Vascular Contributions to Cognitive Impairment and Dementia: Topical Review of Animal Models.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Stroke

• Publication date

  2016-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/STROKEAHA.116.012066PMID 27301939PMCID PMC4927375
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of White Matter Injury in a Rat Model of Chronic Cerebral Hypoperfusion

  2016cited by this paper
• Chronic treatment with resveratrol, a natural polyphenol found in grapes, alleviates oxidative stress and apoptotic cell death in ovariectomized female rats subjected to chronic cerebral hypoperfusion

  2016cited by this paper
• ST09, a Novel Thioester Derivative of Tacrine, Alleviates Cognitive Deficits and Enhances Glucose Metabolism in Vascular Dementia Rats

  2016cited by this paper
• Resveratrol Reverses the Synaptic Plasticity Deficits in a Chronic Cerebral Hypoperfusion Rat Model.

  2016cited by this paper
• Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID).

  2016influential reference
• Sex Dimorphism Profile of Alzheimer’s Disease-Type Pathologies in an APP/PS1 Mouse Model

  2016cited by this paper
• Fructus mume Ethanol Extract Prevents Inflammation and Normalizes the Septohippocampal Cholinergic System in a Rat Model of Chronic Cerebral Hypoperfusion

  2016cited by this paper
• Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory

  2016cited by this paper
• Endothelial depletion of murine SRF/MRTF provokes intracerebral hemorrhagic stroke

  2015cited by this paper
• Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment

  2015cited by this paper
• Central role for PICALM in amyloid–β blood–brain barrier transcytosis and clearance

  2015cited by this paper
• Repetitive transcranial magnetic stimulation enhances spatial learning and synaptic plasticity via the VEGF and BDNF–NMDAR pathways in a rat model of vascular dementia

  2015cited by this paper
• Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

  2015cited by this paper
• The NOTCH3 score: a pre-clinical CADASIL biomarker in a novel human genomic NOTCH3 transgenic mouse model with early progressive vascular NOTCH3 accumulation

  2015cited by this paper
• Monomeric C-reactive protein-a key molecule driving development of Alzheimer’s disease associated with brain ischaemia?

  2015cited by this paper
• Gliovascular Disruption and Cognitive Deficits in a Mouse Model with Features of Small Vessel Disease

  2015influential reference
• Angiotensin-(1-7) is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer’s Disease

  2015cited by this paper
• Sodium thiosulfate protects brain in rat model of adenine induced vascular calcification.

  2015cited by this paper
• In vivo imaging of tau pathology using multi-parametric quantitative MRI

  2015cited by this paper
• Neurobehavioral and Imaging Correlates of Hippocampal Atrophy in a Mouse Model of Vascular Cognitive Impairment

  2015cited by this paper
• Neuroprotective Effects of Clostridium butyricum against Vascular Dementia in Mice via Metabolic Butyrate

  2015cited by this paper
• Involuntary, Forced and Voluntary Exercises Equally Attenuate Neurocognitive Deficits in Vascular Dementia by the BDNF–pCREB Mediated Pathway

  2015cited by this paper
• A Novel Mouse Model of Subcortical Infarcts with Dementia

  2015influential reference
• Hypoxia-Induced Neuroinflammatory White-Matter Injury Reduced by Minocycline in SHR/SP

  2015cited by this paper
• Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

  2015cited by this paper
• Comorbid Rat Model of Ischemia and β‐Amyloid Toxicity: Striatal and Cortical Degeneration

  2015cited by this paper
• Protective effects of Bacopa monnieri on ischemia-induced cognitive deficits in mice: the possible contribution of bacopaside I and underlying mechanism.

  2015cited by this paper
• Efficacy of Cilostazol a selective phosphodiesterase-3 inhibitor in rat model of Streptozotocin diabetes induced vascular dementia.

  2015cited by this paper
• Micro-Heterogeneity of Flow in a Mouse Model of Chronic Cerebral Hypoperfusion Revealed by Longitudinal Doppler Optical Coherence Tomography and Angiography

  2015cited by this paper
• White matter hyperintensities, cognitive impairment and dementia: an update

  2015cited by this paper
• Activation of Cdk5/p25 and tau phosphorylation following chronic brain hypoperfusion in rats involves microRNA‐195 down‐regulation

  2015cited by this paper
• Mouse model of CADASIL reveals novel insights into Notch3 function in adult hippocampal neurogenesis.

  2015cited by this paper
• Endothelial Cells and Human Cerebral Small Vessel Disease

  2015cited by this paper
• Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil-DNA glycosylase impair learning in a mouse model of vascular cognitive impairment.

  2015cited by this paper
• Allopurinol protects against ischemic insults in a mouse model of cortical microinfarction.

  2015cited by this paper
• Diabetes augments cognitive dysfunction in chronic cerebral hypoperfusion by increasing neuronal cell death: implication of cilostazol for diabetes mellitus-induced dementia.

  2015cited by this paper
• Melatonin receptor and KATP channel modulation in experimental vascular dementia.

  2015cited by this paper
• Sex Dimorphism Profile of Alzheimer’s Disease-Type Pathologies in an APP/PS1 Mouse Model

  2015cited by this paper
• Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia

  2015cited by this paper
• Association of amyloid burden, brain atrophy and memory deficits in aged apolipoprotein ε4 mice.

  2014cited by this paper
• Pathophysiological rat model of vascular dementia: magnetic resonance spectroscopy, microimaging and behavioral study.

  2014cited by this paper
• Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke

  2014cited by this paper
• Ameliorative Effect of a Selective Endothelin ETA Receptor Antagonist in Rat Model of L-Methionine-induced Vascular Dementia

  2014cited by this paper
• Dynamic changes of Apo A1 mediated by LXR/RXR/ABCA1 pathway in brains of the aging rats with cerebral hypoperfusion.

  2014cited by this paper
• Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease

  2014cited by this paper
• Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias

  2014cited by this paper
• Neuronal damage, central cholinergic dysfunction and oxidative damage correlate with cognitive deficits in rats with chronic cerebral hypoperfusion.

  2014cited by this paper
• Effect of dehydroepiandrosterone (DHEA) on memory and brain derived neurotrophic factor (BDNF) in a rat model of vascular dementia.

  2014cited by this paper
• β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice

  2014influential reference
• Apoptosis Signal–Regulating Kinase 1 Is a Novel Target Molecule for Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion

  2014cited by this paper
• A mouse model of chronic cerebral hypoperfusion characterizing features of vascular cognitive impairment.

  2014cited by this paper
• Effects of Lithium and Lamotrigine on Oxidative–Nitrosative Stress and Spatial Learning Deficit After Global Cerebral Ischemia

  2014cited by this paper
• Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion.

  2014cited by this paper
• Comparison of cognitive performance between two rat models of vascular dementia

  2014cited by this paper
• Bone marrow mononuclear cell transplantation promotes therapeutic angiogenesis via upregulation of the VEGF-VEGFR2 signaling pathway in a rat model of vascular dementia.

  2014cited by this paper
• Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling

  2014cited by this paper
• Resveratrol treatment has neuroprotective effects and prevents cognitive impairment after chronic cerebral hypoperfusion

  2014cited by this paper
• Effects of donepezil, an acetylcholinesterase inhibitor, on neurogenesis in a rat model of vascular dementia.

  2014cited by this paper
• Protective effects of gallic acid against chronic cerebral hypoperfusion-induced cognitive deficit and brain oxidative damage in rats.

  2014cited by this paper
• Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau and behavioral deficits in mice

  2014cited by this paper
• Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease.

  2014cited by this paper
• Tissue Oxygen is Reduced in White Matter of Spontaneously Hypertensive-Stroke Prone Rats: A Longitudinal Study with Electron Paramagnetic Resonance

  2014cited by this paper
• Change of Nrf2 expression in rat hippocampus in a model of chronic cerebral hypoperfusion

  2014cited by this paper
• Activation of GABAB Receptors Ameliorates Cognitive Impairment via Restoring the Balance of HCN1/HCN2 Surface Expression in the Hippocampal CA1 Area in Rats With Chronic Cerebral Hypoperfusion

  2014cited by this paper
• Early white matter changes in CADASIL: evidence of segmental intramyelinic oedema in a pre-clinical mouse model

  2014cited by this paper
• Pharmacological modulation of I(1)-imidazoline and α2-adrenoceptors in sub acute brain ischemia induced vascular dementia.

  2014cited by this paper
• Astrogliosis in the brain of obese Zucker rat: a model of metabolic syndrome.

  2013cited by this paper
• Mouse Models to Study the Effect of Cardiovascular Risk Factors on Brain Structure and Cognition

  2013cited by this paper
• Induction of Hyperhomocysteinemia Models Vascular Dementia by Induction of Cerebral Microhemorrhages and Neuroinflammation

  2013cited by this paper
• Oxidative Stress Interferes With White Matter Renewal After Prolonged Cerebral Hypoperfusion in Mice

  2013cited by this paper
• An MRI-Histological Study of White Matter in Stroke-Free SHRSP

  2013cited by this paper
• Nox2 Deficiency Prevents Hypertension-Induced Vascular Dysfunction and Hypertrophy in Cerebral Arterioles

  2013cited by this paper
• A Tetramethylpyrazine Piperazine Derivate CXC137 Prevents Cell Injury in SH-SY5Y Cells and Improves Memory Dysfunction of Rats with Vascular Dementia

  2013cited by this paper
• Mitochondrial bioenergetic deficits in the hippocampi of rats with chronic ischemia-induced vascular dementia.

  2013cited by this paper
• Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex.

  2013cited by this paper
• Biphasic Functional Regulation in Hippocampus of Rat with Chronic Cerebral Hypoperfusion Induced by Permanent Occlusion of Bilateral Common Carotid Artery

  2013cited by this paper
• Performance of conventional pigs and Göttingen miniature pigs in a spatial holeboard task: effects of the putative muscarinic cognition impairer Biperiden

  2013cited by this paper
• Involvement of glial P2Y1 receptors in cognitive deficit after focal cerebral stroke in a rodent model

  2013cited by this paper
• Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia

  2013cited by this paper
• Evaluation of Hippocampal Injury and Cognitive Function Induced by Embolization in the Rat Brain

  2013cited by this paper
• Homocysteine has anti-inflammatory properties in a hypercholesterolemic rat model in vivo

  2012cited by this paper
• Central Cardiovascular Circuits Contribute to the Neurovascular Dysfunction in Angiotensin II Hypertension

  2012cited by this paper
• Myelin Loss Associated With Neuroinflammation in Hypertensive Rats

  2012influential reference
• Effects of long-term moderate ethanol and cholesterol on cognition, cholinergic neurons, inflammation, and vascular impairment in rats

  2012cited by this paper
• Cognitive Deficits and Delayed Neuronal Loss in a Mouse Model of Multiple Microinfarcts

  2012cited by this paper
• Chronic vascular risk factors (cholesterol, homocysteine, ethanol) impair spatial memory, decline cholinergic neurons and induce blood–brain barrier leakage in rats in vivo

  2012cited by this paper
• Homocysteine alters cerebral microvascular integrity and causes remodeling by antagonizing GABA-A receptor

  2012cited by this paper
• Pre-clinical models of human cerebral small vessel disease: utility for clinical application.

  2012cited by this paper
• S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice.

  2012cited by this paper
• A Surgical Model of Permanent and Transient Middle Cerebral Artery Stroke in the Sheep

  2012cited by this paper
• Dairy cow feeding space requirements assessed in a Y-maze choice test.

  2012cited by this paper
• Antibodies to the α1-Adrenergic Receptor Cause Vascular Impairments in Rat Brain as Demonstrated by Magnetic Resonance Angiography

  2012cited by this paper
• Brain Deletion of Insulin Receptor Substrate 2 Disrupts Hippocampal Synaptic Plasticity and Metaplasticity

  2012cited by this paper
• Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

  2012influential reference
• The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit

  2012cited by this paper
• Selective white matter abnormalities in a novel rat model of vascular dementia.

  2012cited by this paper
• Old World Monkeys Compare to Apes in the Primate Cognition Test Battery

  2012cited by this paper
• Cognitive and neurochemical alterations in hyperhomocysteinemic rat

  2012cited by this paper
• Middle cerebral artery alterations in a rat chronic hypoperfusion model.

  2012cited by this paper
• Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline

  2011cited by this paper

• Interplay Between Vascular Dysfunction and Neurodegenerative Pathology: New Insights into Molecular Mechanisms and Management

  2025influential citation
• A Minimally Invasive Framework Reveals Region‐Specific Cerebrovascular Remodeling in Aging Using Intravital Functional Ultrasound Imaging and Ultrasound Localization Microscopy (fUS‐ULM)

  2025cites this paper
• Mechanistic Insights and Translational Therapeutics of Neurovascular Unit Dysregulation in Vascular Cognitive Impairment.

  2025cites this paper
• Health Benefits of Phytosterols in the Management of Several Non‐Communicable Disorders

  2025cites this paper
• Cerebrovascular p16INK4A expression induces cerebral small vessel disease-related phenotypes

  2025cites this paper
• Hippocampal Neurogenesis: Bridging Stress, Cognitive Decline, and Therapeutic Strategies for Neural Health.

  2025cites this paper
• Cerebrovascular reactivity MRI as a biomarker for cerebral small vessel disease–related cognitive decline: Multi‐site validation in the MarkVCID Consortium

  2024cites this paper
• Combination treatment with cilostazol and isosorbide mononitrate attenuates microemboli-mediated vascular cognitive impairment and improves imaging and plasma biomarkers in diabetic rats.

  2024cites this paper
• Progressive Disruption of Sphingosine-1-Phosphate Receptor 1 Correlates with Blood-Brain Barrier Leakage in A Rat Model of Chronic Hypoxic Hypoperfusion

  2024cites this paper
• Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel Disease

  2023cites this paper
• A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia

  2023cites this paper
• PNA5, A Novel Mas Receptor Agonist, Improves Neurovascular and Blood-Brain-Barrier Function in a Mouse Model of Vascular Cognitive Impairment and Dementia

  2023cites this paper
• Role of natural bioactive compounds in the management of neurodegenerative disorders

  2023cites this paper
• Natural Bioactive Molecules as Neuromedicines for the Treatment/Prevention of Neurodegenerative Diseases

  2023cites this paper
• Microglial inflammation and cognitive dysfunction in comorbid rat models of striatal ischemic stroke and alzheimer's disease: effects of antioxidant catalase-SKL on behavioral and cellular pathology.

  2022cites this paper
• Deeper cerebral hypoperfusion leads to spatial cognitive impairment in mice

  2022cites this paper
• Vascular cognitive impairment and dementia: An early career researcher perspective

  2022cites this paper
• Cognitive Sequelae of Silent Ischemic Lesions Following Carotid Artery Stenting: Possible Role of Age-Related Moderation

  2022cites this paper
• A functional cerebral endothelium is necessary to protect against cognitive decline

  2021cites this paper
• Characterizing the Neuroimaging and Histopathological Correlates of Cerebral Small Vessel Disease in Spontaneously Hypertensive Stroke-Prone Rats

  2021cites this paper
• Effects of cerebral hypoperfusion on the cerebral white matter: a meta‑analysis.

  2021cites this paper
• White Matter Damage as a Consequence of Vascular Dysfunction in a Spontaneous Mouse Model of Chronic Hypoperfusion with eNOS Deficiency

  2021cites this paper
• Exploring the Potential of Mesenchymal Stem Cell-Based Therapy in Mouse Models of Vascular Cognitive Impairment

  2020cites this paper
• Coniferaldehyde attenuates Alzheimer's pathology via activation of Nrf2 and its targets

  2020cites this paper
• UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings

  2020cites this paper
• University of Dundee UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment McFall,

  2020cites this paper
• Long-term effects of experimental carotid stenosis on hippocampal infarct pathology, neurons and glia and amelioration by environmental enrichment.

  2020cites this paper
• Experimental models and plant‑based therapy for experimental cerebral ischemia (Review)

  2020cites this paper
• Diabetic rats are more susceptible to cognitive decline in a model of microemboli-mediated vascular contributions to cognitive impairment and dementia.

  2020cites this paper
• Ameliorative effect of ozagrel, a thromboxane A2 synthase inhibitor, in hyperhomocysteinemia‐induced experimental vascular cognitive impairment and dementia

  2020cites this paper
• Animal Models of Chronic Cerebral Hypoperfusion: From Mouse to Primate

  2019cites this paper
• Posterior reversible encephalopathy syndrome in stroke-prone spontaneously hypertensive rats on high-salt diet

  2019cites this paper
• Protective effects of sulforaphane in experimental vascular cognitive impairment: Contribution of the Nrf2 pathway

  2019cites this paper
• Carotid artery disease in post‐stroke survivors and effects of enriched environment on stroke pathology in a mouse model of carotid artery stenosis

  2019cites this paper
• Protective Role of Levetiracetam Against Cognitive Impairment And Brain White Matter Damage in Mouse prolonged Cerebral Hypoperfusion.

  2019cites this paper
• CADASIL : a pure model for studying cerebral small vessel disease

  2019cites this paper
• Review: Vascular dementia: clinicopathologic and genetic considerations

  2018cites this paper
• Multi-Parametric Classification of Vascular Cognitive Impairment and Dementia: The Impact of Diverse Cerebrovascular Injury Biomarkers

  2018cites this paper
• The effects of environmental enrichment on white matter pathology in a mouse model of chronic cerebral hypoperfusion

  2018cites this paper
• Editorial: Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America

  2018cites this paper
• Brain Structural Imaging in Alzheimer’s Disease

  2018cites this paper
• Vascular Cognitive Impairment Linked to Brain Endothelium Inflammation in Early Stages of Heart Failure in Mice

  2018cites this paper
• MMP-9 inhibitors impair learning in spontaneously hypertensive rats

  2018cites this paper
• Keeping the Extracellular Matrix Well Structured to Keep Healthy Vessels.

  2018cites this paper
• Translational models for vascular cognitive impairment: a review including larger species

  2017influential citation
• Interaction of Vascular Damage and Alzheimer Dementia: Focal Damage and Disconnection.

  2017cites this paper
• Diagnostic and Prognostic Potential of Retinal Biomarkers in Early On-Set Alzheimer's Disease.

  2017cites this paper
• Protective effects of D-Limonene against transient cerebral ischemia in stroke-prone spontaneously hypertensive rats

  2017cites this paper
• Executive dysfunction and blockage of brain microvessels in a rat model of vascular cognitive impairment

  2017cites this paper
• Effects of Environmental Enrichment on White Matter Pathology in a Mouse Model of Chronic Cerebral Hypoperfusion

  2017cites this paper
• Effects of environmental enrichment on white matter glial responses in a mouse model of chronic cerebral hypoperfusion

  2017cites this paper
• The impact of cerebrovascular aging on vascular cognitive impairment and dementia.

  2017cites this paper
• Mechanisms of vascular disease in dementia: what does industry want to know?

  2017cites this paper
• Small vessels, dementia and chronic diseases-molecular mechanisms and pathophysiology.

  2016cites this paper
• Phytosterols and Dementia

  2016cites this paper
• Dementia, Preclinical Studies in Neurodegeneration and its Potential for Translational Medicine in South America

  2016cites this paper
• Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

  2016cites this paper
• "Cerebral Small Vessel Disease in subclinical and clinical stages, role of inflammation for risk prediction and potential treatment targets, and management strategies".

  2016cites this paper