Sleep to Remember

Scientific investigation into the possible role of sleep in memory consolidation began with the early studies of Jenkins and Dallenbach (1924). Despite nearly a century of investigation with a waxing and waning of interest, the role of sleep in memory processing remains controversial and elusive. This review provides the historical background for current views and considers the relative contribution of two sleep states, rapid eye movement sleep and slow-wave sleep, to offline memory processing. The sequential hypothesis, until now largely ignored, is discussed, and recent literature supporting this view is reviewed.

• Publication year

  2017

• Venue

  Journal of Neuroscience

• Publication date

  2017-01-18

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1523/JNEUROSCI.0297-16.2017PMID 28100730PMCID PMC6596760
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sleep-dependent memory consolidation and its implications for psychiatry

  2017cited by this paper
• Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?

  2016cited by this paper
• Causal evidence for the role of REM sleep theta rhythm in contextual memory consolidation

  2016cited by this paper
• REM Sleep-Dependent Bidirectional Regulation of Hippocampal-Based Emotional Memory and LTP.

  2016cited by this paper
• A Dual Role for Sleep Spindles in Sleep-Dependent Memory Consolidation?

  2015cited by this paper
• How to become an expert: A new perspective on the role of sleep in the mastery of procedural skills.

  2015cited by this paper
• Not only … but also: REM sleep creates and NREM Stage 2 instantiates landmark junctions in cortical memory networks.

  2015cited by this paper
• Targeted Memory Reactivation during Sleep Depends on Prior Learning.

  2015cited by this paper
• Locus Coeruleus in time with the making of memories.

  2015cited by this paper
• Memory cueing during sleep modifies the interpretation of ambiguous scenes in adolescents and adults

  2015influential reference
• The Consolidation and Transformation of Memory.

  2015cited by this paper
• Impairment of sleep-related memory consolidation in schizophrenia: relevance of sleep spindles?

  2015cited by this paper
• Experience-dependent upregulation of multiple plasticity factors in the hippocampus during early REM sleep.

  2015cited by this paper
• Coupling of Thalamocortical Sleep Oscillations Are Important for Memory Consolidation in Humans

  2015cited by this paper
• REM-Enriched Naps Are Associated with Memory Consolidation for Sad Stories and Enhance Mood-Related Reactivity

  2015cited by this paper
• Memory trace replay: the shaping of memory consolidation by neuromodulation

  2015cited by this paper
• Hierarchical nesting of slow oscillations, spindles and ripples in the human hippocampus during sleep

  2015cited by this paper
• The role of REM sleep theta activity in emotional memory

  2015influential reference
• The effect of selective REM-sleep deprivation on the consolidation and affective evaluation of emotional memories.

  2015cited by this paper
• Version final SOURCE ( OR PART OF THE FOLLOWING SOURCE ) : Type article Title Slow oscillations during sleep coordinate interregional communication in cortical networks

  2014cited by this paper
• The impact of diurnal sleep on the consolidation of a complex gross motor adaptation task

  2014cited by this paper
• Reactivating Memories during Sleep by Odors: Odor Specificity and Associated Changes in Sleep Oscillations

  2014cited by this paper
• Enhancement of sleep slow waves: underlying mechanisms and practical consequences

  2014cited by this paper
• Slow-Wave Sleep-Imposed Replay Modulates Both Strength and Precision of Memory

  2014cited by this paper
• Sleep memory processing: the sequential hypothesis

  2014cited by this paper
• Slow Oscillations during Sleep Coordinate Interregional Communication in Cortical Networks

  2014cited by this paper
• About sleep's role in memory.

  2013cited by this paper
• The Role of Sleep Spindles and Slow-Wave Activity in Integrating New Information in Semantic Memory

  2013cited by this paper
• Reduced sleep spindles and spindle coherence in schizophrenia: mechanisms of impaired memory consolidation?

  2012cited by this paper
• Biasing the content of hippocampal replay during sleep

  2012cited by this paper
• Sleep Spindles and Hippocampal Functional Connectivity in Human NREM Sleep

  2011cited by this paper
• Transcranial Electrical Currents to Probe EEG Brain Rhythms and Memory Consolidation during Sleep in Humans

  2011cited by this paper
• Regional slow waves and spindles in human sleep.

  2011cited by this paper
• The reorganization and reactivation of hippocampal maps predict spatial memory performance

  2010cited by this paper
• Reactivation, Retrieval, Replay and Reconsolidation in and Out of Sleep: Connecting the Dots

  2010cited by this paper
• Noradrenergic neurons of the locus coeruleus are phase locked to cortical up-down states during sleep.

  2010cited by this paper
• Rewarded outcomes enhance reactivation of experience in the hippocampus.

  2009cited by this paper
• Sleepy synapses. Commentary on Hanlon et al. "Effects of skilled training on sleep slow wave activity and cortical gene expression in the rat" Sleep 2009;32:719-729.

  2009cited by this paper
• Hippocampal Sharp Wave/Ripples during Sleep for Consolidation of Associative Memory

  2009cited by this paper
• Effects of skilled training on sleep slow wave activity and cortical gene expression in the rat.

  2009cited by this paper
• Disruption of ripple‐associated hippocampal activity during rest impairs spatial learning in the rat

  2009cited by this paper
• The influence of learning on sleep slow oscillations and associated spindles and ripples in humans and rats

  2009cited by this paper
• Selective suppression of hippocampal ripples impairs spatial memory

  2009cited by this paper
• Faculty Opinions recommendation of Selective suppression of hippocampal ripples impairs spatial memory.

  2009cited by this paper
• Learning-dependent, transient increase of activity in noradrenergic neurons of locus coeruleus during slow wave sleep in the rat: brain stem-cortex interplay for memory consolidation?

  2008cited by this paper
• Dynamics of a memory trace: effects of sleep on consolidation.

  2008cited by this paper
• The effect of a REM sleep deprivation procedure on different aspects of memory function in humans.

  2008cited by this paper
• Sustained increase in hippocampal sharp-wave ripple activity during slow-wave sleep after learning.

  2008cited by this paper
• Schemas and Memory Consolidation

  2007cited by this paper
• Odor Cues During Slow-Wave Sleep Prompt Declarative Memory Consolidation

  2007cited by this paper
• Reduced sleep spindle activity in schizophrenia patients.

  2007cited by this paper
• Slow wave sleep and REM sleep awakenings do not affect sleep dependent memory consolidation.

  2007cited by this paper
• Boosting slow oscillations during sleep potentiates memory

  2006cited by this paper
• Twenty-four hours retention of visuospatial memory correlates with the number of parietal sleep spindles.

  2006cited by this paper
• Elevated Sleep Spindle Density after Learning or after Retrieval in Rats

  2006cited by this paper
• Hippocampal sharp wave-ripples linked to slow oscillations in rat slow-wave sleep.

  2006cited by this paper
• How sleep affects the developmental learning of bird song

  2005cited by this paper
• Reward expectation, orientation of attention and locus coeruleus‐medial frontal cortex interplay during learning

  2004cited by this paper
• Learning increases human electroencephalographic coherence during subsequent slow sleep oscillations.

  2004cited by this paper
• Noradrenergic action in prefrontal cortex in the late stage of memory consolidation.

  2004cited by this paper
• Sleep and Dreaming: The case against memory consolidation in REM sleep

  2003cited by this paper
• Communication between neocortex and hippocampus during sleep in rodents

  2003cited by this paper
• Grouping of Spindle Activity during Slow Oscillations in Human Non-Rapid Eye Movement Sleep

  2002cited by this paper
• Practice with sleep makes perfect: sleep-dependent motor skill learning.

  2002cited by this paper
• Induction of Hippocampal Long-Term Potentiation during Waking Leads to Increased Extrahippocampal zif-268 Expression during Ensuing Rapid-Eye-Movement Sleep

  2002cited by this paper
• Learning-Dependent Increases in Sleep Spindle Density

  2002cited by this paper
• Sleep states and memory processes in humans: procedural versus declarative memory systems.

  2001cited by this paper
• Book Review: Reward Signaling by Dopamine Neurons

  2001cited by this paper
• The REM Sleep-Memory Consolidation Hypothesis

  2001cited by this paper
• The Slow Wave

  2001cited by this paper
• Commentary — reconsolidation: Strengthening the shaky trace through retrieval

  2000cited by this paper
• Strengthening the shaky trace through retrieval.

  2000cited by this paper
• Brain gene expression during REM sleep depends on prior waking experience.

  1999cited by this paper
• Reactivation of Hippocampal Cell Assemblies: Effects of Behavioral State, Experience, and EEG Dynamics

  1999cited by this paper
• Memory consolidation during sleep: a neurophysiological perspective

  1998influential reference
• Coordinated interactions between hippocampal ripples and cortical spindles during slow-wave sleep.

  1998cited by this paper
• Effects of Early and Late Nocturnal Sleep on Declarative and Procedural Memory

  1997cited by this paper
• Replay of Neuronal Firing Sequences in Rat Hippocampus During Sleep Following Spatial Experience

  1996cited by this paper
• Inhibitory influence of frontal cortex on locus coeruleus neurons.

  1995cited by this paper
• The sequential hypothesis of the function of sleep.

  1995cited by this paper
• Reactivation of hippocampal ensemble memories during sleep.

  1994cited by this paper
• The slow (< 1 Hz) oscillation in reticular thalamic and thalamocortical neurons: scenario of sleep rhythm generation in interacting thalamic and neocortical networks

  1993cited by this paper
• Plasticity of sensory responses of locus coeruleus neurons in the behaving rat: implications for cognition.

  1991cited by this paper
• Two-stage model of memory trace formation: a role for "noisy" brain states.

  1989cited by this paper
• The sequential hypothesis on sleep function. I. Evidence that the structure of sleep depends on the nature of the previous waking experience.

  1988cited by this paper
• Noradrenergic modulation of firing pattern in guinea pig and cat thalamic neurons, in vitro.

  1988cited by this paper
• Impairment of learning by cueing during postlearning slow-wave sleep in rats.

  1987cited by this paper
• Sleep states and learning: a review of the animal literature.

  1985cited by this paper
• Improvement of learning by cueing during postlearning paradoxical sleep.

  1985cited by this paper
• The consolidation hypothesis for REM sleep function: stress and other confounding factors--a review.

  1984cited by this paper
• The function of dream sleep

  1983cited by this paper
• Long-lasting potentiation of the dentate gyrus population spike by norepinephrine.

  1983cited by this paper
• Paradoxical sleep and memory storage processes.

  1977cited by this paper
• Dreams and dreaming: The current state of the art

  1975cited by this paper
• A review of REM sleep deprivation.

  1975cited by this paper
• Increased paradoxical sleep in mice during acquisition of a shock avoidance task.

  1974cited by this paper
• Disruptive effects of rapid eye movement sleep deprivation on long-term memory.

  1971cited by this paper
• La fonction du sommeil paradoxal : faits et hypothèses

  1971cited by this paper
• [The function of paradoxical sleep: facts and theories].

  1971cited by this paper
• [Deficiency in retention of conditioning after deprivation of paradoxical sleep in rats].

  1970cited by this paper

• Sleep's contribution to memory formation.

  2025cites this paper
• Noradrenergic therapies in neurodegenerative disease: from symptomatic to disease modifying therapy?

  2025cites this paper
• Bayesian meta-analysis reveals the mechanistic role of slow oscillation-spindle coupling in sleep-dependent memory consolidation

  2025cites this paper
• Neither fifty percent slow-wave sleep suppression nor fifty percent rapid eye movement sleep suppression does impair memory consolidation

  2024cites this paper
• A review of the application of exercise intervention on improving cognition in patients with Alzheimer’s disease: mechanisms and clinical studies

  2024cites this paper
• International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology

  2024cites this paper
• Thalamocortical Dynamics during Rapid Eye Movement Sleep in the Mouse Somatosensory Pathway

  2024cites this paper
• Impact of single‐trial avoidance learning on subsequent sleep

  2024cites this paper
• Engram mechanisms of memory linking and identity

  2024cites this paper
• Wavelet-Detected Changes in Nocturnal Brain Electrical Activity in Patients with Non-Motor Disorders Indicative of Parkinson’s Disease

  2024cites this paper
• Does slow oscillation-spindle coupling contribute to sleep-dependent memory consolidation? A Bayesian meta-analysis

  2024cites this paper
• From childhood adversity to latent stress vulnerability in adulthood: the mediating roles of sleep disturbances and HPA axis dysfunction

  2023cites this paper
• Sleep Continuity, Stability and Cyclic Organization Are Impaired in Insomniacs: A Case–Control Study

  2023cites this paper
• Deep-learning detection of mild cognitive impairment from sleep electroencephalography for patients with Parkinson’s disease

  2023cites this paper
• Pontine Waves Accompanied by Short Hippocampal Sharp Wave-Ripples During Non-rapid Eye Movement Sleep

  2023cites this paper
• Deep Learning for Parkinson's Disease Diagnosis: A Short Survey

  2023cites this paper
• Neuromodulatory Mechanisms of a Memory Loss-Preventive Effect of Alpha-Lipoic Acid in an Experimental Rat Model of Dementia

  2022cites this paper
• REM Sleep Deprivation Alters Learning-Induced Cell Proliferation and Generation of Newborn Young Neurons in the Dentate Gyrus of the Dorsal Hippocampus.

  2022cites this paper
• Chemogenetic inhibition of MCH neurons does not alter memory performance in mice.

  2022cites this paper
• The Effect of Early-Life Seizures on Cognitive and Motor Development: A Case Series

  2022cites this paper
• Importance of the locus coeruleus-norepinephrine system in sleep-wake regulation: Implications for aging and Alzheimer's disease.

  2022cites this paper
• Cocaine increases quantal norepinephrine secretion through NET-dependent PKC activation in locus coeruleus neurons.

  2022cites this paper
• Altered intrinsic brain activity in mild Alzheimer’s disease patients with sleep disturbances

  2021cites this paper
• Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model

  2021cites this paper
• Sleep and Immunity

  2021cites this paper
• Cognitive effects of rapid-acting treatments for resistant depression: Just adverse, or contributing to clinical efficacy?

  2021cites this paper
• Ultrastructural evidence for mu and delta opioid receptors at noradrenergic dendrites and glial profiles in the cat nucleus locus coeruleus.

  2021cites this paper
• Locus coeruleus: a new look at the blue spot

  2020cites this paper
• Sleep loss immediately after fear memory reactivation attenuates fear memory reconsolidation.

  2020cites this paper
• State-dependent brainstem ensemble dynamics and their interactions with hippocampus across sleep states

  2020cites this paper
• Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?

  2020cites this paper
• Neurotensin in reward processes.

  2020cites this paper
• Sleep as a window to treat affective disorders

  2020cites this paper
• Standards for preclinical research and publications in developmental anaesthetic neurotoxicity: expert opinion statement from the SmartTots preclinical working group.

  2020cites this paper
• Up and Down States and Memory Consolidation Across Somatosensory, Entorhinal, and Hippocampal Cortices

  2020cites this paper
• Impaired Phasic Discharge of Locus Coeruleus Neurons Based on Persistent High Tonic Discharge—A New Hypothesis With Potential Implications for Neurodegenerative Diseases

  2020cites this paper
• Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2

  2020cites this paper
• Molecular mechanisms of forgetting

  2020cites this paper
• No cognitive processing in the unconscious, anesthetic‐like, state of sleep

  2020cites this paper
• Power and Coherence in the EEG of the Rat: Impact of Behavioral States, Cortical Area, Lateralization and Light/Dark Phases

  2020cites this paper
• Healthy Lifestyle Behaviors: Sleep to Remain Well Around the Clock

  2020cites this paper
• Narratives bridge the divide between distant events in episodic memory

  2020cites this paper
• Immediate and long-lasting cognitive consequences of adolescent chronic sleep restriction.

  2019cites this paper
• Circuit mechanisms and computational models of REM sleep

  2019cites this paper
• Sharp-wave ripples as a signature of hippocampal-prefrontal reactivation for memory during sleep and waking states.

  2019cites this paper
• Functions and Circuits of REM Sleep

  2019cites this paper
• Sleep Impact on Perception, Memory, and Emotion in Adults and the Effects of Early-Life Experience

  2019cites this paper
• Neuropsychologie der Bedürfnisse

  2019cites this paper
• β‐adrenergic modulation of discrimination learning and memory in the auditory cortex

  2019cites this paper
• Getting the full picture

  2019influential citation
• Temporal Flexibility of Systems Consolidation and the Synaptic Occupancy/Reset Theory (SORT): Cues About the Nature of the Engram

  2019cites this paper
• Pharmacosynthetic Deconstruction of Sleep-Wake Circuits in the Brain.

  2019cites this paper
• Stimulating the sleeping brain: Current approaches to modulating memory-related sleep physiology.

  2019cites this paper
• Phase discontinuities underlie increased drowsiness and diminished sleep quality in older humans

  2019cites this paper
• State-dependent pontine ensemble dynamics and interactions with cortex across sleep states

  2019cites this paper
• Locus coeruleus-norepinephrine: basic functions and insights into Parkinson’s disease

  2019cites this paper
• Interactions between sleep disturbances and Alzheimer’s disease on brain function: a preliminary study combining the static and dynamic functional MRI

  2019cites this paper
• Unraveling why we sleep: Quantitative analysis reveals abrupt transition from neural reorganization to repair in early development

  2019cites this paper
• Disturbances of sleep quality, timing and structure and their relationship with other neuropsychiatric symptoms in Alzheimer's disease and schizophrenia: Insights from studies in patient populations and animal models

  2019cites this paper
• Sleep Physiology Correlations and Human Memory Consolidation: Where Do We Go From Here?

  2018cites this paper
• Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory.

  2018cites this paper
• Making Memories: Why Time Matters

  2018cites this paper
• Neuromodulation and a Reconceptualization of Autism Spectrum Disorders: Using the Locus Coeruleus Functioning as an Exemplar

  2018cites this paper
• The Emergent Engram: A Historical Legacy and Contemporary Discovery

  2018influential citation
• Human Memory Reconsolidation: A Guiding Framework and Critical Review of the Evidence

  2018cites this paper
• Pharmacologically induced amnesia for learned fear is time and sleep dependent

  2018cites this paper
• University ’ s repository of research publications and other research outputs Making Memories : Why Time Matters Journal Item

  2018cites this paper
• A Critical Time-Window for the Selective Induction of Hippocampal Memory Consolidation by a Brief Episode of Slow-Wave Sleep

  2018cites this paper
• The Effect of REM Sleep Deprivation on Spatial Memory in Male and Female Rats

  2018cites this paper
• Dream Content and Procedural Learning in Vipassana Meditators and Controls

  2018cites this paper
• Slow-wave sleep predicts long-term social functioning in severe mental illness

  2018cites this paper
• Neural Coding of Cell Assemblies via Spike-Timing Self-Information

  2018cites this paper
• Levodopa‐induced dyskinesia in Parkinson disease: Sleep matters

  2018cites this paper
• Sleep and emotional processing.

  2017cites this paper
• Sleeping on the motor engram: The multifaceted nature of sleep‐related motor memory consolidation

  2017cites this paper
• Switching between internal and external modes: A multiscale learning principle

  2017cites this paper
• Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus.

  2017cites this paper
• Neural Synchrony and Memory In and Out of Sleep

  2017cites this paper