Calpain in Breast Cancer: Role in Disease Progression and Treatment Response

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Pathobiology (Basel)

• Publication date

  2015-08-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1159/000430464PMID 26330354
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stress-induced cleavage of Myc promotes cancer cell survival

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• The calpain system and diabetes.

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• Capn4 is a marker of poor clinical outcomes and promotes nasopharyngeal carcinoma metastasis via nuclear factor-κB-induced matrix metalloproteinase 2 expression

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• Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response

  2014cited by this paper
• Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis.

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• The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling.

  2014cited by this paper
• Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer

  2014cited by this paper
• HER2 regulates Brk/PTK6 stability via upregulating calpastatin, an inhibitor of calpain.

  2013cited by this paper
• Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas

  2013cited by this paper
• The genesis and unique properties of the lymphovascular tumor embolus are because of calpain-regulated proteolysis of E-cadherin

  2013cited by this paper
• Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer

  2012cited by this paper
• Calpain system protein expression in basal-like and triple-negative invasive breast cancer

  2012cited by this paper
• Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation

  2012cited by this paper
• Calpain4 is required for activation of HER2 in breast cancer cells exposed to trastuzumab and its suppression decreases survival and enhances response

  2012cited by this paper
• Calpain 2‐dependent IκBα degradation mediates CPT‐11 secondary resistance in colorectal cancer xenografts

  2012cited by this paper
• Calpain 2 Regulates Akt-FoxO-p27Kip1 Protein Signaling Pathway in Mammary Carcinoma*

  2012cited by this paper
• Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla

  2012cited by this paper
• Calpastatin is associated with lymphovascular invasion in breast cancer.

  2011cited by this paper
• Calpain‐1 expression is associated with relapse‐free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy

  2011cited by this paper
• Calpain-mediated Proteolysis of Paxillin Negatively Regulates Focal Adhesion Dynamics and Cell Migration*

  2011cited by this paper
• The calpain system and cancer

  2011cited by this paper
• Suppression of NHE1 by small interfering RNA inhibits HIF-1α-induced angiogenesis in vitro via modulation of calpain activity.

  2011cited by this paper
• Limb-girdle muscular dystrophy 2A.

  2011cited by this paper
• Expanding members and roles of the calpain superfamily and their genetically modified animals.

  2010cited by this paper
• Calpain regulates sensitivity to trastuzumab and survival in HER2-positive breast cancer

  2010cited by this paper
• Investigation of peroxiredoxin IV as a calpain-regulated pathway in cancer.

  2010cited by this paper
• Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in endometrial cancer.

  2010cited by this paper
• Calpain 8/nCL-2 and Calpain 9/nCL-4 Constitute an Active Protease Complex, G-Calpain, Involved in Gastric Mucosal Defense

  2010cited by this paper
• Calpain 2 is Required for Glioblastoma Cell Invasion: Regulation of Matrix Metalloproteinase 2

  2010cited by this paper
• Cell adhesion: integrating cytoskeletal dynamics and cellular tension

  2010cited by this paper
• Novel variants of muscle calpain 3 identified in human melanoma cells: cisplatin-induced changes in vitro and differential expression in melanocytic lesions.

  2009cited by this paper
• Calpain-1 Cleaves and Activates Caspase-7*

  2009cited by this paper
• μ‐Calpain regulates caspase‐dependent and apoptosis inducing factor‐mediated caspase‐independent apoptotic pathways in cisplatin‐induced apoptosis

  2009cited by this paper
• Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains

  2008cited by this paper
• Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion

  2008cited by this paper
• Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis.

  2008cited by this paper
• Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin

  2008cited by this paper
• Calpain-Mediated Signaling Mechanisms in Neuronal Injury and Neurodegeneration

  2008cited by this paper
• OGG1 is degraded by calpain following oxidative stress and cisplatin exposure.

  2008cited by this paper
• Cross-talk between calpain and caspase-3/-7 in cisplatin-induced apoptosis of melanoma cells: a major role of calpain inhibition in cell death protection and p53 status

  2007cited by this paper
• Improved Methods of Detection of Lymphovascular Invasion Demonstrate That It is the Predominant Method of Vascular Invasion in Breast Cancer and has Important Clinical Consequences

  2007cited by this paper
• Hypoxia-induced cell death of HepG2 cells involves a necrotic cell death mediated by calpain

  2007cited by this paper
• Ubiquitous Calpains Promote Both Apoptosis and Survival Signals in Response to Different Cell Death Stimuli*

  2006cited by this paper
• Protein kinase Ciota promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of micro- and m-calpains.

  2006cited by this paper
• Calpain involvement in the remodeling of cytoskeletal anchorage complexes

  2006cited by this paper
• Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia

  2006cited by this paper
• Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis

  2006cited by this paper
• Ubiquitous Calpains Promote Caspase-12 and JNK Activation during Endoplasmic Reticulum Stress-induced Apoptosis*

  2006cited by this paper
• Invadopodia: Specialized Cell Structures for Cancer Invasion

  2006cited by this paper
• Protein Kinase Cι Promotes Nicotine-induced Migration and Invasion of Cancer Cells via Phosphorylation of μ- and m-Calpains*

  2006cited by this paper
• Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype.

  2005cited by this paper
• Four promoters direct expression of the calpastatin gene.

  2005cited by this paper
• Overexpression of m-calpain in human colorectal adenocarcinomas.

  2004cited by this paper
• Expression of calpastatin isoforms in muscle and functionality of multiple calpastatin promoters.

  2004cited by this paper
• Isoform specific function of calpain 2 in regulating membrane protrusion.

  2004cited by this paper
• Degradation of fodrin by m-calpain in fibroblasts adhering to fibrillar collagen I gel.

  2004cited by this paper
• Calpain Mediates Progressive Plasma Membrane Permeability and Proteolysis of Cytoskeleton-Associated Paxillin, Talin, and Vinculin during Renal Cell Death

  2003cited by this paper
• The calpain system.

  2003cited by this paper
• Cyclin E in breast tumors is cleaved into its low molecular weight forms by calpain

  2003cited by this paper
• The Calpastatin-Derived Calpain Inhibitor CP1B Reduces mRNA Expression of Matrix Metalloproteinase-2 and -9 and Invasion by Leukemic THP-1 Cells

  2003cited by this paper
• Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax.

  2003cited by this paper
• MEKK1 regulates calpain‐dependent proteolysis of focal adhesion proteins for rear‐end detachment of migrating fibroblasts

  2003cited by this paper
• Ionomycin-activated Calpain Triggers Apoptosis

  2002cited by this paper
• Calpain is required for MMP-2 and u-PA expression in SV40 large T-antigen-immortalized cells.

  2002cited by this paper
• Cutting to the chase: calpain proteases in cell motility.

  2002cited by this paper
• Her-2/neu overexpression induces NF-κB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IκB-α that can be inhibited by the tumor suppressor PTEN

  2001cited by this paper
• Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.

  2001cited by this paper
• Calpastatin expression in porcine cardiac and skeletal muscle and partial gene structure.

  2001cited by this paper
• Inhibition of rat PC12 cell calpain activity by glutathione, oxidized glutathione and nitric oxide.

  2001cited by this paper
• Membrane Proximal ERK Signaling Is Required for M-calpain Activation Downstream of Epidermal Growth Factor Receptor Signaling*

  2001cited by this paper
• The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.

  2000cited by this paper
• N‐terminal cleavage of Bax by calpain generates a potent proapoptotic 18‐kDa fragment that promotes Bcl‐2‐independent cytochrome C release and apoptotic cell death

  2000cited by this paper
• Four types of calpastatin isoforms with distinct amino-terminal sequences are specified by alternative first exons and differentially expressed in mouse tissues.

  2000cited by this paper
• Direct Cleavage by the Calcium-activated Protease Calpain Can Lead to Inactivation of Caspases*

  2000cited by this paper
• Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines.

  2000cited by this paper
• Structure of mouse calpastatin isoforms: implications of species-common and species-specific alternative splicing.

  1999cited by this paper
• The involvement of calpain-dependent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas

  1999cited by this paper
• Procaspase-3 and poly(ADP)ribose polymerase (PARP) are calpain substrates.

  1999cited by this paper
• Regulation of matrix metalloproteinase expression in tumor invasion

  1999cited by this paper
• Tumor Necrosis Factor-α-inducible IκBα Proteolysis Mediated by Cytosolic m-Calpain

  1999cited by this paper
• Degraded Collagen Fragments Promote Rapid Disassembly of Smooth Muscle Focal Adhesions That Correlates with Cleavage of Pp125FAK, Paxillin, and Talin

  1999cited by this paper
• Expression of calpain I messenger RNA in human renal cell carcinoma: Correlation with lymph node metastasis and histological type

  1999cited by this paper
• Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation.

  1999cited by this paper
• Crystal structure of calpain reveals the structural basis for Ca2+‐dependent protease activity and a novel mode of enzyme activation

  1999cited by this paper
• Rapid degradation of PrxI and PrxII induced by silica in Rat2 cells.

  1999cited by this paper
• The involvement of calpain-independent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas

  1998cited by this paper
• Rat brain contains multiple mRNAs for calpastatin.

  1998cited by this paper
• Bax cleavage is mediated by calpain during drug-induced apoptosis

  1998cited by this paper
• Rat brain contains multiple mRNAs for calpastatin 1

  1998cited by this paper
• Regulation of Cell Migration by the Calcium-dependent Protease Calpain*

  1997cited by this paper
• Proteolysis by calpains: a possible contribution to degradation of p53

  1997cited by this paper
• Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability

  1997cited by this paper
• On the involvement of calpains in the degradation of the tumor suppressor protein p53

  1997cited by this paper
• Possible involvement of calpain in the growth of estrogen receptor positive breast cancer cells.

  1996cited by this paper
• Unphosphorylated and tyrosine‐phosphorylated forms of a focal adhesion protein, paxillin, are substrates for calpain II in vitro: Implications for the possible involvement of calpain II in mitosis‐specific degradation of paxillin

  1994cited by this paper
• Spatial resolution of fodrin proteolysis in postischemic brain.

  1993cited by this paper
• Positive regulation of mu-calpain action by polyphosphoinositides.

  1992cited by this paper
• Calcium-activated neutral protease (calpain) system: structure, function, and regulation.

  1991cited by this paper
• Degradation of transcription factors, c‐Jun and c‐Fos, by calpain

  1991cited by this paper
• Proteolysis of protein kinase C by calpain: effect of acidic phospholipids.

  1991cited by this paper

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• Calpain-mediated Mechanoptosis in Breast Adenocarcinoma.

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• Construction of a prognostic risk assessment model for HER2 + breast cancer based on autophagy-related genes

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• Machine learning assisted analysis of breast cancer gene expression profiles reveals novel potential prognostic biomarkers for triple-negative breast cancer

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• Calpain as a therapeutic target in cancer

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• Calpain-2 regulates hypoxia/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis.

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• MammaPrint and BluePrint comprehensively capture the cancer hallmarks in early‐stage breast cancer patients

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• Enhanced tumor cell killing by ultrasound after microtubule depolymerization

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  2020cites this paper
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• Therapeutic role of recurrent ESR1-CCDC170 gene fusions in breast cancer endocrine resistance

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• Front & Back Matter

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  2019cites this paper
• Calpain Small Subunit 1 Protein in the Prognosis of Cancer Survivors and Its Clinicopathological Correlation

  2019cites this paper
• FRET-Based Assays to Determine Calpain Activity.

  2019cites this paper
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• A framework for transcriptome-wide association studies in breast cancer in diverse study populations

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• Alteration of Androgen Receptor Protein Stability by Triptolide in LNCaP Cells

  2018cites this paper
• An easy-to-use FRET protein substrate to detect calpain cleavage in vitro and in vivo.

  2018cites this paper
• Blocking the Cleavage of Filamin A by Calpain Inhibitor Decreases Tumor Cell Growth.

  2018cites this paper
• New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status

  2018cites this paper
• Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib

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• Cytoplasmic FOXP1 expression is correlated with ER and calpain II expression and predicts a poor outcome in breast cancer

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• Sphingosine 1-phosphate attenuates MMP2 and MMP9 in human anaplastic thyroid cancer C643 cells: Importance of S1P2

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  2017cites this paper
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  2017cites this paper
• Fibronectin induces epithelial-mesenchymal transition in human breast cancer MCF-7 cells via activation of calpain.

  2017cites this paper
• Endogenous Proteases in Tumoral Progression

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• Clinical correlation of calpain-1 and glypican-3 expression with gallbladder carcinoma

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