Lymphocytic Thyroiditis and Diabetes in the BB/W Rat: A New Model of Autoimmune Endocrinopathy

No abstract is available for this paper.

• Publication year

  1981

• Venue

  Diabetes

• Publication date

  1981-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.2337/diab.30.12.1058PMID 6895508
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes.

  1979cited by this paper
• Spontaneous Diabetes in the Gnotobiotic BB/W Rat

  1979cited by this paper
• The genetics of Graves' disease.

  1978cited by this paper
• Decreased thyroid function and high plasma prolactin levels in rats of the Buffalo strain.

  1978cited by this paper
• The spontaneously diabetic Wistar rat (the "BB" rat). Studies prior to and during development of the overt syndrome.

  1978cited by this paper
• The Spontaneously Diabetic Wistar Rat: Metabolic and Morphologic Studies

  1977cited by this paper
• A review: The obese strain (OS) of chickens: an animal model with spontaneous autoimmune thyroiditis.

  1974cited by this paper
• Relation between the Major Histocompatibility (B) Locus and Autoimmune Thyroiditis in Obese Chickens

  1974cited by this paper
• Spontaneous thyroiditis in thymectomized and irradiated Wistar rats.

  1973cited by this paper
• Thyroid, gastric and adrenal auto-immunity in diabetes mellitus.

  1973cited by this paper
• Genetics of Graves' disease.

  1972cited by this paper
• Diabetes mellitus, autoimmunity, and ageing.

  1971cited by this paper
• Suppression of spontaneous autoimmune thyroiditis in obese strain (OS) chickens with anti-bursa and anti-thymus sera.

  1971cited by this paper
• Spontaneous thyroiditis in the obese strain of chickens. IV. The effect of thymectomy and thymo-bursectomy on the development of the disease.

  1970cited by this paper
• Spontaneous thyroiditis in the obese strain of chickens. 3. The effect of bursectomy on the development of the disease.

  1970cited by this paper
• Thyroid and gastric autoimmunity in patients with diabetes mellitus.

  1970cited by this paper
• Diabetes mellitus: the incidence of circulating antibodies against thyroid, gastric, and adrenal tissue.

  1970cited by this paper
• Spontaneous thyroiditis in laboratory rats

  1969cited by this paper
• Dog thyroiditis: occurrence and similarity to Hashimoto's struma.

  1968cited by this paper
• Hereditary hypothyroidism in the domestic fowl.

  1966cited by this paper
• EXPERIMENTAL ALLERGIC THYROIDITIS (AND PARATHYROIDITIS) IN NEONATALLY THYMECTOMIZED AND BURSECTOMIZED CHICKENS. PARTICIPATION OF THE THYMUS IN THE DEVELOPMENT OF DISEASE.

  1965cited by this paper
• The effect of thymectomy on the course of isoimmune thyroiditis in guinea-pigs.

  1965cited by this paper
• Antithyroid antibody and chronic thyroiditis in diabetes.

  1963cited by this paper
• Thyroiditis in a group of laboratory dogs. A study of 167 beagles.

  1962cited by this paper

• Development of Improved Animal Models for the Study of Diabetes

  2013cites this paper
• cDNA Immunization of Mice with Human Thyroglobulin Generates Both Humoral and T Cell Responses: A Novel Model of Thyroid Autoimmunity

  2011cites this paper
• Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats

  2011cites this paper
• Pillars article: immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995.

  2011cites this paper
• The autoimmunity of primary biliary cirrhosis and the clonal selection theory

  2010cites this paper
• autoimmune diseases self-tolerance causes various Breakdown of a single mechanism of receptor alpha-chains (CD25). by activated T cells expressing IL-2 Immunologic self-tolerance maintained

  2010cites this paper
• Genetic Loci Contributing to Spontaneous Autoimmune Diabetes

  2009cites this paper
• The BB rat as a model for autoimmune thyroiditis: relevance for the pathogenesis of human disease

  2009cites this paper
• Iodine and tri-iodo-thyronine reduce the incidence of type 1 diabetes mellitus in the autoimmune prone BB rats

  2009cites this paper
• The non-obese diabetic (NOD) mouse: An animal model for autoimmune thyroiditis

  2009cites this paper
• Defects in Antigen-Presenting Cells in the BB-DP Rat Model of Diabetes

  2008cites this paper
• Increased Epinephrine-Induced Diabetic BB / W Rat Liver cAMP Response in Severely

  2006cites this paper
• Utility of murine models for the study of spontaneous autoimmune type 1 diabetes

  2005cites this paper
• Immunoregulation of experimental autoimmune thyroid disease

  2005cites this paper
• Models of autoimmune thyroiditis

  2004cites this paper
• Autoantigens in thyroid diseases

  2004cites this paper
• Neonatal stimulation of the thyroid gland with iodine or suppression during adolescence with triiodothyronine changes the prevalence of autoimmune thyroiditis in BB rats.

  2004cites this paper
• Aberrancies in Antigen-presenting Cells and T Cells in Autoimmune Thyroid Disease. A Role in Faulty Tolerance Induction

  2003cites this paper
• Autoreactivity to lipoate and a conjugated form of lipoate in primary biliary cirrhosis.

  2003cites this paper
• Polymorphisms of HLA Class II Predispose Children and Adolescents with Type 1 Diabetes Mellitus to Autoimmune Thyroid Disease

  2003cites this paper
• Autoimmune Thyroid Diseases

  2003cites this paper
• The role of monocytes and monocyte-derived dendritic cells in type 1 diabetes mellitus and autoimmune thyroid disease

  2003cites this paper
• Animal models of autoimmune polyglandular syndrome.

  2002cites this paper
• Animales de laboratorio en la endocrinología: Biomodelos de las enfermedades tiroideas

  2002cites this paper
• Animal models of endocrine/organ-specific autoimmune diseases: do they really help us to understand human autoimmunity?

  2002cites this paper
• Iodine and Thyroid Autoimmune Disease in Animal Models

  2001cites this paper
• IL-10 Kinetics in Thyroiditis-Prone BB/Wor Rats

  2000cites this paper
• Susceptibility to diabetes is widely distributed in normal class IIu haplotype rats

  2000cites this paper
• Cytokine actions on the thyroid gland.

  2000cites this paper
• The pattern of a T(H)1 cytokine in autoimmune thyroiditis.

  2000cites this paper
• The genetics of Hashimoto's disease.

  2000cites this paper
• Clinical features and pathogenesis of thyrotoxicosis in adult Melanesians in Papua New Guinea

  2000cites this paper
• The Oral Administration of Human Thyroglobulin Does Not Affect the Incidence of Lymphocytic Thyroiditis in the Biobreeding Worcester Rat

  1999cites this paper
• Virus and autoimmunity: induction of autoimmune disease in mice by mouse T lymphotropic virus (MTLV) destroying CD4+ T cells.

  1999cites this paper
• Models to study the pathogenesis of thyroid autoimmunity.

  1999cites this paper
• Lymphotropic Virus ( MTLV ) Destroying CD 4 Autoimmune Disease in Mice by Mouse T Virus and Autoimmunity : Induction of

  1999cites this paper
• Both CD4(+) T cells and CD8(+) T cells are required for iodine accelerated thyroiditis in NOD mice.

  1999cites this paper
• Major histocompatibility class II genes polymorphism in insulin dependent diabetes mellitus with or without associated thyroid autoimmunity.

  1998cites this paper
• Increased expression of tumor necrosis factor-alpha and decreased expression of thyroglobulin and thyroid peroxidase mRNA levels in the thyroids of iodide-treated BB/Wor rats.

  1998cites this paper
• Dehydroepiandrosterone sulfate does not prevent spontaneous and iodine-induced lymphocytic thyroiditis and diabetes mellitus in the BB/Wor rat.

  1998cites this paper
• Interleukin-1 beta induced transient diabetes mellitus in rats. A model of the initial events in the pathogenesis of insulin-dependent diabetes mellitus?

  1998cites this paper
• Increased epinephrine-induced cAMP response in severely diabetic BB/W rat liver.

  1997cites this paper
• Searching for pathogenic epitopes in thyroglobulin: parameters and caveats.

  1997cites this paper
• Experimental models of autoimmune thyroid disease

  1996cites this paper
• Interleukin-1 beta inhibits rat thyroid cell function in vivo and in vitro by an NO-independent mechanism and induces hypothyroidism and accelerated thyroiditis in diabetes-prone BB rats.

  1996cites this paper
• T cell-mediated maintenance of natural self-tolerance: its breakdown as a possible cause of various autoimmune diseases.

  1996cites this paper
• The biobreeding worcester rat – a model of organ-specific autoimmunity

  1996cites this paper
• Histomorphological Aspects of the Development of Thyroid Autoimmune Diseases: Consequences for Our Understanding of Endocrine Ophthalmopathy

  1996cites this paper
• Alterations in myocardial contractile proteins in diabetes mellitus.

  1996cites this paper
• Cytokine gene expression in islets and thyroids of BB rats. IFN-gamma and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats.

  1996cites this paper
• The biobreeding Worcester rat--a model of organ-specific autoimmunity.

  1996cites this paper
• The pathogenicity of spontaneously-occurring thyroglobulin-reactive T lymphocytes from BB/WOR rats.

  1996cites this paper
• Thyroglobulin-reactive T lymphocytes in thyroiditis-prone BB/Wor rats

  1995cites this paper
• Genetics of the BB rat: association of autoimmune disorders (diabetes, insulitis, and thyroiditis) with lymphopenia and major histocompatibility complex class II.

  1995cites this paper
• Animal models of autoimmune endocrine disease and their uses in developing new methods of intervention.

  1995cites this paper
• Two-step development of Hashimoto-like thyroiditis in genetically autoimmune prone non-obese diabetic mice: effects of iodine-induced cell necrosis.

  1995cites this paper
• Excess iodine induces the expression of thyroid solid cell nests in lymphocytic thyroiditis-prone BB/W rats.

  1995cites this paper
• Thyroiditis in the BB rat is associated with lymphopenia but occurs independently of diabetes.

  1995cites this paper
• Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

  1995cites this paper
• Immunogenetic heterogeneity in type 1 (insulin-dependent) diabetes among Japanese--class II antigen and autoimmune thyroid disease.

  1995cites this paper
• A study of thyroid function and prevalence of thyroid autoantibodies in an African diabetic population.

  1995cites this paper
• The role of NK cell activity in the pathogenesis of poly I:C accelerated and spontaneous diabetes in the diabetes prone BB rat.

  1995cites this paper
• Experimental Autoimmune Thyroiditis in the Mouse and Rat

  1994cites this paper
• Effect of insulin on the altered thyroid function and adrenergic responsiveness in the diabetic rat.

  1993cites this paper
• Autoimmune thyroid disease.

  1993cites this paper
• Diabetes-Prone and Diabetes-Resistant BB Rats: Animal Models of Spontaneous and Virally Induced Diabetes Mellitus, Lymphocytic Thyroiditis, and Collagen-Induced Arthritis

  1993cites this paper
• High frequency of thymic ectopy in thyroids from autoimmune prone nonobese diabetic female mice.

  1993cites this paper
• Acute iodine ingestion increases intrathyroidal glutathione

  1993cites this paper
• Studies of thyroid xenografts from Graves' disease in severe combined immunodeficient mice.

  1993cites this paper
• Iodine induced lymphocytic thyroiditis in the BB/W rat: early and late immune phenomena.

  1993cites this paper
• Autoimmune diabetes mellitus in the BB rat.

  1992cites this paper
• The effect of iodine on lipid peroxidation and ultrastructure in the thyroids of BB/Wor rats

  1992cites this paper
• High Incidence of Thyroiditis and Anti-Thyroid Autoantibodies in NOD Mice

  1992cites this paper
• Tissue specific binding of lymphocytes to the thyroid gland of BB/W rats may be an early event in the development of thyroiditis.

  1992cites this paper
• The role of iodine in the development of autoimmune thyroiditis.

  1992cites this paper
• Iodine content of rat thyroglobulin affects its antigenicity in inducing lymphocytic thyroiditis in the BB/Wor rat.

  1992cites this paper
• Islet cells but not thyrocytes are susceptible to lysis by NK cells.

  1991cites this paper
• Variable prevalence of lymphocytic thyroiditis among diabetes-prone sublines of BB/W or rats.

  1991cites this paper
• Interleukin-1 beta regulation of islet and thyroid autoimmunity in the BB rat.

  1991cites this paper
• Insulin dependent diabetes mellitus hypothesis of autoimmunity.

  1991cites this paper
• Disturbance of thyroidal iodine metabolism in BB/W rat.

  1991cites this paper
• The immune-hypothalamo-pituitary-adrenal axis and autoimmunity.

  1991cites this paper
• FK 506 prevents spontaneous diabetes in the BB rat.

  1991cites this paper
• Interleukin-1β regulation of islet and thyroid autoimmunity in the BB rat

  1991cites this paper
• Thyroglobulin induced lymphocytic thyroiditis in two sublines of BB/Wor rats.

  1991cites this paper
• Cardiac dysfunction in isolated perfused hearts from spontaneously diabetic BB rats.

  1990cites this paper
• The effect of ciamexone on lymphocytic thyroiditis and insulin-dependent diabetes mellitus in the BB/Wor rat.

  1990cites this paper
• Genetic susceptibility to the development of spontaneous insulin-dependent diabetes mellitus in the rat.

  1990cites this paper
• Thymus and autoimmunity: capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for their induction of autoimmune disease

  1990cites this paper
• The effect of pre-operative potassium iodide therapy on antibody production.

  1990cites this paper
• IL-1 beta modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat.

  1990cites this paper
• Genetic susceptibility to the development of spontaneous insulin-dependent diabetes mellitus in the rat.

  1990cites this paper
• Dendritic cells and class II MHC expression on thyrocytes during the autoimmune thyroid disease of the BB rat.

  1990cites this paper
• Effect of thalidomide on the incidence of iodine-induced and spontaneous lymphocytic thyroiditis and spontaneous diabetes mellitus in the BB/Wor rat.

  1990cites this paper
• High endothelial venules present in lymphoid cell accumulations in thyroids affected by autoimmune disease: a study in men and BB rats of functional activity and development.

  1989cites this paper
• Immunologic and genetic studies of diabetes in the BB rat.

  1989cites this paper
• Effect of dietary iodine on autoimmune thyroiditis in the BB Wistar rats.

  1989cites this paper
• The goitre of the BB/O rat: an animal-model for studying the role of immunoglobulins stimulating growth of thyroid cells.

  1989cites this paper
• Are the mast cells antigen presenting cells?

  1989cites this paper
• Cardiac function in spontaneously diabetic BB rats treated with low and high dose insulin.

  1989cites this paper