CHFR, a potential tumor suppressor, downregulates interleukin-8 through the inhibition of NF-κB

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Oncogene

• Publication date

  2009-07-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/onc.2009.123PMID 19448676
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• NO-donating aspirin inhibits the activation of NF-kappaB in human cancer cell lines and Min mice.

  2008cited by this paper
• Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma

  2008cited by this paper
• CHFR: A Novel Mitotic Checkpoint Protein and Regulator of Tumorigenesis.

  2008cited by this paper
• A Humanized Tumor Necrosis Factor Receptor 1 (TNFR1)-specific Antagonistic Antibody for Selective Inhibition of Tumor Necrosis Factor (TNF) Action

  2008cited by this paper
• Cytokine-based transformation of immune surveillance into tumor-promoting inflammation

  2008cited by this paper
• The Anti-Proliferative Effects of the CHFR Depend on the Forkhead Associated Domain, but not E3 Ligase Activity Mediated by Ring Finger Domain

  2008influential reference
• Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

  2007cited by this paper
• Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation.

  2007cited by this paper
• Mutation of an IKK phosphorylation site within the transactivation domain of REL in two patients with B-cell lymphoma enhances REL's in vitro transforming activity

  2007cited by this paper
• Integrative genomic approaches identify IKBKE as a breast cancer oncogene.

  2007cited by this paper
• Regulation of the G2–M cell cycle progression by the ERK5–NFκB signaling pathway

  2007cited by this paper
• Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression.

  2007cited by this paper
• Gene amplification and overexpression of PRDM14 in breast cancers.

  2007cited by this paper
• Chfr is required for tumor suppression and Aurora A regulation

  2005cited by this paper
• Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors

  2005cited by this paper
• The role of interleukin-8 in cancer cells and microenvironment interaction.

  2005cited by this paper
• Regulation of NF-κB/Rel by IκB is essential for ascidian notochord formation

  2005cited by this paper
• Regulation of NF-kappaB/Rel by IkappaB is essential for ascidian notochord formation.

  2005cited by this paper
• Mutant human cells with constitutive activation of NF-kappaB.

  2004cited by this paper
• A Xenopus cell-free system for analysis of the Chfr ubiquitin ligase involved in control of mitotic entry.

  2004cited by this paper
• A Xenopus Cell-Free System for Functional Analysis of the Chfr Ubiquitin Ligase Involved in Control of Mitotic Entry

  2004cited by this paper
• PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein

  2004cited by this paper
• Relationship between Urokinase-Type Plasminogen Receptor, Interleukin-8 Gene Expression and Clinicopathological Features in Gastric Cancer

  2004cited by this paper
• Additive interaction of oxaliplatin and 17-allylamino-17-demethoxygeldanamycin in colon cancer cell lines results from inhibition of nuclear factor kappaB signaling.

  2003cited by this paper
• Promyelocytic Leukemia Protein Sensitizes Tumor Necrosis Factor α-Induced Apoptosis by Inhibiting the NF-κB Survival Pathway*

  2003cited by this paper
• Promyelocytic leukemia protein sensitizes tumor necrosis factor alpha-induced apoptosis by inhibiting the NF-kappaB survival pathway.

  2003cited by this paper
• Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer.

  2003cited by this paper
• Epigenetic inactivation of CHFR in human tumors

  2003cited by this paper
• Inactivating I kappa B epsilon mutations in Hodgkin/Reed–Sternberg cells

  2003cited by this paper
• Mutant human cells with constitutive activation of NF-κB

  2003cited by this paper
• NF-κB in cancer: from innocent bystander to major culprit

  2002cited by this paper
• The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition

  2002cited by this paper
• NF-kappaB in cancer: from innocent bystander to major culprit.

  2002cited by this paper
• The p53 Family Member Genes Are Involved in the Notch Signal Pathway*

  2002cited by this paper
• The FHA domain

  2002cited by this paper
• Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63 induces cell cycle arrest and apoptosis in colorectal cancer cell lines: potential application to gene therapy of colorectal cancer

  2001cited by this paper
• PDZ domain-dependent suppression of NF-kappaB/p65-induced Abeta42 production by a neuron-specific X11-like protein.

  2000cited by this paper
• Chfr defines a mitotic stress checkpoint that delays entry into metaphase

  2000cited by this paper
• The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases.

  2000cited by this paper
• PDZ Domain-dependent Suppression of NF-κB/p65-induced Aβ42 Production by a Neuron-specific X11-like Protein*

  2000cited by this paper
• Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IκBα

  1999cited by this paper
• Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.

  1999cited by this paper
• Expression of interleukin‐8 detected by in situ hybridization correlates with worse prognosis in primary cutaneous melanoma

  1999cited by this paper
• Aberrant rel/nfkb genes and activity in human cancer

  1999cited by this paper
• Increasing complexity of Ras signaling

  1998cited by this paper
• Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B

  1995cited by this paper
• The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors.

  1995cited by this paper
• Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma

  1994cited by this paper
• Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.

  1993cited by this paper
• NF-kappa B subunit-specific regulation of the interleukin-8 promoter

  1993cited by this paper
• Interleukin-8 as a macrophage-derived mediator of angiogenesis.

  1992cited by this paper
• Characterization of GRO α, β and γ expression in human colonic tumours: potential significance of cytokine involvement

  1992cited by this paper
• Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene.

  1992cited by this paper
• Characterization of GRO alpha, beta and gamma expression in human colonic tumours: potential significance of cytokine involvement.

  1992cited by this paper
• Activation of interleukin-6 gene expression through the NF-kappa B transcription factor

  1990cited by this paper
• A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family.

  1990cited by this paper

• Metastasis and chemoresistance in breast cancer: Crucial function of ZEB1/2 proteins.

  2025cites this paper
• EagleC: A deep-learning framework for detecting a full range of structural variations from bulk and single-cell contact maps

  2022cites this paper
• CHFR regulates chemoresistance in triple-negative breast cancer through destabilizing ZEB1

  2021cites this paper
• Human papillomavirus-positivity is associated with EREG down-regulation and promoter hypermethylation in head and neck squamous cell carcinoma.

  2020cites this paper
• Epigenetics and the Environment in Airway Disease: Asthma and Allergic Rhinitis.

  2020cites this paper
• chFr promotes the migration of human gastric cancer cells by inducing epithelial-to-mesenchymal transition in a hDac1-dependent manner

  2019cites this paper
• CHFR promotes the migration of human gastric cancer cells by inducing epithelial-to-mesenchymal transition in a HDAC1-dependent manner

  2019cites this paper
• DNA Methylation Research - My Experience in Johns Hopkins University -

  2018cites this paper
• Structural and functional studies on CHFR autoubiquitination

  2018influential citation
• Juntendo Medical Journal

  2018cites this paper
• Upregulation of the checkpoint protein CHFR is associated with tumor suppression in pancreatic cancers

  2017cites this paper
• RNF8 negatively regulates NF-kappaB signaling by targeting IkappaB kinase: implications for the regulation of inflammation signaling.

  2017cites this paper
• Clinicopathological significance of CHFR promoter methylation in gastric cancer: a meta-analysis

  2015cites this paper
• Role of SIRT6 in Chromatin

  2015cites this paper
• Aberrant expression of the CHFR prophase checkpoint gene in human B-cell non-Hodgkin lymphoma.

  2015cites this paper
• Rlim, an E3 ubiquitin ligase, influences the stability of Stathmin protein in human osteosarcoma cells.

  2014cites this paper
• Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism

  2014cites this paper
• Differential DNA methylation profiles of infants exposed to maternal asthma during pregnancy

  2014influential citation
• Epigenetic regulation of airway inflammation in asthma

  2014cites this paper
• CHFR aberrant methylation involves a subset of human lung adenocarcinoma associated with poor clinical outcomes.

  2013cites this paper
• Aggregated Low-Density Lipoprotein Induces LRP1 Stabilization Through E3 Ubiquitin Ligase CHFR Downregulation in Human Vascular Smooth Muscle Cells

  2013cites this paper
• Epigenetic silencing of checkpoint with fork-head associated and ring finger gene expression in esophageal cancer

  2013cites this paper
• Emerging evidence for CHFR as a cancer biomarker: from tumor biology to precision medicine

  2013cites this paper
• (Epi-) genetic profiling of colorectal cancer : prognostic and biological relevance, with emphasis on tumor-hypoxia

  2012cites this paper
• CHFR Protein Regulates Mitotic Checkpoint by Targeting PARP-1 Protein for Ubiquitination and Degradation*

  2012cites this paper
• Gastrointestinal , Hepatobiliary , and Pancreatic Pathology Methylation-Dependent Activation of CDX 1 through NF-B A Link from Inflammation to Intestinal Metaplasia in the Human Stomach

  2012cites this paper
• The diverse and complex roles of NF-κB subunits in cancer

  2012cites this paper
• Methylation-dependent activation of CDX1 through NF-κB: a link from inflammation to intestinal metaplasia in the human stomach.

  2012cites this paper
• Microreviews in Cell and Molecular Biology 2012 CHFR: A Silenced Suppressor Gene

  2012cites this paper
• CHIP functions as a novel suppressor of tumour angiogenesis with prognostic significance in human gastric cancer

  2012cites this paper
• TWEAK and cIAP1 Regulate Myoblast Fusion Through the Noncanonical NF-κB Signaling Pathway

  2012cites this paper
• Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-κB–mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis

  2011cites this paper
• Association of CHFR Promoter Methylation with Disease Recurrence in Locally Advanced Colon Cancer

  2011influential citation
• Regulation and Function of the Mitotic Checkpoint Protein CHFR.

  2011cites this paper
• CHFR hypermethylation and EGFR mutation are mutually exclusive and exhibit contrastive clinical backgrounds and outcomes in non‐small cell lung cancer

  2011cites this paper
• NF-κB and cancer: a paradigm of Yin-Yang.

  2011cites this paper
• Connections between CHFR, the cell cycle, and chemosensitivity: Are they critical in cancer?

  2010cites this paper
• The nuclear signaling of NF-κB: current knowledge, new insights, and future perspectives

  2010cites this paper
• CHFR functions as a ubiquitin ligase for HLTF to regulate its stability and functions.

  2010cites this paper
• KRAB zinc finger protein ZNF382 is a proapoptotic tumor suppressor that represses multiple oncogenes and is commonly silenced in multiple carcinomas.

  2010cites this paper
• Cancer esearch cular and Cellular Pathobiology B Zinc Finger Protein ZNF 382 Is a Proapoptotic Tumor pressor That Represses Multiple Oncogenes and Is R monly Silenced in Multiple Carcinomas

  2010cites this paper
• Emerging Role of Flavonoids in Inhibition of NF-B-Mediated Signaling Pathway : A Review

  2009cites this paper