Toward Pathogenesis of Apert Cleft Palate: FGF, FGFR, and TGFβ Genes Are Differentially Expressed in Sequential Stages of Human Palatal Shelf Fusion

No abstract is available for this paper.

• Publication year

  2002

• Venue

  The Cleft Palate-Craniofacial Journal

• Publication date

  2002-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1597/1545-1569_2002_039_0332_tpoacp_2.0.co_2PMID 12019011
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rapid disappearance of the medial epithelial seam during palatal fusion occurs by multifocal breakdown that is preceded by expression of alpha smooth muscle actin in the epithelium.

  2000cited by this paper
• Double tongue, intraoral anomalies, and cleft palate--case reports and a discussion of developmental pathology.

  2000cited by this paper
• Medial edge epithelial cell fate during palatal fusion.

  2000cited by this paper
• An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis.

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• Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

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  1999cited by this paper
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  1999cited by this paper
• Decreased proliferation and altered differentiation in osteoblasts from genetically and clinically distinct craniosynostotic disorders.

  1999cited by this paper
• A rare case of upper airway obstruction in an infant caused by basal encephalocele complicating facial midline deformity

  1999cited by this paper
• Pathogenesis of cleft palate in TGF-beta3 knockout mice.

  1999cited by this paper
• Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand.

  1998cited by this paper
• TGFbeta3 promotes transformation of chicken palate medial edge epithelium to mesenchyme in vitro.

  1998influential reference
• Increased calvaria cell differentiation and bone matrix formation induced by fibroblast growth factor receptor 2 mutations in Apert syndrome.

  1998cited by this paper
• TGF-beta s stimulate cell proliferation via an autocrine production of FGF-2 in corneal stromal fibroblasts.

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Activation of Statl by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism

  1997cited by this paper
• Basic fibroblast growth factor induces apoptosis in myofibroblastic cells isolated from rat palatal mucosa.

  1997cited by this paper
• Transforming growth factor‐β3 regulates transdifferentiation of medial edge epithelium during palatal fusion and associated degradation of the basement membrane

  1997cited by this paper
• Transforming growth factor-beta3 regulates transdifferentiation of medial edge epithelium during palatal fusion and associated degradation of the basement membrane.

  1997cited by this paper
• Differential effects of FGFR2 mutations on syndactyly and cleft palate in Apert syndrome.

  1996influential reference
• Palate development in the TGF-beta 3 knockout mouse. Low vacuum scanning electron microscopy reveals changes in the medial edge epithelium.

  1996cited by this paper
• Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

  1995cited by this paper
• Transforming growth factor-beta 3 is required for secondary palate fusion.

  1995cited by this paper
• Transforming growth factor–β3 is required for secondary palate fusion

  1995cited by this paper
• Inhibition of TGF-beta 3 (but not TGF-beta 1 or TGF-beta 2) activity prevents normal mouse embryonic palate fusion.

  1995cited by this paper
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  1995cited by this paper
• The function of KGF in morphogenesis of epithelium and reepithelialization of wounds.

  1994cited by this paper
• Cytochemical identification of programmed cell death in the fusing fetal mouse palate by specific labelling of DNA fragmentation

  1994cited by this paper
• Localisation of acidic and basic fibroblast growth factors during mouse palate development and their effects on mouse palate mesenchyme cells in vitro

  1993cited by this paper
• Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2).

  1993cited by this paper
• The oral manifestations of Apert syndrome.

  1992cited by this paper
• Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.

  1992cited by this paper
• Epithelial-mesenchymal transformation during palatal fusion: carboxyfluorescein traces cells at light and electron microscopic levels.

  1992cited by this paper
• Medial edge epithelium fate traced by cell lineage analysis during epithelial-mesenchymal transformation in vivo.

  1992cited by this paper
• The Oral Manifestation of Apertʼs Syndrome

  1992cited by this paper
• The fate of medial edge epithelial cells during palatal fusion in vitro: an analysis by DiI labelling and confocal microscopy.

  1992cited by this paper
• Growth factor signaling: where is the specificity?

  1992cited by this paper
• Molecular and morphologic changes during the epithelial-mesenchymal transformation of palatal shelf medial edge epithelium in vitro.

  1991cited by this paper
• Cloning and expression of two distinct high‐affinity receptors cross‐reacting with acidic and basic fibroblast growth factors.

  1990cited by this paper
• Medial edge epithelium transforms to mesenchyme after embryonic palatal shelves fuse.

  1987cited by this paper
• Nasopharyngeal dysmorphology in the syndromes of Apert and Crouzon.

  1981cited by this paper
• Palatal anomalies in the syndromes of Apert and Crouzon.

  1974cited by this paper
• Fine structure of midline epithelium in the developing palate of the mouse

  1968cited by this paper

• Cleft Palate in Apert Syndrome

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  2022cites this paper
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  2020cites this paper
• A review of FGF signaling in palate development.

  2018cites this paper
• Analysis of the Fgfr2C342Y mouse model shows condensation defects due to misregulation of Sox9 expression in prechondrocytic mesenchyme

  2017cites this paper
• Anterior Skull Base and Pericranial Flap Ossification after Frontofacial Monobloc Advancement

  2017cites this paper
• Research advances in Apert syndrome.

  2017cites this paper
• Palatogenesis and cutaneous repair: A two‐headed coin

  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2013cites this paper
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  2013influential citation
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  2012cites this paper
• Development of the lip and palate: FGF signalling.

  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
• Facial suture synostosis of newborn Fgfr1(P250R/+) and Fgfr2(S252W/+) mouse models of Pfeiffer and Apert syndromes.

  2011cites this paper
• Expression of Fgf signalling pathway related genes during palatal rugae development in the mouse.

  2010cites this paper
• 10.of the Craniofacial Complex

  2010cites this paper
• Development of the Craniofacial Complex

  2010cites this paper
• Beyond the closed suture in apert syndrome mouse models: Evidence of primary effects of FGFR2 signaling on facial shape at birth

  2010cites this paper
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  2006cites this paper
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  2006cites this paper
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  2006cites this paper
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  2005cites this paper
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