Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Toxicological Sciences

• Publication date

  2004-11-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1093/TOXSCI/KFH253PMID 15310864
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Comparative studies of the hepatic effects of di- and mono-n-octyl phthalates, di-(2-ethylhexyl) phthalate and clofibrate in the rat.

  2009cited by this paper
• Glucuronidation patterns of common urinary and serum monoester phthalate metabolites

  2005influential reference
• Peroxisome-proliferator-activated receptors and cancers: complex stories

  2004influential reference
• Activation of nuclear hormone receptor peroxisome proliferator–activated receptor-δ accelerates intestinal adenoma growth

  2004influential reference
• PPAR signaling exacerbates mammary gland tumor development

  2004cited by this paper
• Peroxisome Proliferator-activated Receptor β (δ)-dependent Regulation of Ubiquitin C Expression Contributes to Attenuation of Skin Carcinogenesis*

  2004cited by this paper
• Peroxisome proliferator-activated receptor beta (delta)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis.

  2004cited by this paper
• Diminished Hepatocellular Proliferation in Mice Humanized for the Nuclear Receptor Peroxisome Proliferator-Activated Receptor α

  2004cited by this paper
• Mono(2-ethyl-5-hydroxyhexyl) phthalate and mono-(2-ethyl-5-oxohexyl) phthalate as biomarkers for human exposure assessment to di-(2-ethylhexyl) phthalate.

  2004influential reference
• Blood burden of di(2-ethylhexyl) phthalate and its primary metabolite mono(2-ethylhexyl) phthalate in pregnant and nonpregnant rats and marmosets.

  2004cited by this paper
• Peroxisome Proliferator-Activated Receptor (PPAR)-β/δ Stimulates Differentiation and Lipid Accumulation in Keratinocytes

  2004cited by this paper
• Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines.

  2004influential reference
• Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis.

  2004influential reference
• Determination of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate in human serum using liquid chromatography-tandem mass spectrometry.

  2004influential reference
• Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes.

  2004cited by this paper
• PPAR gamma signaling exacerbates mammary gland tumor development.

  2004cited by this paper
• Roles of peroxisome proliferator-activated receptor δ in skeletal muscle function and adaptation

  2004cited by this paper
• Recent advances in peroxisome proliferator-activated receptor science.

  2003influential reference
• Internal exposure of the general population to DEHP and other phthalates--determination of secondary and primary phthalate monoester metabolites in urine.

  2003cited by this paper
• Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity.

  2003cited by this paper
• Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000.

  2003influential reference
• Activation of PPARα and PPARγ by Environmental Phthalate Monoesters

  2003influential reference
• PPARα Agonist-Induced Rodent Tumors: Modes of Action and Human Relevance

  2003influential reference
• Prenatal exposures to phthalates among women in New York City and Krakow, Poland.

  2003cited by this paper
• Hepatotoxicity of thiazolidinediones

  2003cited by this paper
• Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

  2003cited by this paper
• Activation of PPARalpha and PPARgamma by environmental phthalate monoesters.

  2003influential reference
• Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers.

  2003cited by this paper
• PPARalpha agonist-induced rodent tumors: modes of action and human relevance.

  2003influential reference
• Teratogenic phthalate esters and metabolites activate the nuclear receptors PPARs and induce differentiation of F9 cells.

  2003influential reference
• Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone.

  2003cited by this paper
• COMPARATIVE EFFECTS OF PHTHALATE MONOESTERS ON GAP JUNCTIONAL INTERCELLULAR COMMUNICATION AND PEROXISOME PROLIFERATION IN RODENT AND PRIMATE HEPATOCYTES

  2002cited by this paper
• NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isononyl phthalate.

  2002cited by this paper
• NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate.

  2002cited by this paper
• The mechanisms of action of PPARs.

  2002influential reference
• NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-octyl phthalate.

  2002cited by this paper
• A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

  2001cited by this paper
• Identification of Peroxisome Proliferator-responsive Human Genes by Elevated Expression of the Peroxisome Proliferator-activated Receptor α in HepG2 Cells*

  2001cited by this paper
• Modulation of keratinocyte gene expression and differentiation by PPAR-selective ligands and tetradecylthioacetic acid.

  2001cited by this paper
• Differential Gene Regulation in Human Versus Rodent Hepatocytes by Peroxisome Proliferator-activated Receptor (PPAR) α

  2001cited by this paper
• Levels of seven urinary phthalate metabolites in a human reference population.

  2000influential reference
• Effects of di-isononyl phthalate, di-2-ethylhexyl phthalate, and clofibrate in cynomolgus monkeys.

  2000cited by this paper
• Comparative in vivo hepatic effects of Di-isononyl phthalate (DINP) and related C7-C11 dialkyl phthalates on gap junctional intercellular communication (GJIC), peroxisomal beta-oxidation (PBOX), and DNA synthesis in rat and mouse liver.

  2000cited by this paper
• A cancer risk assessment of di(2-ethylhexyl)phthalate: application of the new U.S. EPA Risk Assessment Guidelines.

  1999influential reference
• trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals.

  1999influential reference
• Effects of di-isononyl phthalate (DINP) on peroxisomal markers in the marmoset-DINP is not a peroxisome proliferator.

  1999cited by this paper
• trans-activation of PPARα and PPARγ by structurally diverse environmental chemicals

  1999influential reference
• Activators of the nuclear receptor PPARgamma enhance colon polyp formation.

  1998cited by this paper
• Subchronic toxicity of Di(2-ethylhexyl)phthalate in common marmosets: lack of hepatic peroxisome proliferation, testicular atrophy, or pancreatic acinar cell hyperplasia.

  1998cited by this paper
• Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

  1998cited by this paper
• Peroxisome proliferation and beta-oxidation in Fao and MH1C1 rat hepatoma cells, HepG2 human hepatoblastoma cells and cultured human hepatocytes: effect of ciprofibrate.

  1997cited by this paper
• Differential activation of adipogenesis by multiple PPAR isoforms.

  1996cited by this paper
• Hepatocarcinogenic potential of di(2-ethylhexyl)phthalate in rodents and its implications on human risk.

  1996cited by this paper
• Fenofibrate: metabolism and species differences for peroxisome proliferation in cultured hepatocytes.

  1995cited by this paper
• PVC as a biomedical polymer--plasticizer and stabilizer toxicity.

  1992cited by this paper
• PVC as a biomedical polymer--plasticizer and stabilizer toxicity.

  1992cited by this paper
• Dermal absorption of phthalate diesters in rats.

  1989cited by this paper
• Peroxisome Induction Studies On Seven Phthalate Esters

  1987cited by this paper
• Comparison of the short-term effects of di(2-ethylhexyl) phthalate, di(n-hexyl) phthalate, and di(n-octyl) phthalate in rats.

  1985cited by this paper
• An established pre-adipose cell line and its differentiation in culture.

  1974cited by this paper
• Identification of the metabolites of simple phthalate diesters in rat urine.

  1974cited by this paper

• Endocrine Disruptors in Child Obesity and Related Disorders: Early Critical Windows of Exposure

  2025cites this paper
• Phthalate exposure from plastics and cardiovascular disease: global estimates of attributable mortality and years life lost

  2025cites this paper
• Relationship of Parental Phthalate Exposure with Fetal Growth and Placental Development at Birth.

  2025cites this paper
• Evaluation of a hypothesized Sertoli cell-based adverse outcome pathway for effects of diisononyl phthalate on the developing testis

  2025influential citation
• Mechanism-based new approach methodologies for in vitro detection of chemical-induced liver steatosis.

  2025cites this paper
• Separating the Role of Gut Enzymatic Transformation in Modulating Internal Exposure to Three Major Phthalates.

  2025cites this paper
• The Association Between Exposure to Phthalates and Cardiovascular Disease: A Comprehensive Study Utilizing NHANES Data from 2005 to 2018 and Network Toxicology.

  2025cites this paper
• Reproductive effects of dibutyl phthalate (DBP) toxicity in the testes of mammalian and avian species.

  2025cites this paper
• The associations between prenatal plastic phthalate exposure and lipid acylcarnitine levels in humans and mice.

  2025cites this paper
• Evaluation of the endocrine disrupting potential of Di-isononyl phthalate

  2025cites this paper
• Phthalate exposure is associated with increased CVD risk in CKD: evidence from NHANES and network toxicology analysis

  2025cites this paper
• Endocrine-disrupting chemicals as prostate carcinogens

  2025cites this paper
• Mixtures of phthalates disrupt expression of genes related to lipid metabolism and peroxisome proliferator-activated receptor signaling in mouse granulosa cells.

  2024cites this paper
• Environmental Obesogens and Their Perturbations in Lipid Metabolism

  2024cites this paper
• Di(2-ethylhexyl)phthalate and type 2 diabetes

  2024influential citation
• Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids

  2024cites this paper
• Associations of phthalates with accelerated aging and the mitigating role of physical activity.

  2024cites this paper
• Association between prenatal exposure to alkylphenols and intelligence quotient among preschool children: sex-specific effects

  2024cites this paper
• Associations of 1.5- and 3-year Phthalate Exposure Levels with Early Adiposity Rebound and Overweight/Obesity in Japanese Children: An Adjunct Study of the Japan Environment and Children's Study.

  2024cites this paper
• Identifying Human Specific Adverse Outcome Pathways of Per- and Polyfluoroalkyl Substances Using Liver-Chimeric Humanized Mice

  2023cites this paper
• Urinary Phthalate Metabolites and Slow Walking Speed in the Korean Elderly Environmental Panel II Study

  2023cites this paper
• Distribution of Micro-Nano PS, DEHP, and/or MEHP in Mice and Nerve Cell Models In Vitro after Exposure to Micro-Nano PS and DEHP

  2023cites this paper
• Nuclear Receptors-Mediated Endocrine Disrupting Effects of Non-Phthalate Plasticizers: A Review.

  2023cites this paper
• Phthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN).

  2023cites this paper
• Maternal exposure to phthalates and total gestational weight gain in the LIFECODES birth cohort.

  2023cites this paper
• Role of Salinity in Perfluorooctane Sulfonate (PFOS) Bioconcentration between Aquatic Species and the Differential Regulation of Transporters in Fundulus Heteroclitus

  2023influential citation
• Association between urinary phthalate biomarker concentrations and adiposity among postmenopausal women.

  2023cites this paper
• Integrative omics-analysis of lipid metabolism regulation by peroxisome proliferator-activated receptor a and b agonists in male Atlantic cod

  2023cites this paper
• Associations of urinary metabolite concentrations of phthalates and phthalate replacements with body composition from mid-childhood to early adolescence.

  2023cites this paper
• The associations between prenatal phthalate exposure and childhood glycolipid metabolism and blood pressure: An updated systematic review and a pilot meta-analysis of prospective cohort studies.

  2023cites this paper
• Transcriptional analysis in peripheral blood cells of individuals with elevated phthalate exposure - Results of the EuroMix study.

  2023cites this paper
• Prenatal Phthalate Exposure and Child Weight and Adiposity from in Utero to 6 Years of Age

  2022cites this paper
• Indoor exposure to phthalates and its burden of disease in China.

  2022cites this paper
• Phthalate Monoesters Act Through Peroxisome Proliferator-Activated Receptors in the Mouse Ovary.

  2022cites this paper
• Occurrences and potential lipid-disrupting effects of phthalate metabolites in humpback dolphins from the South China Sea.

  2022cites this paper
• Phthalate Exposure, PPARα Variants, and Neurocognitive Development of Children at Two Years

  2022cites this paper
• ASSOCIATION BETWEEN PHTHALATE EXPOSURE AND INSULIN RESISTANCE: A REVIEW

  2022cites this paper
• Combinations of an acetyl CoA carboxylase inhibitor with hepatic lipid modulating agents do not augment antifibrotic efficacy in preclinical models of NASH and fibrosis

  2022cites this paper
• Phthalate exposures and placental health in animal models and humans: a systematic review.

  2022cites this paper
• Phthalate exposure is associated with more rapid body fat gain in midlife women: The Study of Women's Health Across the Nation (SWAN) Multi-Pollutant Study.

  2022cites this paper
• Consequences of in vitro benzyl butyl phthalate exposure for blubber gene expression and insulin-induced Akt activation in juvenile grey seals.

  2022cites this paper
• Serum PFAS and Urinary Phthalate Biomarker Concentrations and Bone Mineral Density in 12-19 Year Olds: 2011-2016 NHANES.

  2022cites this paper
• Exposure to endocrine-disrupting compounds such as phthalates and bisphenol A is associated with an increased risk for obesity.

  2021cites this paper
• Perfluorooctane sulfonate (PFOS) exposure of bovine oocytes affects early embryonic development at human-relevant levels in an in vitro model.

  2021cites this paper
• Seasonal exposure to phthalates and inflammatory parameters: A pilot study with repeated measures.

  2021cites this paper
• Predicting the Effects of Per- and Polyfluoroalkyl Substance Mixtures on Peroxisome Proliferator-Activated Receptor Alpha Activity in Vitro

  2021influential citation
• Associations between urinary phthalate metabolite concentrations and markers of liver injury in the US adult population.

  2021cites this paper
• A Roadmap to the Structure-Related Metabolism Pathways of Per- and Polyfluoroalkyl Substances in the Early Life Stages of Zebrafish (Danio rerio)

  2021cites this paper
• Development of a putative adverse outcome pathway network for male rat reproductive tract abnormalities with specific considerations for the androgen sensitive window of development

  2021cites this paper
• Development of a Gestational and Lactational Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctane Sulfonate (PFOS) in Rats and Humans and Its Implications in the Derivation of Health-Based Toxicity Values

  2021cites this paper
• Phthalate metabolites: Characterization, toxicities, global distribution, and exposure assessment.

  2021cites this paper
• Prenatal exposure to phthalates and maternal metabolic outcomes in a high-risk pregnant Latina population.

  2021cites this paper
• Exposure to short-chain chlorinated paraffins inhibited PPARα-mediated fatty acid oxidation and stimulated aerobic glycolysis in vitro in human cells.

  2021cites this paper
• Health effects associated with phthalate activity on nuclear receptors

  2021cites this paper
• Environmental pollutants: an immunoendocrine perspective on phthalates.

  2021cites this paper
• Perfluorooctanesulfonic acid (PFOS) administration shifts the hepatic proteome and augments dietary outcomes related to hepatic steatosis in mice.

  2020cites this paper
• Phthalate exposure linked to high blood pressure in Chinese children.

  2020cites this paper
• Exposure to di-n-octyl phthalate during puberty induces hypergonadotropic hypogonadism caused by Leydig cell hyperplasia but reduced steroidogenic function in male rats.

  2020cites this paper
• Adipogenesis Regulation and Endocrine Disruptors: Emerging Insights in Obesity

  2020cites this paper
• Endocrine activities of phthalate alternatives; assessing the safety profile of furan dicarboxylic acid esters using a panel of human cell based reporter gene assays

  2020cites this paper
• Short- and long-term effects of perinatal phthalate exposures on metabolic pathways in the mouse liver

  2020cites this paper
• Mechanisms of action, chemical characteristics, and model systems of obesogens

  2020cites this paper
• Indoor airborne phthalates in university campuses and exposure assessment

  2020cites this paper
• Multisystemic alterations in humans induced by bisphenol A and phthalates: Experimental, epidemiological and clinical studies reveal the need to change health policies.

  2020cites this paper
• Urinary concentrations of phthalate biomarkers and weight change among postmenopausal women: a prospective cohort study

  2019cites this paper
• Comparing the disrupting effects of short-, medium- and long-chain chlorinated Paraffins on cell viability and metabolism.

  2019cites this paper
• Phthalates exposure and uterine fibroid burden among women undergoing surgical treatment for fibroids: a preliminary study.

  2019cites this paper
• Short-chain chlorinated paraffins (SCCPs) disrupt hepatic fatty acid metabolism in liver of male rat via interacting with peroxisome proliferator-activated receptor α (PPARα).

  2019cites this paper
• Longitudinal Metabolic Impacts of Perinatal Exposure to Phthalates and Phthalate Mixtures in Mice.

  2019cites this paper
• The Role of Dietary Phytoestrogens and the Nuclear Receptor PPARγ in Adipogenesis: An in Vitro Study

  2019cites this paper
• Integration of metabolomics and transcriptomics reveals short-chain chlorinated paraffin-induced hepatotoxicity in male Sprague-Dawley rat.

  2019cites this paper
• Early-Life Environmental Exposures and Blood Pressure in Children.

  2019cites this paper
• Exposure to phthalate metabolites, phenols and organophosphate pesticide metabolites and blood pressure during pregnancy.

  2019cites this paper
• Molecular docking and simulation analysis for elucidation of toxic effects of dicyclohexyl phthalate (DCHP) in glucocorticoid receptor-mediated adipogenesis

  2019cites this paper
• Dibutyl phthalate-induced activation of ROS and ERK1/2 causes hepatic and renal damage in Kunming mice

  2019cites this paper
• Phthalates: Exposure and Health Effects

  2019cites this paper
• Prenatal exposure to phthalates and neurocognitive development in children at two years of age.

  2019cites this paper
• DEHP deregulates adipokine levels and impairs fatty acid storage in human SGBS-adipocytes

  2018cites this paper
• New EU criteria for endocrine disrupters

  2018cites this paper
• Di-N-octylphthalate acts as a proliferative agent in murine cell hepatocytes by regulating the levels of TGF-β and pro-apoptotic proteins.

  2018cites this paper
• Relationship between maternal phthalate exposure and offspring size at birth.

  2018cites this paper
• Low‐level perfluorooctanoic acid enhances 3 T3‐L1 preadipocyte differentiation via altering peroxisome proliferator activated receptor gamma expression and its promoter DNA methylation

  2018cites this paper
• Dietary sources of cumulative phthalates exposure among the U.S. general population in NHANES 2005-2014.

  2018cites this paper
• Levels of Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) in Northern Goshawk (Accipiter gentilis) nestlings from Norway and Spain and potential effect on innate immune system signalling pathways

  2018cites this paper
• Lipidome-wide disturbances of human placental JEG-3 cells by the presence of MEHP.

  2018cites this paper
• Phthalate exposure during pregnancy and long‐term weight gain in women

  2018cites this paper
• Di‐n‐butylphthalat [MAK Value Documentation in German language, 2017]

  2017cites this paper
• The role and regulation of the peroxisome proliferator activated receptor alpha in human liver.

  2017cites this paper
• Associations of Phthalate Metabolites and Obesity-Related Metabolic Factors

  2017cites this paper
• Adverse Outcome Pathway: Peroxisome Proliferator-Activated Receptor α Activation and Reproductive Toxicity—Development and Application in Assessment of Endocrine Disruptors/Reproductive Toxicants

  2017cites this paper
• Peroxisome proliferator-activated receptors (PPARs), phthalates and reproduction in the female zebrafish (Danio rerio)

  2017cites this paper
• The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions

  2017cites this paper
• The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression

  2017influential citation
• Phthalate Sample Preparation Methods and Analysis in Food and Food Packaging: a Review

  2017cites this paper
• Di‐(2‐ethylhexyl) phthalate could disrupt the insulin signaling pathway in liver of SD rats and L02 cells via PPAR&ggr;

  2017cites this paper
• Maternal diethylhexyl phthalate exposure affects adiposity and insulin tolerance in offspring in a PCNA‐dependent manner

  2017cites this paper
• Obesogens in the aquatic environment: an evolutionary and toxicological perspective.

  2017cites this paper
• The association between total phthalate concentration and non‐communicable diseases and chronic inflammation in South Australian urban dwelling men

  2017cites this paper
• Effects of Di-(2-ethylhexyl) Phthalate on Lipid Metabolism by the JAK/STAT Pathway in Rats

  2016cites this paper
• Monoethylhexyl Phthalate Elicits an Inflammatory Response in Adipocytes Characterized by Alterations in Lipid and Cytokine Pathways

  2016cites this paper