Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Disease Models & Mechanisms

• Publication date

  2010-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dmm.004440PMID 20142330PMCID PMC2869492
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• β-catenin mediates glandular formation and dysregulation of β-catenin induces hyperplasia formation in the murine uterus

  2009cited by this paper
• The LKB1–AMPK pathway: metabolism and growth control in tumour suppression

  2009cited by this paper
• mTOR and HIF-1α-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

  2009cited by this paper
• Targeting the mTOR signaling network for cancer therapy.

  2009cited by this paper
• Somatic LKB1 Mutations Promote Cervical Cancer Progression

  2009cited by this paper
• Chemopreventive efficacy of rapamycin on Peutz-Jeghers syndrome in a mouse model.

  2009cited by this paper
• Somatic Alterations of the Serine/Threonine Kinase LKB1 Gene in Squamous Cell (SCC) and Large Cell (LCC) Lung Carcinoma

  2009cited by this paper
• Loss of Tuberous Sclerosis Complex-2 Function and Activation of Mammalian Target of Rapamycin Signaling in Endometrial Carcinoma

  2008cited by this paper
• Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms

  2008cited by this paper
• Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice.

  2008cited by this paper
• LKB1; linking cell structure and tumor suppression

  2008cited by this paper
• Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.

  2008cited by this paper
• Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.

  2008cited by this paper
• Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis.

  2008cited by this paper
• Lkb1 deficiency causes prostate neoplasia in the mouse.

  2008cited by this paper
• BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models

  2008cited by this paper
• Suppression of Peutz-Jeghers Polyposis by Targeting Mammalian Target of Rapamycin Signaling

  2008cited by this paper
• Differential roles of telomere attrition in type I and II endometrial carcinogenesis.

  2008cited by this paper
• High-throughput lung cancer cell line screening for genotype-correlated sensitivity to an EGFR kinase inhibitor.

  2008cited by this paper
• LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.

  2008cited by this paper
• Genomewide Discovery and Classification of Candidate Ovarian Fertility Genes in the Mouse

  2007cited by this paper
• LKB1 modulates lung cancer differentiation and metastasis

  2007cited by this paper
• Maximizing mouse cancer models

  2007cited by this paper
• Endometrial stem cells

  2007cited by this paper
• Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling

  2007cited by this paper
• Cancer Statistics, 2007

  2007influential reference
• Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model.

  2007cited by this paper
• Generation of a germ cell‐specific mouse transgenic Cre line, Vasa‐Cre

  2007cited by this paper
• Ten‐year results of a prospective study on the prognostic role of ploidy in endometrial carcinoma

  2007cited by this paper
• Molecular correlates associated with a phase II study of temsirolimus (CCI-779) in patients with metastatic or recurrent endometrial cancer-NCIC IND 160.

  2006cited by this paper
• LKB1-dependent signaling pathways.

  2006cited by this paper
• Crystallization of hepatocyte nuclear factor 1beta in complex with DNA.

  2006influential reference
• Gene expression pattern and hormonal regulation of small proline-rich protein 2 family members in the female mouse reproductive system during the estrous cycle and pregnancy.

  2006cited by this paper
• High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma.

  2005cited by this paper
• Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus.

  2004cited by this paper
• Focus on endometrial and cervical cancer.

  2004cited by this paper
• Dragon ERE Finder version 2: a tool for accurate detection and analysis of estrogen response elements in vertebrate genomes

  2003influential reference
• Global gene profiling analysis of mouse uterus during the oestrous cycle.

  2003cited by this paper
• Mouse Sprr locus: a tandem array of coordinately regulated genes

  2003cited by this paper
• Manipulating the Mouse Embryo: A Laboratory Manual

  2002cited by this paper
• Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR

  2001cited by this paper
• Generalized lacZ expression with the ROSA26 Cre reporter strain

  1999influential reference
• Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues.

  1999cited by this paper
• Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.

  1997cited by this paper
• Principles and Practice of Gynecologic Oncology

  1997cited by this paper
• Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting.

  1993cited by this paper

• Effect of Metformin on Endometrial Thickness in Postmenopausal Breast Cancer Patients Receiving Tamoxifen

  2026cites this paper
• Preclinical research models for endometrial cancer: development and selection of animal models

  2025cites this paper
• A Cxcl15 Cre Recombinase Mouse Model Useful to Study Gland Development in the Uterus

  2025cites this paper
• Revolutionizing Implantation Studies: Uterine-Specific Models and Advanced Technologies

  2025cites this paper
• SIRT7 facilitates endometrial cancer progression by regulating PTEN stability in an estrogen-dependent manner

  2025cites this paper
• The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progression

  2024cites this paper
• Hallmarks of uterine receptivity predate placental mammals

  2024cites this paper
• LKB1 and STRADα Promote Epithelial Ovarian Cancer Spheroid Cell Invasion

  2024cites this paper
• Insights into targeting LKB1 in tumorigenesis

  2024cites this paper
• A New Type of Endometrial Cancer Models in Mice Revealing the Functional Roles of Genetic Drivers and Exploring their Susceptibilities

  2023cites this paper
• In Vivo Intra‐Uterine Delivery of TAT‐Fused Cre Recombinase and CRISPR/Cas9 Editing System in Mice Unveil Histopathology of Pten/p53‐Deficient Endometrial Cancers

  2023cites this paper
• Histone modifications in embryo implantation and placentation: insights from mouse models

  2023cites this paper
• In vivo intra-uterine delivery of TAT-fused Cre recombinase and CRISPR/Cas9 editing unveil histopathology of Pten/p53-deficient endometrial cancers

  2023cites this paper
• Development of adverse outcome pathways relevant for the identification of substances having endocrine disruption properties Uterine adenocarcinoma as adverse outcome

  2023cites this paper
• Features of the endometrial microenvironment in developing of endometrioid adenocarcinoma

  2022cites this paper
• Differences in the Active Endometrial Microbiota across Body Weight and Cancer in Humans and Mice

  2022cites this paper
• Prss29 Cre recombinase mice are useful to study adult uterine gland function

  2022cites this paper
• Non-phosphorylatable cyclin D1 mutant potentiates endometrial hyperplasia and drives carcinoma with Pten loss

  2022cites this paper
• Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer

  2022cites this paper
• Clinical impact of STK11 mutation in advanced-stage non-small cell lung cancer.

  2022cites this paper
• Different Cre systems induce differential microRNA landscapes and abnormalities in the female reproductive tracts of Dgcr8 conditional knockout mice

  2021cites this paper
• Two-Way Development of the Genetic Model for Endometrial Tumorigenesis in Mice: Current and Future Perspectives

  2021cites this paper
• The role of TNFTNFα/p53 pathway in endometrial cancer mouse model administered with apple seed extract.

  2021cites this paper
• Uterine kisspeptin receptor critically regulates epithelial estrogen receptor Α transcriptional activity at the time of embryo implantation in a mouse model.

  2021cites this paper
• Feasibility and utility of MRI and dynamic 18F-FDG-PET in an orthotopic organoid-based patient-derived mouse model of endometrial cancer

  2021cites this paper
• Detecting survival-associated biomarkers from heterogeneous populations

  2021cites this paper
• LKB1 and cancer: The dual role of metabolic regulation.

  2020cites this paper
• An immune competent orthotopic model of endometrial cancer with metastasis

  2020cites this paper
• Study on the VEGF Gene Expression and the Role of PMSG Hormone in the Development of Endometrial Cancer in Mice

  2020cites this paper
• A new genetic method to predict the prognostic outcome of melanoma

  2020cites this paper
• Sprr2f protects against renal injury by decreasing the level of reactive oxygen species in female mice.

  2020cites this paper
• A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response.

  2020cites this paper
• Synthetic lethality targeting LKB1 mutant and EGFR wild type human non-small cell lung cancer cells by glucose starvation and SGLT2 inhibition

  2019cites this paper
• The Effect of LKB1 Activity on the Sensitivity to PI3K/mTOR Inhibition in Non-Small Cell Lung Cancer.

  2019cites this paper
• Liver kinase B1 suppresses the metastasis and angiogenesis of lung cancer: involvement of the Shh signaling pathway.

  2019cites this paper
• Imaging of Preclinical Endometrial Cancer Models for Monitoring Tumor Progression and Response to Targeted Therapy

  2019cites this paper
• LKB1/AMPK Pathway and Drug Response in Cancer: A Therapeutic Perspective

  2019cites this paper
• Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition

  2019cites this paper
• Efficacy of molecularly targeted agents given in the randomised trial SHIVA01 according to the ESMO Scale for Clinical Actionability of molecular Targets.

  2019cites this paper
• A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms

  2019cites this paper
• Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening

  2019cites this paper
• Loss of FGL1 induces epithelial‑mesenchymal transition and angiogenesis in LKB1 mutant lung adenocarcinoma.

  2019cites this paper
• PI3K Pathway Effectors pAKT and FOXO1 as Novel Markers of Endometrioid Intraepithelial Neoplasia

  2019cites this paper
• Molecular Genetics of Endometrial Carcinoma.

  2019cites this paper
• Modeling Endometrial Cancer: Past, Present, and Future

  2018cites this paper
• The benefits of adding metformin to tamoxifen to protect the endometrium—A randomized placebo‐controlled trial

  2018cites this paper
• Obesity and Endometrial Cancer: Mouse Models for Preclinical Prevention Studies

  2018cites this paper
• The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten

  2018cites this paper
• SOX17 regulates uterine epithelial–stromal cross-talk acting via a distal enhancer upstream of Ihh

  2018cites this paper
• MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT

  2018cites this paper
• Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability

  2017cites this paper
• MIG-6 negatively regulates STAT3 phosphorylation in uterine epithelial cells

  2017cites this paper
• Cyclin B1 mediates the effect of UCHL1 in promoting cell cycle progression in uterine papillary serous carcinoma

  2017cites this paper
• Reversal of obesity-driven aggressiveness of endometrial cancer by metformin.

  2017cites this paper
• Gynecological tissue homeostasis and tumorigenesis studies using mouse models

  2017cites this paper
• Tissue-Specific Ablation of the LIF Receptor in the Murine Uterine Epithelium Results in Implantation Failure

  2017cites this paper
• LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies.

  2017cites this paper
• Metformin is Probably A New Option in the Treatment of Endometrial Cancer

  2016cites this paper
• Loss of LKB1 and p53 synergizes to alter fallopian tube epithelial phenotype and high-grade serous tumorigenesis

  2016cites this paper
• Tumor progression, metastasis, and modulators of epithelial-mesenchymal transition in endometrioid endometrial carcinoma: an update.

  2016cites this paper
• Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives

  2016cites this paper
• Conditional deletion of Sox17 reveals complex effects on uterine adenogenesis and function.

  2016cites this paper
• Energy sensing and cancer: LKB1 function and lessons learnt from Peutz-Jeghers syndrome.

  2016cites this paper
• Somatic PIK3CA mutations as a driver of sporadic venous malformations

  2016cites this paper
• The double-edged sword of AMPK signaling in cancer and its therapeutic implications

  2015cites this paper
• LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment.

  2015cites this paper
• Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo

  2015cites this paper
• ARID1A Is Essential for Endometrial Function during Early Pregnancy

  2015cites this paper
• Phase I combination of pazopanib and everolimus in PIK3CA mutation positive/PTEN loss patients with advanced solid tumors refractory to standard therapy

  2015cites this paper
• LKB1 gene inactivation does not sensitize non-small cell lung cancer cells to mTOR inhibitors in vitro

  2015cites this paper
• The double-edged sword of AMPK signaling in cancer and its therapeutic implications

  2015cites this paper
• Regulation of the tumor suppressor LKB1 by the acetyltransferase GCN5

  2015cites this paper
• Symposium on advances in endometrial cancer epidemiology and biology.

  2015cites this paper
• Is 5´-AMP-Activated Protein Kinase Both Jekyll and Hyde in Bladder Cancer?

  2015cites this paper
• Targeting LKB1 in cancer – exposing and exploiting vulnerabilities

  2015influential citation
• A phase I study of temsirolimus and thoracic radiation in non--small-cell lung cancer.

  2014cites this paper
• Genetic Engineering of Mice to Investigate Uterine Function in Early Pregnancy

  2014cites this paper
• Novel Posttranslational Modification in LKB1 Activation and Function

  2014cites this paper
• Anti-HER2 combination chemotherapy for advanced gastric cancer associated with the Peutz-Jeghers syndrome: a case report and literature review

  2014cites this paper
• The small GTPase Rheb is required for spermatogenesis but not oogenesis.

  2014cites this paper
• Axons hooked to Schwann cell metabolism

  2014cites this paper
• Loss of LKB1 in high‐grade endometrial carcinoma: LKB1 is a novel transcriptional target of p53

  2014cites this paper
• An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential.

  2014cites this paper
• Lactoferrin-iCre: a new mouse line to study uterine epithelial gene function.

  2014influential citation
• Targeting the LKB1 tumor suppressor.

  2014cites this paper
• Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway.

  2014cites this paper
• Recent Progress on Liver Kinase B1 (LKB1): Expression, Regulation, Downstream Signaling and Cancer Suppressive Function

  2014cites this paper
• Inhibition of Endometrial Cancer by n-3 Polyunsaturated Fatty Acids in Preclinical Models

  2014cites this paper
• A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition.

  2014cites this paper
• Physiological and molecular determinants of embryo implantation.

  2013cites this paper
• N-methylnitrosourea aggravates gastrointestinal polyposis in Lkb1+/- mice.

  2013cites this paper
• Dysregulation of mTOR activity through LKB1 inactivation

  2013cites this paper
• Clonality analysis suggests that STK11 gene mutations are involved in progression of lobular endocervical glandular hyperplasia (LEGH) to minimal deviation adenocarcinoma (MDA)

  2013cites this paper
• Impact of genetic alterations on mTOR-targeted cancer therapy

  2013cites this paper
• Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressor

  2013cites this paper
• Long-term estradiol exposure is a direct mitogen for insulin/EGF-primed endometrial cells and drives PTEN loss-induced hyperplasic growth.

  2013cites this paper
• Targeting LKB1 signaling in cancer.

  2013cites this paper
• The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues

  2013cites this paper
• The LKB 1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues

  2013cites this paper
• Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model.

  2013cites this paper