Steroid hormone modulation of RET through two estrogen responsive enhancers in breast cancer.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Human Molecular Genetics

• Publication date

  2011-07-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/hmg/ddr291PMID 21737465PMCID PMC3168285
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• POSTER PRESENTATION Open Access

  2013cited by this paper
• RET in breast cancer: functional and therapeutic implications.

  2011cited by this paper
• Chromatin accessibility pre-determines glucocorticoid receptor binding patterns

  2011cited by this paper
• Non-cell-autonomous retinoid signaling is crucial for renal development

  2010cited by this paper
• Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer.

  2010cited by this paper
• A CTCF-independent role for cohesin in tissue-specific transcription.

  2010cited by this paper
• Biological reprogramming in acquired resistance to endocrine therapy of breast cancer

  2010cited by this paper
• Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance

  2010cited by this paper
• Cell-type-specific long-range looping interactions identify distant regulatory elements of the CFTR gene

  2010cited by this paper
• Novel gene rearrangements in transformed breast cells identified by high-resolution breakpoint analysis of chromosomal aberrations.

  2010cited by this paper
• Estrogen Receptor Regulates E2F1 Expression to Mediate Tamoxifen Resistance

  2010cited by this paper
• Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells

  2010cited by this paper
• Supplementary information for Integrative model of genomic factors for determining binding site selection by estrogen receptor α

  2010cited by this paper
• Diverse somatic mutation patterns and pathway alterations in human cancers.

  2010cited by this paper
• Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation

  2010cited by this paper
• Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells

  2010influential reference
• Artemin is estrogen regulated and mediates antiestrogen resistance in mammary carcinoma

  2010cited by this paper
• Integrative model of genomic factors for determining binding site selection by estrogen receptor-α

  2010cited by this paper
• Global characterization of transcriptional impact of the SRC-3 coregulator.

  2010influential reference
• Overexpression of TFAP2C in invasive breast cancer correlates with a poorer response to anti‐hormone therapy and reduced patient survival

  2009cited by this paper
• The completion of the Mammalian Gene Collection (MGC).

  2009cited by this paper
• Sexual Dimorphism in Mouse Metanephroi Exposed to 17β-Estradiol in vitro

  2009cited by this paper
• An Oestrogen Receptor α-bound Human Chromatin Interactome

  2009cited by this paper
• Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription.

  2009cited by this paper
• Epistasis between RET and BBS mutations modulates enteric innervation and causes syndromic Hirschsprung disease

  2009cited by this paper
• Functional autonomy of distant-acting human enhancers.

  2009cited by this paper
• Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs)

  2009influential reference
• Genomic antagonism between retinoic acid and estrogen signaling in breast cancer.

  2009influential reference
• ChIP‐Seq of ERα and RNA polymerase II defines genes differentially responding to ligands

  2009cited by this paper
• Asymmetrical distribution of non-conserved regulatory sequences at PHOX2B is reflected at the ENCODE loci and illuminates a possible genome-wide trend

  2009cited by this paper
• Genomic actions of estrogen receptor alpha: what are the targets and how are they regulated?

  2009cited by this paper
• Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b.

  2008cited by this paper
• FoxA1 as a lineage-specific oncogene in luminal type breast cancer.

  2008cited by this paper
• FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription.

  2008cited by this paper
• The Ret receptor tyrosine kinase pathway functionally interacts with the ERalpha pathway in breast cancer.

  2008cited by this paper
• AKT Alters Genome-Wide Estrogen Receptor α Binding and Impacts Estrogen Signaling in Breast Cancer

  2008cited by this paper
• Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

  2007cited by this paper
• A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET/GFR alpha 1 receptor up-regulation in breast cancer.

  2007cited by this paper
• Mechanisms of primary and secondary estrogen target gene regulation in breast cancer cells

  2007cited by this paper
• Whole-Genome Cartography of Estrogen Receptor α Binding Sites

  2007cited by this paper
• Wwox and Ap2γ Expression Levels Predict Tamoxifen Response

  2007cited by this paper
• The RET oncogene is a critical component of transcriptional programs associated with retinoic acid–induced differentiation in neuroblastoma

  2007cited by this paper
• Wwox and Ap2gamma expression levels predict tamoxifen response.

  2007cited by this paper
• Retinoic acid induces functional c-Ret tyrosine kinase in human neuroblastoma

  2007cited by this paper
• Conservation of RET Regulatory Function from Human to Zebrafish Without Sequence Similarity

  2006cited by this paper
• Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approach.

  2006cited by this paper
• Evaluating the biological relevance of putative enhancers using Tol2 transposon-mediated transgenesis in zebrafish

  2006cited by this paper
• Genome-wide analysis of estrogen receptor binding sites

  2006cited by this paper
• A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk

  2005cited by this paper
• TRANSFAC® and its module TRANSCompel®: transcriptional gene regulation in eukaryotes

  2005cited by this paper
• The three 'C' s of chromosome conformation capture: controls, controls, controls

  2005cited by this paper
• MatInspector and beyond: promoter analysis based on transcription factor binding sites

  2005cited by this paper
• Evaluation of the RET regulatory landscape reveals the biological relevance of a HSCR-implicated enhancer.

  2005cited by this paper
• rVISTA 2.0: evolutionary analysis of transcription factor binding sites

  2004cited by this paper
• ACTR/AIB1 Functions as an E2F1 Coactivator To Promote Breast Cancer Cell Proliferation and Antiestrogen Resistance

  2004influential reference
• Vitamin A controls epithelial/mesenchymal interactions through Ret expression

  2001cited by this paper
• Developmental Regulation of the κ Locus Involves Both Positive and Negative Sequence Elements in the 3′ Enhancer That Affect Synergy with the Intron Enhancer*

  1999cited by this paper
• Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse.

  1999cited by this paper
• Regulation of c-ret expression by retinoic acid in rat metanephros: implication in nephron mass control.

  1998cited by this paper
• Expression of neurturin, GDNF, and their receptors in the adult mouse CNS

  1998cited by this paper
• Regulation of c-ret expression by retinoic acid in rat metanephros: implication in nephron mass control.

  1998cited by this paper
• The zebrafish homologue of the ret receptor and its pattern of expression during embryogenesis

  1997influential reference
• Expression of c-ret in the zebrafish embryo: potential roles in motoneuronal development.

  1997cited by this paper
• Development of mammary and cutaneous gland tumors in transgenic mice carrying the RET/PTC1 oncogene.

  1996cited by this paper
• Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC

  1994cited by this paper
• Mutations of the RET proto-oncogene in Hirschsprung's disease

  1994cited by this paper

• Kinase Plasticity in Response to Vandetanib Enhances Sensitivity to Tamoxifen in Estrogen Receptor Positive Breast Cancer

  2025cites this paper
• RET overexpression leads to increased brain metastatic competency in luminal breast cancer

  2024cites this paper
• Enhancer‐activated RET confers protection against oxidative stress to KMT2A‐rearranged acute myeloid leukemia

  2024cites this paper
• REThinking the role of the RET oncogene in breast cancer

  2024cites this paper
• Super-enhancers: drivers of cells' identities and cells' debacles.

  2024cites this paper
• Patient Sex and Origin Influence Distribution of Driver Genes and Clinical Presentation of Paraganglioma

  2024cites this paper
• RET signaling in breast cancer therapeutic resistance and metastasis

  2023cites this paper
• Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views

  2023cites this paper
• Kinome Reprogramming Is a Targetable Vulnerability in ESR1 Fusion-Driven Breast Cancer

  2023cites this paper
• JMJD6 orchestrates a transcriptional program in favor of endocrine resistance in ER+ breast cancer cells

  2022cites this paper
• Super-enhancer-controlled positive feedback loop BRD4/ERα–RET–ERα promotes ERα-positive breast cancer

  2022cites this paper
• RET signaling pathway and RET inhibitors in human cancer

  2022cites this paper
• Building integrative functional maps of gene regulation.

  2022cites this paper
• Evidence for additive and synergistic action of mammalian enhancers during cell fate determination

  2021cites this paper
• Ret Receptor Has Distinct Alterations and Functions in Breast Cancer

  2020cites this paper
• Highly interconnected enhancer communities control lineage-determining genes in human mesenchymal stem cells

  2020cites this paper
• Highly interconnected enhancer communities control lineage-determining genes in human mesenchymal stem cells

  2020cites this paper
• DSCAM-AS1-Driven Proliferation of Breast Cancer Cells Involves Regulation of Alternative Exon Splicing and 3′-End Usage

  2020cites this paper
• RET in breast cancer: pathogenic implications and mechanisms of drug resistance

  2019cites this paper
• Enhancer Interactions in Developmental Gene Regulation

  2019cites this paper
• GDNF and the RET Receptor in Cancer: New Insights and Therapeutic Potential

  2019cites this paper
• Role of Estrogens in the Size of Neuronal Somata of Paravaginal Ganglia in Ovariectomized Rabbits

  2017cites this paper
• ER-positive breast cancer cells are poised for RET-mediated endocrine resistance

  2017cites this paper
• Multiplex Enhancer Interference Reveals Collaborative Control of Gene Regulation by Estrogen Receptor α-Bound Enhancers.

  2017cites this paper
• Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution.

  2016cites this paper
• EGFR Is Regulated by TFAP2C in Luminal Breast Cancer and Is a Target for Vandetanib

  2016cites this paper
• Genetic and epigenetic factors affect RET gene expression in breast cancer cell lines and influence survival in patients

  2016cites this paper
• Molecular genetic investigation of medullary thyroid cancer

  2015cites this paper
• Identifying long-range control elements of the BRCA1 promoter

  2015cites this paper
• 210 Genetic and epigenetic factors affect RET gene expression in breast cancer cell lines and influence survival in patients

  2015influential citation
• The ureteric bud epithelium: Morphogenesis and roles in metanephric kidney patterning

  2015cites this paper
• Receptor Tyrosine Kinase Expression Predicts Response to Sunitinib in Breast Cancer

  2015cites this paper
• The RET Receptor Family

  2015cites this paper
• Inhibition of RET Increases the Efficacy of Antiestrogen and Is a Novel Treatment Strategy for Luminal Breast Cancer

  2014cites this paper
• Expression Variability and Function of the RET Gene in Adult Peripheral Blood Mononuclear Cells

  2014cites this paper
• Distinct Pathways Regulated by RET and Estrogen Receptor in Luminal Breast Cancer Demonstrate the Biological Basis for Combination Therapy

  2014cites this paper
• Cancer Therapy : Preclinical InhibitionofRET Increases theEf fi cacyofAntiestrogenand Is a Novel Treatment Strategy for Luminal Breast Cancer

  2014cites this paper
• Chromosome 21 Scan in Down Syndrome Reveals DSCAM as a Predisposing Locus in Hirschsprung Disease

  2013cites this paper
• Stromal Protein Ecm1 Regulates Ureteric Bud Patterning and Branching

  2013cites this paper
• Long‐range transcriptional regulation of breast cancer genes

  2013influential citation
• Expression of the RET Proto-oncogene Is Regulated by TFAP2C in Breast Cancer Independent of the Estrogen Receptor

  2013cites this paper
• Identification of integrin α3 as a molecular marker of cells undergoing epithelial–mesenchymal transition and of cancer cells with aggressive phenotypes

  2013cites this paper
• GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors.

  2013cites this paper
• Characterising response and resistance mechanisms toFaslodex in breast cancer

  2013cites this paper
• The Contributions of RET Noncoding Variation to Hirschsprung Disease

  2012cites this paper
• Tamoxifen resistance in breast cancer : a proteomic approach

  2012cites this paper