E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Cell

• Publication date

  2002-07-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0092-8674(02)00801-2PMID 12150994
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline‐rich motif

  2002cited by this paper
• Transcription: Sibling rivalry in the E2F family

  2002cited by this paper
• E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints.

  2002cited by this paper
• c-myc Is a Downstream Target of the Smad Pathway* 210

  2002cited by this paper
• SMIF, a Smad4-interacting protein that functions as a co-activator in TGFβ signalling

  2002cited by this paper
• TGF-β signaling in tumor suppression and cancer progression

  2001cited by this paper
• TGF-beta signaling in tumor suppression and cancer progression.

  2001cited by this paper
• Structural basis of Smad1 activation by receptor kinase phosphorylation.

  2001cited by this paper
• TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation

  2001cited by this paper
• The E2F1–3 transcription factors are essential for cellular proliferation

  2001cited by this paper
• The TGF beta receptor activation process: an inhibitor- to substrate-binding switch.

  2001cited by this paper
• p107 and p130: versatile proteins with interesting pockets.

  2001cited by this paper
• Genetic programs of epithelial cell plasticity directed by transforming growth factor-β

  2001cited by this paper
• Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.

  2001cited by this paper
• TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

  2001cited by this paper
• Deconstructing myc.

  2001cited by this paper
• OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways.

  2000cited by this paper
• Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif.

  2000cited by this paper
• Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization.

  2000cited by this paper
• Distinct Oligomeric States of SMAD Proteins in the Transforming Growth Factor-β Pathway*

  2000cited by this paper
• E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control.

  2000cited by this paper
• Structural basis of Smad2 recognition by the Smad anchor for receptor activation.

  2000cited by this paper
• Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression.

  2000cited by this paper
• TGFbeta signaling in growth control, cancer, and heritable disorders.

  2000cited by this paper
• Transcriptional control by the TGF‐β/Smad signaling system

  2000cited by this paper
• The Myc/Max/Mad network and the transcriptional control of cell behavior.

  2000cited by this paper
• A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest.

  2000cited by this paper
• Transforming growth factor beta(1) selectively inhibits the cyclic AMP-dependent proliferation of primary thyroid epithelial cells by preventing the association of cyclin D3-cdk4 with nuclear p27(kip1).

  2000cited by this paper
• Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP.

  1999influential reference
• Smad4/DPC4 Silencing and Hyperactive Ras Jointly Disrupt Transforming Growth Factor-β Antiproliferative Responses in Colon Cancer Cells*

  1999cited by this paper
• E2F and Histone Deacetylase Mediate Transforming Growth Factor β Repression of cdc25A during Keratinocyte Cell Cycle Arrest

  1999cited by this paper
• Interaction of the Ski Oncoprotein with Smad3 Regulates TGF-β Signaling

  1999cited by this paper
• A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras.

  1999cited by this paper
• Myc Downregulation by Transforming Growth Factor β Required for Activation of the p15Ink4b G1 Arrest Pathway

  1999cited by this paper
• Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling.

  1999cited by this paper
• The Human Tap Nuclear RNA Export Factor Contains a Novel Transportin-dependent Nuclear Localization Signal That Lacks Nuclear Export Signal Function*

  1999cited by this paper
• Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

  1999cited by this paper
• The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling.

  1999cited by this paper
• SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.

  1998cited by this paper
• Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2.

  1998cited by this paper
• Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling.

  1998cited by this paper
• TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein.

  1998cited by this paper
• Determinants of specificity in TGF-beta signal transduction.

  1998cited by this paper
• Smad3 mutant mice develop metastatic colorectal cancer.

  1998cited by this paper
• Transcriptional Activators of TGF-β Responses: Smads

  1998cited by this paper
• The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF‐β receptors

  1998cited by this paper
• TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300.

  1998cited by this paper
• The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation.

  1998cited by this paper
• Smads and early developmental signaling by the TGFbeta superfamily.

  1998cited by this paper
• Strain-Dependent Myeloid Hyperplasia, Growth Deficiency, and Accelerated Cell Cycle in Mice Lacking the Rb-Related p107 Gene

  1998cited by this paper
• The retinoblastoma gene family: cousins with overlapping interests.

  1998cited by this paper
• Physical and Functional Interaction of SMADs and p300/CBP*

  1998cited by this paper
• Smads: transcriptional activators of TGF-beta responses.

  1998cited by this paper
• TGF-beta signal transduction.

  1998cited by this paper
• TGF-β signalling from cell membrane to nucleus through SMAD proteins

  1997cited by this paper
• The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.

  1997cited by this paper
• Biology of TGF-beta in knockout and transgenic mouse models.

  1997cited by this paper
• TGF-beta signalling from cell membrane to nucleus through SMAD proteins.

  1997cited by this paper
• Smad4 and FAST-1 in the assembly of activin-responsive factor

  1997cited by this paper
• Biology of TGF-β in knockout and transgenic mouse models

  1997cited by this paper
• Constitutive Protection of E2F Recognition Sequences in the Human Thymidine Kinase Promoter during Cell Cycle Progression*

  1997cited by this paper
• A structural basis for mutational inactivation of the tumour suppressor Smad4

  1997cited by this paper
• Cell Cycle Regulation of E2F Site Occupation in Vivo

  1996cited by this paper
• E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry

  1996cited by this paper
• Targeted disruption of p107: functional overlap between p107 and Rb.

  1996cited by this paper
• Shared role of the pRB-related p130 and p107 proteins in limb development.

  1996cited by this paper
• Transforming Growth Factor β and Cell Cycle Regulation

  1995cited by this paper
• Molecular and functional characterisation of E2F-5, a new member of the E2F family.

  1995cited by this paper
• Cloning and characterization of human DP2, a novel dimerization partner of E2F.

  1995cited by this paper
• Transforming growth factor beta and cell cycle regulation.

  1995cited by this paper
• Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.

  1995cited by this paper
• Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

  1995cited by this paper
• Transforming growth factor beta modulates growth and differentiation of fetal hepatocytes in primary culture.

  1995cited by this paper
• The retinoblastoma protein: more than a tumor suppressor.

  1994cited by this paper
• The retinoblastoma protein binds to a family of E2F transcription factors

  1993cited by this paper
• Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

  1992cited by this paper
• Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.

  1992cited by this paper
• Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line

  1988cited by this paper
• Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

  1986cited by this paper

• Research progress on cell cycle arrest in dermal fibroblasts

  2025cites this paper
• MiR-146b overexpression promotes bladder cancer cell growth via the SMAD4/C-MYC/Cyclin D1 axis

  2025cites this paper
• The MYC-dependent lncRNA MB3 inhibits apoptosis in Group 3 Medulloblastoma by regulating the TGF-β pathway via HMGN5

  2025cites this paper
• Elevated Expression of TGFB1 in PBMCs Is Associated with Intracranial Aneurysm Formation, but TGFB3 Expression Implicated Rupture

  2025cites this paper
• The pivotal role of TGF-β/Smad pathway in fibrosis pathogenesis and treatment

  2025cites this paper
• Impact of the Transforming Growth Factor β (TGF-β) on Brain Aneurysm Formation and Development: A Literature Review

  2025cites this paper
• Non-small cell lung cancer map and analysis: exploring interconnected oncogenic signal integrators

  2025cites this paper
• Targeted therapy for liver cancer: Current status and future directions.

  2025cites this paper
• Lysosome-dependent nutrient scavenging underlies stress adaptation during epithelial-to-mesenchymal transition

  2025cites this paper
• p53 regulates DREAM complex-mediated repression in a p21-independent manner

  2025cites this paper
• Fu Zheng Xiao Yu San Jie Decoction affects the proliferation of renal cell carcinoma via regulating E2F5 gene

  2025cites this paper
• CIP/KIP and INK4 families as hostages of oncogenic signaling

  2024cites this paper
• Deciphering TGF-β1's Role in Drug Resistance and Leveraging Plant Bioactives for Cancer Therapy.

  2024cites this paper
• Hepatitis B virus X protein and TGF-β: partners in the carcinogenic journey of hepatocellular carcinoma

  2024cites this paper
• Receptor-activated transcription factors and beyond: multiple modes of Smad2/3-dependent transmission of TGF-β signaling.

  2024cites this paper
• Advancements in TGF-β Targeting Therapies for Head and Neck Squamous Cell Carcinoma

  2024cites this paper
• Potential therapeutic targets of gastric cancer explored under endogenous network modeling of clinical data

  2024cites this paper
• A new framework for exploratory network mediator analysis in omics data

  2024cites this paper
• Platelet PI3Kβ regulates breast cancer metastasis

  2024cites this paper
• Targeting SMAD-Dependent Signaling: Considerations in Epithelial and Mesenchymal Solid Tumors

  2024cites this paper
• Inflammation and Related Signaling Pathways in Acute Myeloid Leukemia

  2024cites this paper
• Characterization of cell cycle, inflammation, and oxidative stress signaling role in non-communicable diseases: Insights into genetic variants, microRNAs and pathways

  2024cites this paper
• TGF-β signaling in health, disease and therapeutics

  2024cites this paper
• Afatinib plus PEM and CBDCA overcome osimertinib resistance in EGFR‐mutated NSCLC with high thrombospondin‐1 expression

  2024cites this paper
• The paradoxical role of transforming growth factor-β in controlling oral squamous cell carcinoma development

  2024cites this paper
• Chimeric provirus of bovine leukemia virus/SMAD family member 3 in cattle with enzootic bovine leukosis

  2024cites this paper
• A novel crosstalk between Nrf2 and Smad2/3 bridged by two nuanced Keap1 isoforms with their divergent effects on these distinct family transcription factors.

  2024cites this paper
• A circuit involving the lncRNA MB3 and the driver genes MYC and OTX2 inhibits apoptosis in Group 3 Medulloblastoma by regulating the TGF-β pathway via HMGN5

  2024cites this paper
• Mammary Alveolar Proliferation and Differentiation During Early Pregnancy is Regulated by E2F5

  2024cites this paper
• CDH2-microRNA Axis Provides Insights into Sustained Breast Cancer Dormancy in the Bone Marrow Niche

  2024cites this paper
• E-cadherin Induces Serine Synthesis to Support Progression and Metastasis of Breast Cancer.

  2024cites this paper
• Overexpression of Ultrabithorax Changes the Development of Silk Gland and the Expression of Fibroin Genes in Bombyx mori

  2023cites this paper
• Multifaceted TGF‐β signaling, a master regulator: From bench‐to‐bedside, intricacies, and complexities

  2023influential citation
• Prognostic Biomarkers in Pituitary Tumours: A Systematic Review

  2023cites this paper
• Blocking LTB4 signaling-mediated TAMs recruitment by Rhizoma Coptidis sensitizes lung cancer to immunotherapy.

  2023cites this paper
• Elucidating the pharmacological effects of Compound Kushen injection on MYC-P15-CCND1 signaling pathway in nasopharyngeal carcinoma - An in vitro study.

  2023cites this paper
• Trim33 masks a non-transcriptional function of E2f4 in replication fork progression

  2023cites this paper
• Serine synthesis pathway upregulated by E-cadherin is essential for the proliferation and metastasis of breast cancers

  2023cites this paper
• MicroRNA-155 and cancer metastasis: Regulation of invasion, migration, and epithelial-to-mesenchymal transition.

  2023cites this paper
• DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features

  2023cites this paper
• Regulation of T Cell Activation and Metabolism by Transforming Growth Factor-Beta

  2023cites this paper
• Mid-trimester dilated fetal bowel leading to diagnosis of interstitial duplication 46,XX,dup(8)(q21.13q21.2) associated with extensive neonatal jejuno-ileal atresia

  2022cites this paper
• Nedd4L suppression in lung fibroblasts facilitates pathogenesis of lung fibrosis.

  2022cites this paper
• Formation of ARC coactivator complex ↗

  2022cites this paper
• Mast4 determines the cell fate of MSCs for bone and cartilage development

  2022cites this paper
• Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics Approach

  2022cites this paper
• Roles of TGF-β in cancer hallmarks and emerging onco-therapeutic design

  2022cites this paper
• Therapeutic Implications of Sonic Hedgehog Pathway in Metabolic Disorders: Novel Target for Effective Treatment.

  2022cites this paper
• Analysis of chromatin accessibility in p53 deficient spermatogonial stem cells for high frequency transformation into pluripotent state

  2022cites this paper
• TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8+ T cells

  2022cites this paper
• Shifting the Focus of Signaling Abnormalities in Colon Cancer

  2022cites this paper
• Targeting TGF-β signal transduction for fibrosis and cancer therapy

  2022cites this paper
• Stromal upregulation of SOX2 promotes tumorigenesis through the generation of a SFRP1/2-expressing cancer-associated fibroblast population

  2021cites this paper
• Diseases of signal transduction by growth factor receptors and second messengers

  2021cites this paper
• The TGFβ and Androgen Receptor Signaling Pathways Converge to Support Anoikis Resistance in Triple Negative Breast Cancer

  2021cites this paper
• E2F Transcription Factors in Cancer, More than the Cell Cycle

  2021cites this paper
• Proteogenomic characterization of pancreatic ductal adenocarcinoma.

  2021cites this paper
• Contribution of “Omic” Studies to the Understanding of Cadasil. A Systematic Review

  2021influential citation
• Pemetrexed Disodium Heptahydrate Induces Apoptosis and Cell-cycle Arrest in Non-small-cell Lung Cancer Carrying an EGFR Exon 19 Deletion

  2021cites this paper
• SNAI2 is induced by transforming growth factor-β1, but is not essential for epithelial-mesenchymal transition in human keratinocyte HaCaT cells

  2021cites this paper
• HIF-1α switches the functionality of TGF-β signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer

  2021cites this paper
• TRIM22 inhibits the proliferation of gastric cancer cells through the Smad2 protein

  2021cites this paper
• A mean-field approach for modeling the propagation of perturbations in biochemical reaction networks

  2021cites this paper
• Comprehensively analyze the expression and prognostic role for ten-eleven translocations (TETs) in acute myeloid leukemia

  2020cites this paper
• Transforming Grown Factor-β Signaling in Immunity and Cancer

  2020cites this paper
• Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment

  2020cites this paper
• MYC Activity Inference Captures Diverse Mechanisms of Aberrant MYC Pathway Activation in Human Cancers

  2020influential citation
• Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression

  2020cites this paper
• Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population.

  2020cites this paper
• Roles of TGF-β signaling pathway in tumor microenvirionment and cancer therapy.

  2020cites this paper
• Identification of Age-Specific and Common Key Regulatory Mechanisms Governing Eggshell Strength in Chicken Using Random Forests

  2020influential citation
• SMAD-oncoprotein interplay: Potential determining factors in targeted therapies.

  2020cites this paper
• The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer

  2020cites this paper
• Targeting centrosome amplification in aneuploid B-cell precursor acute lymphoblastic leukemia

  2020cites this paper
• Human Skin Keratinocytes on Sustained TGF-β Stimulation Reveal Partial EMT Features and Weaken Growth Arrest Responses

  2020cites this paper
• Recent Advances in Understanding Mechanisms of TGF Beta Signaling and Its Role in Glioma Pathogenesis.

  2020cites this paper
• Exploring MYC relevance to cancer biology from the perspective of cell competition.

  2020cites this paper
• Pax Genes in Drosophila Myogenesis: Their Functions and Regulation

  2019cites this paper
• Wnt, Notch, and TGF-β Pathways Impinge on Hedgehog Signaling Complexity: An Open Window on Cancer

  2019cites this paper
• The TGF-β induced gene, PMEPA1, attenuates antitumor efficacy of aspirin in triple-negative breast cancer by regulating TGF-β1

  2019cites this paper
• TGF-BETA IN THE NATURAL HISTORY OF PROSTATE CANCER

  2019cites this paper
• Characterization of the human E2F4 promoter region and its response to 12-O-tetradecanoylphorbol-13-acetate.

  2019cites this paper
• Loss of function BMP4 mutation supports the implication of the BMP/TGF‐β pathway in the etiology of combined pituitary hormone deficiency

  2019cites this paper
• A New Switch for TGFβ in Cancer.

  2019cites this paper
• TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis

  2019cites this paper
• Motor neurons from ALS patients with mutations in C9ORF72 and SOD1 exhibit distinct transcriptional landscapes.

  2019cites this paper
• A Longitudinal Study of the Association between Mammographic Density and Gene Expression in Normal Breast Tissue

  2019cites this paper
• Transforming Growth Factor-β Signaling in Immunity and Cancer.

  2019cites this paper
• Association of Overexpressed MYC Gene with Altered PHACTR3 and E2F4 Genes Contributes to Non-small Cell Lung Carcinoma Pathogenesis

  2019cites this paper
• Precancerous niche (PCN), a product of fibrosis with remodeling by incessant chronic inflammation

  2019cites this paper
• Hsa-miR-587 Regulates TGFβ/SMAD Signaling and Promotes Cell Cycle Progression

  2019cites this paper
• Blocking TGF-β Signaling To Enhance The Efficacy Of Immune Checkpoint Inhibitor

  2019cites this paper
• Rôle de la cytidine désaminase dans le contrôle du métabolisme énergétique tumoral pancréatique

  2019cites this paper
• The Effects of Smad3 on Adrenocorticotropic Hormone-Secreting Pituitary Adenoma Development, Cell Proliferation, Apoptosis, and Hormone Secretion.

  2018cites this paper
• Contextual determinants of TGFβ action in development, immunity and cancer

  2018cites this paper
• The Long (lncRNA) and Short (miRNA) of It: TGFβ-Mediated Control of RNA-Binding Proteins and Noncoding RNAs

  2018cites this paper
• Key Age-Imposed Signaling Changes That Are Responsible for the Decline of Stem Cell Function.

  2018cites this paper
• Single Nucleotide Polymorphism in SMAD7 and CHI3L1 and Colorectal Cancer Risk

  2018cites this paper
• Unraveling SSc Pathophysiology; The Myofibroblast

  2018cites this paper
• Transforming growth factor-β signaling in head and neck squamous cell carcinoma: Insights into cellular responses.

  2018cites this paper