T Cell Activation Leads to Protein Kinase Cθ-Dependent Inhibition of TGF-β Signaling

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Immunology

• Publication date

  2010-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.1000137PMID 20592275
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Endocytic regulation of TGF-β signaling

  2009cited by this paper
• Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse

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• PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice.

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• Deficiency of Protein Kinase C-Theta Facilitates Tolerance Induction

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• Why T Cells of Thymic Versus Extrathymic Origin Are Functionally Different1

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• TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

  2008cited by this paper
• Dual Roles of Immunoregulatory Cytokine TGF-β in the Pathogenesis of Autoimmunity-Mediated Organ Damage1

  2008cited by this paper
• SnapShot: The TGFbeta pathway interactome.

  2008cited by this paper
• TGF-beta: a master of all T cell trades.

  2008influential reference
• Negative regulation of TGF-β receptor/Smad signal transduction

  2007influential reference
• A tale of two proteins: Differential roles and regulation of Smad2 and Smad3 in TGF‐β signaling

  2007cited by this paper
• T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation.

  2007cited by this paper
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  2007cited by this paper
• Human resting CD4+ T cells are constitutively inhibited by TGF beta under steady-state conditions.

  2007cited by this paper
• A Key Role for TGF-β Signaling to T Cells in the Long-Term Acceptance of Allografts1

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• Prediction of Graft-Versus-Host Disease in Humans by Donor Gene-Expression Profiling

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• Human Resting CD4+ T Cells Are Constitutively Inhibited by TGFβ under Steady-State Conditions12

  2007cited by this paper
• TGFbeta signalling in control of T-cell-mediated self-reactivity.

  2007cited by this paper
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  2007cited by this paper
• TGFβ signalling in control of T-cell-mediated self-reactivity

  2007cited by this paper
• Negative regulation of TGF-beta receptor/Smad signal transduction.

  2007cited by this paper
• Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

  2006cited by this paper
• Protein kinase C (PKC) alpha and PKC theta are the major PKC isotypes involved in TCR down-regulation.

  2006cited by this paper
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• Protein Kinase C (PKC) and PKC Are the Major PKC Isotypes Involved in TCR Down-Regulation

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• Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.

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• Role of transforming growth factor-beta in hematologic malignancies.

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• Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms.

  2006cited by this paper
• A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance

  2006cited by this paper
• T Cell Zones of Lymphoid Organs Constitutively Express Th1 Cytokine mRNA: Specific Changes during the Early Phase of an Immune Response1

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• Protein Kinase C (PKC)α and PKCθ Are the Major PKC Isotypes Involved in TCR Down-Regulation1

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• TGF-β signaling in T cells: roles in lymphoid and epithelial neoplasia

  2005cited by this paper
• TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia.

  2005cited by this paper
• Smad transcription factors.

  2005cited by this paper
• SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS

  2005cited by this paper
• Specificity and versatility in tgf-beta signaling through Smads.

  2005cited by this paper
• Global Analysis of Smad2/3-Dependent TGF-β Signaling in Living Mice Reveals Prominent Tissue-Specific Responses to Injury1

  2005cited by this paper
• The structure and location of SIMP/STT3B account for its prominent imprint on the MHC I immunopeptidome.

  2005influential reference
• Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

  2004cited by this paper
• A role for the immunological synapse in lineage commitment of CD4 lymphocytes

  2004cited by this paper
• Jurkat T cells and development of the T-cell receptor signalling paradigm

  2004cited by this paper
• PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3

  2004cited by this paper
• Do thymically and strictly extrathymically developing T cells generate similar immune responses?

  2004cited by this paper
• Smad3 Is Essential for TGF-β1 to Suppress IL-2 Production and TCR-Induced Proliferation, but Not IL-2-Induced Proliferation1

  2004cited by this paper
• PKCθ Signals Activation versus Tolerance In Vivo

  2004cited by this paper
• PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3.

  2004cited by this paper
• Emerging and diverse roles of protein kinase C in immune cell signalling.

  2003cited by this paper
• Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

  2003cited by this paper
• Hierarchical model of gene regulation by transforming growth factor β

  2003cited by this paper
• Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover.

  2003cited by this paper
• Differential Expression of Smad7 Transcripts Identifies the CD4+CD45RChigh Regulatory T Cells That Mediate Type V Collagen-Induced Tolerance to Lung Allografts 1

  2003cited by this paper
• Blockade of TGF-β signaling in T cells prevents the development of experimental glomerulonephritis

  2003cited by this paper
• Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

  2003influential reference
• Insulin-like Growth Factor-I Inhibits Transcriptional Responses of Transforming Growth Factor-β by Phosphatidylinositol 3-Kinase/Akt-dependent Suppression of the Activation of Smad3 but Not Smad2*

  2003cited by this paper
• The PKC gene module: molecular biosystematics to resolve its T cell functions

  2003cited by this paper
• Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

  2003cited by this paper
• Protein Kinase C (cid:2) Affects Ca 2 (cid:3) Mobilization and NFAT Cell Activation in Primary Mouse T Cells

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• Cutting Edge: Quantitative Imaging of Raft Accumulation in the Immunological Synapse

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• Interaction between Smad anchor for receptor activation and Smad3 is not essential for TGF-beta/Smad3-mediated signaling.

  2001cited by this paper
• Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease.

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• Control of CYP11B2 Gene Expression through Differential Regulation of Its Promoter by Atypical and Conventional Protein Kinase C Isoforms*

  2001cited by this paper
• T cell receptor signalling.

  2001cited by this paper
• Blockade of TGF-β Signaling in T Cells Prevents the Development of Experimental Glomerulonephritis1

  2001cited by this paper
• How cells read TGF-β signals

  2000cited by this paper
• Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease.

  2000cited by this paper
• PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes.

  2000cited by this paper
• How cells read TGF-beta signals.

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• PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

  2000cited by this paper
• Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

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• Regulation of Smad7 Promoter by Direct Association with Smad3 and Smad4*

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• SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.

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• Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

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• Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.

  1997cited by this paper
• Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression.

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• Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

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  1987cited by this paper

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