Nature of the stimulus leading to lymphocyte-induced angiogenesis.

Experiments are described that characterize the nature of the stimulus leading to lymphocyte-induced angiogenesis (LIA), a reaction previously shown to reflect a local in vivo graft-vs-host reaction. The studies demonstrate that circulating cells of the host animal provide the stimulation essential for activation of donor lymphocytes and that the major allogeneic stimulus in congenic lines of mice is correlated with I-region disparity, primarily associated with IA-controlled determinants. The results are readily compatible with the hypothesis that is proposed that LIA is in large part of the consequence of the release of soluble mediators or lymphokines that may act either directly on endothelial cells or indirectly by activating macrophages, which in turn generate the vascular reaction.

• Publication year

  1979

• Venue

  Journal of Immunology

• Publication date

  1979-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.123.2.751PMID 37274
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The effects of leukocyte depletion on corneal neovascularization.

  1978cited by this paper
• Regional differences in the incidence and growth of mouse tumors following intradermal or subcutaneous inoculation.

  1978cited by this paper
• The sequence of events in the regression of corneal capillaries.

  1978cited by this paper
• Angiogenic activity in culture supernatant of antigen‐stimulated lymph node cells

  1978cited by this paper
• Regional differences in tumor growth: Studies of the vascular system

  1978cited by this paper
• Activated macrophages induce vascular proliferation

  1977cited by this paper
• INDUCTION OF SPLENOMEGALY WITH STIMULATED LEUKOCYTE CULTURE SUPERNATANTS1

  1977cited by this paper
• The role of histocompatibility gene products in lymphocyte triggering and differentiation.

  1976cited by this paper
• Differential function of major histocompatibility complex antigens in T-lymphocyte activation

  1976cited by this paper
• Lymphocyte-induced angiogenesis in tumor-bearing mice

  1976cited by this paper
• On soluble mediators of immunologic regulation.

  1976cited by this paper
• Angiogenesis induction by tumors, embryonic tissues, and lymphocytes.

  1976cited by this paper
• Lymphocyte-induced angiogenesis: a quantitative and sensitive assay of the graft-vs.-host reaction

  1975cited by this paper
• THE HUMAN MIXED LYMPHOCYTE‐ENDOTHELIUM CULTURE INTERACTION

  1975cited by this paper
• The identification of HL-A antigens on fresh and cultured human endothelial cells.

  1975cited by this paper
• GRAFT-VERSUS-HOST REACTION ACROSS DIFFERENT REGIONS OF THE H-2 COMPLEX OF THE MOUSE

  1973cited by this paper
• STUDIES ON NORMAL AND IMMUNE LYMPHOCYTE TRANSFER REACTIONS IN GUINEA PIGS, WITH SPECIAL REFERENCE TO THE CELLULAR CONTRIBUTION OF THE HOST

  1972cited by this paper
• TUMOR ANGIOGENESIS

  1972cited by this paper
• The passenger cell concept in transplantation immunology.

  1971cited by this paper
• Pathogenesis of a local graft versus host reaction: immunogenicity of circulating host leukocytes.

  1968cited by this paper
• THE INTERACTION OF DONOR AND HOST LYMPHOID CELLS IN THE PATHOGENESIS OF RENAL CORTICAL DESTRUCTION INDUCED BY A LOCAL GRAFT VERSUS HOST REACTION

  1966cited by this paper

• Association of Vascular Endothelial Growth Factor 936 C/T Gene Polymorphism with Renal Allograft Outcome: A Study from North India.

  2022cites this paper
• Tumor angiogenesis

  2020cites this paper
• Microvasculature partial endothelial mesenchymal transition in early posttransplant biopsy with acute tubular necrosis identifies poor recovery renal allografts

  2020cites this paper
• Calcineurin inhibitors augment endothelial-to-mesenchymal transition by enhancing proliferation in association with cytokine-mediated activation.

  2019cites this paper
• DEPTOR at the Nexus of Cancer, Metabolism, and Immunity.

  2018cites this paper
• Molecular Regulation of Sprouting Angiogenesis.

  2017cites this paper
• ROLE OF THE MICROVASCULATURE IN SHAPING THE INTRAGRAFT MICROENVIRONMENT : A PARADIGM FOR UNDERSTANDING LOCAL IMMUNOREGULATION AND TOLERANCE

  2016influential citation
• The intragraft microenvironment as a central determinant of chronic rejection or local immunoregulation/tolerance

  2016influential citation
• Translational implications of endothelial cell dysfunction in association with chronic allograft rejection

  2015cites this paper
• The relationship between intervention in the CD40 signal pathway and choroidal neovascularization

  2014cites this paper
• The relationship between intervention in the CD40 signal pathway and choroidal neovascularization

  2014cites this paper
• Graft microvascular disease in solid organ transplantation

  2014cites this paper
• The relationship between intervention in the CD40 signal pathway and choroidal neovascularization

  2014cites this paper
• proinflammatory and angiogenic responses DEPTOR regulates vascular endothelial cell activation and

  2013cites this paper
• DEPTOR regulates vascular endothelial cell activation and proinflammatory and angiogenic responses.

  2013cites this paper
• Targeting the intragraft microenvironment and the development of chronic allograft rejection.

  2012cites this paper
• Regulation of Vascular Endothelial Cell Polarization and Migration by Hsp70/Hsp90-Organizing Protein

  2012cites this paper
• Key Features of the Intragraft Microenvironment that Determine Long-Term Survival Following Transplantation

  2012influential citation
• Increased Neovascularization in Advanced Lipid-Rich Atherosclerotic Lesions Detected by Gadofluorine-M–Enhanced MRI: Implications for Plaque Vulnerability

  2009cites this paper
• angiogenesis in inflammatory bowel disease regulating mucosal inflammation-driven Critical role of the CD40CD40-ligand pathway in

  2008cites this paper
• The lymphocyte in inflammatory angiogenesis

  2008cites this paper
• Every allograft needs a silver lining.

  2007cites this paper
• Statin treated patients have reduced intraplaque angiogenesis in carotid endarterectomy specimens.

  2007cites this paper
• Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis.

  2007cites this paper
• Angiogenesis and endothelial cell repair in renal disease and allograft rejection.

  2006cites this paper
• Influence of zymosan (a non-specific macrophage stimulator) and of indomethacin on liver tumours—an experimental study in rats

  2005cites this paper
• Phosphatidylinositol 3-Kinase Growth Factor Involves Ras and Overexpression of Vascular Endothelial Endothelial Cells Resulting in the The CD 40-Induced Signaling Pathway in

  2004influential citation
• Ultrastructural study of pseudo-Kaposi's sarcoma (Bluefarb-Stewart type)

  2004cites this paper
• The CD40-Induced Signaling Pathway in Endothelial Cells Resulting in the Overexpression of Vascular Endothelial Growth Factor Involves Ras and Phosphatidylinositol 3-Kinase1

  2004influential citation
• X-rays affect the expression of genes involved in angiogenesis.

  2004cites this paper
• Activated T lymphocytes in epiretinal membranes from eyes of patients with proliferative diabetic retinopathy

  2004cites this paper
• Proinflammatory functions of vascular endothelial growth factor in alloimmunity.

  2003cites this paper
• Cu/Zn Superoxide Dismutase Plays Important Role in Immune Response1

  2003cites this paper
• InteractionsProangiogenic Function of CD40 Ligand-CD40

  2003cites this paper
• Important Role in Immune Response Cu/Zn Superoxide Dismutase Plays

  2003cites this paper
• Proangiogenic Function of CD40 Ligand-CD40 Interactions 12

  2003cites this paper
• Cu/Zn Superoxide Dismutase Plays Important Role in Immune Response

  2003cites this paper
• Role of macrophages and lymphocytes in the induction of neovascularization in renal allograft rejection.

  2002cites this paper
• Acroangiodermatitis: review of the literature and report of a case associated with symmetrical foot ulcers.

  2002cites this paper
• Plaque angiogenesis: its functions and regulation.

  2002cites this paper
• Angiogenesis and Allograft Rejection

  2002cites this paper
• ArePlaque angiogenesis and atherosclerosis

  2001cites this paper
• Plaque angiogenesis and atherosclerosis.

  2001cites this paper
• Ultrastructural characterization of microvasculature in photoaging.

  2001cites this paper
• CHAPTER 54 – Coronary Atherosclerosis and Restenosis

  2001cites this paper
• Vascular Density (Tumor Angiogenesis) in Non-Hodgkin's Lymphomas and Florid Follicular Hyperplasia: A Morphometric Study

  2000cites this paper
• Angiogenesis in the Bovine Corpus Luteum: An Immunocytochemical and Ultrastructural Study*

  1999cites this paper
• Pityriasis lichenoides chronica with acral distribution mimicking palmoplantar syphilid.

  1999cites this paper
• Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice.

  1999cites this paper
• Angiodermatitis associated with congenital arteriovenous malformation on the elbow.

  1999cites this paper
• Angiogenesis in the huPBL-SCID model of human transplant rejection.

  1999cites this paper
• Aging and cancer: issues of basic and clinical science.

  1997cites this paper
• A variable neovascularization threshold in tumor-bearing mice.

  1997cites this paper
• Failure of thalidomide to inhibit tumor growth and angiogenesis in vivo.

  1996cites this paper
• The spectrum of African Kaposi's sarcoma: is it consequential upon diverse immunological responses?

  1996cites this paper
• Acro-angiodermatitis: review of the literature and report of a case.

  1995cites this paper
• Regulation of interleukin-8 expression in human melanoma cells by the organ environment.

  1995cites this paper
• Lymphocyte-induced angiogenesis: effect of different antigenic stimuli.

  1995cites this paper
• Leukocyte-induced Angiogenesis and Subcutaneous Growth of B16 Melanoma

  1994cites this paper
• Laser photocoagulation for corneal stromal vascularization.

  1992cites this paper
• [The elderly with cancer: oncology's excluded patients].

  1992cites this paper
• Immunohistochemical characterization of vascular endothelial cells in cutaneous T-cell malignancies with special references to heterogenous expression of surface antigens associated with monocytes and macrophages

  1991cites this paper
• The influence of immunosenescence on tumor growth and spread: lessons from animal models.

  1991cites this paper
• Lymphocyte-induced angiogenesis: a morphometric study in the chick embryo chorioallantoic membrane.

  1991cites this paper
• Cellular events associated with inflammatory angiogenesis in the mouse cornea.

  1991cites this paper
• Assays for angiogenesis: a review.

  1991cites this paper
• An in oculo model for quantitation of vascular growth in the rat heart.

  1991cites this paper
• Increased angiogeneic activity of spleen cells in spontaneous hypertensive rats (SHR).

  1991cites this paper
• Angiogenesis in wound healing.

  1991cites this paper
• [The nature of angiogenic factors (review of the literature)].

  1990cites this paper
• Ultrastructure and three-dimensional organization of the telangiectases of hereditary hemorrhagic telangiectasia.

  1990cites this paper
• Some effects of mechanical trauma on the development of primary cancers and their metastases.

  1990cites this paper
• Studies of bronchoalveolar lavage cells and fluids in pulmonary sarcoidosis. I. Enhanced capacity of bronchoalveolar lavage cells from patients with pulmonary sarcoidosis to induce angiogenesis in vivo.

  1989cites this paper
• Pathogenesis of pterygium

  1989cites this paper
• [The clinical picture and pathogenetic aspects of Kaposi's sarcoma].

  1989cites this paper
• Evidence that chronic hyperglycemia in mice does not adversely affect fetal islet cell allograft function.

  1989cites this paper
• A review of Kaposi's sarcoma.

  1989cites this paper
• The importance of immunesenescence in the incidence and malignant properties of cancer in hosts of advanced age.

  1989cites this paper
• The change in tumor aggressiveness with age: lessons from experimental animals.

  1989cites this paper
• Development of intimal lesions after leukocyte migration into the vascular wall.

  1989cites this paper
• The effects of total lymphoid irradiation upon corneal vascularization in the rat following chemical cautery.

  1989cites this paper
• [Immunological indices of patients with radiation-induced edema of the upper extremities following combined treatment of breast cancer].

  1988cites this paper
• Angiogenesis induction by CD-4 positive lymphocytes.

  1988cites this paper
• Angiogenic activity by spleen cell supernatants from tumor‐bearing and tumor‐resected mice

  1988cites this paper
• Neovascularisation associated with posterior uveitis.

  1987cites this paper
• Vascularization of normal human thyroid tissue transplanted to nude mice.

  1987cites this paper
• Ocular angiogenesis.

  1986cites this paper
• Modulation of sulfated proteoglycan synthesis by bovine aortic endothelial cells during migration

  1986cites this paper
• A mitogenic factor for endothelial cells obtained from mouse secondary mixed leukocyte cultures.

  1986cites this paper
• Critical factors controlling angiogenesis: cell products, cell matrix, and growth factors.

  1986cites this paper
• Lymphocyte-induced angiogenesis: correlation with the metastatic incidence of two murine mammary adenocarcinomas.

  1986cites this paper
• [Effect of actions inhibiting neovascularization of the metastasis of Lewis lung carcinoma].

  1985cites this paper
• Comparison of the neovascular effects of stimulated macrophages and neutrophils in autologous rabbit corneas.

  1985cites this paper
• Effects of cortisone with and without heparin on angiogenesis induced by prostaglandin e1 and by s180 cells, and on growth of murine transplantable tumours

  1985cites this paper
• Lymphokines induce changes in morphology and enhance motility of endothelial cells.

  1985cites this paper
• Collateral arterial formation. Lymph draining ischemic kidneys contains a neovascular stimulating agent of high molecular weight.

  1985cites this paper
• Human endothelial cell cultures: Phenotypic modulation by leukocyte interleukins

  1985cites this paper
• Evidence that indomethacin inhibits lymphocyte-induced angiogenesis.

  1985cites this paper
• Interspecies chimeras: an experimental approach for studies on embryonic angiogenesis.

  1985cites this paper
• [Regulation of angiogenesis and tumor growth].

  1985cites this paper