Role of mucus layers in gut infection and inflammation.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Current Opinion in Microbiology

• Publication date

  2012-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mib.2011.11.002PMID 22177113PMCID PMC3716454
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stromal IFN-γR-Signaling Modulates Goblet Cell Function During Salmonella Typhimurium Infection

  2011cited by this paper
• The Genome of Akkermansia muciniphila, a Dedicated Intestinal Mucin Degrader, and Its Use in Exploring Intestinal Metagenomes

  2011cited by this paper
• Function of the CysD domain of the gel-forming MUC2 mucin

  2011cited by this paper
• The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine

  2011cited by this paper
• Mucin dynamics and enteric pathogens

  2011cited by this paper
• Keeping Bacteria at a Distance

  2011cited by this paper
• Life at the margins

  2011cited by this paper
• Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice.

  2011cited by this paper
• Lactobacillus and Bifidobacterium species do not secrete protease that cleaves the MUC2 mucin which organises the colon mucus.

  2010cited by this paper
• Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress

  2010cited by this paper
• The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions

  2010cited by this paper
• A human gut microbial gene catalogue established by metagenomic sequencing

  2010cited by this paper
• Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa

  2010cited by this paper
• Bacteria Penetrate the Inner Mucus Layer before Inflammation in the Dextran Sulfate Colitis Model

  2010cited by this paper
• Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria

  2010cited by this paper
• Expression of the BabA Adhesin during Experimental Infection with Helicobacter pylori

  2010cited by this paper
• Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein.

  2009cited by this paper
• Helicobacter pylori moves through mucus by reducing mucin viscoelasticity

  2009cited by this paper
• A complex, but uniform O-glycosylation of the human MUC2 mucin from colonic biopsies analyzed by nanoLC/MSn.

  2009cited by this paper
• MUC1 Limits Helicobacter pylori Infection both by Steric Hindrance and by Acting as a Releasable Decoy

  2009cited by this paper
• Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

  2008cited by this paper
• A Potential Role for Drosophila Mucins in Development and Physiology

  2008cited by this paper
• The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

  2008cited by this paper
• Gel-forming mucins appeared early in metazoan evolution

  2007cited by this paper
• IgA response to symbiotic bacteria as a mediator of gut homeostasis.

  2007cited by this paper
• Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel.

  2006cited by this paper
• Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection.

  2006cited by this paper
• Host-Bacterial Mutualism in the Human Intestine

  2005cited by this paper
• Streptomycin-Pretreated Mice Serovar Typhimurium Colitis in Salmonella enterica Efficient Induction of Flagella and Chemotaxis Are Required for

  2004cited by this paper
• Entamoeba histolytica Cysteine Proteinases Disrupt the Polymeric Structure of Colonic Mucin and Alter Its Protective Function

  2003cited by this paper
• The N Terminus of the MUC2 Mucin Forms Trimers That Are Held Together within a Trypsin-resistant Core Fragment*

  2002cited by this paper
• Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2

  2002cited by this paper
• The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.

  2002cited by this paper
• Bacterial strategies for overcoming host innate and adaptive immune responses

  2002cited by this paper
• The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo.

  2001cited by this paper
• Acid transport through channels in the mucous layer of rat stomach.

  2000cited by this paper
• Studies on the “Insoluble” Glycoprotein Complex from Human Colon

  1999cited by this paper
• O-Glycosylated MUC2 Monomer and Dimer from LS 174T Cells Are Water-soluble, whereas Larger MUC2 Species Formed Early during Biosynthesis Are Insoluble and Contain Nonreducible Intermolecular Bonds*

  1998cited by this paper
• Dimerization of the Human MUC2 Mucin in the Endoplasmic Reticulum Is Followed by a N-Glycosylation-dependent Transfer of the Mono- and Dimers to the Golgi Apparatus*

  1998cited by this paper
• Molecular cloning of a cDNA coding for a region of an apoprotein from the 'insoluble' mucin complex of rat small intestine.

  1994cited by this paper
• Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor.

  1994cited by this paper
• Hydrogen ion concentration in the mucus layer on top of acid-stimulated and -inhibited rat gastric mucosa.

  1994cited by this paper
• Characterization of two different glycosylated domains from the insoluble mucin complex of rat small intestine.

  1993cited by this paper
• Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens.

  1993cited by this paper
• Animal glycosphingolipids as membrane attachment sites for bacteria.

  1989cited by this paper
• Carbohydrate-specific adhesion of bacteria to thin-layer chromatograms: a rationalized approach to the study of host cell glycolipid receptors.

  1985cited by this paper

• Immunomodulators in poultry: natural pathways to enhanced health and productivity

  2026cites this paper
• Targeting Enterotoxins: Advancing Vaccine Development for Enterotoxigenic Escherichia coli ETEC

  2025cites this paper
• Development study of the inflammatory process during colibacillosis enteritis in broiler chickens in the east of Algeria

  2025cites this paper
• Intestinal Mucin Glycosylation: Structural Regulation, Homeostasis Maintenance and Disease Association

  2025cites this paper
• Effect of Marine‐Derived Scallop Peptide Hydrolysate on Immune Modulation and Gut Microbiota Restoration in Cyclophosphamide‐Induced Immunosuppressed Mice

  2025cites this paper
• PEDV infection downregulates goblet cell differentiation through activating the Notch pathway

  2025cites this paper
• Relationship of maternal high-fat diet to intestinal barrier integrity and disease in offspring.

  2025cites this paper
• Unique physiological and regulatory activity drives divergent toxin and non-toxin gene expression in rattlesnake accessory venom glands.

  2025cites this paper
• Mucins: Progress in Understanding Physiological Functions and Involvement in Pathological Processes and Prospects for Use (A Review)

  2025cites this paper
• Microbes Saving Lives and Reducing Suffering

  2025cites this paper
• The Biology of Akkermansia.

  2025cites this paper
• Effects of energy density of diets and dietary Pediococcus acidilactici supplementation on productive performance, egg quality, and intestinal function in laying hens

  2025cites this paper
• Regulation of Intestinal Permeability in Health and Disease: Possible Therapeutic Applications.

  2025cites this paper
• Introduction to cancer biology and current research trends.

  2025cites this paper
• Orally administered Chrysophyta polysaccharide ameliorates DSS-induced colitis via intestinal barrier improvement, oxidative stress regulation, NF-κB pathway inhibition, and gut microbiota modulation.

  2025cites this paper
• A Review on Piccha Basti as a Pharacotherapeutic Option for Acute Inflammatory Conditions of Lower Gastrointestina

  2025cites this paper
• Chlorogenic acid reduces Lipopolysaccharide-Induced intestinal inflammation through Inhibition of acetylcholinesterase and activation of muscarinic receptors

  2025cites this paper
• Enhancing the persistence of engineered biotherapeutics in the gut: Adhesion, glycan metabolism, and environmental resistance.

  2025cites this paper
• Probiotic Administration Contributes to the Improvement in Intestinal Dysregulation Induced by Allergic Contact Dermatitis

  2025cites this paper
• Deep crypt secretory cells shape region-specific mucin glycosylation patterns in the mouse colon

  2025cites this paper
• Food as Medicine for Hypertension: Microbiota as Mediators

  2025cites this paper
• Effect of Food Matrix on Regulation of Intestinal Barrier and Microbiota Homeostasis by Polysaccharides Sulfated Carrageenan

  2025cites this paper
• Alleviation effects of Lactobacillus plantarum in colitis aggravated by a high-salt diet depend on intestinal barrier protection, NF-κB pathway regulation, and oxidative stress improvement.

  2025cites this paper
• Probiotics an emerging therapeutic approach towards gut-brain-axis oriented chronic health issues induced by microplastics: A comprehensive review

  2024cites this paper
• The disturbance of intestinal microbiome caused by the novel duck reovirus infection in Cherry Valley ducklings can induce intestinal damage

  2024cites this paper
• NF-κB pathway activation by Octopus peptide hydrolysate ameliorates gut dysbiosis and enhances immune response in cyclophosphamide-induced mice

  2024cites this paper
• A mannose-rich exopolysaccharide-1 isolated from Bifidobacterium breve mitigates ovalbumin-induced intestinal damage in mice by modulation CD4 + T cell differentiation and inhibiting NF-κB signaling pathway.

  2024cites this paper
• Intestinal epithelial glycocalyx and intestinal disease

  2024cites this paper
• Bacteroides fragilis capsular polysaccharide A ameliorates ulcerative colitis in rat by recovering intestinal barrier integrity and restoring gut microbiota

  2024cites this paper
• Polysaccharides from Lactarius volemus Fr. ameliorate high-fat and high-fructose diet induced metabolic disorders and intestinal barrier dysfunction.

  2024cites this paper
• Microbial Extracellular Vesicles in Host-Microbiota Interactions.

  2024cites this paper
• Potency of tubers and rhizomes of Java local foods as prebiotics and their effects toward bacterial diversity in mice cecum

  2024cites this paper
• Characterization, Expression Pattern Analysis, and Cellular Localization of Two Homologous MUC2 Genes in Japanese Flounder (Paralichthys olivaceus)

  2024cites this paper
• Autoprobiotics in the Treatment of Patients with Colorectal Cancer in the Early Postoperative Period

  2024cites this paper
• Bovine Colostrum in Increased Intestinal Permeability in Healthy Athletes and Patients: A Meta-Analysis of Randomized Clinical Trials

  2024cites this paper
• Predicting nanocarrier permeation across the human intestine in vitro: Model matters

  2024cites this paper
• Mechanical Characterization of Mucus on Intestinal Tissues by Atomic Force Microscopy.

  2024cites this paper
• Tongfu Lifei Decoction Attenuated Sepsis-Related Intestinal Mucosal Injury Through Regulating Th17/Treg Balance and Modulating Gut Microbiota

  2024cites this paper
• Long-term use of etomidate disrupts the intestinal homeostasis and nervous system in mice.

  2024cites this paper
• Morphofunctional and morphometric features of the small intestine in experimental rats with inflammation of the abdominal cavity

  2024cites this paper
• An enteric ultrastructural surface atlas of the model insect Manducasexta

  2024cites this paper
• Antenatal Ureaplasma Infection Causes Colonic Mucus Barrier Defects: Implications for Intestinal Pathologies

  2024cites this paper
• Competing Mechanisms in Bacterial Invasion of Human Colon Mucus Probed with Agent-based Modeling.

  2024cites this paper
• Enhancement of Oral Bioavailability of Protein and Peptide by Polysaccharide-based Nanoparticles.

  2024cites this paper
• Disruption of intestinal epithelial permeability in the Co-system of Caco-2/HT29-MTX cells exposed individually or simultaneously to acrylamide and ochratoxin A.

  2024cites this paper
• Active nanoparticle targeting of MUC5AC ameliorates therapeutic outcome in experimental colitis.

  2024cites this paper
• Effect of Lifelong Exposure to Dietary Plant and Marine Sources of n-3 Polyunsaturated Fatty Acids on Morphologic and Gene Expression Biomarkers of Intestinal Health in Early Life

  2024cites this paper
• Nutrient-Epigenome interactions: Implications for personalized nutrition against aging-associated diseases.

  2024cites this paper
• Polyphenolic Compounds: Orchestrating Intestinal Microbiota Harmony during Aging

  2024cites this paper
• Current Understanding of Giardia lamblia and Pathogenesis of Stunting and Cognitive Deficits in Children from Low- and Middle-Income Countries

  2024cites this paper
• Association between Bacteroides fragilis and Fusobacterium nucleatum infection and colorectal cancer in Vietnamese patients.

  2024cites this paper
• Dietary fiber pectin: challenges and potential anti-inflammatory benefits for preterms and newborns

  2024cites this paper
• Teleost Muc2 and Muc5ac: Key guardians of mucosal immunity in flounder (Paralichthys olivaceus).

  2024cites this paper
• Ileal mucus viscoelastic properties differ in Crohn’s disease

  2024cites this paper
• Lab-on-chip technologies for exploring the gut-immune axis in metabolic disease.

  2024cites this paper
• Gut Distribution, Impact Factor, and Action Mechanism of Bacteriocin-Producing Beneficial Microbes as Promising Antimicrobial Agents in Gastrointestinal Infection

  2024cites this paper
• Gut Goo: Physiology, Diet, and Therapy of Intestinal Mucus and Biofilms in Gastrointestinal Health and Disease.

  2024cites this paper
• Intestinal permeability disturbances: causes, diseases and therapy

  2024cites this paper
• Global Solution and Stability of a Haptotaxis Mathematical Model for Complex MAP

  2024cites this paper
• Organic Matrix Derived from Host–Microbe Interplay Contributes to Pathological Renal Biomineralization

  2023cites this paper
• Effect of Lactobacillus salivarius SNK-6 on egg quality, intestinal morphology, and cecal microbial community of laying hens

  2023cites this paper
• A mucin-regulated adhesin determines the spatial organization and inflammatory character of a bacterial symbiont in the vertebrate gut.

  2023cites this paper
• Current status and advances in esophageal drug delivery technology: influence of physiological, pathophysiological and pharmaceutical factors

  2023cites this paper
• Ultrasound and Microbubbles can Lodge qDots into Murine ex-vivo Small Intestine

  2023cites this paper
• Current progress in pharmacokinetic studies of vaccines: Impact of carrier, ADME and its modulation on immune responses.

  2023cites this paper
• Mucin levels in glands of the colonic mucosa of rats with diversion colitis subjected to enemas containing sucralfate and n-acetylcysteine alone or in combination

  2023cites this paper
• Scytosiphon lomentaria fucoidan ameliorates DSS-induced colitis in dietary fiber-deficient mice via modulating the gut microbiota and inhibiting the TLR4/NF-κB/MLCK pathway.

  2023cites this paper
• miR-125a-5p regulates the sialyltransferase ST3GAL1 in murine model of human intestinal campylobacteriosis

  2023cites this paper
• Long‐term oral administration of burdock fructooligosaccharide alleviates DSS‐induced colitis in mice by mediating anti‐inflammatory effects and protection of intestinal barrier function

  2023cites this paper
• Colon-targeted delivery of polyphenols: construction principles, targeting mechanisms and evaluation methods

  2023cites this paper
• Undaria pinnatifida fucoidan contributes to anti-inflammation activity of Bacteroides in fiber-deficient mice via modulation of gut microbiota and protection of intestinal barrier integrity.

  2023cites this paper
• Recent advances in mucus-penetrating nanomedicines for oral treatment of colonic diseases

  2023cites this paper
• Understanding the potential causes of gastrointestinal dysfunctions in multiple system atrophy.

  2023cites this paper
• Epidemiology, Clinical Characteristics and Risk Factors for Severity of Chronic Disseminated Candidiasis in Jerusalem, Israel

  2023cites this paper
• Vaccination against microbiota motility protects mice from the detrimental impact of dietary emulsifier consumption

  2023cites this paper
• Evaluation of Rouxiella badensis Subsp Acadiensis (Canan SV-53) as a Potential Probiotic Bacterium

  2023cites this paper
• Gut microbiome as a therapeutic target for liver diseases.

  2023cites this paper
• Effects of microplastics in aquatic environments on inflammatory bowel disease.

  2023cites this paper
• Organoids/organs-on-a-chip: new frontiers of intestinal pathophysiological models.

  2023cites this paper
• Hydrogels for Mucosal Drug Delivery.

  2023cites this paper
• The Triple Alliance: Microbiome, Mitochondria, and Metabolites in the Context of Age-Related Cognitive Decline and Alzheimer's Disease.

  2023cites this paper
• Avian influenza and gut microbiome in poultry and humans: A “One Health” perspective

  2023cites this paper
• Nanoparticle transport in biomimetic polymer-linked emulsions.

  2023cites this paper
• The gut microbiota and its biogeography

  2023cites this paper
• In Vitro and In Vivo Evaluation of Carbopol 71G NF-Based Mucoadhesive Minitablets as a Gastroretentive Dosage Form.

  2023cites this paper
• Apigenin-7-O-glucoside alleviates DSS-induced colitis by improving intestinal barrier function and modulating gut microbiota

  2023cites this paper
• Polysaccharides from the seeds of Gleditsia sinensis Lam. attenuate DSS-induced colitis in mice via improving gut barrier homeostasis and alleviating gut microbiota dybiosis.

  2023cites this paper
• The stability and absorption of naturally occurring cAMP by its weak interactions with jujube polysaccharides were greatly improved

  2022cites this paper
• Hyaluronate Spreading Validates Mucin-Agarose Analogs as Test Systems to Replace Porcine Nasal Mucosa Explants – an Experimental and Theoretical Investigation

  2022cites this paper
• Disaggregation as an interaction mechanism among intestinal bacteria

  2022cites this paper
• From Static to Dynamic: A Review on the Role of Mucus Heterogeneity in Particle and Microbial Transport.

  2022cites this paper
• Bovine lactoferricin ameliorates intestinal inflammation and mucosal barrier lesions in colitis through NF-κB/NLRP3 signaling pathways

  2022cites this paper
• A mucin-regulated adhesin determines the intestinal biogeography and inflammatory character of a bacterial symbiont

  2022cites this paper
• STRUKTUR HISTOLOGI DAN JUMLAH SEL GOBLET PADA SEDIAAN HISTOPATOLOGIS RADANG USUS BESAR DENGAN PEWARNAAN HEMATOXYLIN-EOSIN (HE) DAN PERIODIC ACID-SCHIFF (PAS)

  2022cites this paper
• Reactive Oxygen Species in Modulating Intestinal Stem Cell Dynamics and Function

  2022cites this paper
• GH18 family glycoside hydrolase Chitinase A of Salmonella enhances virulence by facilitating invasion and modulating host immune responses

  2022cites this paper
• Lactobacillus salivarius CML352 Isolated from Chinese Local Breed Chicken Modulates the Gut Microbiota and Improves Intestinal Health and Egg Quality in Late-Phase Laying Hens

  2022cites this paper
• Transcytosis of Galectin-3 in Mouse Intestine.

  2022cites this paper
• Aronia melanocarpa (Michx.) Elliott. attenuates dextran sulfate sodium-induced Inflammatory Bowel Disease via regulation of inflammation-related signaling pathways and modulation of the gut microbiota.

  2022cites this paper
• The Intestinal Microbiota May Be a Potential Theranostic Tool for Personalized Medicine

  2022cites this paper