Methylation of α-synuclein and leucine-rich repeat kinase 2 in leukocyte DNA of Parkinson's disease patients.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Parkinsonism & Related Disorders

• Publication date

  2014-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.parkreldis.2013.12.002PMID 24398085
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.

  2013cited by this paper
• Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutation

  2012cited by this paper
• No evidence for differential methylation of α‐synuclein in leukocyte DNA of Parkinson's disease patients

  2012cited by this paper
• DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology

  2012cited by this paper
• Epigenetics in neurodegeneration: a new layer of complexity.

  2011cited by this paper
• Global methylation profiles in DNA from different blood cell types

  2011cited by this paper
• Next-Generation Sequencing Reveals Regional Differences of the α-Synuclein Methylation State Independent of Lewy Body Disease

  2011cited by this paper
• Advances in Epigenetics and Epigenomics for Neurodegenerative Diseases

  2011cited by this paper
• Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases.

  2011cited by this paper
• Verification of expressions of Kir2 as potential peripheral biomarkers in lymphocytes from patients with Parkinson's disease.

  2011cited by this paper
• Genome‐Wide Association Study Confirms SNPs in SNCA and the MAPT Region as Common Risk Factors for Parkinson Disease

  2010cited by this paper
• CpG Demethylation Enhances Alpha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease

  2010cited by this paper
• Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

  2010cited by this paper
• Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease

  2009cited by this paper
• Genomewide association study for susceptibility genes contributing to familial Parkinson disease

  2009cited by this paper
• Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases.

  2009cited by this paper
• DNA Cytosine demethylation: are we getting close?

  2008cited by this paper
• DNA methylation signatures within the human brain.

  2007cited by this paper
• Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia.

  2007cited by this paper
• Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.

  2006cited by this paper
• DNA methylation: Bisulphite modification and analysis

  2006cited by this paper
• Early detection of breast cancer based on gene-expression patterns in peripheral blood cells

  2005cited by this paper
• α-Synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication

  2004cited by this paper
• Alpha-synuclein locus duplication as a cause of familial Parkinson's disease.

  2004cited by this paper
• Amount of DNA in plasma and cancer risk: A prospective study

  2004cited by this paper
• α-synuclein locus duplication as a cause of familial Parkinson's disease

  2004cited by this paper
• Comparison of kindreds with parkinsonism and α‐synuclein genomic multiplications

  2004cited by this paper
• Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications.

  2004cited by this paper
• The role of alpha-synuclein in Parkinson's disease: insights from animal models.

  2003cited by this paper
• alpha-Synuclein locus triplication causes Parkinson's disease.

  2003cited by this paper
• α-Synuclein Locus Triplication Causes Parkinson's Disease

  2003cited by this paper
• The role of α-synuclein in Parkinson's disease: insights from animal models

  2003cited by this paper
• A Drosophila model of Parkinson's disease

  2000cited by this paper

• Decreased DNA methyltransferase 1 level in blood cells in Parkinson's disease.

  2025cites this paper
• Characterization of methylation profile in biofluid cell-free DNA and identification of differentially methylated genes for phenotypic representations in Parkinson's disease.

  2025cites this paper
• Epigenetics and the neurodegenerative process.

  2024cites this paper
• Emerging Role of Environmental Epitranscriptomics and RNA Modifications in Parkinson’s Disease

  2024cites this paper
• A recognition of exosomes as regulators of epigenetic mechanisms in central nervous system diseases

  2024cites this paper
• Review article: the role of epigenetics as an underlying regulator of the immune responses in Parkinson’s disease

  2024cites this paper
• α‐Synuclein Gene Hypomethylation in LRRK2 Parkinson's Disease Patients

  2024cites this paper
• SNCA Gene Methylation in Parkinson’s Disease and Multiple System Atrophy

  2023cites this paper
• Epigenetic modification in Parkinson’s disease

  2023cites this paper
• Parkinson’s Disease: From Genetics and Epigenetics to Treatment, a miRNA-Based Strategy

  2023cites this paper
• Unraveling the Complex Interplay between Alpha-Synuclein and Epigenetic Modification

  2023cites this paper
• Methylation of MAPT Gene in Neurodegenerative Synucleinopathies

  2022cites this paper
• Epigenetic Modifications and Neurodegenerative Disorders: A Biochemical Perspective.

  2022cites this paper
• Does the Expression and Epigenetics of Genes Involved in Monogenic Forms of Parkinson’s Disease Influence Sporadic Forms?

  2022influential citation
• Parkinson’s disease-associated, sex-specific changes in DNA methylation at PARK7 (DJ-1), SLC17A6 (VGLUT2), PTPRN2 (IA-2β), and NR4A2 (NURR1) in cortical neurons

  2022cites this paper
• Parkinson’s Disease-Associated, Sex-specific Changes in DNA Methylation at PARK7 (DJ-1), ATXN1, SLC17A6, NR4A2, and PTPRN2 in Cortical Neurons

  2021cites this paper
• Exosome-Derived MicroRNAs of Human Milk and Their Effects on Infant Health and Development

  2021cites this paper
• Synergistic Effects of Milk-Derived Exosomes and Galactose on α-Synuclein Pathology in Parkinson’s Disease and Type 2 Diabetes Mellitus

  2021cites this paper
• DNA Methyltransferase 1 Is Dysregulated in Parkinson’s Disease via Mediation of miR-17

  2021cites this paper
• Epigenetics and cognitive disorders

  2021cites this paper
• Biomarkers in Parkinson’s Disease

  2021cites this paper
• Comprehensive methylation profile of CSF cfDNA revealed pathogenesis and diagnostic markers for early-onset PD.

  2021cites this paper
• Roles of physical exercise in neurodegeneration: reversal of epigenetic clock

  2021cites this paper
• The SNCA-Rep1 Polymorphic Locus: Association with the Risk of Parkinson’s Disease and SNCA Gene Methylation

  2020cites this paper
• Transforming Curry Extract to Liposomal Curcumin (LipocurcTM)in Parkinson Disease (PD) Therapeutics Landscape: EmergingRole of Epigenetics Signaling and Nanotechnology

  2020cites this paper
• Hypermethylation of the Gene Coding for PGC-1α in Peripheral Blood Leukocytes of Patients With Parkinson’s Disease

  2020cites this paper
• DRD2 methylation to differentiate dementia with Lewy bodies from Parkinson's disease

  2020cites this paper
• DNA methylation in Parkinson disease

  2020cites this paper
• Recent Evidence in Epigenomics and Proteomics Biomarkers for Early and Minimally Invasive Diagnosis of Alzheimer’s and Parkinson’s Diseases

  2020cites this paper
• Hypomethylation of SNCA in Idiopathic REM Sleep Behavior Disorder Associated With Phenoconversion

  2020cites this paper
• One-carbon epigenetics and redox biology of neurodegeneration.

  2020cites this paper
• Association of the Plasma Long Non-coding RNA MEG3 With Parkinson's Disease

  2020cites this paper
• Influence of Prenatal Methamphetamine Abuse on the Brain

  2020cites this paper
• Epigenetic Changes and Its Intervention in Age-Related Neurodegenerative Diseases

  2020cites this paper
• Epigenetics in Lewy Body Diseases: Impact on Gene Expression, Utility as a Biomarker, and Possibilities for Therapy

  2020cites this paper
• DNA Methylation in Neuronal Development and Disease

  2019cites this paper
• Progress in the Genetic Analysis of Parkinson's Disease.

  2019cites this paper
• Diverse and Dynamic DNA Modifications in Brain and Diseases.

  2019cites this paper
• Omics and Epigenetics of Polyphenol-Mediated Neuroprotection: The Curcumin Perspective

  2019cites this paper
• DNA Methylation in Neurodegenerative Diseases

  2019cites this paper
• Genome-wide brain DNA methylation analysis suggests epigenetic reprogramming in Parkinson disease

  2019cites this paper
• Diverse and dynamic DNA modifications in brain and diseases

  2019cites this paper
• Evaluating the Effect of Iron (II) Chloride Induced Oxidative Stress in SH-SY5Y Cells and Its Role in Upregulation of α-Synuclein Expression

  2019cites this paper
• Relação entre Doença de Parkinson e Modulação Epigenética

  2019cites this paper
• Epigenetic mechanisms of neurodegenerative diseases and acute brain injury.

  2019cites this paper
• miR-124 and Parkinson's disease: a biomarker with therapeutic potential.

  2019cites this paper
• Alpha synuclein in hematopoiesis and immunity

  2019cites this paper
• Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death.

  2019cites this paper
• White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy

  2019cites this paper
• Lack of Association Between DNMT3B Polymorphisms and Sporadic Parkinson’s Disease in a Han Chinese Population

  2018cites this paper
• Alternative Splicing of Alpha- and Beta-Synuclein Genes Plays Differential Roles in Synucleinopathies

  2018cites this paper
• Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative Disease

  2018cites this paper
• Epigenetic Modifications of the α-Synuclein Gene and Relative Protein Content Are Affected by Ageing and Physical Exercise in Blood from Healthy Subjects

  2018cites this paper
• Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress

  2018cites this paper
• DYNC1H1 gene methylation correlates with severity of spinal muscular atrophy

  2018cites this paper
• Epigenetic Study in Parkinson’s Disease: A Pilot Analysis of DNA Methylation in Candidate Genes in Brain

  2018cites this paper
• Understanding Epigenetic Alterations in Alzheimer's and Parkinson's Disease: Towards Targeted Biomarkers and Therapies.

  2017cites this paper
• Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson’s disease

  2017cites this paper
• Deregulation of &agr;‐synuclein in Parkinson's disease: Insight from epigenetic structure and transcriptional regulation of SNCA

  2017cites this paper
• Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases

  2017cites this paper
• CpG demethylation in the neurotoxicity of 1-methyl-4-phenylpyridinium might mediate transcriptional up-regulation of α-synuclein in SH-SY5Y cells.

  2017influential citation
• Synucleins and Gene Expression: Ramblers in a Crowd or Cops Regulating Traffic?

  2017cites this paper
• Epigenetics and cognitive disorders-translational aspects

  2017cites this paper
• Association between DNA methyltransferase gene polymorphism and Parkinson's disease.

  2017cites this paper
• DNA methylation changes at SNCA intron 1 in patients with dementia with Lewy bodies

  2017cites this paper
• Epigenetic approach to early-onset Parkinson’s disease: low methylation status of SNCA and PARK2 promoter regions

  2017cites this paper
• Expression of the Parkinson’s Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32

  2017cites this paper
• DNA methyltransferase 1-targeting miRNA-148a of dairy milk: a potential bioactive modifier of the human epigenome

  2017cites this paper
• Comparison of α-synuclein gene methylation in peripheral blood mononuclear cells of Uighur and Han patients with sporadic Parkinson's disease

  2017cites this paper
• Parkinson’s disease is associated with DNA methylation levels in human blood and saliva

  2017cites this paper
• ParkinsonâÂÂs Disease (Pathogenesis and Its Management): An Overview

  2016cites this paper
• Implication of Epigenetic Modifications in Neurodegenerative Disorders:Traces and Imprints

  2016cites this paper
• DNA Methylation in Cellular Mechanisms of Neurodegeneration

  2016cites this paper
• Systematic literature review on Parkinson's disease and Childhood Leukaemia and mode of actions for pesticides

  2016cites this paper
• The role of biomarkers and imaging in Parkinson’s disease

  2016cites this paper
• Complex Effects of the ZSCAN21 Transcription Factor on Transcriptional Regulation of α-Synuclein in Primary Neuronal Cultures and in Vivo*

  2016cites this paper
• DNA methylation in Parkinson's disease

  2016cites this paper
• [Epigenetics in Parkinson's Disease].

  2016cites this paper
• The yin and yang of α-synuclein-associated epigenetics in Parkinson's disease.

  2016cites this paper
• Transcriptome profiling in Parkinson's leukocytes: from early diagnostics to neuroimmune therapeutic prospects.

  2016cites this paper
• The Role of DNA Methylation and Histone Modifications in Neurodegenerative Diseases: A Systematic Review

  2016cites this paper
• Methylation status of DJ-1 in leukocyte DNA of Parkinson’s disease patients

  2016cites this paper
• Epigenetic regulation in Parkinson’s disease

  2016cites this paper
• The role of biomarkers and imaging in Parkinson’s disease

  2016cites this paper
• Epigenetic Biomarkers for Parkinson’s Disease: From Diagnostics to Therapeutics

  2016cites this paper
• Epigenetic DNA Methylation Profiling with MSRE: A Quantitative NGS Approach Using a Parkinson's Disease Test Case

  2016cites this paper
• Elevated mRNA Expression and Low Methylation of SNCA in Japanese Alzheimer’s Disease Subjects

  2016cites this paper
• The rs3756063 polymorphism is associated with SNCA methylation in the Chinese Han population.

  2016cites this paper
• Age-related epigenetic regulation in the brain and its role in neuronal diseases

  2016cites this paper
• DNA methylation dynamics in plants and mammals: overview of regulation and dysregulation

  2016cites this paper
• Parkinson's disease correlates with promoter methylation in the α‐synuclein gene

  2015cites this paper
• Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease

  2015cites this paper
• Alpha-synuclein A53T mutation is not frequent on a sample of Brazilian Parkinson's disease patients.

  2015cites this paper
• Epigenetic Variations Underlying the Pathogenesis of Parkinson’s Disease

  2015cites this paper
• Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases?

  2015cites this paper
• Epigenetic mechanisms in Parkinson's disease.

  2015cites this paper
• Blood transcriptomics of drug-naïve sporadic Parkinson’s disease patients

  2015cites this paper
• Progress in unraveling the genetic etiology of Parkinson disease in a genomic era.

  2015cites this paper
• Role of 5-hydroxymethylcytosine in neurodegeneration.

  2015influential citation
• L‐dopa increases α‐synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro

  2015cites this paper