ER stress-induced cell death mechanisms.

The endoplasmic-reticulum (ER) stress response constitutes a cellular process that is triggered by a variety of conditions that disturb folding of proteins in the ER. Eukaryotic cells have developed an evolutionarily conserved adaptive mechanism, the unfolded protein response (UPR), which aims to clear unfolded proteins and restore ER homeostasis. In cases where ER stress cannot be reversed, cellular functions deteriorate, often leading to cell death. Accumulating evidence implicates ER stress-induced cellular dysfunction and cell death as major contributors to many diseases, making modulators of ER stress pathways potentially attractive targets for therapeutics discovery. Here, we summarize recent advances in understanding the diversity of molecular mechanisms that govern ER stress signaling in health and disease. This article is part of a Special Section entitled: Cell Death Pathways.

• Publication year

  2013

• Venue

  Biochimica et Biophysica Acta

• Publication date

  2013-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bbamcr.2013.06.028PMID 23850759PMCID PMC3834229
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• ER stress-induced cellular dysfunction and cell death are highlighted as major contributors to many diseases, supporting ER stress pathways as therapeutic targets for therapeutics discovery.

  Confidence 0.90

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• Persistent endoplasmic reticulum stress can cause cellular functions to deteriorate and ultimately lead to cell death.

  Confidence 0.95

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• Endoplasmic reticulum stress activates the unfolded protein response to clear unfolded proteins and restore ER homeostasis.

  Confidence 0.92

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewAK (4715169a40) review

• cell death

  outcome

  The loss of cellular viability that can follow unresolved endoplasmic reticulum stress.

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• endoplasmic reticulum stress

  cellular process

  A stress condition in which protein folding in the endoplasmic reticulum is disturbed.

  Aliases: ER stress

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• er homeostasis

  cellular state

  The balanced endoplasmic-reticulum state that supports proper protein folding and cell function.

  Aliases: endoplasmic reticulum homeostasis

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• er stress-induced cellular dysfunction

  pathological process

  Impaired cell function associated with sustained endoplasmic reticulum stress.

  Aliases: endoplasmic-reticulum stress-induced cellular dysfunction

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• er stress pathways

  signaling pathway

  The molecular signaling routes that transmit and regulate endoplasmic-reticulum stress responses.

  Aliases: ER stress signaling pathways

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• therapeutics discovery

  research process

  The process of identifying candidate therapeutic targets or interventions.

  Aliases: drug discovery

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• unfolded protein response

  cellular response

  An evolutionarily conserved adaptive signaling program that responds to unfolded proteins in the endoplasmic reticulum.

  Aliases: UPR

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewAK (4715169a40) review

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