The contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer: no evidence for other ovarian cancer-susceptibility genes.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  American Journal of Human Genetics

• Publication date

  1999-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1086/302583PMID 10486320PMCID PMC1288234
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Clues to the Function of the Tumour Susceptibility Gene BRCA2

  2002cited by this paper
• An Alu-mediated 6-kb duplication in the BRCA1 gene: a new founder mutation?

  1999influential reference
• Survival in familial, BRCA1-associated, and BRCA2-associated epithelial ovarian cancer. United Kingdom Coordinating Committee for Cancer Research (UKCCCR) Familial Ovarian Cancer Study Group.

  1999cited by this paper
• Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.

  1998cited by this paper
• BRCA1, BRCA2, and DNA damage response: collision or collusion?

  1998cited by this paper
• Haplotype and phenotype analysis of nine recurrent BRCA2 mutations in 111 families: results of an international study.

  1998cited by this paper
• The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment.

  1998cited by this paper
• A systematic review and meta‐analysis of family history and risk of ovarian cancer

  1998cited by this paper
• Breast cancer genes—what are the real risks?

  1997cited by this paper
• Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene

  1997cited by this paper
• Frequently occurring germ-line mutations of the BRCA1 gene in ovarian cancer families from Russia.

  1997cited by this paper
• Association of BRCA1 with Rad51 in mitotic and meiotic cells.

  1997cited by this paper
• A 1-kb Alu-mediated germ-line deletion removing BRCA1 exon 17.

  1997cited by this paper
• RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2 *

  1997cited by this paper
• BRCA1 genomic deletions are major founder mutations in Dutch breast cancer patients

  1997cited by this paper
• Mutation analysis of BRCA1 and BRCA2 in a male breast cancer population.

  1997cited by this paper
• Identification of a 14 kb deletion involving the promoter region of BRCA1 in a breast cancer family.

  1997cited by this paper
• Analysis of BRCA1 and BRCA2 mutations in Hungarian families with breast or breast-ovarian cancer.

  1997cited by this paper
• Identification of the breast cancer susceptibility gene BRCA2

  1996cited by this paper
• A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes

  1996cited by this paper
• The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds

  1996cited by this paper
• Haplotype and phenotype analysis of six recurrent BRCA1 mutations in 61 families: results of an international study.

  1996cited by this paper
• Transcriptional activation by BRCA1

  1996cited by this paper
• Recurrent BRCA2 6174delT mutations in Ashkenazi Jewish women affected by breast cancer

  1996cited by this paper
• Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype–phenotype correlation

  1995cited by this paper
• Identification of the breast cancer susceptibility gene BRCA2

  1995cited by this paper
• A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening.

  1995cited by this paper
• The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individuals

  1995cited by this paper
• An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium.

  1995cited by this paper
• Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence.

  1995cited by this paper
• Familial site-specific ovarian cancer is linked to BRCA1 on 17q12-21.

  1994cited by this paper
• A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

  1994cited by this paper
• Mutation of a mutL homolog in hereditary colon cancer.

  1994cited by this paper
• Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.

  1993cited by this paper
• Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

  1993cited by this paper
• Genetic analysis of breast cancer in the cancer and steroid hormone study.

  1991cited by this paper
• Programs for pedigree analysis: Mendel, Fisher, and dGene

  1988cited by this paper
• Programs for Pedigree Analysis: MENDEL, FISHER, and dGENE.

  1988cited by this paper
• Surveillance and Management of Patients at High Genetic Risk for Ovarian Carcinoma

  1982cited by this paper

• Evaluation of risk-reducing radical fimbriectomy followed by delayed oophorectomy in high-risk Women: A single-center retrospective study.

  2025cites this paper
• Predictive biomarkers for targeted therapy in daily anatomic pathology for ovarian tumors

  2025cites this paper
• Diagnostic, prognostic, and immunological roles of CDSN in ovarian cancer

  2024cites this paper
• Gynecologic and breast cancers with hereditary cancer predisposition syndromes

  2024cites this paper
• BRCA1 Protein Expression in Epithelial Ovarian Cancer and Associated Clinicopathological Factors in Uganda

  2024cites this paper
• Increased prevalence of the founder BRCA1 c.5309G>T and recurrent BRCA2 c.1310_1313delAAGA mutations in breast cancer families from Northerstern region of Morocco: evidence of geographical specificity and high relevance for genetic counseling

  2023cites this paper
• Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci

  2022cites this paper
• Peripheral blood BRCA1 methylation profiling to predict familial ovarian cancer

  2021cites this paper
• Genome-wide association and functional interrogation identified a variant at 3p26.1 modulating ovarian cancer survival among Chinese women

  2021cites this paper
• Germline genomic patterns are associated with cancer risk, oncogenic pathways, and clinical outcomes

  2020cites this paper
• Association between BRCA 1, BRCA 2 and Ovarian Reserve: Current Evidence and Future Possibilities via a Review of the Literature

  2020influential citation
• Spectrum of germline BRCA mutations in hereditary breast and ovarian cancer syndrome in Indian population: A central reference laboratory experience

  2020cites this paper
• Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers

  2019cites this paper
• Hereditary Endometrial and Ovarian Cancers

  2019cites this paper
• Germline genomic patterns are associated with cancer risk, oncogenic pathways and clinical outcomes

  2019cites this paper
• Genetic epidemiology of ovarian cancer in the 22 Arab countries: A systematic review.

  2019cites this paper
• Whole‐exome sequencing of ovarian cancer families uncovers putative predisposition genes

  2019cites this paper
• MYC Distant Enhancers Underlie Ovarian Cancer Susceptibility at the 8q24.21 Locus

  2018cites this paper
• Genetic epidemiology of ovarian cancer and prospects for polygenic risk prediction.

  2017cites this paper
• The Prevalence And Clinical Significance Of Mutations BRIP 1 , BARD 1 , PALB 2 And NBN Genes In Women With Ovarian Cancer

  2017cites this paper
• Hereditary Ovarian Cancer

  2017cites this paper
• Systematic meta-analyses of gene-specific genetic association studies in prostate cancer

  2016cites this paper
• Exploiting synthetic lethality in ovarian cancer

  2016cites this paper
• Germline Mutations in the BRIP 1 , BARD 1 , PALB 2 , and NBN Genes in Women With Ovarian Cancer

  2015cites this paper
• MTHFR A1298C polymorphism and ovarian cancer risk: a meta-analysis.

  2015cites this paper
• Breast Cancer Risks and Risk Prediction Models

  2015cites this paper
• A risk prediction algorithm for ovarian cancer incorporating BRCA1, BRCA2, common alleles and other familial effects

  2015cites this paper
• [Oncogenetics in the management of ovarian cancer: State-of-the art].

  2015cites this paper
• Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer.

  2015cites this paper
• MTHFR A 1298 C polymorphism and ovarian cancer risk : a meta-analysis

  2015cites this paper
• The changing landscape of genetic testing for hereditary breast and ovarian cancer.

  2014cites this paper
• BRCA 1 and BRCA 2 germline mutations screening in Algerian breast / ovarian cancer families

  2014cites this paper
• An Integrated in Silico Approach to Analyze the Involvement of Single Amino Acid Polymorphisms in FANCD1/BRCA2-PALB2 and FANCD1/BRCA2-RAD51 Complex

  2014cites this paper
• BRCA-Associated Ovarian Cancer: From Molecular Genetics to Risk Management

  2014cites this paper
• Next generation sequencing approaches to identify novel susceptibility genes for epithelial ovarian cancer

  2014cites this paper
• The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population.

  2014cites this paper
• BRCA1 and BRCA2 germline mutation spectrum in hereditary breast/ovarian cancer families from Maghrebian countries

  2013cites this paper
• Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE.

  2013cites this paper
• Functional analysis of low-moderate risk susceptibility genes emerging from pathway based approaches and genome wide association studies in epithelial ovarian cancer

  2013cites this paper
• Role of DNA repair and cell cycle control genes in ovarian cancer susceptibility

  2013cites this paper
• Analysis of Human TACC3 in Cellular Responses to Polycyclic Aromatic Hydrocarbons

  2012cites this paper
• Mutation analysis of RAD51D in non-BRCA1/2 ovarian and breast cancer families

  2012cites this paper
• Al/PANI-MWNT/Au-Plastic Schottky Diode Solar Cells

  2012cites this paper
• UG repeats/TDP-43 interactions near 5' splice sites exert unpredictable effects on splicing modulation.

  2012cites this paper
• Hereditary gynecologic cancers: risk assessment, counseling, testing and management.

  2012cites this paper
• Germline mutations in RAD51D confer susceptibility to ovarian cancer

  2011cites this paper
• Hereditary Ovarian Cancer and Other Gynecologic Malignancies

  2011cites this paper
• Identifying common genetic variants associated with disease risk and clinical outcome in epithelial ovarian cancer

  2011cites this paper
• Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer

  2011cites this paper
• The inherited genetics of ovarian and endometrial cancer.

  2010cites this paper
• Title Clinical and pathological characteristics of Chinese patients withBRCA related breast cancer

  2010cites this paper
• Cancer prevalence in 129 breast-ovarian cancer families tested for BRCA1 and BRCA2 mutations.

  2010cites this paper
• BRCA1 and BRCA2 Germline Mutations Screening in Algerian Breast/Ovarian Cancer Families

  2010cites this paper
• Cancer genetics and reproduction.

  2010cites this paper
• Breast cancer susceptibility variants alter risk in familial ovarian cancer

  2010cites this paper
• Genetic/familial high-risk assessment: breast and ovarian.

  2010cites this paper
• Psychological and Behavioral Aspects of Receiving Genetic Counseling for Hereditary Cancer

  2010cites this paper
• Best Practice & Research Clinical Obstetrics and Gynaecology

  2010cites this paper
• Evaluation of Common Inherited Variants in Mitochondrial-Related and MicroRNA-Related Genes as Novel Risk Factors for Ovarian Cancer

  2010cites this paper
• A Genome-Wide Association Study Identifies A New Ovarian Cancer Susceptibility Locus On 9 p 22 . 2

  2010cites this paper
• Kin-cohort Estimate of Penetrance with Piecewise Weibull Model

  2009cites this paper
• BRCA1 and BRCA2 germline mutation analysis among Indian women from south India: identification of four novel mutations and high-frequency occurrence of 185delAG mutation

  2009influential citation
• BRCA 1 and BRCA 2 germline mutation analysis among Indian women from south India : identifi cation of four novel mutations and high-frequency occurrence of 185 delAG mutation

  2009cites this paper
• Proteasome system of protein degradation and processing

  2009cites this paper
• Cancer surveillance behaviors in women presenting for clinical BRCA genetic susceptibility testing.

  2009cites this paper
• Association between Common Germline Genetic Variation in 94 Candidate Genes or Regions and Risks of Invasive Epithelial Ovarian Cancer

  2009cites this paper
• Somatic Genetic Development in Epithelial Ovarian Cancer

  2009influential citation
• Complex Segregation Analysis of Pedigrees from the Gilda Radner Familial Ovarian Cancer Registry Reveals Evidence for Mendelian Dominant Inheritance

  2009cites this paper
• Tagging single-nucleotide polymorphisms in candidate oncogenes and susceptibility to ovarian cancer

  2009cites this paper
• A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2

  2009cites this paper
• Clinical and pathological characteristics of Chinese patients with BRCA related breast cancer

  2009cites this paper
• The Contribution of BRCA1 and BRCA2 to Ovarian Cancer

  2009cites this paper
• Accuracy of self-reported family history of cancer in a large case–control study of ovarian cancer

  2008cites this paper
• Probability of BRCA1/2 mutation varies with ovarian histology: results from screening 442 ovarian cancer families

  2008cites this paper
• BRCA1 and BRCA2 Mutation Prevalence and Clinical Characteristics of a Population-Based Series of Ovarian Cancer Cases from Denmark

  2008cites this paper
• Clinical factors and biomarkers in ovarian tumors development.

  2008cites this paper
• CÁNCER HEREDITARIO DE MAMA

  2008cites this paper
• Estrogen Receptor (ER) β or p53 Attenuates ERα-mediated Transcriptional Activation on the BRCA2 Promoter*

  2008cites this paper
• Contribution of BRCA1 and BRCA2 mutations to inherited ovarian cancer

  2007influential citation
• Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer.

  2007influential citation
• Prediction of BRCA1/2 mutation status in patients with ovarian cancer from a hospital-based cohort

  2007cites this paper
• Screening for the BRCA1‐ins6kbEx13 mutation: potential for misdiagnosis

  2007influential citation
• BRCA1 Suppresses Osteopontin-mediated Breast Cancer*

  2006cites this paper
• Prevalence of BRCA1 and BRCA2 mutations in Pakistani breast and ovarian cancer patients

  2006cites this paper
• Risk prediction models for familial breast cancer.

  2006cites this paper
• Establishment and characterization of xenografts and cancer cell cultures derived from BRCA1 -/- epithelial ovarian cancers.

  2006cites this paper
• Genetic mutations in gynaecological cancers

  2006cites this paper
• Ovarian cancer and genetic susceptibility in relation to the BRCA1 and BRCA2 genes. Occurrence, clinical importance and intervention

  2006influential citation
• Aberrations of TACC1 and TACC3 are associated with ovarian cancer

  2005influential citation
• Increased risk of ovarian cancer in integrin beta3 Leu33Pro homozygotes.

  2005cites this paper
• Common variation in EMSY and risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs

  2005cites this paper
• Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility: Systematic Evidence Review for the U.S. Preventive Services Task Force

  2005cites this paper
• BRCA1 and BRCA2 as ovarian cancer susceptibility genes.

  2005cites this paper
• Prophylactic salpingo-oophorectomy in 51 women with familial breast–ovarian cancer: importance of fallopian tube dysplasia

  2005cites this paper
• Does the occurrence of certain rare cancers indicate an inherited cancer susceptibility?

  2004cites this paper
• The presence of hereditary BRCA1 gene mutations in women with familial breast or ovarian cancer and the frequency of occurrence of these tumours in their relatives.

  2004cites this paper
• Familial breast and ovarian cancers

  2004cites this paper
• BRCA2, but not BRCA1, mutations account for familial ovarian cancer in Iceland: a population-based study.

  2004cites this paper
• Histopathology, FIGO Stage, and BRCA Mutation Status of Ovarian Cancers from the Gilda Radner Familial Ovarian Cancer Registry

  2004cites this paper
• Hereditary Ovarian Cancer and Other Gynecologic Malignancies

  2004cites this paper