CD44 Engagement Promotes Matrix-Derived Survival through the CD44-SRC-Integrin Axis in Lipid Rafts

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Molecular and Cellular Biology

• Publication date

  2008-07-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.00186-08PMID 18644869PMCID PMC2546932
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1991cited by this paper

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