Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663

BackgroundDifferentiation of the acute myeloid leukemia (AML) cell line HL-60 can be induced by all trans-retinoic acid (ATRA); however, the mechanism regulating this process has not been fully characterized.MethodsUsing bioinformatics and in vitro experiments, we identified the microRNA gene expression profile of HL-60 cells during ATRA induced granulocytic differentiation.ResultsSix microRNAs were upregulated by ATRA treatment, miR-663, miR-494, miR-145, miR-22, miR-363* and miR-223; and three microRNAs were downregulated, miR-10a, miR-181 and miR-612. Additionally, miR-663 expression was regulated by ATRA. We used a lentivirus (LV) backbone incorporating the spleen focus forming virus (SFFV-F) promoter to drive miR-663 expression, as the CMV (Cytomegalovirus) promoter is ineffective in some lymphocyte cells. Transfection of LV-miR-663 induced significant HL-60 cell differentiation in vitro.ConclusionsOur results show miR-663 may play an important role in ATRA induced HL-60 cell differentiation. Lentivirus delivery of miR-663 could potentially be used directly as an anticancer treatment in hematological malignancies

• Publication year

  2011

• Venue

  Journal of Hematology & Oncology

• Publication date

  2011-04-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/1756-8722-4-20PMID 21518431PMCID 3094392
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• miR-1423 p restricts cAMP production in CD 4 þ CD 25 T cells and CD 4 þ CD 25 þ TREG cells by targeting AC 9 mRNA

  2013cited by this paper
• MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2

  2011cited by this paper
• miRNA-21 regulates arsenic-induced anti-leukemia activity in myelogenous cell lines

  2011cited by this paper
• Levels of miR‐29b do not predict for response in patients with acute myelogenous leukemia treated with the combination of 5‐azacytidine, valproic acid, and ATRA

  2011cited by this paper
• Expression profiling of cytogenetically normal acute myeloid leukemia identifies MicroRNAs that target genes involved in monocytic differentiation

  2011cited by this paper
• Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage.

  2011cited by this paper
• MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells.

  2011cited by this paper
• Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrest in human gastric cancer cells.

  2010influential reference
• Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD.

  2010cited by this paper
• Complexity of miR-223 regulation by CEBPA in human AML.

  2010cited by this paper
• miR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and CEBP-β

  2010cited by this paper
• Differential expression of cellular microRNAs in HPV-11 transfected cells. An analysis by three different array platforms and qRT-PCR.

  2010cited by this paper
• [Targeted regulation of mll-af4 fusion gene by miR-142-3p].

  2010cited by this paper
• Modulation of p53, c-fos, RARE, cyclin A, and cyclin D1 expression in human leukemia (HL-60) cells exposed to arsenic trioxide

  2009cited by this paper
• MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation.

  2009cited by this paper
• miR‐142‐3p restricts cAMP production in CD4+CD25− T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA

  2009cited by this paper
• microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification.

  2009cited by this paper
• Nargenicin enhances 1,25-dihydroxyvitamin D(3)- and all-trans retinoic acid-induced leukemia cell differentiation via PKCbetaI/MAPK pathways.

  2009cited by this paper
• Gene expression analysis of human promyelocytic leukemia HL-60 cell differentiation and cytotoxicity induced by natural and synthetic retinoids.

  2009cited by this paper
• Gene expression analysis of human promyelocytic leukemia HL-60 cell differentiation and cytotoxicity induced by natural and synthetic retinoids.

  2009cited by this paper
• All-trans retinoic acid induces different immunophenotypic changes on human HL60 and NB4 myeloid leukaemias.

  2008influential reference
• Differential expression of microRNAs in hematopoietic cell lineages

  2008cited by this paper
• Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein.

  2007cited by this paper
• The role of microRNA and other non-coding RNA in the pathogenesis of chronic lymphocytic leukemia.

  2007cited by this paper
• Hematopoietic-specific microRNA expression in human cells.

  2006cited by this paper
• The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation

  2006cited by this paper
• Ligand-induced Structural Changes of the CD44 Hyaluronan-binding Domain Revealed by NMR*

  2006cited by this paper
• Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181.

  2006cited by this paper
• Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells.

  2004cited by this paper
• Induction of Differentiation in Acute Promyelocytic Leukemia Cells (HL-60) by the Verticillin Derivative Sch 52900

  2002influential reference
• [Induction of cell differentiation and development of new anticancer drugs].

  2002cited by this paper
• Enhanced transgene expression in primitive hematopoietic progenitor cells and embryonic stem cells efficiently transduced by optimized retroviral hybrid vectors

  2002cited by this paper
• Differentiation induction of HL60 cells by 1,25(OH)2D3, all trans retinoic acid, rTGF-beta2 and their combinations.

  1997cited by this paper
• Downregulation of telomerase activity in HL60 cells by differentiating agents is accompanied by increased expression of telomerase‐associated protein

  1997cited by this paper
• The effect of dexamethasone on functional properties of HL60 cells during all-trans retinoic acid induced differentiation. Are there implications for the retinoic acid syndrome?

  1996cited by this paper

• The Influences of RARγ on the Behavior of Normal and Cancer Stem Cells

  2026cites this paper
• MitoBADY-based Raman sensing of neutrophil-like cells

  2024cites this paper
• Dietary modulation of microRNAs in insulin resistance and type 2 diabetes.

  2024cites this paper
• Combinations of grape seed procyanidin extract and milk thistle silymarin extract against lung cancer - The role of Mir-663a and Fhit.

  2023cites this paper
• The emerging role of microRNA-22 in the Leukemia: experimental and clinical implications

  2023cites this paper
• The Therapeutic Potential of a Strategy to Prevent Acute Myeloid Leukemia Stem Cell Reprogramming in Older Patients

  2023cites this paper
• Double-edged sword role of miRNA-633 and miRNA-181 in human cancers.

  2023cites this paper
• Comparative analysis of the effects of retinoic acid versus paclitaxel and everolimus on HL60 cells proliferation and viability

  2023cites this paper
• Choosing the Right Cell Line for Acute Myeloid Leukemia (AML) Research

  2023cites this paper
• Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/PAD4 pathway

  2023cites this paper
• Proteomic approach to investigate the expression, localization, and functions of the protein product of the SOWAHD gene during granulocytic differentiation

  2023cites this paper
• Proteomic Approach to Investigating Expression, Localization, and Functions of the SOWAHD Gene Protein Product during Granulocytic Differentiation

  2023cites this paper
• Nuclear Proteomics of Induced Leukemia Cell Differentiation

  2022cites this paper
• Serum amyloid A1 recruits neutrophils to the invasive front of T1 colorectal cancers

  2022cites this paper
• Nutrients and phytonutrients as promising epigenetic nutraceuticals

  2021cites this paper
• Low Expression of miR-663a Indicates Poor Prognosis and Promotes Cell Proliferation, Migration, and Invasion in Breast Cancer

  2021cites this paper
• Recent Advances in the Development of Exogenous dsRNA for the Induction of RNA Interference in Cancer Therapy

  2021cites this paper
• Plasma microRNAs profiling distinguishes patients with frontotemporal dementia from healthy subjects

  2021cites this paper
• Up-regulated miR-155 is associated with poor prognosis in childhood acute lymphoblastic leukemia and promotes cell proliferation targeting ZNF238

  2020cites this paper
• Metformin Increases the Chemosensitivity of Pancreatic Cancer Cells to Gemcitabine by Reversing EMT Through Regulation DNA Methylation of miR-663

  2020cites this paper
• Intelligent frequency-shifted optofluidic time-stretch quantitative phase imaging.

  2020cites this paper
• All-trans retinoic acid reverses malignant biological behavior of hepatocarcinoma cells by regulating miR-200 family members

  2020cites this paper
• Characterization of iPS87, a prostate cancer stem cell-like cell line

  2020cites this paper
• Nutritive vitamins as epidrugs

  2020cites this paper
• Retinoic acid and microRNA.

  2020cites this paper
• OTT_A_261570 10417..10429

  2020cites this paper
• Discrimination of cell-differentiation using a cell-binding assay based on the conversion of cell-patterns with dielectrophoresis.

  2020cites this paper
• Monoclonal antibody 2C5 specifically targets neutrophil extracellular traps

  2020cites this paper
• Plasma microRNA profiling distinguishes patients with frontotemporal dementia from healthy subjects.

  2019cites this paper
• MicroRNA-663 induces immune dysregulation by inhibiting TGF-β1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus

  2019cites this paper
• MicroRNA and Retinoic Acid.

  2019cites this paper
• Inducible overexpression of zebrafish microRNA-722 suppresses chemotaxis of human neutrophil like cells

  2019cites this paper
• MicroRNA-663 antagonizes apoptosis antagonizing transcription factor to induce apoptosis in epithelial cells

  2019cites this paper
• MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol

  2018cites this paper
• miR-663a inhibits tumor growth and invasion by regulating TGF-β1 in hepatocellular carcinoma

  2018cites this paper
• MicroRNA-663 induces immune dysregulation by inhibiting TGF-β1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus

  2018cites this paper
• microRNA-494 Favors HO-1 Expression in Neuroblastoma Cells Exposed to Oxidative Stress in a Bach1-Independent Way

  2018cites this paper
• MiR-663a/MiR-423-5p are involved in the pathogenesis of lupus nephritis via modulating the activation of NF-κB by targeting TNIP2.

  2017cites this paper
• The over expression of long non-coding RNA ANRIL promotes epithelial-mesenchymal transition by activating the ATM-E2F1 signaling pathway in pancreatic cancer: An in vivo and in vitro study.

  2017cites this paper
• The Association Between Oxidative Stress, Cellular Differentiation And Galectins In Human Promyelocytic Leukemia Cells (HL-60)

  2016cites this paper
• RARα2 and PML-RAR similarities in the control of basal and retinoic acid induced myeloid maturation of acute myeloid leukemia cells

  2016cites this paper
• MicroRNA-663a is downregulated in non-small cell lung cancer and inhibits proliferation and invasion by targeting JunD

  2016cites this paper
• MicroRNA-663 suppresses cell invasion and migration by targeting transforming growth factor beta 1 in papillary thyroid carcinoma

  2016cites this paper
• Current state of phenolic and terpenoidal dietary factors and natural products as non-coding RNA/microRNA modulators for improved cancer therapy and prevention

  2016cites this paper
• Functional analysis of epithelium-specific Ets transcription factor-1 in inflammation

  2016cites this paper
• Natural Epigenetic-Modifying Molecules in Medical Therapy

  2016cites this paper
• The Third Dimension of Genetics: The Role of Spatial Genetics as Revealed by Common Human Variation

  2016cites this paper
• Retraction Note: miR-663 attenuates tumor growth and invasiveness by targeting eEF1A2 in pancreatic cancer

  2015cites this paper
• Interaction of autophagy with microRNAs and their potential therapeutic implications in human cancers.

  2015cites this paper
• De Novo Acute Myeloid Leukemia in Adults: Suppression of MicroRNA-223 is Independent of LMO2 Protein Expression BUT Associate With Adverse Cytogenetic Profile and Undifferentiated Blast Morphology

  2015cites this paper
• Reprimo , is downregulated by promoter hypermethylation in pediatric acute myeloid leukemia

  2015cites this paper
• Retinoic Acid as the Stimulating Factor for Differentiation of Wharton's Jelly-Mesenchymal Stem Cells into Hepatocyte-like Cells

  2015cites this paper
• Circulating microRNA expression profile in B-cell acute lymphoblastic leukemia

  2015cites this paper
• APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation

  2015cites this paper
• Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia

  2015cites this paper
• Hypermethylation of the GATA binding protein 4 (GATA4) promoter in Chinese pediatric acute myeloid leukemia

  2015cites this paper
• miR-663 attenuates tumor growth and invasiveness by targeting eEF1A2 in pancreatic cancer

  2015cites this paper
• Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells

  2015cites this paper
• Aberrant expression of the microRNA cluster in 14q32 is associated with del(5q) myelodysplastic syndrome and lenalidomide treatment.

  2015cites this paper
• tp53-dependent G2 arrest mediator candidate gene, Reprimo, is down-regulated by promoter hypermethylation in pediatric acute myeloid leukemia

  2015cites this paper
• Microfluidic device capable of medium recirculation for non-adherent cell culture.

  2014cites this paper
• The polysaccharides from fermented Ganoderma lucidum mycelia induced miRNAs regulation in suppressed HepG2 cells.

  2014cites this paper
• MicroRNA signatures in subtypes of follicular lymphoma.

  2014cites this paper
• Adhesion of suspension cells on a coverslip in serum-free conditions.

  2014cites this paper
• MicroRNA‐302b‐inhibited E2F3 transcription factor is related to all trans retinoic acid‐induced glioma cell apoptosis

  2014cites this paper
• RARs and microRNAs.

  2014cites this paper
• Downregulation of adenomatous polyposis coli by microRNA-663 promotes odontogenic differentiation through activation of Wnt/beta-catenin signaling.

  2014cites this paper
• Metallothionein III (MT3) is a putative tumor suppressor gene that is frequently inactivated in pediatric acute myeloid leukemia by promoter hypermethylation

  2014cites this paper
• The emerging role of microRNAs and nutrition in modulating health and disease.

  2014cites this paper
• Primate-Specific miR-663 Functions as a Tumor Suppressor by Targeting PIK3CD and Predicts the Prognosis of Human Glioblastoma

  2014cites this paper
• The role of vitamins and minerals in modulating the expression of microRNA

  2014cites this paper
• MicroRNA-663 Regulates Human Vascular Smooth Muscle Cell Phenotypic Switch and Vascular Neointimal Formation

  2013cites this paper
• Acute promyelocytic leukemia mutated to radioresistance suppressed monocyte lineage differentiation by phorbol 12-myristate 13-acetate.

  2013cites this paper
• The promoter of miR-663 is hypermethylated in Chinese pediatric acute myeloid leukemia (AML)

  2013cites this paper
• An MLPA‐Based Strategy for Discrete CNV Genotyping: CNV‐miRNAs as an Example

  2013cites this paper
• The not‐so‐neutral role of microRNAs in neutrophil biology

  2013cites this paper
• MicroRNA-22 Is a Master Regulator of Bone Morphogenetic Protein-7/6 Homeostasis in the Kidney*

  2013cites this paper
• The epigenetically‐regulated miR‐663 targets H‐ras in K‐562 cells

  2013cites this paper
• Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744

  2013influential citation
• Integrated miRNA-mRNA Analysis Revealing the Potential Roles of miRNAs in Chordomas

  2013cites this paper
• MicroRNAs to boost the productivity of Chinese hamster ovary producer cells

  2013cites this paper
• Characterization of MicroRNA Expression Profiles and the Discovery of Novel MicroRNAs Involved in Cancer during Human Embryonic Development

  2013cites this paper
• Diverse functions of miR-125 family in different cell contexts

  2013cites this paper
• MECHANISMS BY WHICH HYPERBARIC OXYGEN THERAPY MAY RESOLVE INFLAMMATION IN CHRONIC WOUNDS

  2013cites this paper
• MicroRNA control of myelopoiesis and the differentiation block in acute myeloid leukaemia

  2012influential citation
• The Critical Role of Redox Homeostasis in Shikonin-Induced HL-60 Cell Differentiation via Unique Modulation of the Nrf2/ARE Pathway

  2012cites this paper
• Inhibition of the ecto-beta subunit of F1F0-ATPase inhibits proliferation and induces apoptosis in acute myeloid leukemia cell lines

  2012cites this paper
• Emerging roles of microRNA-22 in human disease and normal physiology.

  2012cites this paper
• Emerging roles for modulation of microRNA signatures in cancer chemoprevention.

  2012cites this paper
• MicroRNAs as targets for dietary and pharmacological inhibitors of mutagenesis and carcinogenesis.

  2012cites this paper
• Trafficking from the Endoplasmic Reticulum to the Golgi complex and gene expression profiling during the cell stress

  2012cites this paper
• An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma

  2011cites this paper
• ATP synthase ecto-α-subunit: a novel therapeutic target for breast cancer

  2011cites this paper