Overexpression of TFAP2C in invasive breast cancer correlates with a poorer response to anti‐hormone therapy and reduced patient survival

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Pathology

• Publication date

  2009-01-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/path.2430PMID 18825690
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Activator protein‐2 in carcinogenesis with a special reference to breast cancer—A mini review

  2007influential reference
• Wwox and Ap2γ Expression Levels Predict Tamoxifen Response

  2007cited by this paper
• Wwox and Ap2gamma expression levels predict tamoxifen response.

  2007cited by this paper
• Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis.

  2006cited by this paper
• Distinct spatial expression patterns of AP-2alpha and AP-2gamma in non-neoplastic human breast and breast cancer

  2005cited by this paper
• Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer.

  2005cited by this paper
• Acquired resistance to oestrogen deprivation: role for growth factor signalling kinases/oestrogen receptor cross-talk revealed in new MCF-7X model.

  2005cited by this paper
• Transcription factor AP‐2γ, a novel marker of gonocytes and seminomatous germ cell tumors

  2005cited by this paper
• Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: a supporting role to the epidermal growth factor receptor.

  2005cited by this paper
• Transcriptional regulation of metastasis-related genes in human melanoma

  2004cited by this paper
• Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: Inhibition by gefitinib (`Iressa', ZD1839)

  2004cited by this paper
• Activator protein-2gamma (AP-2gamma) expression is specifically induced by oestrogens through binding of the oestrogen receptor to a canonical element within the 5'-untranslated region.

  2004cited by this paper
• Transcription Factor AP-2γ Is a Developmentally Regulated Marker of Testicular Carcinoma In situ and Germ Cell Tumors

  2004cited by this paper
• Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects.

  2004cited by this paper
• Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb.

  2003cited by this paper
• Expression of Tfap2d, the gene encoding the transcription factor Ap-2 delta, during mouse embryogenesis.

  2003cited by this paper
• Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells.

  2003cited by this paper
• Molecular cloning and characterization of AP-2 epsilon, a fifth member of the AP-2 family.

  2003cited by this paper
• Overexpression of transcription factor AP-2alpha suppresses mammary gland growth and morphogenesis.

  2003cited by this paper
• Transcription factor AP-2gamma stimulates proliferation and apoptosis and impairs differentiation in a transgenic model.

  2003cited by this paper
• Elevated expression levels of NCOA3, TOP1, and TFAP2C in breast tumors as predictors of poor prognosis

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  2003cited by this paper
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  2002cited by this paper
• Transcription factor gene AP-2 gamma essential for early murine development.

  2002cited by this paper
• Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development.

  2002cited by this paper
• Reduced nuclear expression of transcription factor AP-2 associates with aggressive breast cancer.

  2002cited by this paper
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  2002cited by this paper
• Endocrine-responsive breast cancer and strategies for combating resistance

  2002cited by this paper
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  2001cited by this paper
• Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex).

  2001cited by this paper
• Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

  2001cited by this paper
• Expression of transcription factor AP-2α predicts survival in epithelial ovarian cancer

  2000cited by this paper
• Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control.

  2000cited by this paper
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  1999cited by this paper
• Immunohistochemical analysis reveals a tumour suppressor‐like role for the transcription factor AP‐2 in invasive breast cancer

  1999influential reference
• Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways.

  1998cited by this paper
• Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta.

  1997cited by this paper
• Five years of tamoxifen--or more?

  1996cited by this paper
• A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma.

  1996cited by this paper
• Transcription factor AP-2 essential for cranial closure and craniofacial development

  1996cited by this paper
• Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2

  1996cited by this paper
• The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma.

  1995cited by this paper
• Immunocytochemical localization of fos protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy

  1994cited by this paper
• Immunocytochemical localization of BCL‐2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy

  1994cited by this paper
• Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. An overview of 61 randomized trials among 28,896 women.

  1989cited by this paper
• Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. An overview of 61 randomized trials among 28,896 women

  1988cited by this paper

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• Discovery of therapeutic targets in cancer using chromatin accessibility and transcriptomic data.

  2024cites this paper
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• Discovery of novel therapeutic targets in cancer using patient-specific gene regulatory networks

  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
• Functional genomics of AP-2α and AP-2γ in cancers: in silico study

  2020cites this paper
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  2020cites this paper
• regSNPs-ASB: A Computational Framework for Identifying Allele-Specific Transcription Factor Binding From ATAC-seq Data

  2020cites this paper
• Indeno[1,2,3-cd]pyrene and picene mediate actions via estrogen receptor α signaling pathway in in vitro cell systems, altering gene expression.

  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
• TransCONFIRM: Identification of a Genetic Signature of Response to Fulvestrant in Advanced Hormone Receptor–Positive Breast Cancer

  2016cites this paper
• Molecular predictors of response to fulvestrant 1 TransCONFIRM : Identification of a genetic signature of response to fulvestrant in advanced hormone receptor positive breast cancer

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  2016cites this paper
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  2016cites this paper
• TFAP2C expression in breast cancer: correlation with overall survival beyond 10 years of initial diagnosis

  2015cites this paper
• Factors Promoting Tamoxifen Resistance in Breast Cancer via Stimulating Breast Cancer Stem Cell Expansion.

  2015cites this paper
• The transcription factor activator protein family of genes in mammary gland development and breast cancer progression

  2015cites this paper
• Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells

  2014cites this paper
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  2014cites this paper
• Estrogen receptor-mediated long-range chromatin interactions and transcription in breast cancer.

  2014cites this paper
• Single-Cell States in the Estrogen Response of Breast Cancer Cell Lines

  2014cites this paper
• High-resolution detection of recurrent aberrations in lung adenocarcinomas by array comparative genomic hybridization and expression analysis of selective genes by quantitative PCR.

  2014cites this paper
• miR-200a inhibits tumor proliferation by targeting AP-2γ in neuroblastoma cells.

  2014cites this paper
• Integrative molecular and functional profiling of ERBB2-amplified breast cancers identifies new genetic dependencies

  2014cites this paper
• TFAP2E hypermethylation was associated with survival advantage in patients with colorectal cancer

  2014cites this paper
• Transcription factor activator protein 2C and downstream redox biology effectors in development and carcinogenesis

  2014cites this paper
• Clinical and molecular evaluation of anti-estrogen therapy resistance in breast cancer. Towards tailored use of anti-estrogens and targeted agents

  2014influential citation
• Pluripotency factors and miRNAs in human ovarian cancer cells and their secreted exosomes regulate gene expression and phenotype

  2014cites this paper
• TFAP2C (transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma))

  2014cites this paper
• Tamoxifen resistance: from bench to bedside.

  2013cites this paper
• Estrogen receptor alpha: Molecular mechanisms and emerging insights

  2013cites this paper
• Hallmarks of aromatase inhibitor drug resistance revealed by epigenetic profiling in breast cancer.

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• Risk score based on expression of AP2-α, CHI3L1 and PBEF1 is a better predictor of prognosis in breast cancer

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  2012cites this paper
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• Atlas of Genetics and Cytogenetics in Oncology and Haematology

  2012cites this paper
• Pioneer factors: directing transcriptional regulators within the chromatin environment.

  2011cites this paper
• AP‐2γ regulates oestrogen receptor‐mediated long‐range chromatin interaction and gene transcription

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• Steroid hormone modulation of RET through two estrogen responsive enhancers in breast cancer.

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  2011cites this paper
• AP‐2γ regulates oestrogen receptor‐mediated long‐range chromatin interaction and gene transcription

  2011cites this paper
• Interference with Activator Protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells

  2010cites this paper
• Regulation of breast tumour cell survival by AP-2 transcription factors

  2010influential citation
• WWOX, tumour suppressor and modifier gene, as a regulator of gene expression and apoptosis in ovarian cancer.

  2010cites this paper
• Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells

  2010cites this paper
• Loss of transcription factor AP‐2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland

  2010cites this paper
• AP‐2γ promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene

  2009influential citation
• Elevated Src kinase activity attenuates tamoxifen response in vitro and is associated with poor prognosis clinically.

  2009cites this paper
• AP-2 c promotes proliferation in breast tumour cells by direct repression of the CDKN 1 A gene

  2009influential citation
• Investigating AP-2 and YY1 protein expression as a cause of high HER2 gene transcription in breast cancers with discordant HER2 gene amplification

  2009cites this paper
• Transcription regulation and candidate diagnostic markers of esophageal cancer

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  2009cites this paper