Current concepts in assessment of microvascular endothelial function using laser Doppler imaging and iontophoresis.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Trends in cardiovascular medicine

• Publication date

  2008-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.tcm.2008.02.001PMID 18555183
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Reproducibility and Repeatability of Peripheral Microvascular Assessment Using Iontophoresis in Conjunction With Laser Doppler Imaging

  2007cited by this paper
• Inflammatory suppression rapidly attenuates microvascular dysfunction in rheumatoid arthritis.

  2007cited by this paper
• Differences in arterial compliance, microvascular function and venous capacitance between patients with heart failure and either preserved or reduced left ventricular systolic function

  2007cited by this paper
• Maximum Skin Hyperaemia Induced by Local Heating: Possible Mechanisms

  2006cited by this paper
• Methodological issues in the assessment of skin microvascular endothelial function in humans.

  2006influential reference
• Effects of metformin on microvascular function and exercise tolerance in women with angina and normal coronary arteries: a randomized, double-blind, placebo-controlled study.

  2006cited by this paper
• Abstracts of the 56th Meeting of the British Microcirculation Society 10 and 11 April 2006, West Park Conference Centre, Dundee, UK

  2006cited by this paper
• Endothelial dysfunction: a comprehensive appraisal

  2006cited by this paper
• Mechanisms of acetylcholine‐mediated vasodilatation in young and aged human skin

  2005influential reference
• Relationship Between Carotid Artery Stiffness and Retinal Arteriolar Narrowing in Healthy Middle-Aged Persons

  2004cited by this paper
• Non‐invasive assessment of endothelial function – relation between vasodilatory responses in skin microcirculation and brachial artery

  2004cited by this paper
• Prevention and Reversal of Premature Endothelial Cell Senescence and Vasculopathy in Obesity-Induced Diabetes by Ebselen

  2004influential reference
• Influence of vehicle resistance on transdermal iontophoretic delivery of acetylcholine and sodium nitroprusside in humans.

  2004cited by this paper
• Nitric oxide synthase-inhibition hypertension is associated with altered endothelial cyclooxygenase function.

  2004cited by this paper
• Non-invasive assessment of microvascular endothelial function by laser Doppler flowmetry in patients with essential hypertension.

  2004cited by this paper
• Reduced arterial elasticity is associated with endothelial dysfunction in persons of advancing age: comparative study of noninvasive pulse wave analysis and laser Doppler blood flow measurement.

  2004cited by this paper
• Endothelial Dysfunction: A Marker of Atherosclerotic Risk

  2003influential reference
• Enhancement of endothelial function by pregnancy: inadequate response in women with type 1 diabetes.

  2003cited by this paper
• Impaired Microvascular Function in Normal Children: Effects of Adiposity and Poor Glucose Handling

  2003cited by this paper
• Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin

  2003influential reference
• Vasodilatation in response to repeated anodal current application in the human skin relies on aspirin‐sensitive mechanisms

  2002cited by this paper
• Elimination of Electrically Induced Iontophoretic Artefacts: Implications for Non-Invasive Assessment of Peripheral Microvascular Function

  2002influential reference
• Current-Induced Vasodilation during Water Iontophoresis (5 min, 0.10 mA) Is Delayed from Current Onset and Involves Aspirin Sensitive Mechanisms

  2002cited by this paper
• Circadian variation in vascular tone and endothelial cell function in normal males.

  2002cited by this paper
• Factors Critical to Iontophoretic Assessment of Vascular Reactivity: Implications for Clinical Studies of Endothelial Dysfunction

  2002influential reference
• The effect of aspirin and various iontophoresis solution vehicles on skin microvascular reactivity.

  2002cited by this paper
• Nitric oxide and neurally mediated regulation of skin blood flow during local heating.

  2001cited by this paper
• Impaired skin microvascular function in children, adolescents, and young adults with type 1 diabetes.

  2000cited by this paper
• Reproducibility of laser Doppler imaging of skin blood flow as a tool to assess endothelial function.

  2000influential reference
• Impact of estradiol blood concentrations on skin capillary Laser Doppler flow in premenopausal women.

  2000cited by this paper
• The biological zero signal in laser doppler fluximetry – origins and practical implications

  1999cited by this paper
• Role of nitric oxide in the vascular effects of local warming of the skin in humans.

  1999cited by this paper
• Microvascular function relates to insulin sensitivity and blood pressure in normal subjects.

  1999cited by this paper
• Nonspecific microvascular vasodilation during iontophoresis is attenuated by application of hyperosmolar saline.

  1999influential reference
• A mathematical analysis on the biological zero problem in laser Doppler flowmetry

  1998cited by this paper
• Influence of puberty on endothelial dysfunction and oxidative stress in young patients with type 1 diabetes.

  1998cited by this paper
• Exercise capacity in heart transplant recipients: relation to impaired endothelium-dependent vasodilation of the peripheral microcirculation.

  1998cited by this paper
• Increased large arterial stiffness and impaired acetylcholine induced skin vasodilatation in women with previous gestational diabetes mellitus

  1998cited by this paper
• Studies with iontophoretic administration of drugs to human dermal vessels in vivo: cholinergic vasodilatation is mediated by dilator prostanoids rather than nitric oxide.

  1998influential reference
• Cutaneous Vascular Responses to Acetylcholine are Mediated by a Prostanoid-Dependent Mechanism in Man

  1997cited by this paper
• Reduced skin hyperemia during tap water iontophoresis after intake of acetylsalicylic acid.

  1997cited by this paper
• Skin blood flow responses to the iontophoresis of acetylcholine and sodium nitroprusside in man: possible mechanisms.

  1996influential reference
• Responses of the skin microcirculation to acetylcholine and sodium nitroprusside in subjects with fasting hyperglycaemia

  1996influential reference
• Advantages and Limitations of One-Point Laser Doppler Perfusion Monitoring in Clinical Practice

  1995cited by this paper
• Responses of the skin microcirculation to acetylcholine and sodium nitroprusside in patients with NIDDM

  1995cited by this paper
• Influence of age and gender on skin vessel reactivity to endothelium-dependent and endothelium-independent vasodilators tested with iontophoresis and a laser Doppler perfusion imager.

  1995cited by this paper
• Close relation of endothelial function in the human coronary and peripheral circulations.

  1995cited by this paper
• The effect of iontophoresis on the cutaneous vasculature: evidence for current-induced hyperemia.

  1995cited by this paper
• Therapy-resistant hypertension associated with central obesity, insulin resistance, and large muscle fibre area.

  1993cited by this paper
• Topographic mapping of the cutaneous microcirculation using two outputs of laser-Doppler flowmetry: flux and the concentration of moving blood cells.

  1992cited by this paper
• Changes in skin blood flow during the menstrual cycle: the influence of the menstrual cycle on the peripheral circulation in healthy female volunteers.

  1990cited by this paper
• Iontophoretic delivery of drugs: Fundamentals, developments and biomedical applications

  1988cited by this paper
• Spatial and temporal variations in human skin blood flow.

  1983cited by this paper
• Attenuation of the microcirculation in young patients with high-output borderline hypertension.

  1983cited by this paper

• Impact of anthocyanin-rich black rice consumption on cognitive function, inflammation and microvascular function in older adults: a crossover intervention trial.

  2026cites this paper
• Ring-segment piezopolymer sensor optimized for cylindrical-wave detection in optical-resolution optoacoustic angiography with extended imaging depth

  2025cites this paper
• The association between cutaneous microvascular dysfunction and pulmonary artery hemodynamics in heart transplant candidates.

  2025cites this paper
• Far infrared therapy improves vascular function by enhancing endothelial function and decreasing arterial stiffness via cytoprotective pathways.

  2025cites this paper
• Endothelial dysfunction in chronic kidney disease: Mechanisms, biomarkers, diagnostics, and therapeutic strategies

  2025cites this paper
• Current methods for microvascular blood flow research

  2025cites this paper
• The impact of skin color and tone on histamine iontophoresis and Doppler flowmetry measurements as a pharmacodynamic biomarker

  2024cites this paper
• The Main Diseases Related to Type 2 Diabetes Mellitus: A Scoping Review

  2024cites this paper
• The Effect of Overweight/Obesity on Cutaneous Microvascular Reactivity as Measured by Laser-Doppler Fluxmetry: A Systematic Review

  2024cites this paper
• Concentration-dependent microvascular responses to repeated iontophoresis of acetylcholine.

  2024cites this paper
• Extracorporeal shockwave therapy compared with standard care for diabetic foot ulcer healing: An updated systematic review

  2022cites this paper
• Comparison of laser speckle contrast imaging with laser Doppler perfusion imaging for tissue perfusion measurement

  2022cites this paper
• Effects of Normal Reference Range of Phosphorus and Corresponding PTH on Endothelial Function in CKD Patients

  2022cites this paper
• Ultrasound monitoring of microcirculation: An original study from the laboratory bench to the clinic

  2022cites this paper
• The effects of whey proteins, their peptides and amino acids on vascular function.

  2022cites this paper
• Skin Microhemodynamics and Mechanisms of Its Regulation in Type 2 Diabetes Mellitus

  2022cites this paper
• Effects of the Treatment with Flavonoids on Metabolic Syndrome Components in Humans: A Systematic Review Focusing on Mechanisms of Action

  2022cites this paper
• Long-term assessment of systemic microcirculatory function and plasma cytokines after coronavirus disease 2019 (COVID-19)

  2022cites this paper
• Effects of eight weeks exercise training on serum levels of adropin in male volleyball players

  2021cites this paper
• Human microvascular reactivity: a review of vasomodulating stimuli and non-invasive imaging assessment

  2021cites this paper
• Tuberculoid leprosy: An in vivo microvascular evaluation of cutaneous lesions

  2020cites this paper
• Weight change and sulfonylurea therapy are related to 3 year change in microvascular function in people with type 2 diabetes

  2020cites this paper
• Laser Doppler Imaging

  2020cites this paper
• Endothelial Function

  2020cites this paper
• Increased blood pressure and impaired endothelial function after accelerated growth in IVF/ICSI children

  2020cites this paper
• Skin microvascular reactivity correlates to clinical microangiopathy in type 1 diabetes: A pilot study

  2020cites this paper
• Assessment of macro and microvascular function in aging males.

  2020cites this paper
• Systemic microvascular endothelial dysfunction and disease severity in COVID-19 patients: Evaluation by laser Doppler perfusion monitoring and cytokine/chemokine analysis

  2020cites this paper
• Citrus Flavonoids in Preventing Cardiovascular Diseases

  2020cites this paper
• In-vivo correlations between skin metabolic oscillations and vasomotion in wild-type mice and in a model of oxidative stress

  2019cites this paper
• Assessment of the Microcirculation in the Neonate

  2019cites this paper
• IVF culture medium and long-term child development

  2019cites this paper
• Advances in cardiovascular imaging

  2019cites this paper
• Interactions between the endothelial mediator’s nitric oxide and prostacyclin, and platelet P2Y12 receptor blockade

  2019influential citation
• A pilot study on the kinetics of metabolites and microvascular cutaneous effects of nitric oxide inhalation in healthy volunteers

  2019cites this paper
• The Effects of Beetroot Juice on Blood Pressure, Microvascular Function and Large-Vessel Endothelial Function: A Randomized, Double-Blind, Placebo-Controlled Pilot Study in Healthy Older Adults

  2019cites this paper
• Altered blood rheology and impaired pressure-induced cutaneous vasodilation in a mouse model of combined type 2 diabetes and sickle cell trait.

  2019cites this paper
• Dysfonction endothéliale au niveau de différents territoires vasculaires en cas de polyarthrite rhumatoïde : physiopathologie et perspectives thérapeutiques

  2019cites this paper
• Methodological Considerations for a Vascular Function Test Battery

  2019cites this paper
• Endothelial Function

  2019cites this paper
• Differences in laser-Doppler indices between skin-surface measurement sites in subjects with diabetes.

  2018cites this paper
• Application of cmOCT and continuous wavelet transform analysis to the assessment of skin microcirculation dynamics

  2018cites this paper
• Association of culture medium with growth, weight and cardiovascular development of IVF children at the age of 9 years

  2018cites this paper
• Role of microcirculatory function and plasma biomarkers in determining the development of cardiovascular adverse events in patients with peripheral arterial disease: A 5-year follow-up

  2018cites this paper
• Chapter 3 Hemodynamic Monitoring in Neonates

  2018cites this paper
• The Markers of Endothelial Activation

  2018cites this paper
• Measures of vascular dysfunction, monocyte subsets and circulating microparticles in patients with diffuse coronary artery disease

  2018influential citation
• Microvascular endothelial function is an independent predictor for albuminuria progression among Asians with type 2 diabetes—A prospective cohort study

  2018cites this paper
• In-vivo assessment of microvascular functional dynamics by combination of cmOCT and wavelet transform

  2018cites this paper
• Effects of insulin analogs as an add-on to metformin on cutaneous microcirculation in type 2 diabetic patients.

  2018cites this paper
• Approaches to improve the predictive value of laser Doppler flowmetry in detection of microcirculation disorders in diabetes mellitus

  2018cites this paper
• Impacts of whole grain oats intake on blood pressure and vascular function : the role of phenolic acids on the renin angiotensin system

  2018cites this paper
• Etiopathology of Type 1 Diabetes: Focus on the Vascular Endothelium

  2018cites this paper
• Structural and functional changes in the microcirculation of lepromatous leprosy patients - Observation using orthogonal polarization spectral imaging and laser Doppler flowmetry iontophoresis

  2017cites this paper
• Marked regional endothelial dysfunction in mottled skin area in patients with severe infections

  2017cites this paper
• The association between diabetes and dermal microvascular dysfunction non-invasively assessed by laser Doppler with local thermal hyperemia: a systematic review with meta-analysis

  2017cites this paper
• Venous gas emboli are involved in post-dive macro, but not microvascular dysfunction

  2017cites this paper
• Cutaneous microvascular reactivity and aortic elasticity in coronary artery disease: Comparison of the laser Doppler flowmetry and echocardiography.

  2017cites this paper
• The Relationship between Low Levels of Urinary Albumin Excretion and Microvascular Function

  2017cites this paper
• The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control

  2017cites this paper
• Ageing, inorganic nitrate and vitamin C : effects on markers of cardiovascular risk

  2017influential citation
• Effects of supervised exercise training on lower-limb cutaneous microvascular reactivity in adults with venous ulcers

  2017cites this paper
• Hemodynamic Monitoring in Neonates

  2017cites this paper
• Prospects of Laser Doppler flowmetry application in assessment of skin microcirculation in diabetes

  2017cites this paper
• A Study of Cardiac Function, Atherosclerosis, and Arrhythmogenicity

  2017cites this paper
• Inflammation-induced microvascular dysfunction in obesity – A translational approach

  2016cites this paper
• Does intermittent fasting improve microvascular endothelial function in healthy middle-aged subjects?

  2016cites this paper
• Effects of volume resuscitation on the microcirculation in animal models of lipopolysaccharide sepsis: a systematic review

  2016cites this paper
• Does third generation left ventricular assist device alter heart failure-related microvascular dysfunction?

  2016cites this paper
• L-arginine as dietary supplement for improving microvascular function

  2016cites this paper
• Effects of Montmorency tart cherry (Prunus Cerasus L.) consumption on vascular function in men with early hypertension.

  2016influential citation
• The Place of Nailfold Capillaroscopy Among Instrumental Methods for Assessment of Some Peripheral Ischaemic Syndromes in Rheumatology

  2016cites this paper
• The significance of micro- and macrovascular biomarkers on cardiovascular outcome in chronic kidney disease: a prospective cohort study

  2016cites this paper
• Simultaneous, non-invasive measurements of skin blood flow and oxygenation in healthy humans

  2016cites this paper
• Endothelial dysfunction in human essential hypertension.

  2016cites this paper
• Contribución a la comprensión de la microcirculación periférica y a su regulación a través de los componentes oscilatórios de flujo medido por láser doppler

  2016cites this paper
• Assessment of microvascular and metabolic responses in the skin

  2016cites this paper
• Growth and endothelial function in the first 2 years of life.

  2015cites this paper
• Retinal Vessel Tortuosity and Its Relation to Traditional and Novel Vascular Risk Markers in Persons with Diabetes

  2015cites this paper
• Skin microvascular endothelial function as a biomarker in cardiovascular diseases?

  2015cites this paper
• Does obstructive sleep apnea cause endothelial dysfunction? A critical review of the literature.

  2015cites this paper
• Determining whether plasma levels of KATP channels are related to vascular function

  2015cites this paper
• The evaluation of penile microvascular endothelial function using laser speckle contrast imaging in healthy volunteers.

  2015cites this paper
• Effects of functional olive oil enriched with its own phenolic compounds on endothelial function in hypertensive patients. A randomised controlled trial.

  2015cites this paper
• Dysfonction endothéliale et polyarthrite rhumatoïde : cinétique, mécanismes et traitements. Etude chez le rat

  2015cites this paper
• Assessing endothelial dysfunction in adolescents and young adults with type 1 diabetes mellitus using a non‐invasive heat stimulus

  2015cites this paper
• Prostanoids are not involved in postocclusive reactive hyperaemia in human skin

  2015cites this paper
• Association Between Arterial Stiffness and Skin Microvascular Function: The SUVIMAX2 Study and The Maastricht Study.

  2015cites this paper
• Association Between Arterial Stiffness and Skin Microvascular Function: The SUVIMAX2 Study and The

  2015cites this paper
• The use of the laser-Doppler method in surgery.

  2015cites this paper
• TREPROSTINIL IONTOPHORESIS IN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION by ADRIANO

  2015cites this paper
• Endothelial-derived hyperpolarization contributes to acetylcholine-mediated vasodilation in human skin in a dose-dependent manner.

  2015cites this paper
• Hudblodflödesmätning vid uppvärmningsprovokation med laser Doppler flowmetry teknik

  2015cites this paper
• Marcadores de aterosclerose subclínica no diabetes

  2015cites this paper
• Holographic laser Doppler imaging of microvascular blood flow.

  2014cites this paper
• Trials and tribulations of skin iontophoresis in therapeutics

  2014cites this paper
• Cardiac autonomic neuropathy in patients with diabetes mellitus.

  2014cites this paper
• Relative indexes of cutaneous blood perfusion measured by real-time laser Doppler imaging (LDI) in healthy volunteers.

  2014cites this paper
• Microvascular imaging: techniques and opportunities for clinical physiological measurements

  2014cites this paper
• The relationship between cardiovascular disease risk prediction scores and vascular function and morphology in rheumatoid arthritis.

  2014cites this paper