Regulation of Apobec3F and Human Immunodeficiency Virus Type 1 Vif by Vif-Cul5-ElonB/C E3 Ubiquitin Ligase

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Virology

• Publication date

  2005-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.79.15.9579-9587.2005PMID 16014920PMCID PMC1181563
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Production of Infectious SIVagm from Human Cells Requires Functional Inactivation but Not Viral Exclusion of Human APOBEC3G*

  2005cited by this paper
• The Vif protein of human immunodeficiency virus type 1 is posttranslationally modified by ubiquitin.

  2004cited by this paper
• Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome

  2004cited by this paper
• A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor.

  2004cited by this paper
• Expression of HIV-1 accessory protein Vif is controlled uniquely to be low and optimal by proteasome degradation.

  2004cited by this paper
• Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteines.

  2004cited by this paper
• A Single Amino Acid Determinant Governs the Species-specific Sensitivity of APOBEC3G to Vif Action*

  2004cited by this paper
• A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif).

  2004cited by this paper
• Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation.

  2004influential reference
• Retroviral restriction by APOBEC proteins

  2004cited by this paper
• Ring Finger Protein ZIN Interacts with Human Immunodeficiency Virus Type 1 Vif

  2004cited by this paper
• Inhibition of Hepatitis B Virus Replication by APOBEC3G

  2004cited by this paper
• Cullin‐based ubiquitin ligases: Cul3–BTB complexes join the family

  2004cited by this paper
• APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo.

  2004influential reference
• Cytidine deamination of retroviral DNA by diverse APOBEC proteins.

  2004influential reference
• Human APOBEC3F Is Another Host Factor That Blocks Human Immunodeficiency Virus Type 1 Replication

  2004influential reference
• APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase.

  2004cited by this paper
• A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV‐1 and HIV‐2 Vif proteins

  2004cited by this paper
• A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion.

  2004cited by this paper
• Influence of Primate Lentiviral Vif and Proteasome Inhibitors on Human Immunodeficiency Virus Type 1 Virion Packaging of APOBEC3G

  2004influential reference
• Vif Overcomes the Innate Antiviral Activity of APOBEC3G by Promoting Its Degradation in the Ubiquitin-Proteasome Pathway*

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• Further Investigation of Simian Immunodeficiency Virus Vif Function in Human Cells

  2004cited by this paper
• HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability.

  2003cited by this paper
• DNA deamination mediates innate immunity to retroviral infection.

  2003influential reference
• Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.

  2003influential reference
• The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

  2003influential reference
• Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

  2003influential reference
• The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G.

  2003cited by this paper
• Hypermutation of HIV-1 DNA in the Absence of the Vif Protein

  2003influential reference
• HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation

  2003cited by this paper
• Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex

  2003influential reference
• The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif

  2003cited by this paper
• Real-Time Quantitative PCR

  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• The F‐box protein Skp2 is a ubiquitylation target of a Cul1‐based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts

  2000cited by this paper
• Association of Human Immunodeficiency Virus Type 1 Vif with RNA and Its Role in Reverse Transcription

  2000cited by this paper
• The Abundance of Cell Cycle Regulatory Protein Cdc4p Is Controlled by Interactions between Its F Box and Skp1p

  1999cited by this paper
• SCF and Cullin/Ring H2-based ubiquitin ligases.

  1999cited by this paper
• Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism.

  1999cited by this paper
• Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases.

  1998cited by this paper
• The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.

  1998cited by this paper
• Indicator cell lines for detection of primary strains of human and simian immunodeficiency viruses.

  1997cited by this paper
• Real time quantitative PCR.

  1996cited by this paper

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  2025cites this paper
• Beyond Pathogenesis: The Nematode Immune Network as the Arbiter of a Host–Virus Truce

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• Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway.

  2023cites this paper
• Rabies virus uniquely reprograms the transcriptome of human monocyte-derived macrophages

  2023cites this paper
• APOBEC3B Potently Restricts HIV-2 but Not HIV-1 in a Vif-Dependent Manner

  2021cites this paper
• Specific Deubiquitinating Enzymes Promote Host Restriction Factors Against HIV/SIV Viruses

  2021cites this paper
• Interactions of APOBEC3s with DNA and RNA.

  2021cites this paper
• Orchestrated efforts on host network hijacking: Processes governing virus replication

  2020cites this paper
• Crystal structure of a soluble APOBEC3G variant suggests ssDNA to bind in a channel that extends between the two domains.

  2020cites this paper
• Post-translational modifications inducing proteasomal degradation to counter HIV-1 infection.

  2020cites this paper
• Cullin-RING Ligase 5: Functional characterization and its role in human cancers.

  2020cites this paper
• Cullin RING Ligase 5 (CRL-5): Neddylation Activation and Biological Functions.

  2020cites this paper
• Role of the Ubiquitin Proteasome System (UPS) in the HIV-1 Life Cycle

  2019cites this paper
• Vif-CBFβ interaction is essential for Vif-induced cell cycle arrest.

  2019cites this paper
• HUSH, a Link Between Intrinsic Immunity and HIV Latency

  2019cites this paper
• Ubiquitination and SUMOylation in HIV Infection: Friends and Foes.

  2019cites this paper
• 24 Ubiquitination and SUMOylation in HIV Infection : Friends and Foes

  2019cites this paper
• Molecular Interactions of a DNA Modifying Enzyme APOBEC3F Catalytic Domain with a Single-Stranded DNA.

  2018cites this paper
• Caractérisation et rôle des lymphocytes T CD4+ mémoires SAMHD1low au cours de l'infection par le VIH-1

  2018cites this paper
• Multiple Inhibitory Factors Act in the Late Phase of HIV-1 Replication: a Systematic Review of the Literature

  2018cites this paper
• Proteasomal Degradation Machinery: Favorite Target of HIV-1 Proteins

  2018cites this paper
• HIV-1 Vif's Capacity To Manipulate the Cell Cycle Is Species Specific

  2018cites this paper
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  2017cites this paper
• CUL5 and APOBEC3G Polymorphisms are Partially Implicated in HIV-1 Infection and Antiretroviral Therapy in a Brazilian Population.

  2017cites this paper
• Nuclear localization signal sequence is required for VACM-1/CUL5-dependent regulation of cellular growth

  2017cites this paper
• Molecular Interactions of APOBEC3F Catalytic Domain with a Single-Stranded DNA.

  2017cites this paper
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  2016cites this paper
• Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia

  2016cites this paper
• The role of cullin 5-containing ubiquitin ligases

  2016cites this paper
• The in vitro Biochemical Characterization of an HIV-1 Restriction Factor APOBEC3F: Importance of Loop 7 on Both CD1 and CD2 for DNA Binding and Deamination.

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• Both Rbx1 and Rbx2 exhibit a functional role in the HIV-1 Vif-Cullin5 E3 ligase complex in vitro.

  2015cites this paper
• Identification of a Novel HIV-1 Inhibitor Targeting Vif-dependent Degradation of Human APOBEC3G Protein*

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• HIV-1 Vpr Protein Induces Proteasomal Degradation of Chromatin-associated Class I HDACs to Overcome Latent Infection of Macrophages*

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• Requirement of HIV-1 Vif C-terminus for Vif-CBF-β interaction and assembly of CUL5-containing E3 ligase

  2014cites this paper
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  2014cites this paper
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• Regulation of TRIM E3 Ligases and Cyclophilin A and the impact on HIV-1 replication and pathogenesis.

  2013cites this paper
• Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-β binding to Vif

  2013cites this paper
• the HIV-1 Vif Protein in Living Cells APOBEC3G Impairs the Multimerization of

  2013cites this paper
• Exploring the binding mode of HIV-1 Vif inhibitors by blind docking, molecular dynamics and MM/GBSA

  2013cites this paper
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• Evolution of human immunodeficiency virus type 1 clade C envelope V1-V5 region during disease progression in non-human primate model

  2013cites this paper
• Role of HIV-1 Vif in viral replication : translational regulation of APOBEC3G and RNA chaperone activity

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• Dispersed and Conserved Hydrophobic Residues of HIV-1 Vif Are Essential for CBFβ Recruitment and A3G Suppression

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• CHEMICAL AND BIOMOLECULAR STRUCTURES IN RECOGNITION OF DNA MODIFICATION

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• APOBEC3G Impairs the Multimerization of the HIV-1 Vif Protein in Living Cells

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• Elevated hypermutation levels in HIV-1 natural viral suppressors.

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• Replication by Targeting of the Interaction between Vif and ElonginC

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• The role of Vif oligomerization and RNA chaperone activity in HIV-1 replication.

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• Suppression of HIV-1 Infection by APOBEC3 Proteins in Primary Human CD4+ T Cells Is Associated with Inhibition of Processive Reverse Transcription as Well as Excessive Cytidine Deamination

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• HIV-2 viral protein X (Vpx) ubiquitination is dispensable for ubiquitin ligase interaction and effects on macrophage infection.

  2012cites this paper
• Characterization of the Interaction of Full-Length HIV-1 Vif Protein with its Key Regulator CBFβ and CRL5 E3 Ubiquitin Ligase Components

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• Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Targeting the Interaction between Vif and ElonginC

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• On the solution conformation and dynamics of the HIV-1 viral infectivity factor.

  2011cites this paper
• Expression of APOBEC3G/3F and G-to-A Hypermutation Levels in HIV-1-Infected Children with Different Profiles of Disease Progression

  2011cites this paper
• The Role of Elongin BC-Containing Ubiquitin Ligases

  2011cites this paper
• HIV-1 Replication in Human Cells Expressing APOBEC1 from Small Animal Species

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• A3G complexes: A novel role of A3G in restricting the late steps of HIV-1 replication

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• HIV-1 Vif Interaction with APOBEC3 Deaminases and its Characterization by a New Sensitive Assay

  2011cites this paper
• APOBEC3F and APOBEC3G Inhibit HIV-1 DNA Integration by Different Mechanisms

  2010cites this paper
• Regulation of HIV-1 infection in cells derived from purified CD34+ cells through manipulation of APOBEC3G expression.

  2010cites this paper
• Reconstitution and Characterization of Human Endogenous Retrovirus-K

  2010influential citation
• Innate Immune Signaling Induces High Levels of TC-specific Deaminase Activity in Primary Monocyte-derived Cells through Expression of APOBEC3A Isoforms*

  2010cites this paper
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  2010cites this paper
• Dual role of host cell factors in HIV-1 replication: restriction and enhancement of the viral cycle.

  2010cites this paper
• Identification of Two APOBEC3F Splice Variants Displaying HIV-1 Antiviral Activity and Contrasting Sensitivity to Vif*

  2010cites this paper
• Polyubiquitination of APOBEC3G Is Essential for Its Degradation by HIV-1 Vif

  2010cites this paper
• APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4+ T-cell counts and plasma viral load

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• Towards Inhibition of Vif-APOBEC3G Interaction: Which Protein to Target?

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• Identification of Specific Determinants of Human APOBEC3F, APOBEC3C, and APOBEC3DE and African Green Monkey APOBEC3F That Interact with HIV-1 Vif

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  2009cites this paper
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• Host restriction of HIV-1 by APOBEC3 and viral evasion through Vif.

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