Neonatal ketamine exposure results in changes in biochemical substrates of neuronal growth and synaptogenesis, and alters adult behavior irreversibly.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Toxicology

• Publication date

  2008-07-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.tox.2008.04.019PMID 18550250
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1983cited by this paper
• The cholinergic hypothesis of geriatric memory dysfunction.

  1982cited by this paper
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  1969cited by this paper
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  1964cited by this paper
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  2012influential citation
• [Neurological consequences after long-term sedation in the ICU].

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  2010cites this paper
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  2010cites this paper
• [Effects of general anaesthetics on the developing brain].

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  2009cites this paper
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