Impact of apoE deficiency on oxidative insults and antioxidant levels in the brain.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Brain Research. Molecular Brain Research

• Publication date

  2001-01-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0169-328X(00)00268-0PMID 11165374
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain.

  2000cited by this paper
• Amyloid β‐Peptide Effects on Synaptosomes from Apolipoprotein E‐Deficient Mice

  2000cited by this paper
• Amyloid beta-peptide effects on synaptosomes from apolipoprotein E-deficient mice.

  2000cited by this paper
• Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice.

  2000cited by this paper
• Brains of Aged Apolipoprotein E‐Deficient Mice Have Increased Levels of F2‐Isoprostanes, In Vivo Markers of Lipid Peroxidation

  1999cited by this paper
• Cholinergic systems and long-term potentiation in memory-impaired apolipoprotein E-deficient mice.

  1999cited by this paper
• Increased cerebral cortical lipid peroxidation and abnormal phospholipids in aged homozygous apoE-deficient C57BL/6J mice.

  1999cited by this paper
• Apolipoprotein E and β-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent

  1999cited by this paper
• Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype.

  1999cited by this paper
• Antioxidant mechanisms in apolipoprotein E deficient mice prior to and following closed head injury.

  1999cited by this paper
• Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase Deficiency

  1998cited by this paper
• Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury.

  1998cited by this paper
• Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice

  1998cited by this paper
• Radical-induced lipoprotein and plasma lipid oxidation in normal and apolipoprotein E gene knockout (apoE-/-) mice: apoE-/- mouse as a model for testing the role of tocopherol-mediated peroxidation in atherogenesis.

  1998cited by this paper
• Apolipoprotein E Isoform-Specific Differences in Outcome from Focal Ischemia in Transgenic Mice

  1998cited by this paper
• Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse.

  1998cited by this paper
• Copper/zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia

  1998cited by this paper
• Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.

  1997cited by this paper
• Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE.

  1997cited by this paper
• Apolipoprotein E-Deficient Mice Have Increased Susceptibility To Focal Cerebral Ischemia

  1997cited by this paper
• Licorice extract and its major polyphenol glabridin protect low-density lipoprotein against lipid peroxidation: in vitro and ex vivo studies in humans and in atherosclerotic apolipoprotein E-deficient mice.

  1997cited by this paper
• Reduced levels of antioxidants in brains of apolipoprotein E-deficient mice following closed head injury.

  1997cited by this paper
• 4‐Hydroxy‐2‐Nonenal Pyrrole Adducts in Human Neurodegenerative Disease

  1997cited by this paper
• Transbilayer Distribution of Cholesterol Is Modified in Brain Synaptic Plasma Membranes of Knockout Mice Deficient in the Low‐Density Lipoprotein Receptor, Apolipoprotein E, or Both Proteins

  1997cited by this paper
• Plastic Neuronal Remodeling Is Impaired in Patients with Alzheimer’s Disease Carrying Apolipoprotein ε4 Allele

  1997cited by this paper
• Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein epsilon 4 allele.

  1997cited by this paper
• Requirement for superoxide in excitotoxic cell death.

  1996cited by this paper
• Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

  1996cited by this paper
• Increased 3-nitrotyrosine in brains of Apo E-deficient mice.

  1996cited by this paper
• Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain.

  1996cited by this paper
• Neural membrane phospholipids in alzheimer disease

  1995cited by this paper
• Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease.

  1995cited by this paper
• Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice.

  1995cited by this paper
• Effect of the antioxidant N,N'-diphenyl 1,4-phenylenediamine (DPPD) on atherosclerosis in apoE-deficient mice.

  1995cited by this paper
• Neurodegeneration in the central nervous system of apoE-deficient mice.

  1995cited by this paper
• Increased plasma and lipoprotein lipid peroxidation in apo E-deficient mice.

  1994cited by this paper
• ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.

  1994cited by this paper
• Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.

  1993cited by this paper
• Transgenic mouse models of lipoprotein metabolism and atherosclerosis.

  1993cited by this paper
• Apolipoprotein E ∈4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases

  1993cited by this paper
• Apolipoprotein E polymorphism and Alzheimer's disease.

  1993cited by this paper
• Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.

  1992cited by this paper
• Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.

  1991cited by this paper
• Age‐Related Differences in Synaptosomal Peroxidative Damage and Membrane Properties

  1991cited by this paper
• Protein measurement using bicinchoninic acid: elimination of interfering substances.

  1989cited by this paper
• Concurrent liquid-chromatographic assay of retinol, alpha-tocopherol, beta-carotene, alpha-carotene, lycopene, and beta-cryptoxanthin in plasma, with tocopherol acetate as internal standard.

  1988cited by this paper
• Genetics of the apolipoprotein E system in man.

  1980cited by this paper
• Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

  1979cited by this paper
• Superoxide dismutase: improved assays and an assay applicable to acrylamide gels.

  1971cited by this paper
• Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.

  1967cited by this paper

• Preventive, ameliorative, and therapeutic effects of steamed mature silkworms on metabolic disorders caused by loss of apolipoprotein E

  2025cites this paper
• Neuroprotective Benefits of Rosmarinus officinalis and Its Bioactives against Alzheimer’s and Parkinson’s Diseases

  2024cites this paper
• Functionalization strategies of polymeric nanoparticles for drug delivery in Alzheimer’s disease: Current trends and future perspectives

  2022cites this paper
• Pharmaceutical and pharmacological studies of Shen Ma Yi Zhi granule for prevention of vascular dementia: A review

  2022cites this paper
• Exploring the Role of Monoamine Oxidase Activity in Aging and Alzheimer's Disease.

  2021cites this paper
• Effect of APOE ε4 allele on levels of apolipoproteins E, J, and D, and redox signature in circulating extracellular vesicles from cognitively impaired with no dementia participants converted to Alzheimer's disease

  2021cites this paper
• Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer’s Disease: The Role of Antioxidants in Prevention and Treatment

  2021cites this paper
• Delineation of Neuroprotective Effects and Possible Benefits of AntioxidantsTherapy for the Treatment of Alzheimer’s Diseases by Targeting Mitochondrial-Derived Reactive Oxygen Species: Bench to Bedside

  2021cites this paper
• Gut Microbiota Composition and Epigenetic Molecular Changes Connected to the Pathogenesis of Alzheimer’s Disease

  2021cites this paper
• Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer's Disease

  2020cites this paper
• Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease.

  2020cites this paper
• The Significance of Apolipoprotein E Measurement in the Screening of Fetal Down Syndrome

  2020cites this paper
• Association between chronic stress and Alzheimer's disease: Therapeutic effects of Saffron.

  2020cites this paper
• Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer’s Disease

  2019cites this paper
• Nanotechnology at the Rescue of Neurodegenerative Diseases: Tools for Early Diagnostic

  2019cites this paper
• Carbon Nanodot Cellular Uptake and Modulation of Tumor Necrosis Factor-Alpha-Induced Endothelial Dysfunction

  2018cites this paper
• A High-fat and High-Cholesterol Diet Potentiates Oxidative Damage in Hippocampus of Mice Lacking Apolipoprotein E

  2018cites this paper
• Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

  2017cites this paper
• Cerebral Oxidative Stress and Microvasculature Defects in TNF-α Expressing Transgenic and Porphyromonas gingivalis-Infected ApoE–/– Mice

  2017cites this paper
• VITAMINANUTRCEUTICAL FORMULATION 6 , 335 , 021 B 1 29 : A . THAT PROVIDES NEUROPROTECTION AND & S . E . 583 HA ' s al MANTAINS OR IMPROVES COGNITIVE 6 , 369058 Bi 42002

  2017cites this paper
• Advanced glycation end products are mitogenic signals and trigger cell cycle reentry of neurons in Alzheimer's disease brain.

  2015cites this paper
• Central nervous system effects of ambient particulate matter: the role of oxidative stress and inflammation

  2014cites this paper
• Alzheimer’s Disease and Animal Models in Retrospect

  2014cites this paper
• Central Nervous System Effects of Ambient Particulate Matter : The role of Oxidative Stress and Inflammation Final Report

  2014cites this paper
• Behavioural, genetic and epigenetic determinants of white matter pathology in a new mouse model of chronic cerebral hypoperfusion

  2013cites this paper
• Apolipoprotein e genotype-dependent paradoxical short-term effects of (56)fe irradiation on the brain.

  2012cites this paper
• Neuroprotective effect of sinapic acid in a mouse model of amyloid β(1-42) protein-induced Alzheimer's disease.

  2012cites this paper
• Ginkgo biloba leaf extract improves the cognitive abilities of rats with D-galactose induced dementia

  2012cites this paper
• IDENTIFICATION OF PROTEINS SECRETED INTO THE MEDIUM BY HUMAN LYMPHOCYTES IRRADIATED IN VITRO WITH OR WITHOUT ADAPTIVE ENVIRONMENTS

  2012cites this paper
• DVT: a new era in anticoagulant therapy.

  2010cites this paper
• Apolipoprotein E genotype and oxidative stress response to traumatic brain injury.

  2010cites this paper
• Oxidized Low-Density Lipoprotein-Activated c-Jun NH2-Terminal Kinase Regulates Manganese Superoxide Dismutase Ubiquitination: Implication for Mitochondrial Redox Status and Apoptosis

  2010cites this paper
• Free Radical–Mediated Damage to Brain in Alzheimer’s Disease: Role of Acrolein and Preclinical Promise of Antioxidant Polyphenols

  2010cites this paper
• Apolipoprotein E3 as a Risk Factor for Alzheimer's Disease Under Conditions of Nutritional Imbalance

  2010cites this paper
• The Role of Apolipoprotein E in Guillain-Barré Syndrome and Experimental Autoimmune Neuritis

  2010cites this paper
• Dietary Deficiency in Folate and Vitamin E Under Conditions of Oxidative Stress Increases Phospho-Tau Levels: Potentiation by ApoE4 and Alleviation by S-Adenosylmethionine

  2009cites this paper
• Olive Oils Modulate Fatty Acid Content and Signaling Protein Expression in Apolipoprotein E Knockout Mice Brain

  2009cites this paper
• Dietary Supplementation with Apple Juice Decreases Endogenous Amyloid-β Levels in Murine Brain

  2009cites this paper
• APOE genotype-specific differences in the innate immune response.

  2009cites this paper
• Oxidative stress in Alzheimer disease

  2009cites this paper
• Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance.

  2009cites this paper
• Cerebrospinal fluid, serum and plasma protein oxidation in Alzheimer’s disease

  2009cites this paper
• Deletion of apolipoprotein E gene modifies the rate of depletion of alpha tocopherol (vitamin E) from mice brains.

  2008cites this paper
• potentiates iron-induced formation of species.

  2008cites this paper
• Dietary and genetic compromise in folate availability reduces acetylcholine, cognitive performance and increases aggression: Critical role of S-adenosyl methionine

  2008cites this paper
• Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways.

  2008cites this paper
• S-Adenosylmethionine Mediates Glutathione Efficacy by Increasing Glutathione S-Transferase Activity: Implications for S-Adenosyl Methionine as A Neuroprotective Dietary Supplement

  2008cites this paper
• Apolipoprotein E genotype is related to nitric oxide production in platelets

  2008cites this paper
• Abeta peptide and Alzheimer's disease : celebrating a century of research

  2007cites this paper
• Radiofrequency Ablation of a Tumor Causing Oncogenic Osteomalacia

  2007cites this paper
• Folate and vitamin E deficiency impair cognitive performance in mice subjected to oxidative stress

  2007cites this paper
• The S-adenosyl homocysteine hydrolase inhibitor 3-deaza-adenosine prevents oxidative damage and cognitive impairment following folate and vitamin E deprivation in a murine model of age-related, oxidative stress-induced neurodegeneration

  2007cites this paper
• Folate deficiency and plasma homocysteine during increased oxidative stress.

  2007cites this paper
• Proteomics study of neuropathic and nonneuropathic dorsal root ganglia: altered protein regulation following segmental spinal nerve ligation injury.

  2007cites this paper
• Identification of differentially expressed proteins in experimental autoimmune encephalomyelitis (EAE) by proteomic analysis of the spinal cord.

  2007cites this paper
• Folate deprivation increases presenilin expression, gamma‐secretase activity, and Abeta levels in murine brain: potentiation by ApoE deficiency and alleviation by dietary S‐adenosyl methionine

  2007cites this paper
• A day in the life of Oscar the cat.

  2007cites this paper
• Neural Stem Cell Grafts and the Influence of Apolipoprotein E in a Mouse Model of Global Ischaemia

  2007cites this paper
• The Aβcentric Pathway of Alzheimer’s Disease

  2007cites this paper
• [Oxidative stress and Alzheimer's disease].

  2006cites this paper
• Apple juice concentrate maintains acetylcholine levels following dietary compromise

  2006cites this paper
• Apolipoprotein E exerts selective and differential control over vitamin E concentrations in different areas of mammalian brain

  2006cites this paper
• Oxidative stress in Alzheimer's disease.

  2006cites this paper
• S-adenosyl methionine: A connection between nutritional and genetic risk factors for neurodegeneration in Alzheimer's disease.

  2006cites this paper
• Translocation and potential neurological effects of fine and ultrafine particles a critical update

  2006cites this paper
• Age-related Alterations of Apolipoprotein E and Interleukin-1β in the Aging Brain

  2006cites this paper
• Dietary and genetically-induced oxidative stress alter tau phosphorylation: Influence of folate and apolipoprotein E deficiency

  2006cites this paper
• Espressione dei recettori dell'endotelina nella malattia d'Alzheimer et la loro regolazione da parte del peptide β-amyloide

  2006cites this paper
• NAD(P)H oxidase-induced oxidative stress in sympathetic ganglia of apolipoprotein E deficient mice.

  2006cites this paper
• Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain.

  2006cites this paper
• Supplementation with apple juice attenuates presenilin-1 overexpression during dietary and genetically-induced oxidative stress

  2006cites this paper
• Expression and activity of methionine cycle genes are altered following folate and vitamin E deficiency under oxidative challenge: Modulation by apolipoprotein E-deficiency

  2006cites this paper
• [Oxidative stress and Alzheimer's disease].

  2006cites this paper
• Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics

  2006cites this paper
• Cigarette smokers differ in their handling of natural (RRR) and synthetic (all rac) alpha-tocopherol: a biokinetic study in apoE4 male subjects.

  2006cites this paper
• Oxidative stress in the brain at early preclinical stages of mouse scrapie.

  2006cites this paper
• Effects of Subchronic Exposures to Concentrated Ambient Particles: VII. Degeneration of Dopaminergic Neurons in Apo E−/− Mice

  2005cites this paper
• N-acteyl cysteine alleviates oxidative damage to central nervous system of ApoE-deficient mice following folate and vitamin E-deficiency

  2005cites this paper
• Oxidative stress, antioxidants and neurodegenerative diseases.

  2005cites this paper
• STUDIES ON APOLIPOPROTEIN E AND HIGH CHOLESTEROL DIET AS RISK FACTORS FOR NEURODEGENERATION

  2005cites this paper
• Apple juice concentrate prevents oxidative damage and impaired maze performance in aged mice

  2005cites this paper
• Lifelong vitamin E intake retards age-associated decline of spatial learning ability in apoE-deficient mice

  2005cites this paper
• A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

  2005cites this paper
• Increased transcription and activity of glutathione synthase in response to deficiencies in folate, vitamin E, and apolipoprotein E

  2004cites this paper
• Differential susceptibity of transgenic mice lacking one or both apolipoprotein alleles to folate and vitamin E deprivation

  2004cites this paper
• Proteomic identification of specific oxidized proteins in ApoE-knockout mice: relevance to Alzheimer's disease.

  2004cites this paper
• Alzheimer's disease pathogenesis and therapeutic interventions.

  2004cites this paper
• Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication.

  2004cites this paper
• Peroxisome Proliferator-Activated Receptor-α Activation as a Mechanism of Preventive Neuroprotection Induced by Chronic Fenofibrate Treatment

  2003cites this paper
• Vitamin E deficiency does not induce compensatory antioxidant increases in central nervous system tissue of apolipoprotein E-deficient mice

  2003influential citation
• Dietary Lipids in the Aetiology of Alzheimer’s Disease

  2003cites this paper
• Alteration of nitric oxide synthase activity in young and aged apolipoprotein E-deficient mice.

  2003cites this paper
• Secreted apolipoprotein E reduces macrophage‐mediated LDL oxidation in an isoform‐dependent way

  2003cites this paper
• Quantification of antioxidant activity in brain tissue homogenates using the 'total equivalent antioxidant capacity'.

  2003cites this paper
• Folate quenches oxidative damage in brains of apolipoprotein E-deficient mice: augmentation by vitamin E.

  2002cites this paper
• Estrogen is Neuroprotective via an Apolipoprotein E—Dependent Mechanism in a Mouse Model of Global Ischemia

  2002cites this paper
• Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue.

  2002cites this paper
• Neuroprotective Effect of Apolipoprotein E against Ischemia

  2002cites this paper
• Protective effect of apolipoprotein E against ischemic neuronal injury is mediated through antioxidant action

  2002cites this paper
• New model of glutathione deficit during development: Effect on lipid peroxidation in the rat brain

  2002cites this paper