Mutually exclusive expression of two dominant-negative helix-loop-helix (dnHLH) genes, Id4 and Id3, in the developing brain of the mouse suggests distinct regulatory roles of these dnHLH proteins during cellular proliferation and differentiation of the nervous system.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research

• Publication date

  1995-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 7547505
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3.

  1994cited by this paper
• The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein.

  1994cited by this paper
• Constitutive expression of the Id1 gene impairs mouse B cell development.

  1994cited by this paper
• Posttranscriptional regulation of Id1 activity in cardiac muscle. Alternative splicing of novel Id1 transcript permits homodimerization.

  1994cited by this paper
• Id proteins control growth induction in mammalian cells.

  1994cited by this paper
• Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.

  1994cited by this paper
• HEN1 encodes a 20-kilodalton phosphoprotein that binds an extended E-box motif as a homodimer

  1994cited by this paper
• Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons.

  1993cited by this paper
• An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types.

  1993cited by this paper
• Expression of the helix-loop-helix factor Id during mouse embryonic development.

  1993cited by this paper
• Neuronal expression of regulatory helix-loop-helix factor Id2 gene in mouse.

  1993cited by this paper
• Consequences of heteromeric interactions among helix-loop-helix proteins.

  1993cited by this paper
• Localization of E2A mRNA expression in developing and adult rat tissues.

  1993cited by this paper
• Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system.

  1993cited by this paper
• Regulation of the proneural gene achaete by helix-loop-helix proteins

  1993cited by this paper
• Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system.

  1992cited by this paper
• Mutually exclusive expression of a helix‐loop‐helix gene and N‐myc in human neuroblastomas and in normal development.

  1992cited by this paper
• NSCL-2: a basic domain helix-loop-helix gene expressed in early neurogenesis.

  1992cited by this paper
• Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins.

  1992cited by this paper
• A human Id-like helix-loop-helix protein expressed during early development.

  1992cited by this paper
• Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae.

  1992cited by this paper
• HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma.

  1992cited by this paper
• DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer.

  1992cited by this paper
• The gene for the helix-loop-helix protein, Id, is specifically expressed in neural precursors.

  1992cited by this paper
• Id expression during mouse development: A role in morphogenesis

  1992cited by this paper
• Helix-loop-helix proteins in the regulation of immunoglobulin gene transcription.

  1992cited by this paper
• Inhibition of myeloid differentiation by the helix-loop-helix protein Id.

  1992cited by this paper
• Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins

  1991cited by this paper
• Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells.

  1991cited by this paper
• An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene.

  1991cited by this paper
• Functional characterization of the developmentally controlled immunoglobulin kappa 3' enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors

  1991cited by this paper
• Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo.

  1991cited by this paper
• Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development

  1991cited by this paper
• The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation.

  1990cited by this paper
• The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein.

  1990cited by this paper
• The protein Id: a negative regulator of helix-loop-helix DNA binding proteins.

  1990cited by this paper
• extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins.

  1990cited by this paper
• MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer.

  1989cited by this paper
• A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins.

  1989cited by this paper
• Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence.

  1989cited by this paper
• The achaete-scute gene complex of D. melanogaster: conserved domains in a subset of genes required for neurogenesis and their homology to myc.

  1987cited by this paper
• Expression of a single transfected cDNA converts fibroblasts to myoblasts.

  1987cited by this paper
• Cell-type-specific contacts to immunoglobulin enhancers in nuclei

  1985cited by this paper
• B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo.

  1985cited by this paper

• Alterations in TGFβ signaling during prostate cancer progression.

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• Emerging Roles of Inhibitor of Differentiation-1 in Alzheimer’s Disease: Cell Cycle Reentry and Beyond

  2020cites this paper
• Inhibitor of DNA binding in heart development and cardiovascular diseases

  2019cites this paper
• Id4 functional analysis during neurogenesis using zebrafish as a model organism

  2017influential citation
• Inhibitor of DNA binding 2 is a novel therapeutic target for stemness of head and neck squamous cell carcinoma

  2017cites this paper
• Id-1, Id-2, and Id-3 co-expression correlates with prognosis in stage I and II lung adenocarcinoma patients treated with surgery and adjuvant chemotherapy

  2016cites this paper
• Introduction of ID2 Enhances Invasiveness in ID2-null Oral Squamous Cell Carcinoma Cells via the SNAIL Axis.

  2016cites this paper
• Id4: an inhibitory function in the control of hair cell formation?

  2016cites this paper
• Targeting ID2 expression triggers a more differentiated phenotype and reduces aggressiveness in human salivary gland cancer cells

  2016cites this paper
• The Role of Id2 Protein in Neuroblatoma in Children

  2015cites this paper
• Inhibitor of differentiation 4 (ID4) acts as an inhibitor of ID-1, -2 and -3 and promotes basic helix loop helix (bHLH) E47 DNA binding and transcriptional activity.

  2015cites this paper
• Differential expression of id genes and their potential regulator znf238 in zebrafish adult neural progenitor cells and neurons suggests distinct functions in adult neurogenesis.

  2015cites this paper
• Characterizing the function of transcription factor 15 (Tcf15) in pluripotent cells

  2015cites this paper
• Epigenetic Silencing of ID4 in Prostate Cancer: Mechanistic Insight

  2015cites this paper
• Mecanismos moleculares involucrados en la diferenciación neuronal de células madre mesenquimales humanas derivadas de tejido adiposo

  2014cites this paper
• Changes in the expression of DNA-binding/differentiation protein inhibitors in neurons and glial cells of the gerbil hippocampus following transient global cerebral ischemia

  2014cites this paper
• REGULATION OF MAMMARY GLAND DEVELOPMENT AND TUMORIGENESIS BY 14-3-3 ZETA

  2014cites this paper
• Targeting Id1 reduces proliferation and invasion in aggressive human salivary gland cancer cells

  2013cites this paper
• The expression and roles of Id1 and Id2 in the aggressive phenotype of human oral squamous cell carcinoma cells

  2013cites this paper
• transcriptional inhibitors Id1 and Id2 Differential regulation of granulopoiesis by the basic Helix Loop Helix

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• Inhibitor of DNA binding 4: a novel tumor suppressor gene in prostate cancer

  2012cites this paper
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• The role of the deubiquitinating enzyme CYLD and its substrate BCL-3 in solid tumors

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• Neural Development and Stem Cells

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• Null Mutation of the Transcription Factor Inhibitor of DNA Binding 3 (Id3) Affects Spermatozoal Motility Parameters and Epididymal Gene Expression in Mice1

  2011cites this paper
• ID4 mediates proliferation of astrocytes after excitotoxic damage in the mouse hippocampus

  2011cites this paper
• ID family protein expression and regulation in hypoxic pulmonary hypertension.

  2010cites this paper
• Regulation of retinal progenitor cell differentiation by bone morphogenetic protein 4 is mediated by the smad/id cascade.

  2010cites this paper
• Running heading: ID proteins in hypoxic pulmonary hypertension

  2010cites this paper
• Overexpression of inhibitor of DNA-binding (ID)-1 protein related to angiogenesis in tumor advancement of ovarian cancers

  2009cites this paper
• Expression of the inhibitor of DNA-binding (ID)-1 protein as an angiogenic mediator in tumour advancement of uterine cervical cancers

  2009cites this paper
• Notch signaling in chondrogenesis.

  2009cites this paper
• Molecular regulation of vasculogenic mimicry in human uveal melanoma cells: role of helix–loop–helix Id2 (inhibitor of DNA binding 2)

  2009cites this paper
• Id2, Id3, and Id4 proteins show dynamic changes in expression during vibrissae follicle development

  2008cites this paper
• Molecular Mechanisms in Differentiation - Induction in Acute Promyelocytic Leukemia.

  2008cites this paper
• Notch1, Jagged1, and HES5 Are Abundantly Expressed in Osteoarthritis

  2008cites this paper
• Expression of the inhibitor of DNA-binding (ID)-1 protein as an angiogenic mediator in tumour advancement of uterine cervical cancers

  2008cites this paper
• Detecting genes for developmental dyslexia on chromosome 6p.

  2006cites this paper
• Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2.

  2005cites this paper
• Id4 is required for the correct timing of neural differentiation.

  2005cites this paper
• Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer

  2005cites this paper
• Negative acting HLH proteins Id1, Id2, Id3, and Id4 are expressed in prostate epithelial cells

  2005cites this paper
• Regulation of Cell Differentiation in C 2 C 12 Myoblasts by the ld 3 Helix-Loop-Helix Protein 1

  2005cites this paper
• Overexpression of Id-1 is significantly associated with tumour angiogenesis in human pancreas cancers

  2004cites this paper
• Id-1 expression and cell survival

  2004cites this paper
• Inhibitors of DNA Binding in Neural Cell Proliferation and Differentiation

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• Id proteins in neural cancer.

  2004cites this paper
• Role of Id-2 in the maintenance of a differentiated and noninvasive phenotype in breast cancer cells.

  2003cites this paper
• Noninvasive Phenotype in Breast Cancer Cells Role of Id-2 in the Maintenance of a Differentiated and Updated Version

  2003cites this paper
• Cloning and characterization of Xenopus Id4 reveals differing roles for Id genes.

  2003cites this paper
• Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis

  2003cites this paper
• Regulation of lineage choices during granulopoiesis

  2003cites this paper
• Mechanisms regulating lineage diversity during mammalian cerebral cortical neurogenesis and gliogenesis.

  2002cites this paper
• Role of Id family proteins in growth control

  2002cites this paper
• Gene induction and categorical reprogramming during in vitro human endometrial fibroblast decidualization.

  2001cites this paper
• Id and development

  2001cites this paper
• The Id proteins and angiogenesis

  2001cites this paper
• Reprogramming the expression of categorically related genes during human uterine fibroblast decidualization

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• Hormonal regulation and differential actions of the helix-loop-helix transcriptional inhibitors of differentiation (Id1, Id2, Id3, and Id4) in Sertoli cells.

  2001cites this paper
• Temporal expression of neuronal connexins during hippocampal ontogeny.

  2000cites this paper
• A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells.

  2000cites this paper
• Id genes in nervous system development.

  2000cites this paper
• Area identity shifts in the early cerebral cortex of Emx2−/− mutant mice

  2000cites this paper
• Evidence That Helix-Loop-Helix Proteins Collaborate with Retinoblastoma Tumor Suppressor Protein to Regulate Cortical Neurogenesis

  2000cites this paper
• Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms

  2000cites this paper
• Reciprocal Id expression and myelin gene regulation in Schwann cells.

  1999cites this paper
• Id gene expression as a key mediator of tumor cell biology.

  1999cites this paper
• Differential biological activities of mammalian Id proteins in muscle cells.

  1999cites this paper
• Id4 expression induces apoptosis in astrocytic cultures and is down-regulated by activation of the cAMP-dependent signal transduction pathway.

  1999cites this paper
• Expression of helix–loop–helix type negative regulators of differentiation during limb regeneration in urodeles and anurans

  1999cites this paper
• Id helix-loop-helix proteins in cell growth and differentiation.

  1998cites this paper
• Structure, chromosomal localisation and expression of the murine dominant negative helix-loop-helix Id4 gene.

  1998cites this paper
• A Role for Sp and Helix-Loop-Helix Transcription Factors in the Regulation of the Human Id4 Gene Promoter Activity*

  1998cites this paper
• Stage- and subcellular-specific expression of Id proteins in male germ and Sertoli cells implicates distinctive regulatory roles for Id proteins during meiosis, spermatogenesis, and Sertoli cell function.

  1998cites this paper
• cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene.

  1998cites this paper
• Lymphoid-specific Expression of the Id3 Gene in Hematopoietic Cells

  1998cites this paper
• Expression of the helix‐loop‐helix genes Id‐1 and NSCL‐1 during cerebellar development

  1997influential citation
• A zebrafish Id homologue and its pattern of expression during embryogenesis.

  1997cites this paper
• Each member of the Id gene family exhibits a unique expression pattern in mouse gastrulation and neurogenesis

  1997cites this paper
• Helix‐loop‐helix proteins in Schwann cells: A study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development

  1997cites this paper
• Regulation of cell differentiation in C2C12 myoblasts by the Id3 helix-loop-helix protein.

  1996cites this paper