TRP functions in the broncho-pulmonary system

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Seminars in Immunopathology

• Publication date

  2016-04-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00281-016-0557-1PMID 27083925
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury.

  2016influential reference
• Structure of the TRPA1 ion channel suggests regulatory mechanisms

  2015cited by this paper
• Prenatal nicotinic exposure augments cardiorespiratory responses to activation of bronchopulmonary C-fibers.

  2015cited by this paper
• Lung Epithelial TRPA1 Transduces the Extracellular ROS into Transcriptional Regulation of Lung Inflammation Induced by Cigarette Smoke: The Role of Influxed Ca2+

  2015cited by this paper
• Transient Receptor Potential A1 Activation Prolongs Isoflurane Induction Latency and Impairs Respiratory Function in Mice

  2015cited by this paper
• TRPA1 mediates the effects of hypothermia on the monocyte inflammatory response.

  2015cited by this paper
• TRPV4 Is Required for Hypoxic Pulmonary Vasoconstriction

  2015cited by this paper
• Hydrogen peroxide-induced calcium influx in lung microvascular endothelial cells involves TRPV4.

  2015cited by this paper
• The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives

  2015cited by this paper
• What is the evidence for the role of TRP channels in inflammatory and immune cells?

  2015cited by this paper
• Lung Epithelial TRPA 1 Transduces the Extracellular ROS into Transcriptional Regulation of Lung Inflammation Induced by Cigarette Smoke : The Role of Influxed Ca 2 +

  2015cited by this paper
• Structure of the TRPA1 ion channel suggests regulatory mechanisms

  2015cited by this paper
• Capsaicin and sensory neurones: a historical perspective.

  2014cited by this paper
• Transient Receptor Potential Vanilloid 4 Activation Constricts the Human Bronchus via the Release of Cysteinyl Leukotrienes

  2014cited by this paper
• TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice.

  2014influential reference
• Transient receptor potential (TRP) channels in the airway: role in airway disease

  2014influential reference
• TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury.

  2014cited by this paper
• The TRPV4 channel.

  2014cited by this paper
• Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways

  2014influential reference
• TRPV4‐Mediated Calcium Influx and Ciliary Activity in Human Native Airway Epithelial Cells

  2014cited by this paper
• Transient receptor potential channels and occupational exposure

  2014cited by this paper
• Sensitization by Pulmonary Reactive Oxygen Species of Rat Vagal Lung C-Fibers: The Roles of the TRPV1, TRPA1, and P2X Receptors

  2014cited by this paper
• The TRPA1 channel in migraine mechanism and treatment

  2014cited by this paper
• De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease.

  2014cited by this paper
• Antagonism of substance P and perception of breathlessness in patients with chronic obstructive pulmonary disease.

  2014cited by this paper
• The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells

  2014cited by this paper
• Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in patients with severe asthma.

  2014influential reference
• Hydrogen sulfide induces hypersensitivity of rat capsaicin-sensitive lung vagal neurons: role of TRPA1 receptors.

  2013cited by this paper
• The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis

  2013cited by this paper
• TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension.

  2013cited by this paper
• Structure of the TRPV1 ion channel determined by electron cryo-microscopy

  2013cited by this paper
• Stimulation of the chemosensory TRPA1 cation channel by volatile toxic substances promotes cell survival of small cell lung cancer cells.

  2013cited by this paper
• Activation of transient receptor potential ankyrin-1 (TRPA1) in lung cells by wood smoke particulate material.

  2013cited by this paper
• Novel therapeutic strategy to prevent chemotherapy-induced persistent sensory neuropathy by TRPA1 blockade.

  2013cited by this paper
• TRP channels and pain.

  2013cited by this paper
• Transient Receptor Potential Channels

  2013cited by this paper
• Hypersensitivity of lung vagal C fibers induced by acute intermittent hypoxia in rats: role of reactive oxygen species and TRPA1

  2012cited by this paper
• Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin

  2012cited by this paper
• TRPV1 induction in airway vagal low-threshold mechanosensory neurons by allergen challenge and neurotrophic factors.

  2012cited by this paper
• An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

  2012cited by this paper
• Transient receptor potential genes, smoking, occupational exposures and cough in adults

  2012cited by this paper
• Transient Receptor Potential Ankyrin 1 Channel Localized to Non-Neuronal Airway Cells Promotes Non-Neurogenic Inflammation

  2012cited by this paper
• Expression of transient receptor potential ankyrin 1 in human dental pulp.

  2012cited by this paper
• Calcium Signaling

  2012cited by this paper
• Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation

  2011cited by this paper
• Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells

  2011influential reference
• Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT‐102 in a randomized healthy volunteer trial

  2011cited by this paper
• American Thoracic Society Documents An Official ATS / ERS / JRS / ALAT Statement : Idiopathic Pulmonary Fibrosis : Evidence-based Guidelines for Diagnosis and Management

  2011cited by this paper
• Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain

  2011cited by this paper
• Pungent General Anesthetics Activate Transient Receptor Potential-A1 to Produce Hyperalgesia and Neurogenic Bronchoconstriction

  2010cited by this paper
• TRPA1 acts as a cold sensor in vitro and in vivo

  2009cited by this paper
• A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

  2009influential reference
• TRP channels and pain.

  2009cited by this paper
• Transient receptor potential ankyrin receptor 1 is a novel target for pro‐tussive agents

  2009cited by this paper
• TRPV1 and TRPA1 Mediate Peripheral Nitric Oxide-Induced Nociception in Mice

  2009cited by this paper
• TRPA1 is a major oxidant sensor in murine airway sensory neurons.

  2008cited by this paper
• Negative-Feedback Loop Attenuates Hydrostatic Lung Edema via a cGMP-Dependent Regulation of Transient Receptor Potential Vanilloid 4

  2008cited by this paper
• General anesthetics activate a nociceptive ion channel to enhance pain and inflammation

  2008cited by this paper
• Effect of Tiotropium on Cough Reflex Sensitivity in Acute Viral Cough

  2008cited by this paper
• A primer on ankyrin repeat function in TRP channels and beyond.

  2008cited by this paper
• Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.

  2008cited by this paper
• Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines

  2008cited by this paper
• Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons

  2008influential reference
• The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions*

  2008cited by this paper
• TRP channel and cardiovascular disease.

  2008cited by this paper
• Activation of transient receptor potential ankyrin 1 by hydrogen peroxide

  2008cited by this paper
• Transient receptor potential (TRP) cation channels: rewarding unique proteins.

  2007cited by this paper
• TRPA1 mediates formalin-induced pain

  2007cited by this paper
• Transient receptor potential A1 mediates acetaldehyde‐evoked pain sensation

  2007cited by this paper
• TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs.

  2007cited by this paper
• An Ion Channel Essential for Sensing Chemical Damage

  2007cited by this paper
• The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

  2007influential reference
• Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs.

  2006cited by this paper
• TRP channel activation by reversible covalent modification

  2006cited by this paper
• TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.

  2006cited by this paper
• Regulation of TRP Channels by Phosphorylation

  2006cited by this paper
• Pungent products from garlic activate the sensory ion channel TRPA1.

  2005cited by this paper
• Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins

  2005cited by this paper
• TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells.

  2004cited by this paper
• Functional TRPV4 channels are expressed in human airway smooth muscle cells.

  2004influential reference
• Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

  2004cited by this paper
• Protease-Activated Receptor 2 Sensitizes the Capsaicin Receptor Transient Receptor Potential Vanilloid Receptor 1 to Induce Hyperalgesia

  2004cited by this paper
• Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin.

  2004cited by this paper
• Disorders of lung matrix remodeling.

  2004cited by this paper
• ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.

  2003influential reference
• International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels: Transient Receptor Potential Channels

  2003cited by this paper
• Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4

  2003cited by this paper
• Transforming growth factor beta stimulates fibroblast-collagen matrix contraction by different mechanisms in mechanically loaded and unloaded matrices.

  2002cited by this paper
• Heat-Evoked Activation of the Ion Channel, TRPV4

  2002cited by this paper
• The NK‐2 receptor antagonist SR 48968C does not improve adenosine hyperresponsiveness and airway obstruction in allergic asthma

  2001cited by this paper
• Tachykinin receptor antagonists: potential in airways diseases.

  2001cited by this paper
• Vanilloid (Capsaicin) receptors and mechanisms.

  1999cited by this paper
• An Ankyrin-like Protein with Transmembrane Domains Is Specifically Lost after Oncogenic Transformation of Human Fibroblasts*

  1999cited by this paper
• The cloned capsaicin receptor integrates multiple pain-producing stimuli.

  1998cited by this paper
• Tachykinin and kinin receptor antagonists: therapeutic perspectives in allergic airway disease.

  1996cited by this paper
• A neurokinin 1-receptor antagonist improves exercise-induced airway narrowing in asthmatic patients.

  1996cited by this paper
• Calcium signaling.

  1995cited by this paper
• Effect of an NK1 receptor antagonist (CP-99,994) on hypertonic saline-induced bronchoconstriction and cough in male asthmatic subjects.

  1995cited by this paper
• Effects of changes in osmolarity on isolated human airways.

  1990cited by this paper
• Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction.

  1989cited by this paper

• TRPA1 mediates ozone-induced murine model of COPD through the Wnt5a/GSK-3β/β-catenin pathway.

  2026cites this paper
• 5-HT promotes bronchopulmonary dysplasia via TGM2-mediated serotonylation

  2025cites this paper
• FUNCTIONAL INTERPLAY BETWEEN BRADYKININ RECEPTORS AND TRANSIENT RECEPTOR POTENTIAL VANILLOID-1 IN LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INJURY IN MICE.

  2025cites this paper
• Modulating TRPV1 and TRPA1 channels: a viable strategy for treating asthma using Chinese herbal medicines

  2025cites this paper
• The efficacy of ophiopogonanone B in treating the cough in mice infected with Mycoplasma pneumoniae

  2025cites this paper
• Exploring the Anti-Inflammatory Effect of Tryptanthrin by Regulating TLR4/MyD88/ROS/NF-κB, JAK/STAT3, and Keap1/Nrf2 Signaling Pathways

  2024cites this paper
• Ion Channels in the Immune Response of Asthma

  2024cites this paper
• Application of automated machine learning in the identification of multi‐target‐directed ligands blocking PDE4B, PDE8A, and TRPA1 with potential use in the treatment of asthma and COPD

  2023cites this paper
• Ingredients of Vicks VapoRub inhibit rhinovirus-induced ATP release

  2023cites this paper
• A review of the pathophysiology and the role of ion channels on bronchial asthma

  2023cites this paper
• TRPA1: A promising target for pulmonary fibrosis?

  2023cites this paper
• Xingbei antitussive granules ameliorate cough hypersensitivity in post-infectious cough guinea pigs by regulating tryptase/PAR2/TRPV1 pathway.

  2023cites this paper
• Effects of TRPV4 channel blocker on airway inflammation and airway defense reflexes in experimentally induced model of allergic asthma.

  2023cites this paper
• Inflammation—the role of TRPA1 channel

  2023cites this paper
• Effect of Houpo-Mahuang Decoction on aggravated asthma induced by cigarette smoke and the expression of TRPA1 and tight junctions in mice.

  2022cites this paper
• Efficiency of using a short-acting β2-agonist for the relief of acute cold bronchospasm in asthma patients with cold airway hyperresponsiveness

  2022cites this paper
• Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle.

  2022cites this paper
• Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential

  2021cites this paper
• TRP Channels in Airway Sensory Nerves.

  2021cites this paper
• Effects of cigarette smoke on the aggravation of ovalbumin-induced asthma and the expressions of TRPA1 and tight junctions in mice.

  2021cites this paper
• Increased expression of transient receptor potential channels and neurogenic factors associates with cough severity in a guinea pig model

  2021cites this paper
• An initial assessment of the involvement of transglutaminase2 in eosinophilic bronchitis using a disease model developed in C57BL/6 mice

  2021cites this paper
• Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review)

  2021cites this paper
• Thermosensory Transient Receptor Potential Ion Channels and Asthma

  2021cites this paper
• Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets

  2020cites this paper
• Multifunctional TRPV1 Ion Channels in Physiology and Pathology with Focus on the Brain, Vasculature, and Some Visceral Systems

  2019cites this paper
• An overview on transient receptor potential channels superfamily.

  2019cites this paper
• Increased expression of lung TRPV1/TRPA1 in a cough model of bleomycin-induced pulmonary fibrosis in Guinea pigs

  2019cites this paper
• A distinct structural mechanism underlies TRPV1 activation by piperine.

  2019cites this paper
• Identification of molecular targets for toxic action by persulfate, an industrial sulfur compound.

  2019cites this paper
• Loss of barrier integrity in alveolar epithelial cells downregulates ENaC expression and activity via Ca2+ and TRPV4 activation

  2018cites this paper
• Regulation of Pain and Itch by TRP Channels

  2018cites this paper
• Medicinal Chemistry, Pharmacology, and Clinical Implications of TRPV1 Receptor Antagonists

  2017cites this paper
• Transient Receptor Potential Ankyrin 1 Ion Channel Facilitates Acute Inflammation Induced by Surgical Incision in Mice

  2017cites this paper
• Modulation of TRP Channel Activity by Hydroxylation and Its Therapeutic Potential

  2017cites this paper
• The emerging role of transient receptor potential channels in chronic lung disease

  2017cites this paper
• Transient Receptor Potential ( TRP ) Channels and Exercise Associated Muscle Cramping ( EAMC ) : A Tale of Multiple Complexities

  2017cites this paper
• Airway Pathogenesis Is Linked to TRP Channels

  2017cites this paper
• TRP Channels and Pain

  2017cites this paper
• Transient receptor potential channels and exercise‐associated muscle cramping: A tale of multiple complexities

  2017cites this paper
• Activation of Human Transient Receptor Potential Melastatin-8 (TRPM8) by Calcium-Rich Particulate Materials and Effects on Human Lung Cells

  2017cites this paper
• TRPA1: Acrolein meets its target.

  2017cites this paper
• Marine Cyclic Guanidine Alkaloids Monanchomycalin B and Urupocidin A Act as Inhibitors of TRPV1, TRPV2 and TRPV3, but not TRPA1 Receptors

  2017cites this paper
• Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch*

  2016cites this paper