Intracellular Ca2+ increases the mitochondrial NADH concentration during elevated work in intact cardiac muscle.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Circulation Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/01.RES.80.1.82PMID 8978326
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of cellular energy metabolism

  2005cited by this paper
• Subcellular origin of the surface fluorescence of reduced nicotinamide nucleotides in the isolated perfused rat heart

  2005cited by this paper
• Increased work in cardiac trabeculae causes decreased mitochondrial NADH fluorescence followed by slow recovery.

  1996cited by this paper
• Effect of substrate on mitochondrial NADH, cytosolic redox state, and phosphorylated compounds in isolated hearts.

  1995cited by this paper
• Differential effects of length on maximum force production and myofibrillar ATPase activity in rat skinned cardiac muscle.

  1994cited by this paper
• The metabolic consequences of an increase in the frequency of stimulation in isolated ferret hearts.

  1994cited by this paper
• Fluorescent properties of rat cardiac trabeculae microinjected with fura-2 salt.

  1993cited by this paper
• Ca2+ cycling between sarcoplasmic reticulum and mitochondria in rabbit cardiac myocytes.

  1993cited by this paper
• Mitochondrial and sarcolemmal Ca2+ transport reduce [Ca2+]i during caffeine contractures in rabbit cardiac myocytes.

  1992cited by this paper
• Ca2+ and Na+ in rat myocytes showing different force-frequency relationships.

  1991cited by this paper
• Diastolic, systolic and sarcoplasmic reticulum [Ca2+] during inotropic interventions in isolated rat myocytes.

  1991cited by this paper
• Regulation of functional muscarinic receptor expression in tracheal smooth muscle cells.

  1991cited by this paper
• Measurement of mitochondrial free Ca2+ concentration in living single rat cardiac myocytes.

  1991cited by this paper
• Dehydrogenase activation by Ca2+ in cells and tissues

  1991cited by this paper
• Control of mitochondrial ATP synthesis in the heart.

  1991cited by this paper
• Energetics of isometric force development in control and volume-overload human myocardium. Comparison with animal species.

  1991cited by this paper
• Role of calcium ions in regulation of mammalian intramitochondrial metabolism.

  1990cited by this paper
• Regulation of the oxidative phosphorylation rate in the intact cell.

  1990cited by this paper
• Simultaneous measurement of Ca2+, contraction, and potential in cardiac myocytes.

  1990cited by this paper
• The role of Ca2+ in the function and dysfunction of heart mitochondria

  1990cited by this paper
• Direct evidence for a role of intramitochondrial Ca2+ in the regulation of oxidative phosphorylation in the stimulated rat heart. Studies using 31P n.m.r. and ruthenium red.

  1989cited by this paper
• Time-invariant oxygen cost of mechanical energy in dog left ventricle: consistency and inconsistency of time-varying elastance model with myocardial energetics.

  1989cited by this paper
• Nicotinamide adenine dinucleotide fluorescence spectroscopy and imaging of isolated cardiac myocytes.

  1989cited by this paper
• CONTROL OF ELECTRON FLUX THROUGH THE RESPIRATORY CHAIN IN MITOCHONDRIA AND CELLS

  1987cited by this paper
• Determination of pyridine nucleotide fluorescence from the perfused heart using an internal standard.

  1987cited by this paper
• Respiratory control in the glucose perfused heart

  1987cited by this paper
• The effects of muscle length on intracellular calcium transients in mammalian cardiac muscle.

  1982cited by this paper
• Blood:bone disequilibrium. III. Linkage between cell energetics and Ca fluxes.

  1979cited by this paper
• Myocardial energetics during isometric twitch contractions of cat papillary muscle.

  1979cited by this paper
• Heat and fluorescence changes in cardiac muscle: effects of substrate and calcium.

  1976cited by this paper
• Calcium and the Heart

  1971cited by this paper
• Differences between the reactivity of endogenous and exogenous adenine nucleotides in mitochondria as studied at low temperature.

  1968cited by this paper

• Impaired Atrial Mitochondrial Calcium Handling in Patients With Atrial Fibrillation.

  2025cites this paper
• Mechano-energetic uncoupling in heart failure

  2025influential citation
• A simulation study on the role of mitochondria‐sarcoplasmic reticulum Ca2+ interaction in cardiomyocyte energetics during exercise

  2024cites this paper
• Role of Mitochondrial ROS for Calcium Alternans in Atrial Myocytes

  2024cites this paper
• Mitochondrial calcium signaling and redox homeostasis in cardiac health and disease

  2023cites this paper
• Testosterone deficiency impairs cardiac interfibrillar mitochondrial function and myocardial contractility while inducing oxidative stress

  2023cites this paper
• Cardiac Involvement in Mitochondrial Disorders

  2023cites this paper
• Loss of mitochondrial Ca2+ uptake protein 3 impairs skeletal muscle calcium handling and exercise capacity

  2023cites this paper
• Visualization of Dynamic Mitochondrial Calcium Fluxes in Isolated Cardiomyocytes

  2022cites this paper
• Stimulation of the mitochondrial calcium uniporter mitigates chronic heart failure-associated ventricular arrhythmia in mice.

  2022cites this paper
• Implications of SGLT Inhibition on Redox Signalling in Atrial Fibrillation

  2021cites this paper
• Metabolic alterations in a rat model of takotsubo syndrome

  2021cites this paper
• Beat-to-beat dynamic regulation of intracellular pH in cardiomyocytes

  2021cites this paper
• Loss of Mitochondrial Ca2+ Uniporter Limits Inotropic Reserve and Provides Trigger and Substrate for Arrhythmias in Barth Syndrome Cardiomyopathy

  2021cites this paper
• The role of oxidative stress on molybdenum enzymes and ischemic reperfusion injury in hyperuricaemic patients. An infrared spectroscopic study

  2020cites this paper
• CaMKII does not control mitochondrial Ca2+ uptake in cardiac myocytes

  2020influential citation
• Mitochondrial Ca2+ in heart failure: Not enough or too much?

  2020cites this paper
• Cardiac Disorders and Pathophysiology of Sarcomeric Proteins.

  2019cites this paper
• Slow Ca2+ Efflux by Ca2+/H+ Exchange in Cardiac Mitochondria Is Modulated by Ca2+ Re-uptake via MCU, Extra-Mitochondrial pH, and H+ Pumping by FOF1-ATPase

  2019cites this paper
• Treatments targeting inotropy A position paper of the Committees on Translational Research and Acute Heart Failure of the Heart Failure Association of the European Society of Cardiology

  2019cites this paper
• Metabolic Alterations in Inherited Cardiomyopathies

  2019influential citation
• Mitofusin 2 Is Essential for IP3-Mediated SR/Mitochondria Metabolic Feedback in Ventricular Myocytes

  2019cites this paper
• Bioenergetic Feedback between Heart Cell Contractile Machinery and Mitochondrial 3D Deformations.

  2018cites this paper
• Treatments targeting inotropy.

  2018cites this paper
• Mitochondrial junctions with cellular organelles: Ca2+ signalling perspective

  2018cites this paper
• Calcium Signaling and Reactive Oxygen Species in Mitochondria

  2018cites this paper
• Pharmacological Modulation of Mitochondrial Ca2+ Content Regulates Sarcoplasmic Reticulum Ca2+ Release via Oxidation of the Ryanodine Receptor by Mitochondria-Derived Reactive Oxygen Species

  2018cites this paper
• A Method Sustaining the Bioelectric, Biophysical, and Bioenergetic Function of Cultured Rabbit Atrial Cells

  2017cites this paper
• Endogenous nitric oxide formation in cardiac myocytes does not control respiration during β‐adrenergic stimulation

  2017cites this paper
• Regulation of oxidative phosphorylation through each-step activation (ESA): Evidences from computer modeling.

  2017influential citation
• Microdomains in the Cardiovascular System

  2017cites this paper
• Calcium Microdomains in Cardiac Cells

  2017cites this paper
• Oxidative stress in ageing and disease development studied by FT-IR spectroscopy.

  2017cites this paper
• Suppression of Arrhythmia by Enhancing Mitochondrial Ca2+ Uptake in Catecholaminergic Ventricular Tachycardia Models

  2017cites this paper
• Murine Electrophysiological Models of Cardiac Arrhythmogenesis.

  2017cites this paper
• Faster and stronger manifestation of mitochondrial diseases in skeletal muscle than in heart related to cytosolic inorganic phosphate (Pi) accumulation.

  2016cites this paper
• Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure.

  2016cites this paper
• Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure.

  2015cites this paper
• Spectroscopic Monitoring of NADH: Historical Overview

  2015cites this paper
• Responses of NADH to Physiological and Pathophysiological Conditions

  2015cites this paper
• Mitochondrial Function In Vivo Evaluated by NADH Fluorescence

  2015cites this paper
• Mitochondrial calcium and the regulation of metabolism in the heart.

  2015cites this paper
• Model of Electrophysiology and Metabolism of The Heart

  2015cites this paper
• How Exercise May Amend Metabolic Disturbances in Diabetic Cardiomyopathy

  2015cites this paper
• Increased Energy Demand during Adrenergic Receptor Stimulation Contributes to Ca(2+) Wave Generation.

  2015cites this paper
• Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications.

  2015cites this paper
• Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes.

  2014cites this paper
• Inhibiting Na+/K+ ATPase Can Impair Mitochondrial Energetics and Induce Abnormal Ca2+ Cycling and Automaticity in Guinea Pig Cardiomyocytes

  2014cites this paper
• Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity

  2014cites this paper
• NADH changes during hypoxia, ischemia, and increased work differ between isolated heart preparations.

  2014cites this paper
• Calcium release microdomains and mitochondria.

  2013cites this paper
• Intracellular Na⁺ and cardiac metabolism.

  2013cites this paper
• Na⁺ transport in the normal and failing heart - remember the balance.

  2013cites this paper
• The Role of Myofilament Modifications in Regulation of Cardiac Function under Acute and Chronic Stress

  2013cites this paper
• Regulation of ATP production by mitochondrial Ca2+

  2012cites this paper
• Chapter 10 – Communication in the Heart: Cardiokines as Mediators of a Molecular Social Network

  2012cites this paper
• Role of mitochondrial Ca2+ in the regulation of cellular energetics.

  2012cites this paper
• Calcium Fluxes and Homeostasis

  2012cites this paper
• Dissertation zur Erlangung des Grades eines Doktors der

  2012cites this paper
• Measuring mitochondrial function in intact cardiac myocytes.

  2012cites this paper
• Molekularbiologische und physiologische Untersuchungen zu G-Protein-gekoppelten Signalwegen in adulten Herzmuskelzellen

  2012cites this paper
• Coupling of ryanodine receptor 2 and voltage-dependent anion channel 2 is essential for Ca²+ transfer from the sarcoplasmic reticulum to the mitochondria in the heart.

  2012cites this paper
• Interplay of defective excitation-contraction coupling, energy starvation, and oxidative stress in heart failure.

  2011cites this paper
• Bioenergetics of the failing heart.

  2011cites this paper
• Computer-aided studies on the regulation of oxidative phosphorylation during work transitions.

  2011cites this paper
• A study of mitochondrial redox state in cardiac muscle

  2011cites this paper
• Rôle de la cytoarchitecture dans la signalisation énergétique du cœur de souris

  2011cites this paper
• Digitalis and Na/Ca exchange: old dog learns new mitochondrial tricks.

  2010cites this paper
• Matching ATP supply and demand in mammalian heart

  2010cites this paper
• Heart Failure Adverse Bioenergetic Consequences of Na-Ca 2 Exchanger-Mediated Ca 2 Influx in Cardiac Myocytes

  2010cites this paper
• Mitochondrial free [Ca2+] increases during ATP/ADP antiport and ADP phosphorylation: exploration of mechanisms.

  2010cites this paper
• Fetal and neonatal development of Ca2+ transients and functional sarcoplasmic reticulum in beating mouse hearts.

  2010cites this paper
• Elevated Cytosolic Na+ Increases Mitochondrial Formation of Reactive Oxygen Species in Failing Cardiac Myocytes

  2010cites this paper
• Dietary omega-3 fatty acids, nutritional preconditioning of the heart against ischemic injury

  2010cites this paper
• Adverse Bioenergetic Consequences of Na+-Ca2+ Exchanger–Mediated Ca2+ Influx in Cardiac Myocytes

  2010cites this paper
• Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription.

  2009cites this paper
• The role of Ca(2+) signaling in the coordination of mitochondrial ATP production with cardiac work.

  2009cites this paper
• Mitochondrial calcium transport in the heart: physiological and pathological roles.

  2009cites this paper
• Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells.

  2009cites this paper
• Mitochondrial Reactive Oxygen Species Production in Excitable Cells: Modulators of Mitochondrial and Cell Function

  2009cites this paper
• Mitochondrial Ca2+ uptake: tortoise or hare?

  2009cites this paper
• Domestication of the cardiac mitochondrion for energy conversion.

  2009cites this paper
• Control and Regulation of Integrated Mitochondrial Function in Metabolic and Transport Networks

  2009cites this paper
• Intracellular calcium, preconditioning and regulation of cellular respiration in heart

  2009cites this paper
• Oxidant and Redox Signaling in Vascular Oxygen Sensing: Implications for Systemic and Pulmonary Hypertension

  2008cites this paper
• Calcium cycling and signaling in cardiac myocytes.

  2008cites this paper
• Mitochondrial Ca2+ and the heart.

  2008cites this paper
• Stimulation‐induced changes in NADH fluorescence and mitochondrial membrane potential in lizard motor nerve terminals

  2007cites this paper
• Regulation of oxidative phosphorylation through parallel activation.

  2007cites this paper
• Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation in pigs

  2007cites this paper
• Excitation-contraction coupling and mitochondrial energetics

  2007influential citation
• Mitochondrial transporters as novel targets for intracellular calcium signaling.

  2007cites this paper
• Mitochondrial Calcium: Role in the Normal and Ischaemic/Reperfused Myocardium

  2007cites this paper
• Effect of Ca2+ on cardiac mitochondrial energy production is modulated by Na+ and H+ dynamics.

  2007cites this paper
• A computational model integrating electrophysiology, contraction, and mitochondrial bioenergetics in the ventricular myocyte.

  2006cites this paper
• Calcium-mediated coupling between mitochondrial substrate dehydrogenation and cardiac workload in single guinea-pig ventricular myocytes.

  2006cites this paper
• Oxygen consumption and metabolite concentrations during transitions between different work intensities in heart.

  2006influential citation
• Integration of rapid cytosolic Ca2+ signals by mitochondria in cat ventricular myocytes.

  2006cites this paper
• Elevated Cytosolic Na+ Decreases Mitochondrial Ca2+ Uptake During Excitation–Contraction Coupling and Impairs Energetic Adaptation in Cardiac Myocytes

  2006cites this paper
• ATP Regulation in Adult Rat Cardiomyocytes

  2006cites this paper