Potential estrogenic and antiestrogenic activity of the cyclic siloxane octamethylcyclotetrasiloxane (D4) and the linear siloxane hexamethyldisiloxane (HMDS) in immature rats using the uterotrophic assay.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Toxicological Sciences

• Publication date

  2001-09-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1093/TOXSCI/63.1.37PMID 11509742
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Estrogen Receptors α and β in the Female Reproductive Tract of the Rat During the Estrous Cycle1

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• Molecular mechanisms of estrogen action: selective ligands and receptor pharmacology.

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• Neonatal exposure to estrogen differentially alters estrogen receptor alpha and beta mRNA expression in rat testis during postnatal development.

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• Estrogen receptors alpha and beta in the female reproductive tract of the rat during the estrous cycle.

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• Induction of hepatic xenobiotic metabolizing enzymes in female Fischer-344 rats following repeated inhalation exposure to decamethylcyclopentasiloxane (D5).

  1999cited by this paper
• The mammary tumor response in triazine-treated female rats: a threshold-mediated interaction with strain and species-specific reproductive senescence.

  1999cited by this paper
• A risk characterization for atrazine: oncogenicity profile.

  1999cited by this paper
• Compartmentalized uterotrophic effects of tamoxifen, toremifene, and estradiol in the ovariectomized Wistar (Han) rat.

  1999cited by this paper
• Assays to measure estrogen and androgen agonists and antagonists.

  1998cited by this paper
• Assessment of polystyrene extract for estrogenic activity in the rat uterotrophic model and an in vitro recombinant receptor reporter gene assay.

  1998cited by this paper
• Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β.

  1998cited by this paper
• Variability in the uterotrophic response assay (an in vivo estrogenic response assay) in untreated control and positive control (DES-DP, 2.5 microG/kg, bid) Wistar and Sprague-Dawley rats.

  1998cited by this paper
• Evaluation of octamethylcyclotetrasiloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: a 28-day inhalation study.

  1998influential reference
• Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.

  1998cited by this paper
• The Effective Free Fraction of Estradiol and Xenoestrogens in Human Serum Measured by Whole Cell Uptake Assays: Physiology of Delivery Modifies Estrogenic Activity

  1998cited by this paper
• Neonatal exposure to coumestrol, a phytoestrogen, does not alter spermatogenic potential in rats

  1997cited by this paper
• The rodent uterotrophic assay: critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay.

  1997cited by this paper
• Endocrine modulation of reproduction.

  1996cited by this paper
• Identification of environmental chemicals with estrogenic activity using a combination of in vitro assays.

  1996cited by this paper
• Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop.

  1996cited by this paper
• Survey and assessment of mammalian estrogen biological assays for hazard characterization.

  1996cited by this paper
• Review Article: Strain as a Determinant Factor in the Differential Responsiveness of Rats to Chemicals

  1995cited by this paper
• Naringenin: a weakly estrogenic bioflavonoid that exhibits antiestrogenic activity.

  1995cited by this paper
• Influence of phytoestrogen diets on estradiol action in the rat uterus.

  1994cited by this paper
• Diagnostic parasitology.

  1989cited by this paper
• Ovulation Rates and Embryo Degeneracy in Female Mice Fed the Phytoestrogen, Coumestrol 1

  1981cited by this paper
• Diethylstilbestrol and estradiol binding to serum albumin and pregnancy plasma of rat and human.

  1979cited by this paper
• Phytoestrogen interaction with estrogen receptors in human breast cancer cells.

  1978cited by this paper
• The effects of various steroids on the vaginal histology in the rat.

  1973cited by this paper
• Structure-activity relationships of organosiloxanes and the female reproductive system.

  1972cited by this paper

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  2025cites this paper
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  2024cites this paper
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  2024cites this paper
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  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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• Exposure of children and unborn children to selected chemical substances: Survey of chemical substances in consumer products No. 158 April 2017

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• Biological relevance of effects following chronic administration of octamethylcyclotetrasiloxane (D4) in Fischer 344 rats.

  2017cites this paper
• Octamethylcyclotetrasiloxane (D4).

  2017cites this paper
• An approach to the environmental prioritisation of volatile methylsiloxanes in several matrices.

  2017cites this paper
• A quantitative weight of evidence assessment of confidence in modes‐of‐action and their human relevance

  2017cites this paper
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  2017cites this paper
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  2016cites this paper
• Genotoxicity of cosmetic chemicals in human breast epithelial cells

  2016cites this paper
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• Endocrine Disruptors as Pollutants in Marine Ecosystem: A Case Study in Egypt

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• Induction of the Estrogenic Marker Calbindn-D9k by Octamethylcyclotetrasiloxane

  2015cites this paper
• Evaluation of the estrogenic activity of Indian medicinal plants in immature rats

  2015cites this paper
• A survey of cyclic and linear siloxanes in indoor dust and their implications for human exposures in twelve countries.

  2015cites this paper
• Sun lotion chemicals as endocrine disruptors

  2015cites this paper
• Environmental chemistry of organosiloxanes.

  2015cites this paper
• Volatile methyl siloxanes as potential hazardous air pollutants.

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• Prenatal exposure to common environmental factors affects brain lipids and increases risk of developing autism spectrum disorders

  2015cites this paper
• What Are Endocrine Disrupters and Where Are They Found

  2015cites this paper
• Occurrence of cyclic and linear siloxanes in indoor air from Albany, New York, USA, and its implications for inhalation exposure.

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• Pharmaceutical residues and other emerging substances in the effluent of sewage treatment plants

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• Regulatory Considerations for Dermal Application of Endocrine Disrupters in Personal Care Products

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• Temporal variations of cyclic and linear volatile methylsiloxanes in the atmosphere using passive samplers and high-volume air samplers.

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• Occurrence of linear and cyclic volatile methyl siloxanes in indoor air samples (UK and Italy) and their isotopic characterization.

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  2012cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
• In utero and lactational exposure to bisphenol A, in contrast to ethinyl estradiol, does not alter sexually dimorphic behavior, puberty, fertility, and anatomy of female LE rats.

  2010influential citation
• Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro

  2009cites this paper
• Low molecular weight cyclic volatile methylsiloxanes in cosmetic products sold in Canada: implication for dermal exposure.

  2009cites this paper
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  2009cites this paper
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  2008cites this paper