The retinoblastoma protein: more than a tumor suppressor.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Annual Review of Cell Biology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1146/ANNUREV.CB.10.110194.000245PMID 7888173
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1995cited by this paper
• The retinoblastoma protein and cell cycle control.

  1995cited by this paper
• Retinoblastoma gene mutations in primary human prostate cancer

  1995cited by this paper
• How cells cycle toward cancer.

  1994cited by this paper
• The retinoblastoma gene product is a cell cycle-dependent, nuclear matrix-associated protein.

  1994cited by this paper
• The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing

  1994cited by this paper
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  1994cited by this paper
• Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance.

  1994cited by this paper
• Identification of discrete structural domains in the retinoblastoma protein. Amino-terminal domain is required for its oligomerization.

  1994cited by this paper
• Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumorigenesis.

  1994cited by this paper
• The B1C8 protein is in the dense assemblies of the nuclear matrix and relocates to the spindle and pericentriolar filaments at mitosis.

  1994cited by this paper
• Visualization of replication factories attached to nucleoskeleton.

  1993cited by this paper
• p53 oncogene mutations in three human prostate cancer cell lines

  1993cited by this paper
• A retinoblastoma-binding protein related to a negative regulator of Ras in yeast

  1993cited by this paper
• Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain.

  1993cited by this paper
• The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.

  1993cited by this paper
• The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

  1993cited by this paper
• Mammalian G1 cyclins.

  1993cited by this paper
• Role of insulin-like growth factors in embryonic and postnatal growth.

  1993cited by this paper
• Expression of a retinoblastoma transgene results in dwarf mice.

  1993cited by this paper
• Okadaic acid regulation of the retinoblastoma gene product is correlated with the inhibition of growth factor-induced cell proliferation in mouse fibroblasts.

  1993cited by this paper
• Cell cycle-specific association of E2F with the p130 E1A-binding protein.

  1993cited by this paper
• Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation.

  1993cited by this paper
• The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

  1993cited by this paper
• Specific enzymatic dephosphorylation of the retinoblastoma protein

  1993cited by this paper
• Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.

  1993cited by this paper
• Physical interaction of the retinoblastoma protein with human D cyclins.

  1993cited by this paper
• Characterization of the retinoblastoma binding proteins RBP1 and RBP2.

  1993cited by this paper
• Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

  1993cited by this paper
• Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

  1993cited by this paper
• The Rb gene suppresses the growth of normal cells.

  1993cited by this paper
• Quantitative effects of the retinoblastoma gene on mouse development and tissue-specific tumorigenesis.

  1993cited by this paper
• A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity

  1993cited by this paper
• Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4.

  1993cited by this paper
• Functional interactions of the retinoblastoma protein with mammalian D-type cyclins.

  1993cited by this paper
• Tumor suppressor activity of RB and p53 genes in human breast carcinoma cells.

  1993cited by this paper
• Braking the cycle.

  1993cited by this paper
• Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells.

  1993cited by this paper
• Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpression.

  1993cited by this paper
• Overproduction of Rb protein after the G1/S boundary causes G2 arrest

  1993cited by this paper
• Failure of RB1 to reverse the malignant phenotype of human tumor cell lines.

  1992cited by this paper
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• Abrogation by c-myc of Gl phase arrest induced by RB protein but not by p53

  1992cited by this paper
• Regulation of retinoblastoma protein functions by ectopic expression of human cyclins.

  1992cited by this paper
• Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

  1992cited by this paper
• Thymidine kinase transcription is regulated at G1/S phase by a complex that contains retinoblastoma-like protein and a cdc2 kinase.

  1992cited by this paper
• Nuclear binding of purified retinoblastoma gene product is determined by cell cycle-regulated phosphorylation

  1992cited by this paper
• In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors.

  1992cited by this paper
• Retinoblastoma gene product activates expression of the human TGF-β2 gene through transcription factor ATF-2

  1992cited by this paper
• A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F.

  1992cited by this paper
• Cell type and differentiation dependent heterogeneity in retinoblastoma protein expression in SCID mouse fetuses.

  1992cited by this paper
• Requirement for a functional Rb-1 gene in murine development

  1992cited by this paper
• Structure and expression of the Xenopus retinoblastoma gene.

  1992cited by this paper
• Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

  1992cited by this paper
• Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

  1992cited by this paper
• The retinoblastoma protein physically associates with the human cdc2 kinase

  1992cited by this paper
• Abrogation by c-myc of Gl phase arrest induced by RB protein but not by p53

  1992cited by this paper
• Biological function of the retinoblastoma protein requires distinct domains for hyperphosphorylation and transcription factor binding

  1992cited by this paper
• Stability of retinoblastoma gene expression determines the tumorigenicity of reconstituted retinoblastoma cells.

  1992cited by this paper
• E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.

  1992cited by this paper
• Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F

  1992cited by this paper
• Expression of the retinoblastoma gene product in bladder carcinoma cells associates with a low frequency of tumor formation.

  1992cited by this paper
• The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression.

  1992cited by this paper
• The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

  1991cited by this paper
• Intraocular tumor formation of RB reconstituted retinoblastoma cells.

  1991cited by this paper
• The E2F transcription factor is a cellular target for the RB protein.

  1991cited by this paper
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• Human papillomavirus 16 E7 protein is associated with the nuclear matrix.

  1991cited by this paper
• Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product.

  1991cited by this paper
• Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides

  1991cited by this paper
• Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells

  1991cited by this paper
• Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

  1991cited by this paper
• The promoter of the prostate-specific antigen gene contains a functional androgen responsive element.

  1991cited by this paper
• Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein.

  1991cited by this paper
• G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment.

  1991cited by this paper
• Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene

  1991cited by this paper
• Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

  1991cited by this paper
• The retinoblastoma gene functions as a growth and tumor suppressor in human bladder carcinoma cells.

  1991cited by this paper
• Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

  1991cited by this paper
• Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

  1991cited by this paper
• The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein.

  1991cited by this paper
• The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle.

  1991cited by this paper
• Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.

  1990cited by this paper
• A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.

  1990cited by this paper
• The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T.

  1990cited by this paper
• The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.

  1990cited by this paper
• Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts.

  1990cited by this paper
• Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.

  1990cited by this paper
• Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.

  1990cited by this paper
• Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

  1990cited by this paper
• A single Cys706 to Phe substitution in the retinoblastoma protein causes the loss of binding to SV40 T antigen.

  1990cited by this paper
• Expression of the RB gene under the control of MuLV-LTR suppresses tumorigenicity of WERI-Rb-27 retinoblastoma cells in immunodefective mice.

  1990cited by this paper
• Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma.

  1990cited by this paper
• C-terminal truncation of the retinoblastoma gene product leads to functional inactivation.

  1990cited by this paper
• Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.

  1990cited by this paper
• DNA-binding activity of retinoblastoma protein is intrinsic to its carboxyl-terminal region.

  1990cited by this paper
• A novel genetic system to detect protein–protein interactions

  1989cited by this paper
• The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element.

  1989cited by this paper
• G1 events and regulation of cell proliferation.

  1989cited by this paper

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