Characterization of the grappa Gene, the Drosophila Histone H3 Lysine 79 Methyltransferase

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Genetics

• Publication date

  2005-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1534/GENETICS.104.033191PMID 15371351PMCID PMC1448877
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Histone H3.3 is enriched in covalent modifications associated with active chromatin.

  2004cited by this paper
• The Rtf1 Component of the Paf1 Transcriptional Elongation Complex Is Required for Ubiquitination of Histone H2B*

  2003influential reference
• A conserved chromatin architecture marks and maintains the restricted germ cell lineage in worms and flies.

  2003cited by this paper
• Methylation of Histone H3 by Set2 in Saccharomyces cerevisiae Is Linked to Transcriptional Elongation by RNA Polymerase II

  2003cited by this paper
• Dynamic Regulation of Histone H3 Methylated at Lysine 79 within a Tissue-specific Chromatin Domain*

  2003cited by this paper
• Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues.

  2003cited by this paper
• Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: A potential mechanism for position-effect variegation

  2003influential reference
• Telomeric associated sequences of Drosophila recruit polycomb-group proteins in vivo and can induce pairing-sensitive repression.

  2003cited by this paper
• Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.

  2002influential reference
• Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain.

  2002cited by this paper
• Gene silencing: Trans-histone regulatory pathway in chromatin

  2002cited by this paper
• Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1

  2002cited by this paper
• Dot1p modulates silencing in yeast by methylation of the nucleosome core.

  2002influential reference
• Disruptor of Telomeric Silencing-1 Is a Chromatin-specific Histone H3 Methyltransferase*

  2002influential reference
• Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain.

  2002influential reference
• Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites.

  2002cited by this paper
• Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes.

  2002cited by this paper
• Chromatin silencing and activation by Polycomb and trithorax group proteins

  2001cited by this paper
• The Polycomb group--no longer an exclusive club?

  2001cited by this paper
• A BAC-based physical map of the major autosomes of Drosophila melanogaster.

  2000cited by this paper
• Silencing at Drosophila telomeres: nuclear organization and chromatin structure play critical roles

  1999cited by this paper
• The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes.

  1999cited by this paper
• The mcp element from the Drosophila melanogaster bithorax complex mediates long-distance regulatory interactions.

  1999cited by this paper
• Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae.

  1998cited by this paper
• Characterization of sequences associated with position-effect variegation at pericentric sites in Drosophila heterochromatin

  1998cited by this paper
• The cell cycle program in germ cells of the Drosophila embryo.

  1998cited by this paper
• Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptor.

  1998cited by this paper
• A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex.

  1997influential reference
• The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function.

  1995cited by this paper
• scute (sis-b) function in Drosophila sex determination

  1995cited by this paper
• Positional signaling by hedgehog in Drosophila imaginal disc development.

  1995cited by this paper
• Genetic and molecular analysis of chromatin domains.

  1993cited by this paper
• The complex set of late transcripts from the Drosophila sex determination gene sex-lethal encodes multiple related polypeptides

  1991cited by this paper

• Discovery of the first-in-class DOT1L PROTAC degrader.

  2025cites this paper
• Molecular insight into histone methylation as a novel target for oral squamous cell carcinoma: future hope in personalised medicine

  2025cites this paper
• Proline‐directed yeast and human MAP kinases phosphorylate the Dot1p/DOT1L histone H3K79 methyltransferase

  2024cites this paper
• The histone methyltransferase DOT1B is dispensable for stage differentiation and macrophage infection of Leishmania mexicana

  2024cites this paper
• Interplay between DOT1L and HDAC1 regulates Leishmania donovani infection in human THP-1 cells.

  2024cites this paper
• Drivers of genomic diversity and phenotypic development in early phases of domestication in Hermetia illucens

  2024cites this paper
• Tracking DOT1L methyltransferase activity by stable isotope labelling using a selective synthetic co-factor

  2024cites this paper
• Loss of DOT1L disrupts neuronal transcription, behavior, and leads to a neurodevelopmental disorder

  2024cites this paper
• The H3K79me3 methyl-transferase Grappa is involved in the establishment and thermal plasticity of abdominal pigmentation in Drosophila melanogaster females

  2024influential citation
• Rare de novo gain-of-function missense variants in DOT1L are associated with developmental delay and congenital anomalies.

  2023cites this paper
• The emerging role of DOT1L in cell proliferation and differentiation: Friend or foe.

  2023cites this paper
• The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae

  2023cites this paper
• Diverse and dynamic forms of gene regulation by the S. cerevisiae histone methyltransferase Set1

  2023cites this paper
• Aldosterone inhibits Dot1l expression in guinea pig cochlea

  2023cites this paper
• The 80th Threonine Residue of Histone H3 Is Important for Maintaining HM Silencing in Saccharomyces cerevisiae

  2023cites this paper
• Cis- and trans-regulation by histone H4 basic patch R17/R19 in metazoan development

  2022influential citation
• Primitive Erythropoiesis in the Mouse is Independent of DOT1L Methyltransferase Activity

  2022cites this paper
• DOT1L Mediated Gene Repression in Extensively Self-Renewing Erythroblasts

  2022cites this paper
• Epigenetic Regulation of ALS and CMT: A Lesson from Drosophila Models

  2021cites this paper
• Hypoxia induces DOT1L in articular cartilage to protect against osteoarthritis

  2021cites this paper
• Lysine methyltransferase inhibitors: where we are now

  2021cites this paper
• Ready, SET, Go: Post-translational regulation of the histone lysine methylation network in budding yeast

  2021cites this paper
• An update on allosteric modulators as a promising strategy targeting histone methyltransferase.

  2021cites this paper
• CBP mediated DOT1L acetylation confers DOT1L stability and promotes cancer metastasis

  2020cites this paper
• Histone Methyltransferase DOT1L Is Involved in Larval Molting and Second Stage Nymphal Feeding in Ornithodoros moubata

  2020cites this paper
• Epigenetic Attire in Ovarian Cancer: The Emperor's New Clothes

  2020cites this paper
• Therapeutic strategies against hDOT1L as a potential drug target in MLL-rearranged leukemias

  2020cites this paper
• DNA binding reorganizes the intrinsically disordered C-terminal region of PSC in Drosophila PRC1

  2020cites this paper
• The epigenetic regulation of centromeres and telomeres in plants and animals

  2020cites this paper
• DOT1L primarily acts as a transcriptional repressor in hematopoietic progenitor cells

  2020cites this paper
• DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans

  2020cites this paper
• Maternal DOT1L is dispensable for mouse development

  2020cites this paper
• Targeted disruption of the histone lysine 79 methyltransferase Dot1L in nephron progenitors causes congenital renal dysplasia

  2020cites this paper
• The miR-216a-Dot1l Regulatory Axis Is Necessary and Sufficient for Müller Glia Reprogramming during Retina Regeneration

  2019cites this paper
• Structural Basis of Dot 1 L S timulation by Histone H 2 B Lysine 120 Ubiquitination Graphical

  2019cites this paper
• Characterization of Copy Number Variations in Oral Cavity Squamous Cell Carcinoma Reveals a Novel Role for MLLT3 in Cell Invasiveness.

  2019cites this paper
• DOT1L complex suppresses transcription from enhancer elements and ectopic RNAi in Caenorhabditis elegans

  2019cites this paper
• Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination.

  2019cites this paper
• KDM2B is a histone H3K79 demethylase and induces transcriptional repression via sirtuin‐1‐mediated chromatin silencing

  2018cites this paper
• DOT1L suppresses nuclear RNAi originating from enhancer elements in Caenorhabditis elegans

  2018cites this paper
• DOT1L and H3K79 Methylation in Transcription and Genomic Stability

  2018cites this paper
• Profiling Developmentally and Environmentally Controlled Chromatin Reprogramming.

  2018cites this paper
• DNA methylation is not involved in dietary restriction induced lifespan extension in adult Drosophila.

  2018cites this paper
• TERRA and the histone methyltransferase Dot1 cooperate to regulate senescence in budding yeast

  2018cites this paper
• Writing, erasing and reading histone lysine methylations

  2017cites this paper
• Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington’s disease

  2017influential citation
• TALEN-Mediated FLAG-Tagging of Endogenous Histone Methyltransferase DOT1L

  2017cites this paper
• Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults

  2017cites this paper
• Histone methyltransferase Dot1L is a coactivator for thyroid hormone receptor during Xenopus development

  2017cites this paper
• Polycomb and Trithorax Group Genes in Drosophila

  2017cites this paper
• KDM2B is a histone H3K79 demethylase and induces transcriptional repression via SIRT1-mediated chromatin silencing

  2017cites this paper
• Regulation of the DNA Damage Response and Gene Expression by the Dot 1 L Histone Methyltransferase and the 53 Bp 1 Tumour Suppressor

  2017cites this paper
• Impacts of Histone Lysine Methylation on Chromatin

  2016cites this paper
• The many faces of histone H 3 K 79 methylation

  2016cites this paper
• Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives

  2016cites this paper
• DOT1L promotes angiogenesis through cooperative regulation of VEGFR2 with ETS-1

  2016cites this paper
• The upstreams and downstreams of H3K79 methylation by DOT1L

  2016cites this paper
• The many faces of histone H3K79 methylation.

  2016cites this paper
• Histone modifications as regulators of life and death in Saccharomyces cerevisiae

  2015cites this paper
• Histone methyltransferase Dot1L plays a role in postembryonic development in Xenopus tropicalis

  2015cites this paper
• Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond.

  2015cites this paper
• The Drosophila Huntington's disease gene ortholog dhtt influences chromatin regulation during development.

  2015cites this paper
• The histone methyltransferase DOT1L: regulatory functions and a cancer therapy target.

  2015cites this paper
• H3K79 methylation: a new conserved mark that accompanies H4 hyperacetylation prior to histone-to-protamine transition in Drosophila and rat

  2014influential citation
• Subtelomeres

  2014cites this paper
• The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle

  2014cites this paper
• DOT1L-mediated H3K79me2 modification critically regulates gene expression during cardiomyocyte differentiation

  2014cites this paper
• H3K79 methylation directly precedes the histone‐to‐protamine transition in mammalian spermatids and is sensitive to bacterial infections

  2014cites this paper
• Effects of RNAi-Mediated Knockdown of Histone Methyltransferases on the Sex-Specific mRNA Expression of Imp in the Silkworm Bombyx mori

  2014influential citation
• Histone methylation during neural development

  2014cites this paper
• The emerging roles of DOT1L in leukemia and normal development

  2014cites this paper
• Histone Methylation in Chromatin Signaling

  2014cites this paper
• Association Between Single Nucleotide Polymorphisms of DOT1L Gene and Risk of Knee Osteoarthritis in a Chinese Han Population

  2014cites this paper
• Resource Quantitative ChIP-Seq Nor malization Reveals Global Modulation of the Epigenome Graphical Abstract Highlights

  2014cites this paper
• The Role of AF9 and AF9-Mediated Protein Interactions in Hematopoiesis and Leukemogenesis

  2014cites this paper
• Subtelomeres in Drosophila and Other Diptera

  2014cites this paper
• AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.

  2014cites this paper
• Sex- and tissue-specific functions of Drosophila doublesex transcription factor target genes.

  2014influential citation
• Quantitative ChIP-Seq normalization reveals global modulation of the epigenome.

  2014cites this paper
• Dynamics and stability: epigenetic conversions in position effect variegation.

  2013cites this paper
• EPIGENETICS DURING HEART DEVELOPMENT: THE ROLE OF THE HISTONE METHYLTRANSFERASE DOT1L IN CARDIAC COMMITMENT

  2013cites this paper
• DOT1L-Mediated H3K79 Methylation in Chromatin Is Dispensable for Wnt Pathway-Specific and Other Intestinal Epithelial Functions

  2013cites this paper
• Effete, a Drosophila Chromatin-Associated Ubiquitin-Conjugating Enzyme That Affects Telomeric and Heterochromatic Position Effect Variegation

  2013cites this paper
• The Tudor protein survival motor neuron (SMN) is a chromatin-binding protein that interacts with methylated lysine 79 of histone H3

  2013cites this paper
• Mitotic phosphorylation of histone H3 threonine 80

  2013cites this paper
• Chapter 6 Chromatin Remodeling in Nucleotide Excision Repair in Mammalian Cells

  2013cites this paper
• Involvement of DOT1L in the Remodeling of Heterochromatin Configuration During Early Preimplantation Development in Mice1

  2013cites this paper
• Chromatin Remodeling in Nucleotide Excision Repair in Mammalian Cells

  2013cites this paper
• Human histone H3K79 methyltransferase DOT1L protein binds actively transcribing RNA polymerase II to regulate gene expression.

  2013cites this paper
• A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.

  2013cites this paper
• Targeting the Epigenetic Lesion in MLL-Rearranged Leukemia

  2013cites this paper
• Epigenetic regulation of transcription in Drosophila.

  2012influential citation
• Histone methylation: a dynamic mark in health, disease and inheritance

  2012cites this paper
• Implication of Posttranslational Histone Modifications in Nucleotide Excision Repair

  2012cites this paper
• Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis

  2012cites this paper
• A Systematic Genetic Screen to Dissect the MicroRNA Pathway in Drosophila

  2012cites this paper
• Lysine methylation: beyond histones.

  2012cites this paper
• Human Histone H3K79 Methyltransferase DOT1L Methyltransferase Binds Actively Transcribing RNA Polymerase II to Regulate Gene Expression*

  2012cites this paper
• Regulation and function of DNA and histone methylations.

  2012cites this paper
• Mechanism for epigenetic variegation of gene expression at yeast telomeric heterochromatin.

  2012cites this paper