

  2013cites this paper
• Модель миелофиброза in vitro с использованием тромболизата человека

  2013cites this paper
• Mesenchymal stem cells: A revolution in therapeutic strategies of age-related diseases

  2013cites this paper
• Emerging drugs for myelofibrosis

  2012cites this paper
• Primary myelofibrosis and the "bad seeds in bad soil" concept

  2012cites this paper
• Trends in Alcoholic Liver Disease Research – Clinical and Scientific Aspects

  2012cites this paper
• Primary myelofibrosis and the "bad seeds in bad soil" concept

  2012cites this paper
• Oxidases and reactive oxygen species during hematopoiesis: A focus on megakaryocytes

  2012cites this paper
• Inflammation and Pulmonary Fibrosis

  2012cites this paper
• Endothelial Markers and Fibrosis in Alcoholic Hepatitis

  2012cites this paper
• Bone marrow fibrosis in myeloproliferative neoplasms-associated myelofibrosis: deconstructing a myth?

  2011cites this paper
• Contributions to the study of morphofunctional interrelations in the liver of the rats treated with certain antipsychotic drugs.

  2011cites this paper
• Fabrication of Biocompatible Microstructures to Support Tissue Regeneration

  2011cites this paper
• CHAPTER 23 – Essential thrombocythemia and primary myelofibrosis

  2011cites this paper
• The role of zinc protoporphyrin measurement in the differentiation between primary myelofibrosis and essential thrombocythaemia

  2011cites this paper
• Evaluation of the bioactive and total transforming growth factor β1 levels in primary myelofibrosis.

  2011cites this paper
• Altered production of extra-cellular matrix components by muscle-derived Duchenne muscular dystrophy fibroblasts before and after TGF-β1 treatment

  2010cites this paper
• Valeriana jatamansi partially reverses liver cirrhosis and tissue hyperproliferative response in rat.

  2010cites this paper
• Microtopographical Cues in 3D Attenuate Fibrotic Phenotype and Extracellular Matrix Deposition: Implications for Tissue Regeneration

  2010cites this paper
• Lymph node involution, T-cell adaptation and T-cell death in HIV infection.

  2010cites this paper
• Thrombocytopenia in myelodysplastic syndromes and myelofibrosis.

  2009cites this paper