Role of the Sodium-Dependent Phosphate Cotransporter, Pit-1, in Vascular Smooth Muscle Cell Calcification

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Circulation Research

• Publication date

  2006-04-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/01.RES.0000216409.20863.e7PMID 16527991
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Smooth muscle cells deficient in osteopontin have enhanced susceptibility to calcification in vitro.

  2005cited by this paper
• Regulation of cardiovascular calcification.

  2004cited by this paper
• Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD.

  2004cited by this paper
• Vascular calcification: in vitro evidence for the role of inorganic phosphate.

  2003cited by this paper
• Characterization of an in vitro model of calcification in retinal pigmented epithelial cells.

  2003cited by this paper
• Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality.

  2003cited by this paper
• Phosphate Is a Specific Signal for ATDC5 Chondrocyte Maturation and Apoptosis‐Associated Mineralization: Possible Implication of Apoptosis in the Regulation of Endochondral Ossification

  2003cited by this paper
• Matrix vesicles and calcification

  2003cited by this paper
• Phosphate overload accelerates vascular calcium deposition in end-stage renal disease patients.

  2003cited by this paper
• High coronary artery calcium scores pose an extremely elevated risk for hard events.

  2002cited by this paper
• Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells.

  2002cited by this paper
• Cardiac calcification in adult hemodialysis patients. A link between end-stage renal disease and cardiovascular disease?

  2002cited by this paper
• Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids.

  2002cited by this paper
• Inactivation of the Osteopontin Gene Enhances Vascular Calcification of Matrix Gla Protein–deficient Mice

  2002cited by this paper
• Phosphate ions mediate chondrocyte apoptosis through a plasma membrane transporter mechanism.

  2001cited by this paper
• Authentic Matrix Vesicles Contain Active Metalloproteases (MMP) A ROLE FOR MATRIX VESICLE-ASSOCIATED MMP-13 IN ACTIVATION OF TRANSFORMING GROWTH FACTOR- b *

  2001cited by this paper
• PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification.

  2001cited by this paper
• Authentic Matrix Vesicles Contain Active Metalloproteases (MMP)

  2001cited by this paper
• Expression of type III sodium-dependent phosphate transporters/retroviral receptors mRNAs during osteoblast differentiation.

  2001cited by this paper
• Abdominal Aortic Calcific Deposits Are an Important Predictor of Vascular Morbidity and Mortality

  2001cited by this paper
• Smooth Muscle Cell Phenotypic Transition Associated With Calcification: Upregulation of Cbfa1 and Downregulation of Smooth Muscle Lineage Markers

  2001cited by this paper
• Calcification of the aortic valve in the dialyzed patient.

  2000cited by this paper
• Phosphate regulation of vascular smooth muscle cell calcification.

  2000influential reference
• Interleukin-1beta induces apoptosis in GL15 glioblastoma-derived human cell line.

  2000cited by this paper
• United States Renal Data System (USRDS).

  2000cited by this paper
• Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis.

  2000cited by this paper
• Apoptosis Regulates Human Vascular Calcification In Vitro: Evidence for Initiation of Vascular Calcification by Apoptotic Bodies

  2000cited by this paper
• Interleukin-1β induces apoptosis in GL15 glioblastoma-derived human cell line

  2000cited by this paper
• Vascular calcification.

  1999cited by this paper
• Calcification of vascular smooth muscle cell cultures: inhibition by osteopontin.

  1999cited by this paper
• Sodium-dependent phosphate co-transporters.

  1999cited by this paper
• In vivo expression of transcripts encoding the Glvr-1 phosphate transporter/retrovirus receptor during bone development.

  1999cited by this paper
• Na+-dependent phosphate cotransporters: the NaPi protein families.

  1998cited by this paper
• Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: a national study.

  1998cited by this paper
• Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein

  1997cited by this paper
• Identification and characterization of a widely expressed phosphate transporter/retrovirus receptor family.

  1996cited by this paper
• Expression and regulation of Na-dependent P(i) transport in matrix vesicles produced by osteoblast-like cells.

  1995cited by this paper
• Expression and Regulation of Na‐Dependent Pi Transport in Matrix Vesicles Produced by Osteoblast‐like Cells

  1995cited by this paper
• Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus.

  1994cited by this paper
• Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus.

  1990cited by this paper
• Role of phosphate and pyrophosphate in soft tissue calcification.

  1978cited by this paper
• Inactivation of the Osteopontin Gene Enhances Vascular Calcification of Matrix Gla Protein–deficient Mice: Evidence for Osteopontin as an Inducible Inhibitor of Vascular Calcification In Vivo

  year unknowncited by this paper

• High-Phosphate-Induced Hypertension: The Pathogenic Role of Fibroblast Growth Factor 23 (FGF23) Signaling in Sympathetic Nervous System Activation

  2026cites this paper
• Peripheral Vascular Calcification.

  2026cites this paper
• Role of Inositol Hexakisphosphate Kinases in Vascular Smooth Muscle Cell Calcification

  2026cites this paper
• Pathophysiology of chronic kidney disease–mineral bone disorder (CKD-MBD): from adaptive to maladaptive mineral homeostasis

  2025cites this paper
• LincRNA-p21 drives apoptosis and calcification of vascular smooth muscle cell via small extracellular vesicles under hyperphosphatemic conditions in chronic kidney disease.

  2025cites this paper
• The role of serum phosphate and calcium levels in coronary artery calcification progression: A multicenter, longitudinal cohort study.

  2025cites this paper
• Evaluation of risk factors in patients with calcific aortic valve disease who underwent aortic valve replacement from 2011 to 2021

  2025cites this paper
• Dysregulation of bone and myocardial inorganic phosphate transporters and downstream cell signals in early-stage mild chronic kidney disease-mineral and bone disorder: An experimental study.

  2025cites this paper
• Differences in risk factors associated with the initiation and progression of mitral annular calcification in asymptomatic individuals

  2025cites this paper
• Phosphate overload via the type III Na-dependent Pi transporter represses aortic wall elastic fiber formation

  2024cites this paper
• Epileptic seizure as the prominent symptom in Fahr syndrome, case report and literature review.

  2024cites this paper
• Similarities and Differences of Vascular Calcification in Diabetes and Chronic Kidney Disease

  2024cites this paper
• SGK3 promotes vascular calcification via Pit-1 in chronic kidney disease

  2024cites this paper
• Zinc Deficiency Promotes Calcification in Vascular Smooth Muscle Cells Independent of Alkaline Phosphatase Action and Partly Impacted by Pit1 Upregulation

  2024cites this paper
• Potential efficacy and mechanism of medicinal plants on chronic kidney disease-associated vascular calcification: a review

  2024cites this paper
• Phosphate in Cardiovascular Disease: From New Insights Into Molecular Mechanisms to Clinical Implications.

  2024cites this paper
• Медиакальциноз у пациентов с сахарным диабетом: этиопатогенетические, патофизиологические гистопатологические аспекты

  2024cites this paper
• Higher serum phosphate within the normal range is associated with the development of calcified aortic valve disease

  2024cites this paper
• Phosphonoformic acid reduces hyperphosphatemia-induced vascular calcification via Pit-1

  2024cites this paper
• Vascular Calcification: A Passive Process That Requires Active Inhibition

  2024cites this paper
• Zinc Ameliorates High Pi and Ca-Mediated Osteogenic Differentiation of Mesenchymal Stem Cells

  2024cites this paper
• In Vitro Models of Cardiovascular Calcification

  2024cites this paper
• Hypoxia-Inducible Factor-1α Regulates High Phosphate-Induced Vascular Calcification via Type III Sodium-Dependent Phosphate Cotransporter 1

  2024cites this paper
• Phosphate sensing in health and disease

  2024cites this paper
• Serum phosphate levels and mortality in incident hemodialysis patients: a national retrospective cohort study.

  2024cites this paper
• Key regulators of vascular calcification in chronic kidney disease: Hyperphosphatemia, BMP2, and RUNX2

  2024cites this paper
• SLC20a1/PiT-1 is required for chorioallantoic placental morphogenesis

  2023cites this paper
• Corneal and Coronary Calcification in Maintenance Hemodialysis: The Face Is No Index to the Heart

  2023cites this paper
• Phosphate Toxicity and Vascular Calcification in Chronic Kidney Disease: A Closer Look Utilizing Transmission Electron Microscopy.

  2023cites this paper
• Inflammatory, Metabolic, and Coagulation Effects on Medial Arterial Calcification in Patients with Peripheral Arterial Disease

  2023influential citation
• Role of transporters in regulating mammalian intracellular inorganic phosphate

  2023cites this paper
• Pit 1 transporter (SLC20A1) as a key factor in the NPP1‐mediated inhibition of insulin signaling in human podocytes

  2023cites this paper
• Phosphate Control in Peritoneal Dialysis Patients: Issues, Solutions, and Open Questions

  2023cites this paper
• Phosphate Is a Cardiovascular Toxin.

  2022cites this paper
• Oxidative Stress Related to Plasmalemmal and Mitochondrial Phosphate Transporters in Vascular Calcification

  2022cites this paper
• Plasma phosphate and all-cause mortality in individuals with and without type 2 diabetes: the Dutch population-based lifelines cohort study

  2022cites this paper
• Hyperglycemic environment disrupts phosphate transporter function and promotes calcification processes in podocytes and isolated glomeruli

  2022cites this paper
• The Interplay between Uremic Toxins and Albumin, Membrane Transporters and Drug Interaction

  2022cites this paper
• Cellular abundance of sodium phosphate cotransporter SLC20A1/PiT1 and phosphate uptake are controlled post-transcriptionally by ESCRT

  2022cites this paper
• Monitoring the in vivo siRNA release from lipid nanoparticles based on the fluorescence resonance energy transfer principle

  2022cites this paper
• Calcium, phosphate, PTH, vitamin D, and FGF-23 in CKD-mineral and bone disorder

  2022cites this paper
• The Pathology of Primary Familial Brain Calcification: Implications for Treatment

  2022cites this paper
• Vascular calcification maladaptively participates in acute phosphate homeostasis.

  2022cites this paper
• Overview on hydrogen sulfide-mediated suppression of vascular calcification and hemoglobin/heme-mediated vascular damage in atherosclerosis

  2022cites this paper
• The forgotten link between atherosclerosis and bone disease.

  2022cites this paper
• The hEag1 K+ Channel Inhibitor Astemizole Stimulates Ca2+ Deposition in SaOS-2 and MG-63 Osteosarcoma Cultures

  2022cites this paper
• Role of the extracellular ATP/pyrophosphate metabolism cycle in vascular calcification

  2022cites this paper
• Inflammation: a putative link between phosphate metabolism and cardiovascular disease.

  2021cites this paper
• Iron Sucrose: A Double-Edged Sword in High Phosphate Media-Induced Vascular Calcification

  2021cites this paper
• Vascular Calcification: Key Roles of Phosphate and Pyrophosphate

  2021cites this paper
• The impact of type III sodium‐dependent phosphate transporters (Pit 1 and Pit 2) on podocyte and kidney function

  2021influential citation
• Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing?

  2021cites this paper
• Phosphate Overload Stimulates Inflammatory Reaction via PiT-1 and Induces Vascular Calcification in Uremia.

  2021cites this paper
• BGP-15 Inhibits Hyperglycemia-Aggravated VSMC Calcification Induced by High Phosphate

  2021cites this paper
• Chronic kidney disease measures for cardiovascular risk prediction.

  2021cites this paper
• Chronic Kidney Disease-Induced Arterial Media Calcification in Rats Prevented by Tissue Non-Specific Alkaline Phosphatase Substrate Supplementation Rather Than Inhibition of the Enzyme

  2021influential citation
• New Insights to the Crosstalk between Vascular and Bone Tissue in Chronic Kidney Disease–Mineral and Bone Disorder

  2021cites this paper
• Klotho deficiency‐induced arterial calcification involves osteoblastic transition of VSMCs and activation of BMP signaling

  2021cites this paper
• Epidemiological Research Advances in Vascular Calcification in Diabetes

  2021cites this paper
• Vascular calcification: Role of vascular smooth muscle cells and its regulation by microRNA

  2021cites this paper
• Roles of Nuclear Receptors in Vascular Calcification

  2021influential citation
• Diabetic mellitus, vascular calcification and hypoxia: A complex and neglected tripartite relationship.

  2021cites this paper
• Case Report: Two Novel Frameshift Mutations in SLC20A2 and One Novel Splice Donor Mutation in PDGFB Associated With Primary Familial Brain Calcification

  2021cites this paper
• Regulation of phosphate in health and disease

  2021cites this paper
• Uraemic extracellular vesicles augment osteogenic transdifferentiation of vascular smooth muscle cells via enhanced AKT signalling and PiT‐1 expression

  2021cites this paper
• Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish

  2021cites this paper
• Contribution of Gut Microbiota-Derived Uremic Toxins to the Cardiovascular System Mineralization

  2021cites this paper
• Regulatory Role of Sex Hormones in Cardiovascular Calcification

  2021influential citation
• Phosphate and fibroblast growth factor 23 in diabetes

  2021cites this paper
• Adapter Protein RapGEF1 Is Required for ERK1/2 Signaling in Response to Elevated Phosphate in Vascular Smooth Muscle Cells

  2021cites this paper
• High phosphate impairs arterial endothelial function through AMPK‐related pathways in mouse resistance arteries

  2020cites this paper
• Zinc Inhibits HIF-Prolyl Hydroxylase Inhibitor-Aggravated VSMC Calcification Induced by High Phosphate

  2020cites this paper
• The role of the gasotransmitter hydrogen sulfide in pathological calcification

  2020cites this paper
• Isolation and Characterization of Three Sodium-Phosphate Cotransporter Genes and Their Transcriptional Regulation in the Grass Carp Ctenopharyngodon idella

  2020cites this paper
• Differential Mechanisms of Arterial and Valvular Calcification

  2020cites this paper
• Modulating phosphate consumption, a novel therapeutic approach for the control of cancer cell proliferation and tumorigenesis.

  2020cites this paper
• Rare Co-occurrence of Beta-Thalassemia and Pseudoxanthoma elasticum: Novel Biomolecular Findings

  2020cites this paper
• Implications of Chronic Kidney Disease on the Epidemiology of Cardiovascular Disease

  2020cites this paper
• Pathophysiology of The Chronic Kidney Disease–Mineral Bone Disorder

  2020cites this paper
• Using 99mTc-(V)-DMSA to follow the vascular calcification process in vascular smooth muscle cells based on pit-1 expression.

  2020cites this paper
• Vascular calcification has a role in acute non-renal phosphate clearance

  2020cites this paper
• Structure of the sodium-dependent phosphate transporter reveals insights into human solute carrier SLC20

  2020cites this paper
• Melatonin Attenuates Calcium Deposition from Vascular Smooth Muscle Cells by Activating Mitochondrial Fusion and Mitophagy via an AMPK/OPA1 Signaling Pathway

  2020cites this paper
• The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification

  2020cites this paper
• Arterial Stiffness

  2020cites this paper
• Gene expression in the cardiovascular system of the domestic sheep (Ovis aries); a new tool to advance our understanding of cardiovascular disease

  2020cites this paper
• Phosphate Transport in Epithelial and Nonepithelial Tissue.

  2020cites this paper
• Amelotin is expressed in retinal pigment epithelium and localizes to hydroxyapatite deposits in dry age-related macular degeneration.

  2020cites this paper
• Chronic Kidney Disease–Mineral and Bone Disorders

  2020cites this paper
• Osteoporosis Entwined with Cardiovascular Disease: The Implication of Osteoprotegerin and Example of Statins.

  2020cites this paper
• Differences in intracellular localisation of ANKH mutants that relate to mechanisms of calcium pyrophosphate deposition disease and craniometaphyseal dysplasia

  2020cites this paper
• Inhibition of tissue‐nonspecific alkaline phosphatase protects against medial arterial calcification and improves survival probability in the CKD‐MBD mouse model

  2020cites this paper
• TDAG51 (T-Cell Death-Associated Gene 51) Is a Key Modulator of Vascular Calcification and Osteogenic Transdifferentiation of Arterial Smooth Muscle Cells

  2020cites this paper
• Interplay between primary familial brain calcification-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis

  2020cites this paper
• Oxidative Stress by Ca2+ Overload is Critical forPhosphate-Induced Vascular Calcification.

  2020cites this paper
• Melatonin attenuates vascular calcification by inhibiting mitochondria fission via an AMPK/Drp1 signalling pathway

  2020cites this paper
• Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease

  2019cites this paper
• Receptor for advanced glycation end products: a key molecule in the genesis of chronic kidney disease vascular calcification and a potential modulator of sodium phosphate co-transporter PIT-1 expression.

  2019cites this paper
• Suppression of Lysophosphatidylcholine-Induced Human Aortic Smooth Muscle Cell Calcification by Protein Kinase A Inhibition.

  2019cites this paper
• Senescent Cells in Early Vascular Ageing and Bone Disease of Chronic Kidney Disease—A Novel Target for Treatment

  2019cites this paper