Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Molecular and Cellular Biology

• Publication date

  1992-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/mcb.12.12.5620-5631.1992PMID 1448092PMCID PMC360501
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Stability of retinoblastoma gene expression determines the tumorigenicity of reconstituted retinoblastoma cells.

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• Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties.

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• Expression of the retinoblastoma gene product in bladder carcinoma cells associates with a low frequency of tumor formation.

  1992cited by this paper
• Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein

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• A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex.

  1992cited by this paper
• Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F

  1992cited by this paper
• A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F.

  1992influential reference
• The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner.

  1992cited by this paper
• RB protein as a cellular "corral" for growth-promoting proteins.

  1991cited by this paper
• Genes induced by serum growth factors

  1991cited by this paper
• Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

  1991cited by this paper
• Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin.

  1991cited by this paper
• The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F.

  1991cited by this paper
• A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product

  1991cited by this paper
• Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

  1991cited by this paper
• Cyclin A and the retinoblastoma gene product complex with a common transcription factor

  1991cited by this paper
• Molecular genetics of the retinoblastoma suppressor gene.

  1991cited by this paper
• The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle.

  1991cited by this paper
• Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A.

  1991cited by this paper
• The E2F transcription factor is a cellular target for the RB protein.

  1991cited by this paper
• Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

  1991cited by this paper
• The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

  1991cited by this paper
• Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product.

  1991cited by this paper
• The retinoblastoma gene functions as a growth and tumor suppressor in human bladder carcinoma cells.

  1991cited by this paper
• A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway.

  1990cited by this paper
• Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins

  1990cited by this paper
• Use of T7 RNA polymerase to direct expression of cloned genes.

  1990cited by this paper
• Expression of the RB gene under the control of MuLV-LTR suppresses tumorigenicity of WERI-Rb-27 retinoblastoma cells in immunodefective mice.

  1990cited by this paper
• C-terminal truncation of the retinoblastoma gene product leads to functional inactivation.

  1990cited by this paper
• The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.

  1990cited by this paper
• DNA-binding activity of retinoblastoma protein is intrinsic to its carboxyl-terminal region.

  1990cited by this paper
• Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.

  1990cited by this paper
• Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma.

  1990cited by this paper
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  1990influential reference
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  1990cited by this paper
• Point mutational inactivation of the retinoblastoma antioncogene.

  1989cited by this paper
• The retinoblastoma protein is phosphorylated during specific phases of the cell cycle.

  1989cited by this paper
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  1989cited by this paper
• The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element.

  1989cited by this paper
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  1989cited by this paper
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  1989cited by this paper
• E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor.

  1989cited by this paper
• Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation.

  1989cited by this paper
• Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex.

  1989cited by this paper
• Scissors-grip model for DNA recognition by a family of leucine zipper proteins.

  1989cited by this paper
• The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product.

  1989cited by this paper
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  1989cited by this paper
• The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.

  1988cited by this paper
• Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.

  1988cited by this paper
• Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.

  1988cited by this paper
• Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma.

  1988cited by this paper
• Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

  1988cited by this paper
• Inactivation of the retinoblastoma susceptibility gene in human breast cancers.

  1988cited by this paper
• SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene.

  1988cited by this paper
• Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells.

  1988cited by this paper
• Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung.

  1988cited by this paper
• GAL4-VP16 is an unusually potent transcriptional activator

  1988cited by this paper
• Structural evidence for the authenticity of the human retinoblastoma gene.

  1987cited by this paper
• Human retinoblastoma susceptibility gene: cloning, identification, and sequence

  1987cited by this paper
• The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

  1987cited by this paper
• Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins

  1986cited by this paper
• A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

  1986cited by this paper
• cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.

  1986cited by this paper
• Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein.

  1986cited by this paper
• Regulation of the yeast HO gene.

  1985cited by this paper
• Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells

  1982cited by this paper

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  2009cites this paper
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