Identification of Two Aflatrem Biosynthesis Gene Loci in Aspergillus flavus and Metabolic Engineering of Penicillium paxilli To Elucidate Their Function

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Applied and Environmental Microbiology

• Publication date

  2009-10-02

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1128/AEM.02146-08PMID 19801473PMCID PMC2786402
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Requirement of LaeA for secondary metabolism and sclerotial production in Aspergillus flavus.

  2008cited by this paper
• Molecular and Genetic Studies of Fusarium Trichothecene Biosynthesis: Pathways, Genes, and Evolution

  2007cited by this paper
• Analysis of Expressed Sequence Tags from the Fungus Aspergillus oryzae Cultured Under Different Conditions

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• Histone Deacetylase Activity Regulates Chemical Diversity in Aspergillus

  2007cited by this paper
• A fragmented aflatoxin-like gene cluster in the forest pathogen Dothistroma septosporum.

  2007cited by this paper
• Fusarium Tri4 encodes a key multifunctional cytochrome P450 monooxygenase for four consecutive oxygenation steps in trichothecene biosynthesis.

  2007cited by this paper
• Production of cyclopiazonic acid, aflatrem, and aflatoxin by Aspergillus flavus is regulated by veA, a gene necessary for sclerotial formation

  2007cited by this paper
• CdpNPT, an N‐Prenyltransferase from Aspergillus fumigatus: Overproduction, Purification and Biochemical Characterisation

  2007cited by this paper
• Defining Paxilline Biosynthesis in Penicillium paxilli

  2007cited by this paper
• A complex gene cluster for indole-diterpene biosynthesis in the grass endophyte Neotyphodium lolii.

  2006cited by this paper
• Four gene products are required for the fungal synthesis of the indole‐diterpene, paspaline

  2006cited by this paper
• The aflatoxin pathway regulator AflR induces gene transcription inside and outside of the aflatoxin biosynthetic cluster.

  2006cited by this paper
• Reverse Prenyltransferase in the Biosynthesis of Fumigaclavine C in Aspergillus fumigatus: Gene Expression, Purification, and Characterization of Fumigaclavine C Synthase FGAPT1

  2006cited by this paper
• Whole genome comparison of Aspergillus flavus and A. oryzae.

  2006cited by this paper
• Molecular cloning and genetic analysis of a symbiosis-expressed gene cluster for lolitrem biosynthesis from a mutualistic endophyte of perennial ryegrass

  2005cited by this paper
• Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae

  2005cited by this paper
• Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

  2005cited by this paper
• Genome sequencing and analysis of Aspergillus oryzae

  2005cited by this paper
• Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products

  2005cited by this paper
• Indole-Diterpene Gene Cluster from Aspergillus flavus

  2004cited by this paper
• The determinant step in ergot alkaloid biosynthesis by an endophyte of perennial ryegrass.

  2004cited by this paper
• Functional demarcation of the Fusarium core trichothecene gene cluster.

  2004cited by this paper
• Indole-Diterpene Biosynthesis in Ascomycetous Fungi

  2004cited by this paper
• Biosynthesis of indole diterpenes, emindole, and paxilline: involvement of a common intermediate.

  2004influential reference
• Characterization of a fusarium 2-gene cluster involved in trichothecene C-8 modification.

  2003cited by this paper
• Molecular analysis of two cytochrome P450 monooxygenase genes required for paxilline biosynthesis in Penicillium paxilli, and effects of paxilline intermediates on mammalian maxi-K ion channels

  2003cited by this paper
• Sequencing and comparison of yeast species to identify genes and regulatory elements

  2003influential reference
• Structure, mechanism and function of prenyltransferases.

  2002cited by this paper
• Biosynthesis of nodulisporic acid A: precursor studies.

  2002cited by this paper
• The P450–1 gene of Gibberella fujikuroi encodes a multifunctional enzyme in gibberellin biosynthesis

  2001cited by this paper
• The P450-4 Gene of Gibberella fujikuroi Encodes ent-Kaurene Oxidase in the Gibberellin Biosynthesis Pathway

  2001cited by this paper
• Molecular cloning and genetic analysis of an indole‐diterpene gene cluster from Penicillium paxilli

  2001cited by this paper
• The phylogeny of plant and animal pathogens in the Ascomycota

  2001cited by this paper
• Lack of Host Specialization inAspergillus flavus

  2000cited by this paper
• The translocation-associated tox1 locus of Cochliobolus heterostrophus is two genetic elements on two different chromosomes.

  1999cited by this paper
• Trichothecene 3-O-Acetyltransferase Protects Both the Producing Organism and Transformed Yeast from Related Mycotoxins

  1998cited by this paper
• Metabolic pathway gene clusters in filamentous fungi.

  1997cited by this paper
• Metabolic Pathway Gene Clusters in Filamentous Fungi

  1997cited by this paper
• Structural alignments of P450s and extrapolations to the unknown.

  1996influential reference
• Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels.

  1994cited by this paper
• Aflavarin and β-Aflatrem: New Anti-Insectan Metabolites from the Sclerotia of Aspergillus flavus

  1992cited by this paper
• The tremorigen aflatrem is a positive allosteric modulator of the gamma-aminobutyric acidA receptor channel expressed in Xenopus oocytes.

  1989cited by this paper
• Cochliobolus Heterostrophus. Cause of Southern Corn Leaf Blight

  1988cited by this paper
• Aflatrem: a tremorgenic mycotoxin with acute neurotoxic effects.

  1985cited by this paper
• Aflatrem, a tremorgenic toxin from Aspergillus flavus

  1980cited by this paper
• Aflatrem, the tremorgenic mycotoxin from aspergillus flavus

  1979cited by this paper

• Mining the Hidden Pharmacopeia: Fungal Endophytes, Natural Products, and the Rise of AI-Driven Drug Discovery

  2026cites this paper
• Double-edged sword: Aspergillus flavus as a threat to food safety and a resource for biotechnology.

  2026cites this paper
• Genomic comparative analysis of Ophiocordyceps unilateralis sensu lato

  2024cites this paper
• Isolation and characterization of koji mold (Aspergillus oryzae) from nature in Niigata.

  2024cites this paper
• Beyond morphogenesis and secondary metabolism: function of Velvet proteins and LaeA in fungal pathogenesis

  2024cites this paper
• Acidic environment favors the development and pathogenicity of the grape white rot fungus Coniella vitis

  2024cites this paper
• Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E—In Vitro and In Silico Investigations

  2024cites this paper
• 28 Minutes Later: Investigating the role of aflatrem-like compounds in Ophiocordyceps parasite manipulation of zombie ants

  2023cites this paper
• Effect of Streptomyces roseolus Cell-Free Supernatants on the Fungal Development, Transcriptome, and Aflatoxin B1 Production of Aspergillus flavus

  2023cites this paper
• The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus

  2023cites this paper
• Biosynthesis of Nodulisporic Acids: A Multifunctional Monooxygenase Delivers a Complex and Highly Branched Array

  2022cites this paper
• Post‐translational modifications drive secondary metabolite biosynthesis in Aspergillus : a review

  2022cites this paper
• Copper starvation induces antimicrobial isocyanide integrated into two distinct biosynthetic pathways in fungi

  2022cites this paper
• Noonindoles A–F: Rare Indole Diterpene Amino Acid Conjugates from a Marine-Derived Fungus, Aspergillus noonimiae CMB-M0339

  2022cites this paper
• Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host.

  2022cites this paper
• 28 Minutes Later: A behavioral and transcriptomic investigation into the potential role of 1 aflatrem-like compounds in establishing Ophiocordyceps extended phenotypes in zombie 2 ants 3

  2022cites this paper
• Branching and converging pathways in fungal natural product biosynthesis

  2022cites this paper
• Aminoacylation of Indole Diterpenes by Cluster-Specific Monomodular NRPS-like Enzymes.

  2022cites this paper
• 28 Minutes Later: A behavioural and transcriptomic investigation into the potential role of 1 aflatrem-like compounds in establishing Ophiocordyceps extended phenotypes in zombie 2 ants 3

  2022cites this paper
• Synthesis of rearranged indole diterpenes of the paxilline type.

  2021cites this paper
• The Solvent Dimethyl Sulfoxide Affects Physiology, Transcriptome and Secondary Metabolism of Aspergillus flavus

  2021cites this paper
• Mass Spectrometry-Based Network Analysis Reveals New Insights Into the Chemodiversity of 28 Species in Aspergillus section Flavi

  2021cites this paper
• Microevolution in the pansecondary metabolome of Aspergillus flavus and its potential macroevolutionary implications for filamentous fungi

  2021cites this paper
• Aspergillus derived mycotoxins in food and the environment: Prevalence, detection, and toxicity

  2021cites this paper
• Biosynthesis of Indole Diterpenes

  2020cites this paper
• Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases.

  2020cites this paper
• Fungal Meroterpenoids

  2020cites this paper
• Transcriptional responses of toxigenic and atoxigenic isolates of Aspergillus flavus to oxidative stress in aflatoxin-conducive and non-conducive media

  2020cites this paper
• Chemical repertoire and biosynthetic machinery of the Aspergillus flavus secondary metabolome: A review.

  2020cites this paper
• Combined Comparative Genomics and Gene Expression Analyses Provide Insights into the Terpene Synthases Inventory in Trichoderma

  2020cites this paper
• Chemistry of fungal meroterpenoid cyclases.

  2020cites this paper
• Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids.

  2020cites this paper
• Comprehensive chemotaxonomic and genomic profiling of a biosynthetically talented Australian fungus, Aspergillus burnettii sp. nov.

  2020cites this paper
• Alkaloids from Marine Fungi: Promising Antimicrobials

  2020cites this paper
• Molecular mechanisms in grass-Epichloë interactions: towards endophyte driven farming to improve plant fitness and immunity

  2020cites this paper
• Genetic Underpinnings of Host Manipulation by Ophiocordyceps as Revealed by Comparative Transcriptomics

  2020cites this paper
• Engineering Saccharomyces cerevisiae for Fungal Natural Product Production

  2020cites this paper
• Isolation and structure determination of two new nosiheptide-type compounds provide insights into the function of the cytochrome P450 oxygenase NocV in nocathiacin biosynthesis

  2020cites this paper
• Databases for Natural Product Research

  2020cites this paper
• A comparative genomics study of 23 Aspergillus species from section Flavi

  2020cites this paper
• Functional characterization of the idtF and idtP genes in the Claviceps paspali indole diterpene biosynthetic gene cluster

  2020cites this paper
• The Aspergilli and Their Mycotoxins: Metabolic Interactions With Plants and the Soil Biota

  2020cites this paper
• Tremorgenic Mycotoxins: Structure Diversity and Biological Activity

  2019cites this paper
• A unique Zn(II)2-Cys6-type protein, KpeA, is involved in secondary metabolism and conidiation in Aspergillus oryzae.

  2019cites this paper
• Tremorgenic and neurotoxic paspaline-derived indole-diterpenes: biosynthetic diversity, threats and applications

  2019cites this paper
• Secondary Metabolite Dereplication and Phylogenetic Analysis Identify Various Emerging Mycotoxins and Reveal the High Intra-Species Diversity in Aspergillus flavus

  2019cites this paper
• Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum

  2019cites this paper
• Final Report “ Metabolic profiling in Aspergillus flavus to determine gene function ” ( March , 2014-August , 2014 )

  2018cites this paper
• Rivera-Gómez, Carlos C. and Galán-Marín, Carmen C. and Bradley, Fiona F. (2014) Analysis of the influence of the fiber type in polymer

  2018cites this paper
• Aspergillus flavus Secondary Metabolites: More than Just Aflatoxins.

  2018cites this paper
• Genetic and Toxigenic Variability within Aspergillus flavus Population Isolated from Maize in Two Diverse Environments in Kenya

  2018cites this paper
• Inactivation of the indole-diterpene biosynthetic gene cluster of Claviceps paspali by Agrobacterium-mediated gene replacement

  2018cites this paper
• MIDAS: A Modular DNA Assembly System for Synthetic Biology.

  2018cites this paper
• Recent advances in reconstructing microbial secondary metabolites biosynthesis in Aspergillus spp.

  2018cites this paper
• Inactivation of the indole-diterpene biosynthetic gene cluster of Claviceps paspali by Agrobacterium-mediated gene replacement

  2018cites this paper
• Characterization of Aspergillus section Flavi : molecular markers as tools to unmask cryptic species

  2018cites this paper
• AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis.

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• The epigenetic reader SntB regulates secondary metabolism, development and global histone modifications in Aspergillus flavus.

  2018cites this paper
• The birth, evolution and death of metabolic gene clusters in fungi

  2018cites this paper
• Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei

  2018cites this paper
• The Transcriptional Regulator Hbx1 Affects the Expression of Thousands of Genes in the Aflatoxin-Producing Fungus Aspergillus flavus

  2018cites this paper
• Advances in molecular and genomic research to safeguard food and feed supply from aflatoxin contamination

  2018influential citation
• Chapter 4 – Recent Advancements on the Role of Biologically Active Secondary Metabolites from Aspergillus

  2018cites this paper
• Genome Mining and Comparative Biosynthesis of Meroterpenoids from Two Phylogenetically Distinct Fungi.

  2018cites this paper
• DMAPP Dimethylallyl diphosphate GPP Geranyl diphosphate GGPP Geranylgeranyl diphosphate CPP Copalyl diphosphate ABBA beta / alpha-fold with antiparallel beta strands

  2018cites this paper
• Aspergillus flavus aswA, a gene homolog of Aspergillus nidulans oefC, regulates sclerotial development and biosynthesis of sclerotium-associated secondary metabolites.

  2017cites this paper
• Aspergillus korhogoensis, a Novel Aflatoxin Producing Species from the Côte d’Ivoire

  2017cites this paper
• Identification and characterization of genes involved in kojic acid biosynthesis in Aspergillus flavus

  2017cites this paper
• Expansion of chemical space for natural products by uncommon P450 reactions.

  2017cites this paper
• Responses of Aspergillus flavus to Oxidative Stress Are Related to Fungal Development Regulator, Antioxidant Enzyme, and Secondary Metabolite Biosynthetic Gene Expression

  2016influential citation
• Oxidative stress and carbon metabolism influence Aspergillus flavus transcriptome composition and secondary metabolite production

  2016cites this paper
• Secondary metabolite arsenal of an opportunistic pathogenic fungus

  2016cites this paper
• Biologically Active Secondary Metabolites from the Fungi

  2016cites this paper
• RNA sequencing of an nsdC mutant reveals global regulation of secondary metabolic gene clusters in Aspergillus flavus.

  2016cites this paper
• Cytochrome P450 for Citreohybridonol Synthesis: Oxidative Derivatization of the Andrastin Scaffold.

  2016cites this paper
• Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism.

  2016cites this paper
• Identification of a novel sesquiterpene biosynthetic machinery involved in astellolide biosynthesis

  2016cites this paper
• Unusual chemistries in fungal meroterpenoid biosynthesis.

  2016cites this paper
• Biosynthesis of fungal meroterpenoids.

  2016cites this paper
• Secondary Metabolite Diversity of the Genus Aspergillus: Recent Advances

  2016cites this paper
• Total Biosynthesis of Fungal Indole Diterpenes Using Cell Factories

  2016cites this paper
• An Aspergillus flavus secondary metabolic gene cluster containing a hybrid PKS-NRPS is necessary for synthesis of the 2-pyridones, leporins.

  2015cites this paper
• Use of UHPLC high-resolution Orbitrap mass spectrometry to investigate the genes involved in the production of secondary metabolites in Aspergillus flavus

  2015cites this paper
• Association of fungal secondary metabolism and sclerotial biology

  2015cites this paper
• Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast.

  2015cites this paper
• Molecular Cloning and Functional Analysis of Gene Clusters for the Biosynthesis of Indole-Diterpenes in Penicillium crustosum and P. janthinellum

  2015cites this paper
• Biosynthesis of terpenoid natural products in fungi.

  2015influential citation
• An overproduction of astellolides induced by genetic disruption of chromatin-remodeling factors in Aspergillus oryzae

  2015cites this paper
• Challenges facing the biological control strategy for eliminating aflatoxin contamination

  2015cites this paper
• Reconstitution of biosynthetic machinery for the synthesis of the highly elaborated indole diterpene penitrem.

  2015cites this paper
• Crystal and molecular structure of aflatrem

  2015cites this paper
• Molecular mechanisms of Aspergillus flavus secondary metabolism and development.

  2014cites this paper
• Rapid Reconstitution of Biosynthetic Machinery for Fungal Metabolites in Aspergillus oryzae: Total Biosynthesis of Aflatrem

  2014cites this paper
• Alterations in gene expression and secondary metabolite production during development of Aspergillus nidulans

  2014cites this paper
• Comparison of Expression of Secondary Metabolite Biosynthesis Cluster Genes in Aspergillus flavus, A. parasiticus, and A. oryzae

  2014cites this paper
• Biosynthesis of fungal indole alkaloids.

  2014cites this paper
• Analysis of the Influence of the Fiber Type in Polymer Matrix/Fiber Bond Using Natural Organic Polymer Stabilizer

  2014cites this paper
• A fungal prenyltransferase catalyzes the regular di-prenylation at positions 20 and 21 of paxilline

  2014cites this paper
• Characterization of the biosynthetic gene cluster for the ribosomally synthesized cyclic peptide ustiloxin B in Aspergillus flavus.

  2014cites this paper
• Genetic safeguard against mycotoxin production and cyclopiazonic acid biosynthesis in Aspergillus oryzae

  2014cites this paper