Methodological Considerations for Optimizing and Validating Behavioral Assays

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Current Protocols in Mouse Biology

• Publication date

  2016-12-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1002/cpmo.17PMID 27906464PMCID PMC6054129
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Repetitive Behavioral Assessments for Compound Screening in Mouse Models of Autism Spectrum Disorders.

  2016cited by this paper
• Role of 5-HT(1A)- and 5-HT(2A) receptors for the murine model of the serotonin syndrome.

  2014cited by this paper
• Rigor or mortis: best practices for preclinical research in neuroscience.

  2014cited by this paper
• Predictive validity of a MK-801-induced cognitive impairment model in mice: implications on the potential limitations and challenges of modeling cognitive impairment associated with schizophrenia preclinically.

  2014cited by this paper
• Serotonin syndrome.

  2014cited by this paper
• The promising trajectory of autism therapeutics discovery.

  2014cited by this paper
• Future Viable Models of Psychiatry Drug Discovery in Pharma

  2013cited by this paper
• A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

  2013cited by this paper
• A comparative phenotypic and genomic analysis of C 57 BL / 6 J and C 57 BL / 6 N mouse strains

  2013cited by this paper
• Disruption of social approach by MK-801, amphetamine, and fluoxetine in adolescent C57BL/6J mice.

  2013cited by this paper
• Vehicles for lipophilic drugs: implications for experimental design, neuroprotection, and drug discovery.

  2013cited by this paper
• Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

  2012cited by this paper
• Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes

  2012cited by this paper
• CHAPTER 20:The Possibilities and Limitations of Animal Models for Psychiatric Disorders

  2012cited by this paper
• Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research †

  2012cited by this paper
• Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism

  2012cited by this paper
• A call for transparent reporting to optimize the predictive value of preclinical research

  2012cited by this paper
• Social peers rescue autism‐relevant sociability deficits in adolescent mice

  2011cited by this paper
• Mouse phenotyping.

  2011cited by this paper
• Automated Three‐Chambered Social Approach Task for Mice

  2011cited by this paper
• Lack of association of a spontaneous mutation of the Chrm2 gene with behavioral and physiologic phenotypic differences in inbred mice.

  2010influential reference
• The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies.

  2010cited by this paper
• How Many Ways Can Mouse Behavioral Experiments Go Wrong? Confounding Variables in Mouse Models of Neurodegenerative Diseases and How to Control Them

  2010cited by this paper
• Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience

  2010cited by this paper
• Construction noise decreases reproductive efficiency in mice.

  2009cited by this paper
• Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals

  2009cited by this paper
• Use of latency to immobility improves detection of antidepressant-like activity in the behavioral despair test in the mouse.

  2009cited by this paper
• New insights of dimethyl sulphoxide effects (DMSO) on experimental in vivo models of nociception and inflammation.

  2008cited by this paper
• Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study.

  2008cited by this paper
• What's Wrong With My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, 2nd ed

  2008cited by this paper
• All is not well in the world of translational research.

  2007cited by this paper
• What's Wrong With My Mouse?

  2007cited by this paper
• Systematic, standardized and comprehensive neurological phenotyping of inbred mice strains in the German Mouse Clinic.

  2006cited by this paper
• The use of behavioral test batteries, II: effect of test interval.

  2006cited by this paper
• Establishing an appropriate period of acclimatization following transportation of laboratory animals.

  2006cited by this paper
• The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice.

  2005cited by this paper
• An analysis of the genetics of alcohol intoxication in inbred mice.

  2005cited by this paper
• Effects of interleukin-1 and endotoxin in the forced swim and tail suspension tests in mice.

  2005cited by this paper
• In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice

  2004cited by this paper
• Laboratory animal science issues in the design and conduct of studies with endocrine-active compounds.

  2004cited by this paper
• Environmental enrichment: effects on stereotyped behavior and dendritic morphology.

  2003cited by this paper
• Different data from different labs: lessons from studies of gene-environment interaction.

  2003cited by this paper
• The fallacy of behavioral phenotyping without standardisation

  2002cited by this paper
• Improving housing conditions for laboratory mice: a review of 'environmental enrichment'

  2002cited by this paper
• Behavioral phenotyping enhanced – beyond (environmental) standardization

  2002cited by this paper
• Comparison of apomorphine, amphetamine and dizocilpine disruptions of prepulse inhibition in inbred and outbred mice strains.

  2001cited by this paper
• Strain-specific effects of amphetamine on prepulse inhibition and patterns of locomotor behavior in mice.

  2001cited by this paper
• The use of behavioral test batteries: effects of training history.

  2001cited by this paper
• Behaviour and the standardization fallacy

  2000cited by this paper
• What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice

  2000cited by this paper
• Differences in anxiety-related behaviours and in sensitivity to diazepam in inbred and outbred strains of mice

  2000cited by this paper
• Methods of Behavior Analysis in Neuroscience

  2000cited by this paper
• Genetics of mouse behavior: interactions with laboratory environment.

  1999cited by this paper
• Neuropharmacology: Propylene Glycol Elicits Anxiolytic‐like Responses to the Elevated Plus‐maze in Male Mice

  1998cited by this paper
• A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice.

  1997cited by this paper
• Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

  1997cited by this paper
• Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay.

  1996cited by this paper
• Behavioral effects of vehicles: DMSO, ethanol, Tween-20, Tween-80, and emulphor-620.

  1995cited by this paper
• Ethopharmacological analysis of the effects of putative 'anxiogenic' agents in the mouse elevated plus-maze.

  1995cited by this paper
• Morphine-induced straub tail response: mediated by central mu2-opioid receptor.

  1994cited by this paper
• Behavioural and pharmacological characterisation of the elevated “zero-maze” as an animal model of anxiety

  1994cited by this paper
• m-Chlorophenylpiperazine enhances neophobic and anxious behaviour in mice.

  1991cited by this paper
• Do functional relationships exist between 5-HT1A and 5-HT2 receptors?

  1990cited by this paper
• The behavioural effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in mice.

  1988cited by this paper
• The value of the reserpine test in psychopharmacology.

  1983cited by this paper
• Behavioral effects of intracerebroventricularly administered neurohypophyseal hormone analogs in mice.

  1982cited by this paper
• Relationship between pentylenetetrazol-induced seizures and brain pentylenetetrazol levels in mice.

  1980cited by this paper
• Blindness-induced hyperactivity in several strains of mice.

  1975cited by this paper
• Effects of opiates and opiate antagonists on the Straub tail reaction in mice

  1969cited by this paper
• A comparative.

  1950cited by this paper
• CALL FOR

  year unknowncited by this paper
• Please Scroll down for Article Journal of Neurogenetics Behavioral Differences among C57bl/6 Substrains: Implications for Transgenic and Knockout Studies Behavioral Differences among C57bl/6 Substrains: Implications for Transgenic and Knockout Studies

  year unknowncited by this paper

• Acute administration of lovastatin had no pronounced effect on motor abilities, motor coordination, gait nor simple cognition in a mouse model of Angelman syndrome

  2025cites this paper
• Characterization of cell-type specific knockout of different elements of the endocannabinoid system in cortical glutamatergic neurons in the context of stress-induced behavioral phenotype

  2025cites this paper
• Fus depleted oligodendrocytes reduce neuronal damage and attenuate AD progression in the AppNL-G-F mouse

  2025cites this paper
• Diurnal behavioral outcomes and BBB integrity in adult male SHR and WKY rats

  2025cites this paper
• Effects of general anesthetics on seizure termination, mortality, and neurological prognosis in a rat model of pediatric refractory status epilepticus: A comparative randomized controlled study.

  2025cites this paper
• Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-Related Intellectual Disability

  2024cites this paper
• Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-related intellectual disability

  2024cites this paper
• Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model

  2024cites this paper
• Time-dependent antidepressant-like effects of reelin and ketamine in the repeated-corticosterone model of chronic stress.

  2024cites this paper
• BAMBI: A new method for automated assessment of bidirectional early-life interaction between maternal behavior and pup vocalization in mouse dam-pup dyads

  2023cites this paper
• Nature and nurture: Comparing mouse behavior in classic versus revised anxiety‐like and social behavioral assays in genetically or environmentally defined groups

  2023cites this paper
• Not so fast: Paradoxically increased variability in the glucose tolerance test due to food withdrawal in continuous glucose-monitored mice

  2023cites this paper
• Effects of Dietary Methionine Restriction on Cognition in Mice

  2023cites this paper
• Hyperexcitability and translational phenotypes in a preclinical model of SYNGAP1 mutations

  2023cites this paper
• Hyperexcitability and translational phenotypes in a preclinical model of SYNGAP1 mutations

  2023cites this paper
• Animal Models for Psychiatric Research: Novel Directions for Behavioral Neuroscience in Translation.

  2023cites this paper
• The essential role of animal models in the advancement of our understanding of human behaviors: A Commentary on the Special issue on the 30th Anniversary of the International Behavioral Neuroscience Society (IBNS).

  2023cites this paper
• Neonatal Behavioral Screen for Mouse Models of Neurodevelopmental Disorders.

  2023cites this paper
• Reconsidering animal models used to study autism spectrum disorder: Current state and optimizing future

  2022cites this paper
• Touchscreen cognitive deficits, hyperexcitability and hyperactivity in males and females using two models of Cdkl5 deficiency

  2022cites this paper
• Acute treatment with 5-hydroxytryptophan increases social approach behaviour but does not activate serotonergic neurons in the dorsal raphe nucleus in juvenile male BALB/c mice: A model of human disorders with deficits of sociability

  2022cites this paper
• Perspectives on Cognitive Phenotypes and Models of Vascular Disease.

  2022cites this paper
• Molecular and histological correlates of cognitive decline across age in male C57BL/6J mice

  2022cites this paper
• Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice

  2021cites this paper
• Top2a promotes the development of social behavior via PRC2 and H3K27me3

  2021cites this paper
• The importance of individual variation for the interpretation of behavioural studies: ethanol effects vary with basal activity level in zebrafish larvae

  2021cites this paper
• Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome

  2021cites this paper
• Effect of Streblus asper Leaf Extract on Scopolamine-Induced Memory Deficits in Zebrafish: The Model of Alzheimer's Disease

  2021cites this paper
• Neuroanatomy and behavior in mice with a haploinsufficiency of AT-rich interactive domain 1B (ARID1B) throughout development

  2020cites this paper
• Translational outcomes relevant to neurodevelopmental disorders following early life exposure of rats to chlorpyrifos

  2020cites this paper
• Optimization and validation of a modified radial-arm water maze protocol using a murine model of mild closed head traumatic brain injury

  2020cites this paper
• Developmental exposure to near roadway pollution produces behavioral phenotypes relevant to neurodevelopmental disorders in juvenile rats

  2020cites this paper
• An active avoidance behavioral paradigm for use in a mild closed head model of traumatic brain injury in mice.

  2020cites this paper
• Validation and standardization of a new radial-arm water maze protocol using a murine model of mild closed head traumatic brain injury

  2020cites this paper
• Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome

  2020cites this paper
• Deletion of a non-canonical promoter regulatory element causes loss of Scn1a expression and epileptic phenotypes in mice

  2019cites this paper
• Cognitive deficits in the Snord116 deletion mouse model for Prader-Willi syndrome.

  2019cites this paper
• Cognitive dysfunction in mice lacking proper glucocorticoid receptor dimerization

  2019cites this paper
• Genetic backgrounds have unique seizure response profiles and behavioral outcomes following convulsant administration.

  2019cites this paper
• Minimum Information in In Vivo Research.

  2019cites this paper
• Autistic traits in epilepsy models: Why, when and how?

  2018cites this paper
• Developmental social communication deficits in the Shank3 rat model of phelan‐mcdermid syndrome and autism spectrum disorder

  2018cites this paper
• Loss of skills and onset patterns in neurodevelopmental disorders: Understanding the neurobiological mechanisms

  2018cites this paper
• Assessing Healthspan and Lifespan Measures in Aging Mice: Optimization of Testing Protocols, Replicability, and Rater Reliability

  2018cites this paper
• Behavioral and neuroanatomical approaches in models of neurodevelopmental disorders: opportunities for translation

  2018cites this paper
• Testing cognitive functions in rodent disease models: Present pitfalls and future perspectives

  2017cites this paper
• Deletion of a non-canonical regulatory sequence causes loss of Scn 1 a 1 expression and epileptic phenotypes in mice 2 3

  year unknowncites this paper