SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Annual Review of Cell and Developmental Biology

• Publication date

  2005-10-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1146/ANNUREV.CELLBIO.21.022404.142018
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• TGF-β signaling *

  2006cited by this paper
• A Direct Intersection between p53 and Transforming Growth Factor β Pathways Targets Chromatin Modification and Transcription Repression of the α-Fetoprotein Gene

  2005influential reference
• Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.

  2005cited by this paper
• Repression of Bone Morphogenetic Protein and Activin-inducible Transcription by Evi-1*

  2005influential reference
• DRAGON, a Bone Morphogenetic Protein Co-receptor*

  2005cited by this paper
• The Smad3 linker region contains a transcriptional activation domain.

  2005cited by this paper
• A flexible activin explains the membrane-dependent cooperative assembly of TGF-beta family receptors.

  2004influential reference
• Smad1, β-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription

  2004cited by this paper
• Endoglin promotes endothelial cell proliferation and TGF‐β/ALK1 signal transduction

  2004cited by this paper
• Recognition of Phosphorylated-Smad2-Containing Complexes by a Novel Smad Interaction Motif

  2004influential reference
• In the Absence of Type III Receptor, the Transforming Growth Factor (TGF)-β Type II-B Receptor Requires the Type I Receptor to Bind TGF-β2*

  2004cited by this paper
• Foxh1 is essential for development of the anterior heart field.

  2004cited by this paper
• Structural Basis of Heteromeric Smad Protein Assembly in TGF-β Signaling

  2004influential reference
• The Cardiac Determination Factor, Nkx2-5, Is Activated by Mutual Cofactors GATA-4 and Smad1/4 via a Novel Upstream Enhancer*

  2004cited by this paper
• Ski and SnoN: negative regulators of TGF-β signaling

  2004cited by this paper
• The Murine Gastrin Promoter Is Synergistically Activated by Transforming Growth Factor-β/Smad and Wnt Signaling Pathways*

  2004cited by this paper
• Molecular recognition of BMP-2 and BMP receptor IA

  2004influential reference
• The Functional Interaction between the Paired Domain Transcription Factor Pax8 and Smad3 Is Involved in Transforming Growth Factor-β Repression of the Sodium/Iodide Symporter Gene*

  2004cited by this paper
• Regulation of transforming growth factor‐β and bone morphogenetic protein signalling by transcriptional coactivator GCN5

  2004cited by this paper
• Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.

  2004cited by this paper
• TGF‐β‐activated Smad3 represses MEF2‐dependent transcription in myogenic differentiation

  2004influential reference
• Integration of TGF‐β/Smad and Jagged1/Notch signalling in epithelial‐to‐mesenchymal transition

  2004influential reference
• Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells

  2004influential reference
• Roles for the MH2 Domain of Smad7 in the Specific Inhibition of Transforming Growth Factor-β Superfamily Signaling*

  2004cited by this paper
• SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer

  2004cited by this paper
• PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3

  2004cited by this paper
• Casein Kinase Iϵ Plays a Functional Role in the Transforming Growth Factor-β Signaling Pathway*

  2004cited by this paper
• Ubiquitination and Proteolysis of Cancer-Derived Smad4 Mutants by SCFSkp2

  2004cited by this paper
• Cyclin-dependent kinases regulate the antiproliferative function of Smads

  2004cited by this paper
• Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element.

  2004influential reference
• Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis

  2004cited by this paper
• Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation

  2003cited by this paper
• Smad-Dependent Recruitment of a Histone Deacetylase/Sin3A Complex Modulates the Bone Morphogenetic Protein-Dependent Transcriptional Repressor Activity of Nkx3.2

  2003cited by this paper
• The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly.

  2003cited by this paper
• A Self-Enabling TGFβ Response Coupled to Stress Signaling: Smad Engages Stress Response Factor ATF3 for Id1 Repression in Epithelial Cells.: Smad Engages Stress Response Factor ATF3 for Id1 Repression in Epithelial Cells.

  2003cited by this paper
• GATA- and Smad1-Dependent Enhancers in the Smad7 Gene Differentially Interpret Bone Morphogenetic Protein Concentrations

  2003cited by this paper
• Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

  2003influential reference
• Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads.

  2003cited by this paper
• Retinoic acid receptors interfere with the TGF-β/Smad signaling pathway in a ligand-specific manner

  2003cited by this paper
• Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling.

  2003cited by this paper
• ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling

  2003cited by this paper
• Smad-dependent and Smad-independent pathways in TGF-β family signalling

  2003influential reference
• Interplay between the tumor suppressor p53 and TGFβ signaling shapes embryonic body axes in Xenopus

  2003cited by this paper
• Interferon-γ Interferes with Transforming Growth Factor-β Signaling through Direct Interaction of YB-1 with Smad3*

  2003cited by this paper
• The interaction of BMP-7 and ActRII implicates a new mode of receptor assembly.

  2003cited by this paper
• Cross-talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3

  2003influential reference
• Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling.

  2003cited by this paper
• Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction.

  2003cited by this paper
• Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads.

  2003cited by this paper
• Smad4 and β-Catenin Co-activators Functionally Interact with Lymphoid-enhancing Factor to Regulate Graded Expression of Msx2*

  2003cited by this paper
• Interaction of Smad3 and SRF-associated complex mediates TGF-beta1 signals to regulate SM22 transcription during myofibroblast differentiation.

  2003cited by this paper
• Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function.

  2003cited by this paper
• Mechanism of a transcriptional cross talk between transforming growth factor-beta-regulated Smad3 and Smad4 proteins and orphan nuclear receptor hepatocyte nuclear factor-4.

  2003cited by this paper
• Integration of Smad and MAPK pathways: a link and a linker revisited.

  2003influential reference
• Smad4 as a Transcription Corepressor for Estrogen Receptor α*

  2003cited by this paper
• Both Max and TFE3 Cooperate with Smad Proteins to Bind the Plasminogen Activator Inhibitor-1 Promoter, but They Have Opposite Effects on Transcriptional Activity* 210

  2003cited by this paper
• Smad6 Recruits Transcription Corepressor CtBP To Repress Bone Morphogenetic Protein-Induced Transcription

  2003influential reference
• Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins

  2003influential reference
• Nuclear Factor YY1 Inhibits Transforming Growth Factor β- and Bone Morphogenetic Protein-Induced Cell Differentiation

  2003influential reference
• Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells

  2003cited by this paper
• Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation

  2003influential reference
• Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

  2003cited by this paper
• Making sense of latent TGFβ activation

  2003influential reference
• Multiple tumor suppressor pathways negatively regulate telomerase.

  2003cited by this paper
• Opposing functions of ZEB proteins in the regulation of the TGFβ/BMP signaling pathway

  2003cited by this paper
• Identification of novel Smad binding proteins.

  2003cited by this paper
• Stoichiometry of Active Smad-Transcription Factor Complexes on DNA*

  2002cited by this paper
• TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2.

  2002cited by this paper
• Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling.

  2002cited by this paper
• Early Endosomal Regulation of Smad-dependent Signaling in Endothelial Cells*

  2002cited by this paper
• Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline‐rich motif

  2002influential reference
• Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage.

  2002cited by this paper
• E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression.

  2002influential reference
• Differential Modulation of Androgen Receptor-mediated Transactivation by Smad3 and Tumor Suppressor Smad4*

  2002cited by this paper
• Cross-talk between bone morphogenic proteins and estrogen receptor signaling.

  2002cited by this paper
• Smurf1 Regulates the Inhibitory Activity of Smad7 by Targeting Smad7 to the Plasma Membrane* 210

  2002cited by this paper
• Balancing the activation state of the endothelium via two distinct TGF‐β type I receptors

  2002influential reference
• Control of Smad7 stability by competition between acetylation and ubiquitination.

  2002cited by this paper
• Casein Kinase I

  2002cited by this paper
• Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control.

  2002cited by this paper
• Interaction between TGFbeta signaling proteins and C/EBP controls basal and Tat-mediated transcription of HIV-1 LTR in astrocytes.

  2002cited by this paper
• SMIF, a Smad4-interacting protein that functions as a co-activator in TGFβ signalling

  2002cited by this paper
• c-myc Is a Downstream Target of the Smad Pathway* 210

  2002cited by this paper
• Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter*

  2002cited by this paper
• Transcriptional Regulation of the Transforming Growth Factor β Type II Receptor Gene by Histone Acetyltransferase and Deacetylase Is Mediated by NF-Y in Human Breast Cancer Cells*

  2002influential reference
• bcn-1 Element-dependent Activation of the Laminin γ1 Chain Gene by the Cooperative Action of Transcription Factor E3 (TFE3) and Smad Proteins*

  2002cited by this paper
• A Nuclear Antagonistic Mechanism of Inhibitory Smads in Transforming Growth Factor-β Signaling*

  2002cited by this paper
• The 1.1 A crystal structure of human TGF-beta type II receptor ligand binding domain.

  2002cited by this paper
• A component of the ARC/Mediator complex required for TGFβ/Nodal signalling

  2002cited by this paper
• Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240.

  2002cited by this paper
• TGFβ receptor internalization into EEA1-enriched early endosomes

  2002cited by this paper
• The Androgen Receptor Represses Transforming Growth Factor-β Signaling through Interaction with Smad3*

  2002cited by this paper
• Physical and functional interaction between GATA-3 and Smad3 allows TGF-beta regulation of GATA target genes.

  2002cited by this paper
• Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis

  2002cited by this paper
• Crystal structure of the human TβR2 ectodomain–TGF-β3 complex

  2002influential reference
• The rasGAP‐binding protein, Dok‐1, mediates activin signaling via serine/threonine kinase receptors

  2002cited by this paper
• The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

  2001influential reference
• The adaptor molecule Disabled‐2 links the transforming growth factor β receptors to the Smad pathway

  2001cited by this paper
• Smad Proteins Suppress CCAAT/Enhancer-binding Protein (C/EBP) β- and STAT3-mediated Transcriptional Activation of the Haptoglobin Promoter*

  2001cited by this paper
• Structural basis of Smad1 activation by receptor kinase phosphorylation.

  2001cited by this paper

• TGF-β drives pulmonary fibrosis through dual dysregulation of TNF pathway transcription and splicing.

  2026cites this paper
• BMP4 dose dictates lineage specification bias in human periodontal ligament stem cells

  2026cites this paper
• Transforming growth factor-β3 attenuates septic cardiomyopathy by reversing cardiomyocyte metabolic reprogramming through Smad7 signaling.

  2026cites this paper
• Loss of YTHDF2 enhances Th9 programming and CAR-Th9 cell antitumor efficacy

  2025cites this paper
• HSF2 drives breast cancer progression by acting as a stage-specific switch between proliferation and invasion

  2025cites this paper
• Mechanisms of vascular endothelial cell injury triggered by blood glucose changes in gestational diabetes mellitus

  2025cites this paper
• Endothelial Cell Responses to Photobiomodulation Treatments in Diabetic Wounds Are Mediated via Concerted PDGF, VEGF and TGF‐β Signalling

  2025cites this paper
• The role of ubiquitination and deubiquitination in urological tumours

  2025cites this paper
• Molecular Mechanisms of Epithelial–Mesenchymal Transition in Retinal Pigment Epithelial Cells: Implications for Age-Related Macular Degeneration (AMD) Progression

  2025cites this paper
• Endothelial RNF20 suppresses endothelial-to-mesenchymal transition and safeguards physiological angiocrine signaling to prevent congenital heart disease

  2025cites this paper
• Analysis of FBN1, TGFβ2, TGFβR1 and TGFβR2 mRNA as Key Molecular Mechanisms in the Damage of Aortic Aneurysm and Dissection in Marfan Syndrome

  2025cites this paper
• Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances

  2025cites this paper
• Blockade of TGF-β1/Smad3 signaling pathway by Bovine Milk-derived extracellular vesicles ameliorates skin fibrosis in systemic sclerosis mice.

  2025cites this paper
• Transforming growth factor-beta gene family in Labeo rohita: Genome-wide molecular characterization and phylogenetic relationship with other vertebrates.

  2025cites this paper
• Interplay between TGF-β signaling and long non-coding RNAs in digestive system cancers: mechanisms and biological implications

  2025cites this paper
• Primary cilia function as hubs for signal transduction

  2025cites this paper
• Role of transforming growth factor-β1 in regulating adipocyte progenitors

  2025cites this paper
• Nanoarchitectonics of PEEK Scaffold with VitaFlux Adaptability: Immune Microenvironment Remodeling and Empowered Activation of Latent TGF-β1 Expression.

  2025cites this paper
• Decoding clinical diversity in monogenic TGFBR1 and TGFBR2 mutations: insights into the interplay of molecular mechanisms and hypomorphicity

  2025cites this paper
• Methionine restriction alleviates kidney fibrosis through epigenetic repression of the TGF-β-Smad3-Hoxc8/P-TEFb axis

  2025cites this paper
• Research progress on the mechanisms of endogenous neural stem cell differentiation in spinal cord injury repair

  2025cites this paper
• Mechanotransduction and musculoskeletal regeneration: Molecular mechanisms and interdisciplinary applications

  2025cites this paper
• Advances in targeting glycogen synthase kinase 3β for diabetes therapy.

  2025cites this paper
• Pre-existing DNA methylation signatures in the prefrontal cortex of alcohol-naïve nonhuman primates define neural vulnerability for future risky ethanol consumption

  2025cites this paper
• New insights into Gremlin-1: A tumour microenvironment landscape re-engineer and potential therapeutic target.

  2025cites this paper
• Regulatory Mechanism of Intestinal Stem Cells Based on Hippo Pathway and Signaling Crosstalk in Chicken

  2025cites this paper
• An exploration of molecular signaling in drug reprocessing for Oral Squamous Cell Carcinoma.

  2025cites this paper
• Involvement of TGF-β signaling pathway-associated genes in the corneal endothelium of patients with Fuchs endothelial corneal dystrophy.

  2025cites this paper
• Structural Basis for TGF-β Mimetic Peptide-Induced Signaling Activation Through Molecular Dynamics Simulations

  2025cites this paper
• Medicinal Chemistry Strategies in Targeting TGF-βR1 Kinase Domain: Unveiling Insights into Inhibitor Structure–Activity Relationship (SAR)

  2025cites this paper
• ERBB4 selectively amplifies TGF-β pro-metastatic responses.

  2025cites this paper
• fam20b-dependent proteoglycans do not affect dermal bone formation and fin regeneration, but Bmp signalling promotes fin regenerate outgrowth.

  2025cites this paper
• Comparing the Bioactive Effects of Ethylenediaminetetraacetic Acid and Maleic Acid on TGF-β1 Release From Dentine and Dental Pulp Stem Cell Activity.

  2025cites this paper
• TGF-β1 Down-Regulates Vascular Cell Adhesion Molecule 1 in Porcine Follicular Granulosa Cells Through Smad2 Signalling Pathways.

  2025cites this paper
• TGF-β signaling in the ovary: Emerging roles in development and disease.

  2025cites this paper
• Caulerpa okamurae extract alleviates pulmonary fibrosis in vitro and in vivo by modulating Tgfβ/SMAD/MAPK signaling and NLRP3 inflammasome activation

  2025cites this paper
• Characterization of an Ischemia-Reperfusion Model for the Formation of a Stage II Pressure Injury in Diabetic Mice

  2025cites this paper
• Targeted Therapies Modulating Mesenchymal–Epithelial Transition-Linked Oncogenic Signaling in the Tumor Microenvironment: Comparative Profiling of Capmatinib, Bemcentinib, and Galunisertib

  2025cites this paper
• The BMP Signaling Pathway: Bridging Maternal-Fetal Crosstalk in Early Pregnancy

  2025cites this paper
• Detrimental Effect of T261I and R287W SMAD3 Variants on Early Osteoarthritis: A Potential Anti‐Inflammatory Molecule for Personalized Treatment

  2025cites this paper
• Matrix-producing neutrophils populate and shield the skin

  2025cites this paper
• Tetrahedral Framework Nucleic Acids Delivery of Pirfenidone for Anti-Inflammatory and Antioxidative Effects to Treat Idiopathic Pulmonary Fibrosis.

  2024cites this paper
• Thermosensitive hydrogel as a sustained release carrier for mesenchymal stem cell-derived extracellular vesicles in the treatment of intrauterine adhesion

  2024cites this paper
• Regulation of myofibroblast dedifferentiation in pulmonary fibrosis

  2024cites this paper
• Menin signaling and therapeutic targeting in breast cancer.

  2024cites this paper
• Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway

  2024cites this paper
• Relationship of Signaling Pathways between RKIP Expression and the Inhibition of EMT-Inducing Transcription Factors SNAIL1/2, TWIST1/2 and ZEB1/2

  2024cites this paper
• Transcriptome analysis of purple and green Apostichopus japonicus reared under different breeding environments

  2024cites this paper
• The role of CD4+ T cells in visceral leishmaniasis; new and emerging roles for NKG7 and TGFβ

  2024cites this paper
• MicroRNAs in the Pathogenesis of Preeclampsia—A Case-Control In Silico Analysis

  2024cites this paper
• Molecular detection of exosomal miRNAs of blood serum for prognosis of colorectal cancer

  2024cites this paper
• Host-microbiota interaction in intestinal stem cell homeostasis

  2024cites this paper
• Alginate Hydrogel Integrated with a Human Fibroblast-Derived Extracellular Matrix Supports Corneal Endothelial Cell Functionality and Suppresses Endothelial-Mesenchymal Transition.

  2024cites this paper
• Increased hepatic gluconeogenesis and type 2 diabetes mellitus.

  2024cites this paper
• Molecular mechanism of BMP signal control by Twisted gastrulation

  2024cites this paper
• Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease

  2024cites this paper
• Advances in the discovery of activin receptor-like kinase 5 (ALK5) inhibitors.

  2024cites this paper
• Structure, unique biological properties, and mechanisms of action of transforming growth factor β.

  2024cites this paper
• Fiery Connections: Macrophage-Mediated Inflammation, the Journey from Obesity to Type 2 Diabetes Mellitus and Diabetic Kidney Disease

  2024cites this paper
• MicroRNAs in adipose tissue fibrosis: Mechanisms and therapeutic potential

  2024cites this paper
• Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy

  2024cites this paper
• Pyroptosis‐related gene GSDMC indicates poor prognosis and promotes tumor progression by activating the AKT/mTOR pathway in lung squamous cell carcinoma

  2024cites this paper
• Research Progress on the Correlation between Lung Cancer and Tumor Inflammatory Microenvironment

  2024cites this paper
• Targeting SMAD-Dependent Signaling: Considerations in Epithelial and Mesenchymal Solid Tumors

  2024cites this paper
• Epigenetic regulation of TGF-β pathway and its role in radiation response

  2024cites this paper
• Molecular pathways in experimental glaucoma models

  2024cites this paper
• Transforming growth factor-β receptors: versatile mechanisms of ligand activation

  2024cites this paper
• TGF-β1, pSmad-2/3, Smad-7, and β-Catenin Are Augmented in the Pulmonary Arteries from Patients with Idiopathic Pulmonary Fibrosis (IPF): Role in Driving Endothelial-to-Mesenchymal Transition (EndMT)

  2024cites this paper
• Expanded phenotypes and pathogenesis of geleophysic dysplasia 3 resulted from a de novo LTBP3 mutation: A case report

  2024cites this paper
• The effect of bta-miR-1296 on the proliferation and extracellular matrix synthesis of bovine mammary fibroblasts

  2024cites this paper
• TGF-β as a therapeutic target in the infarcted and failing heart: cellular mechanisms, challenges, and opportunities

  2024cites this paper
• The underlying mechanism and targeted therapy strategy of miRNAs cross-regulating EMT process through multiple signaling pathways in hepatocellular carcinoma

  2024cites this paper
• The role of transforming growth factor β in cervical carcinogenesis.

  2024cites this paper
• Kinome-wide CRISPR-Cas9 screens revealed EXOSC10 as a positive regulator of TGF-β signaling

  2024cites this paper
• Ethanol extract of Nymphaea lotus Linn. inhibited hepatic fibrogenesis in carbon tetrachloride-intoxicated Wistar rats

  2024cites this paper
• Proteomics-based network pharmacology and molecular docking reveal the potential mechanisms of 5,6,7,4′-tetramethoxyflavone against HeLa cancer cells

  2024cites this paper
• Transcriptional regulators ensuring specific gene expression and decision-making at high TGFβ doses

  2024cites this paper
• Repulsive guidance molecules b (RGMb): molecular mechanism, function and role in diseases

  2024cites this paper
• Kinex infers causal kinases from phosphoproteomics data

  2024cites this paper
• Machine learning unveils RNA polymerase II binding as a predictor for SMAD2‐dependent transcription dynamics in response to Actvin signalling

  2024cites this paper
• Advancing Proteolysis Targeting Chimera (PROTAC) Nanotechnology in Protein Homeostasis Reprograming for Disease Treatment.

  2024cites this paper
• A role for TGFβ signaling in Gli1+ tendon and enthesis cells

  2024cites this paper
• Gestational Intermittent Hypoxia Enhances Mammary Stem Cells and Alters Tumor Phenotype in Adult Female Offspring

  2024influential citation
• Functional Study of PTSMAD4 in the Spermatogenesis of the Swimming Crab Portunus trituberculatus

  2024cites this paper
• Antagonism between Prdm16 and Smad4 specifies the trajectory and progression of pancreatic cancer

  2023influential citation
• Upregulated TGF-β1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling

  2023cites this paper
• Biscroyunoid A, an Anti-Hepatic Fibrotic 19-nor-Clerodane Diterpenoid Dimer with a C-16-C-12' Linkage from Croton yunnanensis.

  2023cites this paper
• The role of TGF-beta3 in cartilage development and osteoarthritis

  2023cites this paper
• The Effect of Hydroxytyrosol in Type II Epithelial-Mesenchymal Transition in Human Skin Wound Healing

  2023cites this paper
• Insulin Receptor Substrate 1 Signaling Inhibits Foxp3 Expression and Suppressive Functions in Treg Cells through the mTORC1 Pathway

  2023cites this paper
• Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia

  2023cites this paper
• Smad4 sequestered in SFPQ condensates prevents TGF-β tumor-suppressive signaling.

  2023cites this paper
• Mutual regulation of TGFβ-induced oncogenic EMT, cell cycle progression and the DDR.

  2023cites this paper
• Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity

  2023cites this paper
• ACVR1: A Novel Therapeutic Target to Treat Anemia in Myelofibrosis

  2023cites this paper
• GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21

  2023cites this paper
• Significance of Premature Vertebral Mineralization in Zebrafish Models in Mechanistic and Pharmaceutical Research on Hereditary Multisystem Diseases

  2023cites this paper
• Regeneration of Pancreatic Beta Cells by Modulation of Molecular Targets Using Plant-Derived Compounds: Pharmacological Mechanisms and Clinical Potential

  2023cites this paper
• Multiple roles of ALK3 in osteoarthritis

  2023cites this paper
• Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets

  2023cites this paper