Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Nature Genetics

• Publication date

  1998-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/534PMID 9620775
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1990cited by this paper
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  1990cited by this paper
• Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.

  1989cited by this paper
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  1982cited by this paper
• Purification and properties of superoxide dismutase from Drosophila melanogaster.

  1981cited by this paper
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  1976cited by this paper
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  1956cited by this paper
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  1955cited by this paper

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  2022cites this paper
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  2022cites this paper
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