Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Neuropsychopharmacology

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1038/sj.npp.1301193PMID 16936707
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype.

  2006cited by this paper
• Insulin modulates hippocampal activity‐dependent synaptic plasticity in a N‐methyl‐d‐aspartate receptor and phosphatidyl‐inositol‐3‐kinase‐dependent manner

  2005cited by this paper
• New twist on neuronal insulin receptor signaling in health, disease, and therapeutics.

  2005cited by this paper
• Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

  2005cited by this paper
• The neuroanatomy of remote memory.

  2005cited by this paper
• Insulin Affects the Neuronal Response in the Medial Temporal Lobe in Humans

  2005cited by this paper
• Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: Link to brain reductions in acetylcholine

  2005cited by this paper
• Hippocampus: cognitive processes and neural representations that underlie declarative memory.

  2004cited by this paper
• Insulin and the insulin receptor in experimental models of learning and memory.

  2004cited by this paper
• Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration.

  2004cited by this paper
• Insulin detemir and insulin aspart: a promising basal-bolus regimen for type 2 diabetes.

  2004cited by this paper
• Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity

  2004cited by this paper
• Review Hippocampus: Cognitive Processes and Neural Representations that Underlie Declarative Memory

  2004cited by this paper
• Insulin analogues (insulin detemir and insulin aspart) versus traditional human insulins (NPH insulin and regular human insulin) in basal-bolus therapy for patients with Type 1 diabetes

  2004cited by this paper
• The neurobiology of consolidations, or, how stable is the engram?

  2004cited by this paper
• Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis.

  2004cited by this paper
• Intranasal insulin improves memory in humans.

  2004influential reference
• Potential roles of insulin and IGF-1 in Alzheimer ’ s disease

  2003cited by this paper
• Potential roles of insulin and IGF-1 in Alzheimer's disease.

  2003cited by this paper
• Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype.

  2003cited by this paper
• The assessment of insulin resistance in man

  2002cited by this paper
• Sniffing neuropeptides: a transnasal approach to the human brain

  2002cited by this paper
• Insulin promotes rapid delivery of N-methyl-d- aspartate receptors to the cell surface by exocytosis

  2001cited by this paper
• Varieties of human spatial memory: a meta-analysis on the effects of hippocampal lesions.

  2001cited by this paper
• Improving Influence of Insulin on Cognitive Functions in Humans

  2001cited by this paper
• NMDA receptors and learning and memory processes.

  2001cited by this paper
• Transport of drugs from the nasal cavity to the central nervous system.

  2000cited by this paper
• Adaptation of cognitive function to hypoglycemia in healthy men.

  2000cited by this paper
• Insulin-Like Growth Factor-I Promotes Neurogenesis and Synaptogenesis in the Hippocampal Dentate Gyrus during Postnatal Development

  2000cited by this paper
• Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use.

  2000cited by this paper
• Insulin analogs with improved pharmacokinetic profiles.

  1999cited by this paper
• Central nervous system effects of intranasally administered insulin during euglycemia in men.

  1999cited by this paper
• The hippocampus and mechanisms of declarative memory.

  1999cited by this paper
• Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose.

  1999cited by this paper
• Brain Insulin Receptors and Spatial Memory

  1999cited by this paper
• Insulin aspart: a novel rapid-acting human insulin analogue.

  1999cited by this paper
• Tracking Insulin to the Mind

  1998cited by this paper
• Structure and function of declarative and nondeclarative memory systems.

  1996cited by this paper
• Memory improvement following induced hyperinsulinemia in Alzheimer's disease.

  1996cited by this paper
• Insulin receptor substrate-1 (IRS-1) expression in rat brain.

  1994cited by this paper
• Comparison of Subcutaneous Soluble Human Insulin and Insulin Analogues (AspB9, GluB27; AspB10; AspB28) on Meal-Related Plasma Glucose Excursions in Type I Diabetic Subjects

  1991cited by this paper
• Monomeric Insulins and Their Experimental and Clinical Implications

  1990cited by this paper
• The temporal course of proactive inhibition for serial lists.

  1962cited by this paper
• Interference and forgetting.

  1957cited by this paper
• For Personal Use. Only Reproduce with Permission the Lancet Publishing Group. Insulin and the Brain Insulin and Neurodegenerative Disease Insulin and Neurodegenerative Disease: Shared and Specific Mechanisms

  year unknowncited by this paper

• Lumbrokinase modulates tissue plasminogen activator and alleviates behavioral and cognitive deficits in mice with chronic social defeat stress.

  2026cites this paper
• Revitalizing GIP: Therapeutic Potential in Metabolic and Neurodegenerative Disorders.

  2026cites this paper
• Intranasal insulin ameliorates prenatal LPS-induced learning and memory impairments in adolescent male rats: A behavioral, electrophysiological, and molecular study.

  2026cites this paper
• Intranasal insulin enhances postoperative sleep quality and delirium in middle-aged cardiac surgery patients: A randomized controlled trial.

  2025cites this paper
• Nose to brain delivery of insulin loaded in PLGA and Chitosan-Coated PLGA Nanoparticles: A Promising Approach for Alzheimer’s disease therapy

  2025cites this paper
• First‐in‐human positron emission tomography study of intranasal insulin in aging and MCI

  2025cites this paper
• Brain insulin resistance mediated cognitive impairment and neurodegeneration: Type-3 diabetes or Alzheimer’s Disease

  2025cites this paper
• Nose-to-brain drug delivery: from bench to bedside

  2025cites this paper
• Intranasal Delivery of Metabolically Resilient Glutathione: In Vivo Pharmacokinetic, Permeation, and Efficacy Studies.

  2025cites this paper
• Intranasally Administered Insulin as Neuromodulating Factor and Medication in Treatment of Neuropsychiatric Disorders—Current Findings from Clinical Trials

  2025cites this paper
• Metabolic breakdown: Linking insulin resistance and mitochondrial dysfunction to neurodegeneration in Alzheimer's disease.

  2025cites this paper
• Intranasal insulin and postoperative delirium in adult surgical patients: a meta-analysis and systematic review of randomized controlled trials

  2025cites this paper
• Intranasal insulin for improving cognitive function in multiple sclerosis

  2025cites this paper
• Exploring the effects of an insulin challenge on neuroimaging outcomes: A scoping review.

  2025cites this paper
• Central cytometabolic functional vascular coupling in health and disease

  2025cites this paper
• Effect of perioperative intranasal insulin on postoperative delirium in elderly hip fracture patients undergoing general anesthesia: a randomized controlled study

  2025cites this paper
• Variable bioenergetic sensitivity of neurons and astrocytes to insulin and extracellular glucose

  2024cites this paper
• Effective Nose-to-Brain Delivery of Blood-Brain Barrier Impermeant Anti-IL-1β Antibody via the Minimally Invasive Nasal Depot (MIND) Technique

  2024cites this paper
• Central effects of acute intranasal insulin on neuroimaging, cognitive, and behavioural outcomes: A systematic review.

  2024cites this paper
• A structural heart-brain axis mediates the association between cardiovascular risk and cognitive function

  2024cites this paper
• The mitochondrial quality control system: a new target for exercise therapeutic intervention in the treatment of brain insulin resistance-induced neurodegeneration in obesity

  2024cites this paper
• Intranasal insulin effect on cognitive and/or memory impairment: a systematic review and meta-analysis

  2024cites this paper
• Emerging role of Metformin in Alzheimer's disease: A translational view.

  2024cites this paper
• Retracted Article: The interaction between insulin resistance and Alzheimer’s disease: a review article

  2024cites this paper
• Intranasal administration of insulin on the incidence of postoperative delirium in middle-aged patients undergoing elective on-pump cardiac surgery (INIPOD-MOPS): a prospective double-blinded randomized control study protocol

  2024cites this paper
• Metabolic Syndrome as a Risk Factor for Alzheimer’s Disease: A Focus on Insulin Resistance

  2023cites this paper
• Different Sources of Sugar Consumption and Cognitive Performance in Older Adults: Data From the National Health and Nutrition Examination Survey 2011-2014.

  2023cites this paper
• Intranasal delivery of full-length anti-Nogo-A antibody: A potential alternative route for therapeutic antibodies to central nervous system targets

  2023cites this paper
• In vivo intranasal delivery of coagulation factor IX: a proof-of-concept study.

  2023cites this paper
• Central nervous system insulin signaling can influence the rate of insulin influx into brain

  2023cites this paper
• Crosstalk between Alzheimer’s disease and diabetes: a focus on anti-diabetic drugs

  2023cites this paper
• Emerging Evidence for the Use of Antidiabetic Drugs, Glucagon-like Peptide 1 Receptor Agonists, for the Treatment of Alzheimer’s Disease

  2023cites this paper
• Outcomes and clinical implications of intranasal insulin on cognition in humans: A systematic review and meta-analysis

  2023cites this paper
• Local Delivery Strategies for Peptides and Proteins into the CNS: Status Quo, Challenges, and Future Perspectives

  2023cites this paper
• Exploring Molecular Targets for Mitochondrial Therapies in Neurodegenerative Diseases

  2023cites this paper
• Repositioning of Anti-Diabetic Drugs against Dementia: Insight from Molecular Perspectives to Clinical Trials

  2023cites this paper
• Brain insulin responsiveness is linked to age and peripheral insulin sensitivity

  2023cites this paper
• Human preterm colostrum stimulates outgrowth in neurogenic tissue

  2023cites this paper
• Hot Spots for the Use of Intranasal Insulin: Cerebral Ischemia, Brain Injury, Diabetes Mellitus, Endocrine Disorders and Postoperative Delirium

  2023cites this paper
• Protective effect of intranasal insulin on postoperative cognitive dysfunction in elderly patients with metabolic syndrome undergoing noncardiac surgery: a randomized clinical trial

  2023cites this paper
• Influencing the Insulin System by Placebo Effects in Patients With Diabetes Type 2 and Healthy Controls: A Randomized Controlled Trial

  2023cites this paper
• Intranasal interferon-beta as a promising alternative for the treatment of Alzheimer's disease

  2022cites this paper
• Current Insights on the Use of Insulin and the Potential Use of Insulin Mimetics in Targeting Insulin Signalling in Alzheimer’s Disease

  2022cites this paper
• A Novel Heart-Brain Axis Mediates the Association Between Cardiovascular Risk and Cognitive Function

  2022cites this paper
• Hindbrain insulin controls feeding behavior

  2022cites this paper
• Voluntary Attention and Quality of Life in Patients With Type 1 and Type 2 Diabetes Mellitus: Differences in Changes Depending on Disease Type and Duration

  2022cites this paper
• Docosahexaenoic acid enhances hippocampal insulin sensitivity to promote cognitive function of aged rats on a high-fat diet

  2022cites this paper
• Voluntary Attention and Quality of Life in Patients With Type 1 and Type 2 Diabetes Mellitus: Differences in Changes Depending on Disease Type and Duration

  2022cites this paper
• Mechanistic and Etiological Similarities in Diabetes Mellitus and Alzheimer's Disease: Antidiabetic Drugs as Optimistic Therapeutics in Alzheimer's Disease.

  2022cites this paper
• Formulation and In Vitro Characterization of a Vacuum-Dried Drug–Polymer Thin Film for Intranasal Application

  2022cites this paper
• Brain insulin resistance as a mechanistic mediator links peripheral metabolic disorders with declining cognition.

  2022cites this paper
• Focused Ultrasound-Mediated Intranasal Brain Drug Delivery Technique (FUSIN).

  2022cites this paper
• Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases

  2022cites this paper
• Astrocytes as Key Regulators of Brain Energy Metabolism: New Therapeutic Perspectives

  2022cites this paper
• A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro

  2022cites this paper
• Dapagliflozin diminishes memory and cognition impairment in Streptozotocin induced diabetes through its effect on Wnt/β-Catenin and CREB pathway.

  2022cites this paper
• Falling Short: The Contribution of Central Insulin Receptors to Gait Dysregulation in Brain Aging

  2022cites this paper
• Insights for Alzheimer's disease pharmacotherapy and current clinical trials.

  2022cites this paper
• FcRn as a Transporter for Nasal Delivery of Biologics: A Systematic Review

  2021cites this paper
• Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1

  2021cites this paper
• Intranasal insulin and orexins to treat age-related cognitive decline.

  2021cites this paper
• Insulin Action in the Brain regulates both Central and Peripheral Functions.

  2021cites this paper
• Alzheimer’s disease and type 2 diabetes mellitus: Pathophysiologic and pharmacotherapeutics links

  2021cites this paper
• Central Nervous System Delivery of Antibodies and Their Single-Domain Antibodies and Variable Fragment Derivatives with Focus on Intranasal Nose to Brain Administration

  2021cites this paper
• A Phase II, Single-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Therapeutic Efficacy of Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer’s Disease

  2021cites this paper
• Diabetes and the Nervous System

  2021cites this paper
• Intranasal insulin

  2021cites this paper
• The Immunopathogenesis of Alzheimer’s Disease Is Related to the Composition of Gut Microbiota

  2021cites this paper
• Placebo controlled phase II clinical trial: Safety and efficacy of combining intranasal insulin & acute exercise

  2021cites this paper
• Targeting Insulin Resistance to Treat Cognitive Dysfunction

  2021cites this paper
• New Insights into Nanoparticulate Carriers for Direct Nose‐to‐Brain Drug Delivery

  2021cites this paper
• Intranasal Insulin for Alzheimer’s Disease

  2021cites this paper
• Systemic Actions of SGLT2 Inhibition on Chronic mTOR Activation as a Shared Pathogenic Mechanism between Alzheimer’s Disease and Diabetes

  2021cites this paper
• GluT4: A central player in hippocampal memory and brain insulin resistance.

  2020cites this paper
• Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches.

  2020cites this paper
• Low-dose intranasal insulin improves cognitive function and suppresses the development of epilepsy.

  2020cites this paper
• Depression and Cognitive Impairment—Extrahepatic Manifestations of NAFLD and NASH

  2020cites this paper
• Diabetes and the Nervous System

  2020cites this paper
• Road From Nose to Brain for Treatment of Alzheimer: The Bumps and Humps.

  2020cites this paper
• Double-Blind Placebo-Controlled Pilot Investigation of the Safety of a Single Dose of Rapid-Acting Intranasal Insulin in Down Syndrome

  2020cites this paper
• Human insulin modulates α-synuclein aggregation via DAF-2/DAF-16 signalling pathway by antagonising DAF-2 receptor in C. elegans model of Parkinson’s disease

  2020cites this paper
• Insulin mediated novel therapies for the treatment of Alzheimer's disease.

  2020cites this paper
• Memory advancement by intranasal insulin in type 2 diabetes (MemAID) randomized controlled clinical trial: Design, methods and rationale.

  2020cites this paper
• Potential role of insulin on the pathogenesis of depression

  2020cites this paper
• Bioenergetic adaptations to HIV infection. Could modulation of energy substrate utilization improve brain health in people living with HIV-1?

  2020cites this paper
• Diabeteskomplikationen – Diabetes und Nervensystem

  2020cites this paper
• Prediabetes and working memory in older adults

  2020cites this paper
• Effects of intranasal insulin as an enhancer of fear extinction: a randomized, double-blind, placebo-controlled experimental study

  2020cites this paper
• Antidiabetic Drugs in Alzheimer’s Disease and Mild Cognitive Impairment: A Systematic Review

  2020cites this paper
• Neonatal Exposure to Anesthesia Leads to Cognitive Deficits in Old Age: Prevention with Intranasal Administration of Insulin in Mice

  2020cites this paper
• Role of Insulin in Neurotrauma and Neurodegeneration: A Review

  2020cites this paper
• Inhibitory Activity of Insulin on Aβ Aggregation Is Restricted Due to Binding Selectivity and Specificity to Polymorphic Aβ States

  2020cites this paper
• Stimulating the sleeping brain: Current approaches to modulating memory-related sleep physiology.

  2019cites this paper
• Nasal insulin administration does not affect hepatic glucose production at systemic fasting insulin levels

  2019cites this paper
• A systematic evaluation of the psychological and behavioural effects of the combined consumption of glucose and caffeine and comparison to the effects produced by consuming either substance in isolation

  2019cites this paper
• Insulin Inhibits Aβ42 Aggregation and Prevents Aβ42-Induced Membrane Disruption.

  2019cites this paper
• P3-011: A DOUBLE-BLIND, PLACEBO-CONTROLLED PILOT INVESTIGATION OF THE SAFETY OF INTRANASAL GLULISINE IN DOWN SYNDROME

  2019cites this paper
• Intranasal Insulin Increases Synaptic Protein Expression and Prevents Anesthesia-Induced Cognitive Deficits Through mTOR-eEF2 Pathway

  2019cites this paper
• Antidiabetic treatment on memory and spatial learning: From the pancreas to the neuron

  2019cites this paper
• CORRECTIONS

  2019cites this paper