17‐Beta‐Estradiol induces transformation and tumorigenesis in human breast epithelial cells

No abstract is available for this paper.

• Publication year

  2006

• Venue

  The FASEB Journal

• Publication date

  2006-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1096/fj.05-5399comPMID 16873885
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Equine estrogen metabolite 4-hydroxyequilenin induces anchorage-independent growth of human mammary epithelial MCF-10A cells: differential gene expression.

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• Transformation of MCF‐10A Human Breast Epithelial Cells by Zeranol and Estradiol‐17β

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• Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells.

  2003cited by this paper
• Breast cancer in young women (≤35 years): Genomic aberrations detected by comparative genomic hybridization

  2003cited by this paper
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• Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies.

  2002cited by this paper
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  2002cited by this paper
• 17Beta-estradiol is carcinogenic in human breast epithelial cells.

  2002cited by this paper
• Loss of heterozygosity and microsatellite instability in epithelial hyperplasia of the breast.

  2002cited by this paper
• SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers.

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• Multipoint development of the weighted pairwise correlation (WPC) linkage method for pedigrees of arbitrary size and application to the analysis of breast cancer and alcoholism familial data

  2001cited by this paper
• Carcinogenicity of estrogens in human breast epithelial cells 1

  2001cited by this paper
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  2001cited by this paper
• Nonrandom chromosomal imbalances in human ovarian surface epithelial cells immortalized by HPV16-E6E7 viral oncogenes.

  2001cited by this paper
• Genetic events during the transformation of a tamoxifen-sensitive human breast cancer cell line into a drug-resistant clone.

  2001cited by this paper
• Imbalance of estrogen homeostasis in kidney and liver of hamsters treated with estradiol: implications for estrogen-induced initiation of renal tumors.

  2001cited by this paper
• A prospective study of estradiol and breast cancer in Japanese women.

  2000cited by this paper
• Chapter 3: Endogenous Estrogens as Carcinogens Through Metabolic Activation

  2000cited by this paper
• Patterns of chromosomal imbalances in invasive breast cancer

  2000cited by this paper
• Genetic changes in breast cancer detected by comparative genomic hybridisation

  2000cited by this paper
• Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogens.

  2000cited by this paper
• Endogenous estrogens as carcinogens through metabolic activation.

  2000cited by this paper
• Frequent loss of 9p21 (p16(INK4A)) and other genomic imbalances in human malignant fibrous histiocytoma.

  2000cited by this paper
• Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data.

  2000influential reference
• Spectral karyotyping of the human colon cancer cell lines SW480 and SW620.

  2000cited by this paper
• Deletion mapping of chromosomal region 1p32‐pter in primary breast cancer

  1999cited by this paper
• Loss of heterozygosity at chromosome 1p in different solid human tumours: association with survival

  1999cited by this paper
• A Mouse Mammary Tumor Virus-Wnt-1 Transgene Induces Mammary Gland Hyperplasia and Tumorigenesis in Mice Lacking Estrogen Receptor-α

  1999cited by this paper
• Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes

  1999cited by this paper
• Pattern of distribution of cells positive for estrogen receptor α and progesterone receptor in relation to proliferating cells in the mammary gland

  1999cited by this paper
• Multiple regions of chromosome 4 demonstrating allelic losses in breast carcinomas.

  1999cited by this paper
• Cytogenetic characterization of 22 human renal cell tumors in relation to a histopathological classification.

  1999cited by this paper
• Molecular cytogenetic analysis of 11 new breast cancer cell lines

  1999cited by this paper
• A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha.

  1999cited by this paper
• Elevated Serum Estradiol and Testosterone Concentrations Are Associated with a High Risk for Breast Cancer

  1999cited by this paper
• Deletion mapping in breast tumor cell lines points to two distinct tumor-suppressor genes in the 1p32-pter region, one of deleted regions (1p36.2) being located within the consensus region of LOH in neuroblastoma.

  1998cited by this paper
• Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women.

  1998cited by this paper
• Mapping of a Breast Cancer Tumor Suppressor Gene Locus to a 4‐cM Interval on Chromosome 18q21

  1997cited by this paper
• A prospective study of endogenous serum hormone concentrations and breast cancer risk in post-menopausal women on the island of Guernsey.

  1997cited by this paper
• Mammary Gland Development and Tumorigenesis in Estrogen Receptor Knockout Mice

  1997cited by this paper
• Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.

  1997cited by this paper
• A prospective study of endogenous serum hormone concentrations and breast cancer risk in premenopausal women on the island of Guernsey.

  1997cited by this paper
• Relationship of serum dehydroepiandrosterone (DHEA), DHEA sulfate, and 5-androstene-3 beta, 17 beta-diol to risk of breast cancer in postmenopausal women.

  1997cited by this paper
• Serum sex hormone levels after menopause and subsequent breast cancer.

  1996cited by this paper
• Mammary gland neoplasia in long-term rodent studies.

  1996cited by this paper
• Relation of prediagnostic serum estrogen and androgen levels to breast cancer risk.

  1996cited by this paper
• Loss of chromosome arm 9p DNA and analysis of the p16 and p15 cyclin-dependent kinase inhibitor genes in human parathyroid adenomas.

  1996cited by this paper
• A prospective study of endogenous estrogens and breast cancer in postmenopausal women.

  1995cited by this paper
• C-ha-ras enhances the neoplastic transformation of human breast epithelial-cells treated with chemical carcinogens.

  1995cited by this paper
• Carcinogenic activities of various steroidal and nonsteroidal estrogens in the hamster kidney: relation to hormonal activity and cell proliferation.

  1995cited by this paper
• A prospective study of endogenous hormones and breast cancer.

  1994cited by this paper
• Detection of DNA amplification in 17 primary breast carcinomas with homogeneously staining regions by a modified comparative genomic hybridization technique

  1994cited by this paper
• Transformation of human breast epithelial cells by chemical carcinogens.

  1993cited by this paper
• Endogenous hormones and breast cancer risk.

  1993cited by this paper
• Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk.

  1993cited by this paper
• Reproductive factors and breast cancer.

  1993cited by this paper
• Sex hormones and postmenopausal breast cancer: a prospective study in an adult community.

  1992cited by this paper
• Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture.

  1988cited by this paper
• Estrogen carcinogenesis in Syrian hamster tissues: role of metabolism.

  1987cited by this paper
• The importance of local synthesis of estrogen within the breast.

  1987cited by this paper
• Estrogen carcinogenesis in Syrian hamster tissues: role of metabolism.

  1987cited by this paper
• Carcinogenicity of catechol estrogens in Syrian hamsters.

  1986cited by this paper
• Cloning of the human oestrogen receptor cDNA.

  1986cited by this paper
• Cloning of the human estrogen receptor cDNA.

  1985cited by this paper
• Relative carcinogenic activity of various synthetic and natural estrogens in the Syrian hamster kidney.

  1983cited by this paper
• Relation of prolactin and estrogen to mammary tumorigenesis in the rat.

  1972cited by this paper
• A receptor molecule for estrogens: studies using a cell-free system.

  1967cited by this paper
• Estrogen excretion following operative and irradiation castration in cases of mammary cancer; a preliminary report.

  1958cited by this paper
• Estrogen excretion following operative and irradiation castration in cases of mammary cancer; a preliminary report.

  1958cited by this paper
• Oophorectomy for Cancer of the Breast

  1900cited by this paper
• On the Treatment of Inoperable Cases of Carcinoma of the Mamma: Suggestions for a New Method of Treatment, with Illustrative Cases

  1896cited by this paper

• Molecular Insights into Phytochemicals Mediated Epigenetic Regulation in Preclinical Models of Breast Cancer

  2025cites this paper
• Molecular Insights on Signaling Cascades in Breast Cancer: A Comprehensive Review

  2025cites this paper
• "Estrogens and human brain networks: A systematic review of structural and functional neuroimaging studies".

  2024cites this paper
• Potent Dual Inhibitors of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse Model.

  2023cites this paper
• Oestrogen receptor-independent actions of oestrogen in cancer

  2023cites this paper
• Epigenetic Regulation in Breast Cancer: Insights on Epidrugs

  2023cites this paper
• Investigation of the Incidence and Geographic Distribution of Bone and Soft Tissue Sarcomas in Canada: A National Population-Based Study

  2023cites this paper
• Ionizing Radiation and Estrogen Affecting Growth Factor Genes in an Experimental Breast Cancer Model

  2022cites this paper
• Mechanistic Effects of Estrogens on Breast Cancer

  2022cites this paper
• Untargeted LC-MS/MS Metabolomics Study on the MCF-7 Cell Line in the Presence of Valproic Acid

  2022cites this paper
• Halogen-Based 17β-HSD1 Inhibitors: Insights from DFT, Docking, and Molecular Dynamics Simulation Studies

  2022cites this paper
• References

  2021cites this paper
• The 3,4-Quinones of Estrone and Estradiol Are the Initiators of Cancer whereas Resveratrol and N-acetylcysteine Are the Preventers

  2021cites this paper
• Synthesis, Docking, and Biological activities of novel Metacetamol embedded [1,2,3]-triazole derivatives

  2021cites this paper
• Perils of Prolonged Ovarian Suppression and Hypoestrogenism in the Treatment of Breast Cancer: Is the Risk of Treatment Worse than the Risk of Recurrence?

  2021cites this paper
• Synthesis, docking and biological activities of novel chromone linked [1,2,3]-triazole derivatives

  2021cites this paper
• Characterization of Alcohol-Mediated Promotion of Breast Cancer Stem Cells

  2021cites this paper
• Human Breast Extracellular Matrix Microstructures and Protein Hydrogel 3D Cultures of Mammary Epithelial Cells

  2021cites this paper
• Association of genetic polymorphisms with local steroid metabolism in human benign breasts.

  2021cites this paper
• The impact of Catechol-O-methyl transferase knockdown on the cell proliferation of hormone-responsive cancers.

  2019cites this paper
• An In Vitro Model of Triple-Negative Breast Cancer.

  2019cites this paper
• Long-term exposure of 4-hydroxyestradiol induces the cancer cell characteristics via upregulating CYP1B1 in MCF-10A cells

  2019cites this paper
• Translational opportunities for broad‐spectrum natural phytochemicals and targeted agent combinations in breast cancer

  2018cites this paper
• Antioxidant properties of NQO2

  2018cites this paper
• Hormonal Carcinogenesis: The Role of Estrogens

  2017cites this paper
• Evaluation of the effect of the new methoxy-stilbenes on expression of receptors and enzymes involved in estrogen synthesis in cancer breast cells

  2017cites this paper
• Lack of effect of the procarcinogenic 17β-estradiol on nutrient uptake by the MCF-7 breast cancer cell line.

  2017cites this paper
• Baicalein has protective effects on the 17β-estradiol-induced transformation of breast epithelial cells

  2017cites this paper
• Association between lifestyle, menstrual/reproductive history, and histological factors and risk of breast cancer in women biopsied for benign breast disease

  2017cites this paper
• Extracellular superoxide dismutase and its role in cancer.

  2017cites this paper
• The influence of the commensal microbiota on distal tumor-promoting inflammation.

  2017cites this paper
• Effect of Genistein and 17-β Estradiol on the Viability and Apoptosis of Human Hepatocellular Carcinoma HepG2 cell line

  2017cites this paper
• A hydroxylated flavonol, fisetin inhibits the formation of a carcinogenic estrogen metabolite

  2017cites this paper
• Regulation of proliferative response by SETD7 in breast cancer

  2017cites this paper
• Comparative α-Naphthoflavone and β-Naphthoflavone Inhibits the Formation of a Carcinogenic Estrogen Metabolite

  2017influential citation
• Targeting oncogenic receptor : From molecular physiology to currently the standard of target therapy

  2017cites this paper
• The effects of 17 alpha-estradiol to inhibit inflammation in vitro

  2017cites this paper
• Estrogen Metabolites in the Etiology of Hormone Related Cancers: Possible Role of Anti-Oxidants in Prevention

  2017cites this paper
• The Windows of Susceptibility to Breast Cancer

  2016cites this paper
• Trends in Breast Cancer Prevention

  2016cites this paper
• Estrogen-estrogen receptor signaling suppresses the transcription of ERRF in breast cancer cells.

  2016cites this paper
• Chromatin Remodeling as the New Target for Breast Cancer Prevention

  2016cites this paper
• Preclincial Models for Studying Breast Cancer

  2016cites this paper
• Genotoxicity of cosmetic chemicals in human breast epithelial cells

  2016cites this paper
• Stem Cells in Breast Cancer

  2016cites this paper
• HSD10 Regulates Cancer Cell Growth and Resistance to Cell Death

  2016cites this paper
• MiR-21 Expression in Grade I, II, and III Breast Cancer

  2016cites this paper
• E2, an Aquatic Hazard Worldwide

  2016cites this paper
• The Pathobiology of the Breast Cancer Invasive Process

  2016cites this paper
• Resveratrol and its methoxy derivatives modulate the expression of estrogen metabolism enzymes in breast epithelial cells by AhR down-regulation

  2016cites this paper
• Development and characterization of two human triple‐negative breast cancer cell lines with highly tumorigenic and metastatic capabilities

  2016cites this paper
• Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer–Associated R438W DNA Polymerase Lambda Protein

  2016cites this paper
• Tamoxifen Resistance: Emerging Molecular Targets

  2016cites this paper
• Inhibition of Depurinating Estrogen-DNA Adduct Formation in the Prevention of Breast and Other Cancers

  2016cites this paper
• ERRF is essential for Estrogen-Estrogen Receptor alpha signaling pathway in ER positive breast cancer cells.

  2016cites this paper
• Oxidative metabolism of estrogens in cancer initiation and prevention

  2015cites this paper
• Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.

  2015cites this paper
• Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme.

  2015cites this paper
• Ovariectomy is associated with metabolic impairments and enhanced mammary tumor growth in MKR mice.

  2015cites this paper
• Estrogen metabolites and breast cancer.

  2015cites this paper
• Wpływ występujących w piwie związków polifenolowych na organizm – przegląd literatury

  2014cites this paper
• The role of androgens in experimental rodent mammary carcinogenesis

  2014cites this paper
• Parabens can enable hallmarks and characteristics of cancer in human breast epithelial cells: a review of the literature with reference to new exposure data and regulatory status

  2014cites this paper
• Imaging Techniques for Evaluation In Vitro Behavior of Normal and Cancerous Breast Tissue

  2014cites this paper
• The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity.

  2014cites this paper
• In Vitro Techniques for Studying the Normal Breast and the Use of Cell Lines in Breast Cancer Research

  2014cites this paper
• Sport et santé, une nécessaire association

  2014cites this paper
• All trans-retinoic acid (ATRA) induces re-differentiation of early transformed breast epithelial cells

  2014cites this paper
• In Vivo Studies of Breast Cancer Cells

  2014cites this paper
• Small molecule detection in solution via the size contraction response of aptamer functionalized nanoparticles.

  2014cites this paper
• Techniques and Methodological Approaches in Breast Cancer Research

  2014cites this paper
• Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker.

  2014cites this paper
• Oxidized derivative of docosahexaenoic acid preferentially inhibit cell proliferation in triple negative over luminal breast cancer cells

  2014cites this paper
• [Sport and health, a necessary combination].

  2014cites this paper
• The Epidemiology of Breast Cancer and the Basis for Prevention

  2013cites this paper
• Parabens enable suspension growth of MCF‐10A immortalized, non‐transformed human breast epithelial cells

  2013influential citation
• Estrogen receptor-dependent and independent mechanisms of breast cancer carcinogenesis.

  2013cites this paper
• Clinical utility of pharmacogenetic testing in compounding pharmacy.

  2013cites this paper
• Aromatase overexpression induces malignant changes in estrogen receptor α negative MCF-10A cells

  2013cites this paper
• Redefining the molecular basis of epithelial mesenchymal transition in breast cancer metastasis

  2013cites this paper
• 17β-estradiol residue determined in minced meat and it’s Carcinogencity in mice

  2013cites this paper
• The Use of In Vitro Three-Dimensional System for Studying Breast Cancer and Preventing Agents

  2013cites this paper
• Molecular mechanisms of oestrogen action on growth of human breast cancer cells in culture

  2012cites this paper
• Molecular basis of pregnancy-induced breast cancer prevention

  2012cites this paper
• Virtual screening and docking exploration on estrogen receptor: An in silico approach to decipher novel anticancer agents

  2012cites this paper
• Interference with Estrogen Receptor-α by Dietary Components: Impact on the Balance Between Cell Proliferation and Cell Death

  2012cites this paper
• [Interactions of insulin and estrogen in the regulation of cell proliferation and carcinogenesis].

  2012cites this paper
• Disruption of 3D MCF-12A Breast Cell Cultures by Estrogens – An In Vitro Model for ER-Mediated Changes Indicative of Hormonal Carcinogenesis

  2012cites this paper
• Epidemiology and pathophysiology of alcohol and breast cancer: Update 2012.

  2012cites this paper
• An in vitro-in vivo model of epithelial mesenchymal transition in triple negative breast cancer.

  2012cites this paper
• Supernatants derived from chemotherapy-treated cancer cell lines can modify angiogenesis

  2012cites this paper
• Hydroxybenzothiazoles as New Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)

  2012cites this paper
• Role of the Transcriptome in Breast Cancer Prevention

  2012cites this paper
• Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure.

  2012cites this paper
• Progressive increase of glucose transporter-3 (GLUT-3) expression in estrogen-induced breast carcinogenesis

  2012influential citation
• The etiology and prevention of breast cancer.

  2012cites this paper
• Mammographic breast density and breast cancer risk by menopausal status, postmenopausal hormone use and a family history of breast cancer

  2012cites this paper
• Estrogen Signaling in Lung Cancer: An Opportunity for Novel Therapy

  2012cites this paper
• Interplay Between Insulin Resistance and Estrogen Deficiency as co- Activators in Carcinogenesis

  2012cites this paper
• Mammary Epithelial cells ( MCF-10 A ) and Estrogen-Induced Malignant Transformation in Human ) Inhibits Oxidative Estrogen Metabolism Humulus lupulus Hops

  2011cites this paper