Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Nitric oxide

• Publication date

  2013-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.niox.2014.03.001PMID 24667534PMCID PMC4156891
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects

  2014cited by this paper
• S-adenosylmethionine limitation induces p38 mitogen-activated protein kinase and triggers cell cycle arrest in G1

  2014cited by this paper
• Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms

  2014cited by this paper
• Enzymology of H2S Biogenesis, Decay and Signaling

  2014cited by this paper
• Thiosulfate in urine as a facilitator in the diagnosis of prostate cancer for patients with prostate-specific antigen less or equal 10 ng/mL

  2013cited by this paper
• Intramitochondrial hydrogen sulfide production by 3‐mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics

  2013cited by this paper
• Cystathionine Beta-Synthase (CBS) Contributes to Advanced Ovarian Cancer Progression and Drug Resistance

  2013cited by this paper
• Hydrogen sulfide augments the proliferation and survival of human induced pluripotent stem cell-derived mesenchymal stromal cells through inhibition of BKCa.

  2013cited by this paper
• Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe.

  2013cited by this paper
• Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

  2013cited by this paper
• Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway.

  2013cited by this paper
• Correction of Cystathionine β‐Synthase Deficiency in Mice by Treatment with Proteasome Inhibitors

  2013cited by this paper
• Oxygen-sensitive mitochondrial accumulation of cystathionine β-synthase mediated by Lon protease

  2013cited by this paper
• Endogenously produced hydrogen sulfide supports tumor cell growth and proliferation

  2013cited by this paper
• Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE)

  2013cited by this paper
• Exhaled volatile organic compounds identify patients with colorectal cancer

  2013cited by this paper
• Structural basis of regulation and oligomerization of human cystathionine β-synthase, the central enzyme of transsulfuration

  2013cited by this paper
• S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer.

  2013cited by this paper
• Physiological implications of hydrogen sulfide: a whiff exploration that blossomed.

  2012cited by this paper
• Selected ion flow tube-MS analysis of headspace vapor from gastric content for the diagnosis of gastro-esophageal cancer.

  2012cited by this paper
• S-adenosylmethionine (SAMe) therapy in liver disease: a review of current evidence and clinical utility.

  2012cited by this paper
• Nutritional Interventions to Prevent and Treat Osteoarthritis. Part II: Focus on Micronutrients and Supportive Nutraceuticals

  2012cited by this paper
• Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress.

  2012cited by this paper
• S-adenosylmethionine in liver health, injury, and cancer.

  2012influential reference
• Characterization of hydrogen sulfide and its synthases, cystathionine β-synthase and cystathionine γ-lyase, in human prostatic tissue and cells.

  2012cited by this paper
• Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation

  2012cited by this paper
• Mitochondria and Sulfide: A Very Old Story of Poisoning, Feeding, and Signaling?

  2011cited by this paper
• Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice.

  2011cited by this paper
• Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels

  2011cited by this paper
• Generation of gaseous sulfur-containing compounds in tumour tissue and suppression of gas diffusion as an antitumour treatment

  2011cited by this paper
• Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools.

  2011cited by this paper
• Hydrogen sulphide and angiogenesis: mechanisms and applications

  2011cited by this paper
• S-Adenosylmethionine-dependent radical-based modification of biological macromolecules.

  2010cited by this paper
• S-Adenosylmethionine Inhibits the Growth of Cancer Cells by Reversing the Hypomethylation Status of c-myc and H-ras in Human Gastric Cancer and Colon Cancer

  2010cited by this paper
• Hydrogen Sulfide Is an Endogenous Inhibitor of Phosphodiesterase Activity

  2010cited by this paper
• Inhibitory effect of S-adenosylmethionine on the growth of human gastric cancer cells in vivo and in vitro.

  2010cited by this paper
• Hydrogen sulfide induces human colon cancer cell proliferation: Role of Akt, ERK and p21

  2010cited by this paper
• Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine β-synthase

  2010cited by this paper
• Hydrogen sulfide is an endogenous stimulator of angiogenesis

  2009cited by this paper
• Relative Contributions of Cystathionine β-Synthase and γ-Cystathionase to H2S Biogenesis via Alternative Trans-sulfuration Reactions*

  2009cited by this paper
• Sulfide, the first inorganic substrate for human cells

  2007cited by this paper
• Oxidant-induced cardiomyocyte injury: identification of the cytoprotective effect of a dopamine 1 receptor agonist using a cell-based high-throughput assay.

  2007cited by this paper
• Hydrogen sulphide and its therapeutic potential

  2007cited by this paper
• S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity.

  2006cited by this paper
• S-adenosylmethionine (SAMe) as treatment for depression: a systematic review.

  2005cited by this paper
• The role of cystathionine beta-synthase in homocysteine metabolism.

  2005cited by this paper
• The Role of Cystathionine β-Synthase in Homocysteine Metabolism

  2005cited by this paper
• Cystathionine β-Synthase: Structure, Function, Regulation, and Location of Homocystinuria-causing Mutations*

  2004cited by this paper
• Cystathionine beta-synthase is coordinately regulated with proliferation through a redox-sensitive mechanism in cultured human cells and Saccharomyces cerevisiae.

  2002cited by this paper
• Cystathionine β‐synthase is coordinately regulated with proliferation through a redox‐sensitive mechanism in cultured human cells and Saccharomyces cerevisiae

  2002cited by this paper
• Deletion mutagenesis of human cystathionine beta-synthase. Impact on activity, oligomeric status, and S-adenosylmethionine regulation.

  2002cited by this paper
• The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener

  2001cited by this paper
• The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener.

  2001cited by this paper
• Trypsin cleavage of human cystathionine beta-synthase into an evolutionarily conserved active core: structural and functional consequences.

  1998cited by this paper
• Secondary structure of recombinant human cystathionine beta-synthase in aqueous solution: effect of ligand binding and proteolytic truncation.

  1997cited by this paper
• New S-adenosylmethionine decarboxylase inhibitors with potent antitumor activity.

  1992cited by this paper
• Comparative effects of L-methionine, S-adenosyl-L-methionine and 5'-methylthioadenosine on the growth of preneoplastic lesions and DNA methylation in rat liver during the early stages of hepatocarcinogenesis.

  1991cited by this paper
• Activation of cystathionine synthase by adenosylmethionine and adenosylethionine.

  1975cited by this paper

• S-Adenosylmethionine: A Multifaceted Regulator in Cancer Pathogenesis and Therapy

  2025influential citation
• H2S-responsive CuSe nanoparticles convert into CuSSe in situ with band gap modulation for oxygen self-supply and enhanced colon cancer phototherapy

  2025cites this paper
• Transsulfuration Pathway Products and H2S-Donors in Hyperhomocysteinemia: Potential Strategies Beyond Folic Acid

  2025cites this paper
• Reconnecting the roots of hydrogen sulfide (H2S) with medicinal chemistry: Lessons accomplished and challenges so far.

  2025cites this paper
• Molecular Alterations in Gastric Intestinal Metaplasia Shed Light on Alteration of Methionine Metabolism: Insight into New Diagnostic and Treatment Approaches

  2025cites this paper
• Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review

  2024cites this paper
• S-Adenosylmethionine (SAMe) for Central Nervous System Health: A Systematic Review

  2024cites this paper
• The potential role of hydrogen sulfide in cancer cell apoptosis

  2024cites this paper
• Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo.

  2024cites this paper
• Heat shock factor 1 directly regulates transsulfuration pathway to promote prostate cancer proliferation and survival

  2024cites this paper
• Hydrogen sulfide and epigenetics: Novel insights into the cardiovascular effects of this gasotransmitter

  2023cites this paper
• Positive Regulation of S-Adenosylmethionine on Chondrocytic Differentiation via Stimulation of Polyamine Production and the Gene Expression of Chondrogenic Differentiation Factors

  2023cites this paper
• Epigenetic Modulators as Therapeutic Agents in Cancer

  2023cites this paper
• Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies

  2023cites this paper
• One-carbon metabolism and related pathways in ruminal and small intestinal epithelium of lactating dairy cows.

  2023cites this paper
• Targeting Homocysteine and Hydrogen Sulfide Balance as Future Therapeutics in Cancer Treatment

  2023cites this paper
• On-Demand Phototoxicity Inhibition of Sensitizers and H2S-Triggered In-Situ Activation for Precise Therapy of Colon Cancer

  2023cites this paper
• Metagenomic Analyses of Multiple Gut Datasets Revealed the Association of Phage Signatures in Colorectal Cancer

  2022cites this paper
• Hydrogen Sulfide Attenuates Lipopolysaccharide-Induced Inflammation via the P-glycoprotein and NF-κB Pathway in Astrocytes

  2022cites this paper
• Sequential Accumulation of ‘Driver’ Pathway Mutations Induces the Upregulation of Hydrogen-Sulfide-Producing Enzymes in Human Colonic Epithelial Cell Organoids

  2022cites this paper
• Regulation of CyR61 expression and release by 3-mercaptopyruvate sulfurtransferase in colon cancer cells

  2022cites this paper
• Excitatory Effects of Astrocytic Hydrogen Sulfide on the Electrical Activity of Oxytocin Neurons in the Supraoptic Nucleus

  2022cites this paper
• 2D Cu-Bipyridine MOF Nanosheet as an Agent for Colon Cancer Therapy: A Three-in-One Approach for Enhancing Chemodynamic Therapy.

  2022cites this paper
• Epigallocatechin gallate is a potent inhibitor of cystathionine beta-synthase: Structure-activity relationship and mechanism of action.

  2022cites this paper
• High Expression of Heat Shock Protein Family D Member 1 Predicts Poor Prognosis of Esophageal Cancer

  2022cites this paper
• mTORC1-independent translation control in mammalian cells by methionine adenosyltransferase 2A and S-adenosylmethionine

  2022cites this paper
• High-Fat Diet Enhances the Liver Metastasis Potential of Colorectal Cancer through Microbiota Dysbiosis

  2022cites this paper
• Emerging roles of cystathionine β-synthase in various forms of cancer

  2022cites this paper
• Overexpression of CBS/H2S inhibits proliferation and metastasis of colon cancer cells through downregulation of CD44

  2022cites this paper
• Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

  2022cites this paper
• Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells

  2021cites this paper
• Acute acrylonitrile exposure inhibits endogenous H2S biosynthesis in rat brain and liver: the role of CBS/3-MPST-H2S pathway in its astrocytic toxicity.

  2021cites this paper
• Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

  2021cites this paper
• Hydrogen sulfide-activatable prodrug-backboned block copolymer micelles for delivery of chemotherapeutics

  2021cites this paper
• Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

  2021cites this paper
• Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer.

  2021cites this paper
• Molecular Functions of Hydrogen Sulfide in Cancer

  2021cites this paper
• A H2S-Triggered Dual-Modal Second Near-Infrared/Photoacoustic Intelligent Nanoprobe for Highly Specific Imaging of Colorectal Cancer.

  2021cites this paper
• Pharmacological induction of mesenchymal-epithelial transition via inhibition of H2S biosynthesis and consequent suppression of ACLY activity in colon cancer cells.

  2021cites this paper
• A covalent organic framework-based nanoagent for H2S-activable phototherapy against colon cancer.

  2021cites this paper
• The Hidden Role of Hydrogen Sulfide Metabolism in Cancer

  2021cites this paper
• The Role of Hydrogen Sulfide in Respiratory Diseases

  2021cites this paper
• Recent advances in fluorescent probes for cellular antioxidants: Detection of NADH, hNQO1, H2S, and other redox biomolecules

  2021cites this paper
• Serum metabolite signatures of epithelial ovarian cancer based on targeted metabolomics.

  2021cites this paper
• Inhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia

  2021cites this paper
• Screening of Heteroaromatic Scaffolds against Cystathionine Beta-Synthase Enables Identification of Substituted Pyrazolo[3,4-c]Pyridines as Potent and Selective Orthosteric Inhibitors

  2020cites this paper
• H2S prevents injury after ischemic stroke by diminishing the assembly of CaMKII with ASK1-MKK3-p38 signaling module.

  2020cites this paper
• Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors

  2020cites this paper
• Human METTL7B Encodes an Alkyl Thiol Methyltransferase that Methylates Hydrogen Sulfide

  2020cites this paper
• Cystathionine-β-synthase: Molecular Regulation and Pharmacological Inhibition

  2020cites this paper
• Production of hydrogen sulfide by the intestinal microbiota and epithelial cells and consequences for the colonic and rectal mucosa.

  2020cites this paper
• MiR-22, regulated by MeCP2, suppresses gastric cancer cell proliferation by inducing a deficiency in endogenous S-adenosylmethionine

  2020cites this paper
• S-adenosylmethionine administration inhibits levodopa-induced vascular endothelial growth factor-A expression

  2020cites this paper
• A Study on the Effect of Vitamins A and C to Modulate the Expression of NKG2D Ligands in Hepatic and Colon Cancer Cells

  2020cites this paper
• Cystathionine β-synthase affects organization of cytoskeleton and modulates carcinogenesis in colorectal carcinoma cells

  2020cites this paper
• A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?

  2019cites this paper
• Decreased expression of cystathionine β-synthase exacerbates intestinal barrier injury in ulcerative colitis.

  2019cites this paper
• Disturbed homocysteine metabolism is associated with cancer

  2019cites this paper
• AP39, a Modulator of Mitochondrial Bioenergetics, Reduces Antiangiogenic Response and Oxidative Stress in Hypoxia-Exposed Trophoblasts: Relevance for Preeclampsia Pathogenesis.

  2019cites this paper
• Role of Hydrogen Sulfide in Chronic Diseases

  2019cites this paper
• Hydrogen sulfide signaling in mitochondria and disease

  2019cites this paper
• Selenosulfides Tethered to Gem-Dimethyl Esters: A Robust and Highly Versatile Framework for H₂S Probe Development.

  2019cites this paper
• Nicotinamide N-Methyltransferase and Its Precursor Substrate Methionine Directly and Indirectly Control Malignant Metabolism During Progression of Renal Cell Carcinoma

  2019cites this paper
• Hydrogen Sulfide: Emerging Role in Bladder, Kidney, and Prostate Malignancies

  2019cites this paper
• GC/MS and LC/MS-based Tissue Metabolomic Analysis Detected Increased Levels of Antioxidant Metabolites in Colorectal Cancer.

  2019cites this paper
• High Spatiotemporal Resolution Observation of Glutathione Hydropersulfides in Living Cells and Tissue via a Two-Photon Ratiometric Fluorescent Probe.

  2019cites this paper
• Betaine-rich sugar beet molasses protects from homocysteine-induced reduction of survival in Caenorhabditis elegans

  2019cites this paper
• Lysosome-Assisted Mitochondrial Targeting Nanoprobe Based on Dye-Modified Upconversion Nanophosphors for Ratiometric Imaging of Mitochondrial Hydrogen Sulfide.

  2018cites this paper
• Cystathionine β-Synthase in Physiology and Cancer

  2018cites this paper
• A near-infrared fluorescent probe for sensitive detection and imaging of sulfane sulfur in living cells and in vivo.

  2018cites this paper
• Expression of hydrogen sulfide synthases and Hh signaling pathway components correlate with the clinicopathological characteristics of papillary thyroid cancer patients.

  2018influential citation
• Colorimetric detection of endogenous hydrogen sulfide production in living cells.

  2017cites this paper
• H2S‐induced S‐sulfhydration of lactate dehydrogenase a (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells

  2017cites this paper
• International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors

  2017influential citation
• Down-regulation of cystathionine-γ-lyase/H2S system inhibits cell growth in human breast cancer MDA-MB-231 cells

  2017cites this paper
• Synergistic Effects of SAM and Selenium Compounds on Proliferation, Migration and Adhesion of HeLa Cells.

  2017cites this paper
• Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis.

  2017cites this paper
• Drug resistance induces the upregulation of H2S‐producing enzymes in HCT116 colon cancer cells

  2017cites this paper
• Metabolic Reprogramming and Oncogenesis: One Hallmark, Many Organelles.

  2017cites this paper
• Emerging Roles of Hydrogen Sulfide in Inflammatory and Neoplastic Colonic Diseases

  2016cites this paper
• Photoacoustic probes for real-time tracking of endogenous H2S in living mice† †Electronic supplementary information (ESI) available: Procedures for the synthesis of BODPA, living mice imaging, characterization data, and supplementary figures. See DOI: 10.1039/c6sc04703c Click here for additional dat

  2016cites this paper
• Cystathionine-β-Synthase Inhibition for Colon Cancer: Enhancement of the Efficacy of Aminooxyacetic Acid via the Prodrug Approach

  2016cites this paper
• AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer's Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons

  2016cites this paper
• Quantification of cysteine hydropersulfide with a ratiometric near-infrared fluorescent probe based on selenium–sulfur exchange reaction

  2016cites this paper
• Hydrogen sulfide-releasing anti-inflammatory drugs for chemoprevention and treatment of cancer.

  2016cites this paper
• A practical guide to working with H2S at the interface of chemistry and biology.

  2016cites this paper
• Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics

  2016cites this paper
• Methylation Status of SP1 Sites within miR-23a-27a-24-2 Promoter Region Influences Laryngeal Cancer Cell Proliferation and Apoptosis

  2016cites this paper
• The Therapeutic Potential of Cystathionine β-Synthetase/Hydrogen Sulfide Inhibition in Cancer

  2015cites this paper
• S-Adenosyl-l-methionine Modulates CO and NO• Binding to the Human H2S-generating Enzyme Cystathionine β-Synthase*

  2015cites this paper
• Analysis of impedance-based cellular growth assays

  2015cites this paper
• Methionine and cystine double deprivation stress suppresses glioma proliferation via inducing ROS/autophagy.

  2015cites this paper
• Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

  2015cites this paper
• Clinical Application of Prognostic Gene Expression Signature in Fusion Gene–Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group

  2015cites this paper
• Monitoring of Endogenous Hydrogen Sulfide in Living Cells Using Surface-Enhanced Raman Scattering.

  2015cites this paper
• Hydrogen sulfide in cancer: Friend or foe?

  2015cites this paper
• Hydrogen Sulfide and Cancer.

  2015cites this paper
• A metabolomic approach to identifying platinum resistance in ovarian cancer

  2014cites this paper
• Enzymology of H2S Biogenesis, Decay and Signaling

  2014cites this paper
• AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro.

  2014cites this paper