Apoptosis induced by erythroid differentiation of human leukemia cell lines is inhibited by Bcl-XL.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Blood

• Publication date

  1996-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD.V87.9.3837.BLOODJOURNAL8793837PMID 8611710
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

  1995cited by this paper
• Overexpression of Bcl-XL by cytotoxic drug exposure confers resistance to ionizing radiation-induced internucleosomal DNA fragmentation.

  1995cited by this paper
• Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

  1995cited by this paper
• Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells.

  1995cited by this paper
• Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2.

  1994cited by this paper
• The Bcl-2 family of proteins: regulators of cell death and survival.

  1994cited by this paper
• Dysregulated bcl-2 expression inhibits apoptosis but not differentiation of retinoic acid-induced HL-60 granulocytes.

  1994cited by this paper
• Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia.

  1994cited by this paper
• Immunohistochemical analysis of in vivo patterns of Bcl-X expression.

  1994cited by this paper
• BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death.

  1994cited by this paper
• Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells.

  1994cited by this paper
• bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.

  1993cited by this paper
• Post-Transcriptional Regulation by Interferonα of ε-Globin Production in Human Erythroleukemia K-562 Cells

  1992cited by this paper
• Regulation of globin gene expression in human K562 cells by recombinant activin A.

  1992cited by this paper
• Post-transcriptional regulation by interferon-alpha of epsilon-globin production in human erythroleukemia K-562 cells.

  1992cited by this paper
• Apoptosis: molecular mechanisms in programmed cell death.

  1991cited by this paper
• Mechanisms and functions of cell death.

  1991cited by this paper
• Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells.

  1990cited by this paper
• Effect of second‐messenger modulators in K‐562 cell differentiation: Dual action of calcium/phospholipid‐dependent protein kinase in the process of differentiation

  1990cited by this paper
• Differential expression of transglutaminase in human erythroleukemia cells in response to retinoic acid.

  1990cited by this paper
• c-myc and c-myb oncoproteins during induced maturation of myeloid and erythroid human leukemic cell lines.

  1989cited by this paper
• Transforming growth factor-beta induces hemoglobin synthesis in a human erythroleukemia cell line.

  1989cited by this paper
• Maintenance by erythropoietin of viability and maturation of murine erythroid precursor cells

  1988cited by this paper
• Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.

  1988cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• HEL cells: a new human erythroleukemia cell line with spontaneous and induced globin expression.

  1982cited by this paper
• Inducers of erythroid differentiation in K562 human leukemia cells.

  1981cited by this paper
• Embryonic erythroid differentiation in the human leukemic cell line K562.

  1981cited by this paper
• The primary structure of the human epsilon-globin gene.

  1980cited by this paper
• The primary structure of the human ϵ-globin gene

  1980cited by this paper
• K562 human leukaemic cells synthesise embryonic haemoglobin in response to haemin

  1979cited by this paper

• Knock Out of miRNA-30a-5p and Reconstitution of the Actin Network Dynamics Partly Restores the Impaired Terminal Erythroid Differentiation during Blood Pharming

  2025cites this paper
• Selective Cytotoxicity of Ochratoxin A: Pro-Apoptotic Effects on Healthy Immune Cells Compared to Leukemia Cells

  2025cites this paper
• Aquaporin 1 confers apoptosis resistance in pulmonary arterial smooth muscle cells from the SU5416 hypoxia rat model

  2023cites this paper
• Neuroinflammation, Early-Life Adversity, and Brain Development

  2022cites this paper
• BCR-ABL1 Tyrosine Kinase Complex Signaling Transduction: Challenges to Overcome Resistance in Chronic Myeloid Leukemia

  2022influential citation
• Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

  2022cites this paper
• Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed

  2019cites this paper
• Triggering apoptosis in tumors: an overview of potential approaches in treatment of leukemia

  2019cites this paper
• Expression of myostatin in human hematopoietic cells unveils novel autocrine/paracrine actions for the hormone

  2018cites this paper
• Loss of Wilms tumor 1 protein is a marker for apoptosis in response to replicative stress in leukemic cells

  2018cites this paper
• Loss of Wilms tumor 1 protein is a marker for apoptosis in response to replicative stress in leukemic cells

  2018cites this paper
• Deoxynucleosides with benzimidazoles as aglycone moiety are potent anticancer agents

  2018cites this paper
• Evaluation of Paclitaxel Effects in The Pattern of Expression of Survival and Apoptotic Genes Regulators in HeLa Cells.

  2016cites this paper
• PI3K/Akt regulates survival during differentiation of human macrophages by maintaining NF‐κB‐dependent expression of antiapoptotic Bcl‐xL

  2014cites this paper
• Large-scale screening identifies a novel microRNA, miR-15a-3p, which induces apoptosis in human cancer cell lines

  2013cites this paper
• Bak-derived BH3 peptide that interacts with membrane-associated Bcl-XL Erythrocyte survival is promoted by plasma and suppressed by a

  2013cites this paper
• Activation of Caspase-3 Through Blockage of Mitochondrial Release of Cytochrome C and Bcr-Abl Exerts Its Antiapoptotic Effect Against Diverse Apoptotic Stimuli

  2013cites this paper
• Tannic Acid Induced Suicidal Erythrocyte Death

  2013cites this paper
• Antiapoptotic Proteins in Human Macrophage Survival, Differentiation, Innate Immunity and Protection from HIV-induced Apoptosis

  2013cites this paper
• Mechanism of folate deficiency-induced apoptosis in mouse embryonic stem cells: Cell cycle arrest/apoptosis in G1/G0 mediated by microRNA-302a and tumor suppressor gene Lats2.

  2012cites this paper
• Sustained exposure to the DNA demethylating agent, 2'-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy.

  2011cites this paper
• Amiloride modulates alternative splicing in leukemic cells and resensitizes Bcr-AblT315I mutant cells to imatinib.

  2011cites this paper
• Alternative Splicing in Leukemic Cells and Resensitizes Bcr-Abl T 315 I Mutant Cells to Imatinib

  2011cites this paper
• A Novel Pathway of TEF Regulation Mediated by MicroRNA-125b Contributes to the Control of Actin Distribution and Cell Shape in Fibroblasts

  2011cites this paper
• Resistance to Apoptosis in Human Myeloma Cell Lines Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and

  2010cites this paper
• c‐FLIP is involved in erythropoietin‐mediated protection of erythroid‐differentiated cells from TNF‐α‐induced apoptosis

  2010influential citation
• Differential antiapoptotic effect of erythropoietin on undifferentiated and retinoic acid‐differentiated SH‐SY5Y cells

  2010cites this paper
• BAX/BCL-XL gene expression ratio inversely correlates with disease progression in chronic myeloid leukemia.

  2010cites this paper
• Caspase-independent apoptosis in Friend’s erythroleukemia cells: role of mitochondrial ATP synthesis impairment in relocation of apoptosis-inducing factor and endonuclease G

  2009cites this paper
• A non‐apoptotic function of caspase‐3 in pharmacologically‐induced differentiation of K562 cells

  2009cites this paper
• PAR bZIP-bik is a novel transcriptional pathway that mediates oxidative stress-induced apoptosis in fibroblasts

  2009cites this paper
• TNF-alpha-induced apoptosis is prevented by erythropoietin treatment on SH-SY5Y cells.

  2009cites this paper
• RESEARCH PAPER A non-apoptotic function of caspase-3 in pharmacologically-induced differentiation of K562 cells

  2009cites this paper
• Retinoic Acid Induced Suicidal Erythrocyte Death

  2008cites this paper
• Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders.

  2008cites this paper
• Disruption of Survivin in K562 cells elevates telomerase activity and protects cells against apoptosis induced by the Bcr-abl kinase inhibitor STI571.

  2008cites this paper
• Continuous expression of Bcl‐xL protein during megakaryopoiesis is post‐translationally regulated by thrombopoietin‐mediated Akt activation, which prevents the cleavage of Bcl‐xL

  2007cites this paper
• Exposure to sodium butyrate, dimethyl sulfoxide, and phorbol-12-myristine-13-acetate alters sensitivity of K562 cells to nonspecific lysis by human or rat leukocytes

  2007cites this paper
• Deficiency of the NF-κB Inhibitor Caspase Activating and Recruitment Domain 8 in Patients with Rheumatoid Arthritis Is Associated with Disease Severity1

  2007cites this paper
• GATA-1 and Gfi-1B Interplay To Regulate Bcl-xL Transcription

  2007cites this paper
• Heme as key regulator of major mammalian cellular functions: molecular, cellular, and pharmacological aspects.

  2006cites this paper
• Effect of erythropoietin on staurosporine-induced apoptosis and differentiation of SH-SY5Y neuroblastoma cells.

  2006influential citation
• CD44 ligation induces caspase-independent cell death via a novel calpain/AIF pathway in human erythroleukemia cells

  2006cites this paper
• Glucosamine sulfate–induced apoptosis in chronic myelogenous leukemia K562 cells is associated with translocation of cathepsin D and downregulation of Bcl-xL

  2006cites this paper
• A Novel Role for Proline- and Acid-rich Basic Region Leucine Zipper (PAR bZIP) Proteins in the Transcriptional Regulation of a BH3-only Proapoptotic Gene*

  2006cites this paper
• In vitro folate deficiency induces apoptosis by a p53, Fas (Apo-1, CD95) independent, bcl-2 related mechanism in phytohaemagglutinin-stimulated human peripheral blood lymphocytes

  2006cites this paper
• Upregulation of Bfl-1/A1 in leukemia cells undergoing differentiation by all-trans retinoic acid treatment attenuates chemotherapeutic agent-induced apoptosis

  2006cites this paper
• The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor.

  2005cites this paper
• Arsenic Trioxide Induces Erythroid Differentiation and Apoptosis of K562 Human Leukemia Cells through the Down-Regulation of Bcl-2

  2005cites this paper
• Blockade of epidermal growth factor receptors chemosensitizes breast cancer cells through up-regulation of Bnip3L.

  2005cites this paper
• Two-phase culture in Diamond Blackfan anemia: localization of erythroid defect.

  2005cites this paper
• Defective binding of transcriptional repressor ZEB via DNA methylation contributes to increased constitutive levels of p73 in Fanconi anemia cells

  2005cites this paper
• Tyrosine kinase inhibitor AG1024 exerts antileukaemic effects on STI571-resistant Bcr-Abl expressing cells and decreases AKT phosphorylation

  2004cites this paper
• Differences in BCL‐XL expression and STAT5 phosphorylation in chronic myeloid leukaemia patients

  2004cites this paper
• Ipaf is upregulated by tumor necrosis factor-alpha in human leukemia cells.

  2004cites this paper
• Early down-regulation of Bcl-xL expression during megakaryocytic differentiation of thrombopoietin-induced CD34+ bone marrow cells in essential thrombocythemia.

  2004cites this paper
• NALP1 is a transcriptional target for cAMP-response-element-binding protein (CREB) in myeloid leukaemia cells.

  2004cites this paper
• Jun N-terminal kinase activity and early growth-response factor-1 gene expression are down-regulated in Fanconi anemia group A lymphoblasts.

  2004cites this paper
• Ipaf is upregulated by tumor necrosis factor‐α in human leukemia cells

  2004cites this paper
• The onset of p53-dependent apoptosis plays a role in terminal differentiation of human normoblasts

  2003cites this paper
• p16(INK4a) induces differentiation and apoptosis in erythroid lineage cells.

  2003cites this paper
• Inducible p27Kip1 expression inhibits proliferation of K562 cells and protects against apoptosis induction by proteasome inhibitors

  2003cites this paper
• Downregulation of Bcl-xL and activation of caspases during retinoic acid-induced apoptosis in an adult T-cell leukemia cell line.

  2003cites this paper
• Erythroid Differentiation Sensitizes K562 Leukemia Cells to TRAIL-Induced Apoptosis by Downregulation of c-FLIP

  2003influential citation
• Induction of cell death by sera from patients with acute brain injury as a mechanism of production of autoantibodies.

  2002cites this paper
• Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation*

  2002cites this paper
• Erythropoietin protects neurons against chemical hypoxia and cerebral ischemic injury by up‐regulating Bcl‐xL expression

  2002cites this paper
• Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-X(L).

  2002cites this paper
• Gene Expression and Biological Significance of Hexokinase in Erythroid Cells

  2002cites this paper
• St. Louis encephalitis virus induced pathology in cultured cells

  2002cites this paper
• The prevention of the staurosporine‐induced apoptosis by Bcl‐XL, but not by Bcl‐2 or caspase inhibitors, allows the extensive differentiation of human neuroblastoma cells

  2002influential citation
• Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells

  2002influential citation
• Erythropoieti nProtect sNeuron sAgainst Chemica lHypoxi aan dCerebra lIschemic Injur yb yUp-Regulatin gBcl-x L Expression

  2002cites this paper
• Inhibition of Bcr–Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells

  2002cites this paper
• Chemically Induced Differentiation of the Cells of Tumor Lines

  2002cites this paper
• Induction of apoptosis by estramustine phosphate mediated by phosphorylation of bcl-2

  2001cites this paper
• A Novel Mechanism of Cooperation between c-Kit and Erythropoietin Receptor

  2001cites this paper
• BCL-X L ANTISENS EOLIGONUCLEOTIDE SINDUC EAPOPTOSI SAND INCREAS ESENSITIVIT YO FPANCREATI CCANCE RCELL ST OGEMCITABINE

  2001cites this paper
• BAD Induces Apoptosis in Cells Over-Expressing Bcl-2 or Bcl-xL without Loss of Mitochondrial Membrane Potential

  2001cites this paper
• The Absence of Oligonucleosomal DNA Fragmentation during Apoptosis of IMR-5 Neuroblastoma Cells

  2001cites this paper
• West Nile virus‐induced bax‐dependent apoptosis

  2001cites this paper
• Bcl-2 expression in F-MuLV-induced erythroleukemias: a role for the anti-apoptotic action of Bcl-2 during tumor progression

  2001cites this paper
• Transcriptional regulation of gene expression in lung carcinoma cells

  2001cites this paper
• DNA damage–induced apoptosis

  2001cites this paper
• Bcl‐xl antisense oligonucleotides induce apoptosis and increase sensitivity of pancreatic cancer cells to gemcitabine

  2001cites this paper
• Antisense Downregulation of the Apoptosis-related Bcl-2 and Bcl-xL Proteins: A New Approach to Cancer Therapy

  2000cites this paper
• Differential Expression of Bcl‐2 Homologs in Human CD34+ Hematopoietic Progenitor Cells Induced to Differentiate into Erythroid or Granulocytic Cells

  2000cites this paper
• Formation and repair of DNA double-strand breaks in gamma-irradiated K562 cells undergoing erythroid differentiation.

  2000cites this paper
• Blockade of the Bcr-Abl Kinase Activity Induces Apoptosis of Chronic Myelogenous Leukemia Cells by Suppressing Signal Transducer and Activator of Transcription 5–Dependent Expression of Bcl-XL

  2000cites this paper
• Transduction of Apaf-1 or caspase-9 induces apoptosis in A-172 cells that are resistant to p53-mediated apoptosis.

  2000cites this paper
• Adenovirus-mediated transfer of Bax with caspase-8 controlled by myelin basic protein promoter exerts an enhanced cytotoxic effect in gliomas

  2000cites this paper
• Role of interleukin-6 signaling via the Jak/Stat pathway in human myeloma and effects on mediators of cell survival and proliferation

  2000cites this paper
• Adenovirus-Mediated Transfer of Caspase-8 Augments Cell Death in Gliomas: Implication for Gene Therapy

  2000cites this paper
• Interferon gamma delays apoptosis of mature erythroid progenitor cells in the absence of erythropoietin.

  2000cites this paper
• Adenovirus-mediated overexpression of Fas induces apoptosis of gliomas

  2000cites this paper
• Effects of Bcl-2 and Bcl-XL protein levels on chemoresistance of hepatoblastoma HepG2 cell line.

  2000cites this paper
• The Survival Function of the Bcr-Abl Oncogene Is Mediated by Bad-Dependent and -Independent Pathways: Roles for Phosphatidylinositol 3-Kinase and Raf

  2000cites this paper
• Primary HIV-1 infection of human CD4+ T cells passaged into SCID mice leads to selection of chronically infected cells through a massive Fas-mediated autocrine suicide of uninfected cells

  2000cites this paper
• Increased sensitivity of multidrug-resistant myeloid leukemia cell lines to lovastatin

  2000cites this paper
• Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells.

  2000cites this paper