Reduced C-afferent fibre density affects perceived pleasantness and empathy for touch.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Brain : a journal of neurology

• Publication date

  2011-04-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1093/brain/awr011PMID 21378097
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010influential reference
• The neurophysiology of unmyelinated tactile afferents.

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  2008influential reference
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• Unmyelinated tactile afferents have opposite effects on insular and somatosensory cortical processing.

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• SAS for Mixed Models

  2007influential reference
• Discriminative touch and emotional touch.

  2007cited by this paper
• The sight of others' pain modulates motor processing in human cingulate cortex.

  2007influential reference
• Functional role of unmyelinated tactile afferents in human hairy skin: sympathetic response and perceptual localization

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