Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth

The A20 protein is a known inhibitor of apoptosis that here is shown to be a novel cancer stem cell-promoting factor associated with poor glioma patient survival.

• Publication year

  2010

• Venue

  PLoS Biology

• Publication date

  2010-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1371/journal.pbio.1000319PMID 20186265PMCID 2826371
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Apoptosis signaling in cancer stem cells.

  2010cited by this paper
• Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation

  2009cited by this paper
• The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

  2009cited by this paper
• Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

  2009cited by this paper
• Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma.

  2009cited by this paper
• Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells

  2009influential reference
• BMI1 Sustains Human Glioblastoma Multiforme Stem Cell Renewal

  2009cited by this paper
• Biology of glioma cancer stem cells

  2009cited by this paper
• TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas.

  2009cited by this paper
• SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma.

  2009cited by this paper
• PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells.

  2009cited by this paper
• Frequent inactivation of A20 in B-cell lymphomas

  2009cited by this paper
• A20 is overexpressed in glioma cells and may serve as a potential therapeutic target

  2009cited by this paper
• Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

  2009cited by this paper
• The side story of stem-like glioma cells.

  2009influential reference
• Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells.

  2009cited by this paper
• TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma.

  2009cited by this paper
• The Increasing Complexity of the Cancer Stem Cell Paradigm

  2009influential reference
• TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

  2009cited by this paper
• A20 deletion is associated with copy number gain at the TNFA/B/C locus and occurs preferentially in translocation‐negative MALT lymphoma of the ocular adnexa and salivary glands

  2009cited by this paper
• TNF‐α‐ and TRAIL‐resistant glioma cells undergo autophagy‐dependent cell death induced by activated microglia

  2009cited by this paper
• Cancer stem cells from human glioma cell line are resistant to Fas-induced apoptosis.

  2009cited by this paper
• The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells

  2008cited by this paper
• Comprehensive genomic characterization defines human glioblastoma genes and core pathways

  2008cited by this paper
• Nuclear Factor κB Signaling Either Stimulates or Inhibits Neurite Growth Depending on the Phosphorylation Status of p65/RelA

  2008cited by this paper
• c-Myc Is Required for Maintenance of Glioma Cancer Stem Cells

  2008cited by this paper
• Cancer stem cells in brain tumor biology.

  2008cited by this paper
• Molecular Cancer BioMed Central

  2008cited by this paper
• Potential identity of multi-potential cancer stem-like subpopulation after radiation of cultured brain glioma

  2008cited by this paper
• The 2007 WHO classification of tumors of the central nervous system – what has changed?

  2008cited by this paper
• NF-kappa B genes have a major role in Inflammatory Breast Cancer

  2008cited by this paper
• Targeting cancer stem cells through L1CAM suppresses glioma growth.

  2008cited by this paper
• Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas

  2008influential reference
• Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor.

  2008cited by this paper
• CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells

  2008influential reference
• Glioblastoma stem cells produce vascular endothelial growth factor by activation of a G‐protein coupled formylpeptide receptor FPR

  2008cited by this paper
• An Integrated Genomic Analysis of Human Glioblastoma Multiforme

  2008cited by this paper
• Brain Cancer Stem Cells Display Preferential Sensitivity to Akt Inhibition

  2008cited by this paper
• NF-kappaB controls growth of glioblastomas/astrocytomas.

  2008cited by this paper
• Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

  2008influential reference
• The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas.

  2008cited by this paper
• The 2007 WHO Classification of Tumours of the Central Nervous System

  2007cited by this paper
• Most C6 cells are cancer stem cells: evidence from clonal and population analyses.

  2007influential reference
• VEGF promotes tumorigenesis and angiogenesis of human glioblastoma stem cells.

  2007cited by this paper
• Tumorigenesis of Chemotherapeutic Drug-Resistant Cancer Stem-Like Cells in Brain Glioma

  2007cited by this paper
• NF-κB controls growth of glioblastomas/astrocytomas

  2007cited by this paper
• A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells

  2007cited by this paper
• CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles.

  2007cited by this paper
• Neuroprotective Effect of A20 on TNF-Induced Postischemic Apoptosis

  2006cited by this paper
• Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.

  2006cited by this paper
• Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

  2006cited by this paper
• Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

  2006cited by this paper
• Tumor Necrosis Factor-α–Induced Protein 3 As a Putative Regulator of Nuclear Factor-κB–Mediated Resistance to O6-Alkylating Agents in Human Glioblastomas

  2006cited by this paper
• NF-kappaB inhibition: a double-edged sword in cancer?

  2006cited by this paper
• Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas.

  2006influential reference
• NF-κB inhibition: A double-edged sword in cancer?

  2006cited by this paper
• Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor.

  2006cited by this paper
• Antiapoptotic effect both in vivo and in vitro of A20 gene when transfected into rat hippocampal neurons

  2005cited by this paper
• Phosphorylation of RelA/p65 on Serine 536 Defines an IκBα-independent NF-κB Pathway*

  2005cited by this paper
• Phosphorylation of RelA/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway.

  2005cited by this paper
• A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions.

  2005cited by this paper
• A20 inhibits NF-κB activation by dual ubiquitin-editing functions

  2005cited by this paper
• NF-kappaB functions as a tumour promoter in inflammation-associated cancer.

  2004cited by this paper
• NF-κB functions as a tumour promoter in inflammation-associated cancer

  2004cited by this paper
• Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration

  2004cited by this paper
• Identification of human brain tumour initiating cells

  2004cited by this paper
• A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation.

  2004cited by this paper
• Measurement of Apoptosis and Other Forms of Cell Death

  2004cited by this paper
• Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma

  2004influential reference
• Identification of a cancer stem cell in human brain tumors.

  2003influential reference
• IKKβ Plays an Essential Role in the Phosphorylation of RelA/p65 on Serine 536 Induced by Lipopolysaccharide1

  2003cited by this paper
• Cancerous stem cells can arise from pediatric brain tumors

  2003influential reference
• Stem cells, cancer, and cancer stem cells

  2001influential reference
• Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice.

  2000cited by this paper
• A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis.

  2000cited by this paper
• Effects of retinoic acid and tumor necrosis factor alpha on GL‐15 glioblastoma cells

  2000cited by this paper
• A20 RNA expression is associated with undifferentiated nasopharyngeal carcinoma and poorly differentiated head and neck squamous cell carcinoma

  1999cited by this paper
• IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain*

  1999cited by this paper
• Adult Mammalian Forebrain Ependymal and Subependymal Cells Demonstrate Proliferative Potential, but only Subependymal Cells Have Neural Stem Cell Characteristics

  1999cited by this paper
• IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain.

  1999cited by this paper
• Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling.

  1999cited by this paper
• Antitumor activity of recombinant human tumor necrosis factor-alpha (rH-TNF alpha) and liposome-entrapped rH-TNF alpha.

  1997cited by this paper
• Antitumor Activity of Recombinant Human Tumor Necrosis Factor-α (rH-TNFα) and Liposome-entrapped rH-TNFα

  1997cited by this paper
• A20 zinc finger protein inhibits TNF and IL-1 signaling.

  1996cited by this paper
• Lymphoid expression and regulation of A20, an inhibitor of programmed cell death.

  1995influential reference
• Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.

  1992cited by this paper
• The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity.

  1992cited by this paper

• The Pivotal Role of NF-κB in Glioblastoma: Mechanisms of Activation and Therapeutic Implications

  2025cites this paper
• A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β

  2025cites this paper
• Polymorphisms and Expression of Genes Associated with JAK/STAT Signaling in Patients with Myeloproliferative Neoplasm

  2025cites this paper
• TRAIL-resistant glioma cells resist Withania somnifera mediated apoptosis via USP5 upregulation

  2025cites this paper
• Cross-Sectional Study: Associations of A20 and Cezanne with Leukocyte Accumulation in B-Cell Acute Lymphoblastic Leukemia

  2025cites this paper
• Role of DEPDC1 in Glioblastoma Malignant Phenotype and Radiosensitivity

  2025cites this paper
• Dissecting the dual role of OTU family proteins in tumor progression and immune escape

  2025cites this paper
• Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival

  2025cites this paper
• Ubiquitination and deubiquitination in cancer: from mechanisms to novel therapeutic approaches

  2024cites this paper
• NAPH-Fluorescence Lifetime Imaging Informed Machine Learning Modelling Reliably Predicts Temozolomide Responsiveness in Glioblastoma

  2024cites this paper
• Signaling controversy and future therapeutical perspectives of targeting sphingolipid network in cancer immune editing and resistance to tumor necrosis factor-α immunotherapy

  2024cites this paper
• An explanation of the role of pyroptosis playing in epilepsy.

  2024cites this paper
• DUBing Primary Tumors of the Central Nervous System: Regulatory Roles of Deubiquitinases

  2023cites this paper
• Concurrent Activation of Both Survival-Promoting and Death-Inducing Signaling by Chloroquine in Glioblastoma Stem Cells: Implications for Potential Risks and Benefits of Using Chloroquine as Radiosensitizer

  2023cites this paper
• Effects of Vinblastine and Vincristine on the function of chronic myeloid leukemic cells through expression of A20 and CYLD.

  2022cites this paper
• Dysregulated FOXM1 Signaling in the regulation of cancer stem cells.

  2022cites this paper
• Digital Digital Defining phenotypic and functional heterogeneity of glioblastoma Defining phenotypic and functional heterogeneity of glioblastoma stem cells by mass cytometry stem cells by mass cytometry

  2022cites this paper
• CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity

  2022cites this paper
• Repurposing Clemastine to Target Glioblastoma Cell Stemness

  2022cites this paper
• The role of E3 ubiquitin ligases in the development and progression of glioblastoma

  2021cites this paper
• Bioactive Compounds with Antiglioma Activity from Marine Species

  2021cites this paper
• Redox regulation of DUBs and its therapeutic implications in cancer

  2021cites this paper
• The dual roles of A20 in cancer.

  2021cites this paper
• Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma

  2021cites this paper
• Tumour‐associated CD204+ microglia/macrophages accumulate in perivascular and perinecrotic niches and correlate with an interleukin‐6‐enriched inflammatory profile in glioblastoma

  2021cites this paper
• Natural Small Molecules Targeting NF-κB Signaling in Glioblastoma

  2021cites this paper
• Defining phenotypic and functional heterogeneity of glioblastoma stem cells by mass cytometry

  2021cites this paper
• Down-regulation of A20 promotes immune escape of lung adenocarcinomas

  2021cites this paper
• Superparamagnetic iron oxide nanoparticles drive miR-485-5p inhibition in glioma stem cells by silencing Tie1 expression

  2020cites this paper
• In situ antitumor vaccination: Targeting the tumor microenvironment

  2020cites this paper
• The impact of DNA demethylation on the upregulation of the NRN1 and TNFAIP3 genes associated with advanced gastric cancer

  2020cites this paper
• Identification and Investigation of miRNAs From Gastrodia elata Blume and Their Potential Function

  2020cites this paper
• A20 promotes melanoma progression via the activation of Akt pathway

  2020cites this paper
• Combined A20 and tripartite motif‐containing 44 as poor prognostic factors for breast cancer patients of the Japanese population

  2020cites this paper
• Targeting the Ubiquitin System in Glioblastoma

  2020cites this paper
• Identifying the p65-Dependent Effect of Sulforaphene on Esophageal Squamous Cell Carcinoma Progression via Bioinformatics Analysis

  2020cites this paper
• TNFAIP3 Suppresses Lung Cancer Progression via Regulating Cell Proliferation and Apoptosis

  2020cites this paper
• Regulation of cell activation by A20 through STAT signaling in acute lymphoblastic leukemia

  2020cites this paper
• Functional analysis of deubiquitylating enzymes in tumorigenesis and development.

  2019cites this paper
• LncRNA MATN1-AS1 prevents glioblastoma cell from proliferation and invasion via RELA regulation and MAPK signaling pathway.

  2019cites this paper
• High A20 expression negatively impacts survival in patients with breast cancer

  2019cites this paper
• A20 at the Crossroads of Cell Death, Inflammation, and Autoimmunity.

  2019cites this paper
• Emerging role of zinc finger protein A20 as a suppressor of hepatocellular carcinoma

  2019cites this paper
• A Role for NF-κB in Organ Specific Cancer and Cancer Stem Cells

  2019cites this paper
• A20 Orchestrates Inflammatory Response in the Oral Mucosa through Restraining NF-κB Activity

  2019cites this paper
• Deubiquitinating enzymes in cancer stem cells: functions and targeted inhibition for cancer therapy.

  2018cites this paper
• Targeting the Ubiquitin Proteasome System in Cancer

  2018cites this paper
• Periarteriolar Glioblastoma Stem Cell Niches Express Bone Marrow Hematopoietic Stem Cell Niche Proteins

  2018cites this paper
• The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20

  2018cites this paper
• An attempt to understand glioma stem cell biology through centrality analysis of a protein interaction network.

  2018cites this paper
• MiR-125b regulates proliferation and apoptosis of nasopharyngeal carcinoma by targeting A20/NF-κB signaling pathway

  2017cites this paper
• IGF2 mRNA binding protein 3 (IMP3) promotes glioma cell migration by enhancing the translation of RELA/p65

  2017cites this paper
• A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1

  2017cites this paper
• Cathepsin K cleavage of SDF-1α inhibits its chemotactic activity towards glioblastoma stem-like cells.

  2017cites this paper
• Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges

  2017cites this paper
• TNFAIP3 overexpression is an independent factor for poor survival in esophageal squamous cell carcinoma.

  2017cites this paper
• MiR-125b Increases Nasopharyngeal Carcinoma Radioresistance by Targeting A20/NF-κB Signaling Pathway

  2017cites this paper
• The bad seed gardener: Deubiquitinases in the cancer stem‐cell signaling network and therapeutic resistance

  2017cites this paper
• NLRP3 inflammasome activation plays a carcinogenic role through effector cytokine IL-18 in lymphoma

  2017cites this paper
• A20 targets caspase-8 and FADD to protect HTLV-I-infected cells

  2016cites this paper
• IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance

  2016cites this paper
• Transcriptome sequencing of neurologic diseases associated genes in HHV-6A infected human astrocyte

  2016cites this paper
• Magnetofection Based on Superparamagnetic Iron Oxide Nanoparticles Weakens Glioma Stem Cell Proliferation and Invasion by Mediating High Expression of MicroRNA-374a

  2016influential citation
• Overexpression of MALT1-A20-NF-κB in adult B-cell acute lymphoblastic leukemia

  2015cites this paper
• Ubiquitin Chains: Degradation and Beyond

  2015cites this paper
• Up-regulated A20 promotes proliferation, regulates cell cycle progression and induces chemotherapy resistance of acute lymphoblastic leukemia cells.

  2015cites this paper
• A20 suppresses hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression

  2015cites this paper
• The Prognostic Role of SOCS3 and A20 in Human Cholangiocarcinoma

  2015cites this paper
• Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells.

  2015cites this paper
• Long Non-Coding RNAs Dysregulation and Function in Glioblastoma Stem Cells

  2015cites this paper
• Cancer stem cells in glioblastoma

  2015influential citation
• DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis.

  2015influential citation
• Title Long Non-Coding RNAs Dysregulation and Function inGlioblastoma Stem Cells

  2015cites this paper
• Nuclear-encoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas

  2015cites this paper
• Inhibition of A20 expression in tumor microenvironment exerts anti-tumor effect through inducing myeloid-derived suppressor cells apoptosis

  2015cites this paper
• The role of the ubiquitin-editing enzyme A20 in diseases of the central nervous system and other pathological processes

  2015cites this paper
• NF-κB signaling in cancer stem cells: a promising therapeutic target?

  2015cites this paper
• The seventh zinc finger motif of A20 is required for the suppression of TNF‐α‐induced apoptosis

  2015cites this paper
• CD133+ and Nestin+ Glioma Stem-Like Cells Reside Around CD31+ Arterioles in Niches that Express SDF-1α, CXCR4, Osteopontin and Cathepsin K

  2015influential citation
• Systems Biology of Glioblastoma Multiforme

  2015cites this paper
• Regulation of NF-κB Signaling by Regulatory Ubiquitination: Specific Pathways and A20

  2015cites this paper
• Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells

  2015cites this paper
• Cancer Stem Cell‐Specific Scavenger Receptor CD36 Drives Glioblastoma Progression

  2014cites this paper
• A20 in inflammation and autoimmunity.

  2014cites this paper
• A20 expressing tumors and anticancer drug resistance.

  2014cites this paper
• Glioblastoma stem cells: new insights in therapeutic strategies

  2014cites this paper
• Self‐Renewal, Induced Proliferation, and Autonomous Cell Growth Represent Distinct Modes of Cell Multiplication

  2014cites this paper
• Understanding two inhibitors of NF-κB: A20 and IκBβ

  2014cites this paper
• Knockout of the HCC suppressor gene Lass2 downregulates the expression level of miR-694.

  2014influential citation
• Using Evolutional Properties of Gene Networks in Understanding Survival Prognosis of Glioblastoma

  2014cites this paper
• NF-κB and STAT3 in glioblastoma: therapeutic targets coming of age

  2014cites this paper
• Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma.

  2013cites this paper
• Therapeutic strategies targeting glioblastoma stem cells.

  2013cites this paper
• Role of microRNAs in mechanisms of glioblastoma resistance to radio- and chemotherapy

  2013cites this paper
• Tumor‐Specific Activation of the C‐JUN/MELK Pathway Regulates Glioma Stem Cell Growth in a p53‐Dependent Manner

  2013cites this paper
• MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem cell-like population of nasopharyngeal carcinoma cells.

  2013cites this paper
• Glycogen synthase kinase-3β (GSK-3β) and its dysregulation in glioblastoma multiforme.

  2013cites this paper
• Tumor and Stem Cell Biology Aptamer Identi fi cation of Brain Tumor – Initiating Cells

  2013cites this paper
• Cytoplasmic TRADD confers a worse prognosis in glioblastoma.

  2013cites this paper
• The cancer stem cell niche(s): the crosstalk between glioma stem cells and their microenvironment.

  2013cites this paper