Biliverdin protects against polymicrobial sepsis by modulating inflammatory mediators.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  American Journal of Physiology - Gastrointestinal and Liver Physiology

• Publication date

  2006-04-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1152/AJPGI.00152.2005PMID 16537973
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium.

  2004cited by this paper
• IκB-kinaseβ-dependent NF-κB activation provides radioprotection to the intestinal epithelium

  2004cited by this paper
• Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.

  2004cited by this paper
• Active Repression of Antiapoptotic Gene Expression by RelA(p65) NF-κB

  2004cited by this paper
• RelA life and death decisions.

  2004cited by this paper
• Pyrrolidine dithiocarbamate attenuates the development of organ failure induced by zymosan in mice

  2003cited by this paper
• Suppression of Inflammatory Cytokine Production by Carbon Monoxide Involves the JNK Pathway and AP-1*

  2003cited by this paper
• The problems and challenges of immunotherapy in sepsis.

  2003cited by this paper
• Protective role of heme oxygenase-1 in the intestinal tissue injury in an experimental model of sepsis

  2003cited by this paper
• Heme oxygenase-1: unleashing the protective properties of heme.

  2003cited by this paper
• Different Faces of the Heme-Heme Oxygenase System in Inflammation

  2003cited by this paper
• Inhaled carbon monoxide suppresses the development of postoperative ileus in the murine small intestine.

  2003cited by this paper
• Induction of heme-oxygenase 1 inhibits endothelial cell activation by endotoxin and oxidant stress.

  2003cited by this paper
• Carbon monoxide modulates endotoxin-induced production of granulocyte macrophage colony-stimulating factor in macrophages.

  2002cited by this paper
• Interleukin‐10 differently regulates monocyte chemoattractant protein‐1 gene expression depending on the environment in a human monoblastic cell line, UG3

  2002cited by this paper
• Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis.

  2002cited by this paper
• Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice

  2002cited by this paper
• Heme Degradation and Human Disease: Diversity Is the Soul of Life

  2002cited by this paper
• MCP-1 causes leukocyte recruitment and subsequently endotoxemic ileus in rat.

  2002cited by this paper
• Monitoring changes in gene expression in renal ischemia-reperfusion in the rat.

  2002cited by this paper
• Heme Oxygenase-1-derived Carbon Monoxide Requires the Activation of Transcription Factor NF-κB to Protect Endothelial Cells from Tumor Necrosis Factor-α-mediated Apoptosis*

  2002cited by this paper
• Differential induction of heme oxygenase-1 in macrophages and hepatocytes during acetaminophen-induced hepatotoxicity in the rat: effects of hemin and biliverdin.

  2002cited by this paper
• Protective Effect of Bilirubin in Ischemia-Reperfusion Injury in the Rat Intestine

  2002cited by this paper
• Cyclosporin A treatment modulates cytokine mRNA expression by inflammatory cells extracted from the spinal cord of rats with experimental autoimmune encephalomyelitis induced by inoculation with myelin basic protein.

  2001cited by this paper
• Upregulation of iNOS by COX-2 in muscularis resident macrophage of rat intestine stimulated with LPS.

  2001cited by this paper
• Effect of bilirubin in ischemia/reperfusion injury on rat small intestine.

  2001cited by this paper
• Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

  2001cited by this paper
• Possible new role for NF-kappaB in the resolution of inflammation.

  2001cited by this paper
• Possible new role for NF-κB in the resolution of inflammation

  2001cited by this paper
• Heme oxygenase: colors of defense against cellular stress.

  2000cited by this paper
• Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods.

  2000cited by this paper
• Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts

  2000cited by this paper
• Heme oxygenase-1 inhibits TNF-alpha-induced apoptosis in cultured fibroblasts.

  2000cited by this paper
• Interleukin 10 gene transfer prevents experimental colitis in rats

  2000cited by this paper
• Immediate-early MEK-1-dependent Stabilization of Rat Smooth Muscle Cell Cyclooxygenase-2 mRNA by Gαq-coupled Receptor Signaling*

  2000cited by this paper
• Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(-/-) mice and intestinal inflammation.

  2000cited by this paper
• Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

  2000cited by this paper
• Induction of heme oxygenase-1 can act protectively against cardiac ischemia/reperfusion in vivo.

  2000cited by this paper
• Effects of inflammatory mediators on gut sensitivity.

  1999cited by this paper
• LPS-induced muscularis macrophage nitric oxide suppresses rat jejunal circular muscle activity.

  1999cited by this paper
• Biphasic response to gut manipulation and temporal correlation of cellular infiltrates and muscle dysfunction in rat.

  1999cited by this paper
• Chemokines in the Inflammatory Bowel Diseases

  1999cited by this paper
• Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1–deficient Mice

  1998cited by this paper
• Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus.

  1998cited by this paper
• Leukocytes of the intestinal muscularis: their phenotype and isolation

  1998cited by this paper
• Identification of an inhibitor targeting macrophage production of monocyte chemoattractant protein-1 as TGF-beta 1.

  1997cited by this paper
• The heme oxygenase system: a regulator of second messenger gases.

  1997cited by this paper
• Lipopolysaccharide activates the muscularis macrophage network and suppresses circular smooth muscle activity.

  1997cited by this paper
• Interleukin 10 reduces mortality from severe peritonitis in mice

  1995cited by this paper
• Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts.

  1994cited by this paper
• Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation.

  1994cited by this paper
• Sepsis and its complications: the clinical problem.

  1994cited by this paper
• Interleukin 10 protects mice from lethal endotoxemia

  1993cited by this paper
• Cytokine serum level during severe sepsis in human IL-6 as a marker of severity.

  1992cited by this paper
• Effect of nitric oxide on circular muscle of the canine small intestine.

  1991cited by this paper
• IL-10 inhibits cytokine production by activated macrophages.

  1991cited by this paper
• Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes

  1991cited by this paper
• Molecular cloning of rat monocyte chemoattractant protein-1 (MCP-1) and its expression in rat spleen cells and tumor cell lines.

  1991cited by this paper
• Laboratory models of sepsis and septic shock.

  1990cited by this paper
• Bilirubin is an antioxidant of possible physiological importance.

  1987cited by this paper
• Accurate measurement of intestinal transit in the rat.

  1981cited by this paper
• Sepsis and septic shock--a review of laboratory models and a proposal.

  1980cited by this paper

• Causal association analysis between blood metabolomes and osteopenia and therapeutic target prediction for mechanomedicine

  2025cites this paper
• Candidiasis in breast cancer: Tumor progression or not?

  2024cites this paper
• Biliverdin as a disease-modifying agent: An integrated viewpoint.

  2023cites this paper
• Challenges and opportunities in the islet transplantation microenvironment: a comprehensive summary of inflammatory cytokine, immune cells, and vascular endothelial cells

  2023cites this paper
• A Novel Derivative of Curcumol, HCL-23, Inhibits the Malignant Phenotype of Triple-Negative Breast Cancer and Induces Apoptosis and HO-1-Dependent Ferroptosis

  2023cites this paper
• Mesobiliverdin IXα ameliorate DSS-induced colitis by inhibiting inflammation and oxidative stress in mice

  2023cites this paper
• Harnessing large language models (LLMs) for candidate gene prioritization and selection

  2023cites this paper
• Mesobiliverdin IXα-enriched microalgae feed additive eliminates reliance on antibiotic tylosin to promote intestinal health of weaning piglets.

  2023cites this paper
• Non-invasive In Vivo Brain Astrogenesis and Astrogliosis Quantification Using a Far-red E2-Crimson Transgenic Reporter Mouse

  2022cites this paper
• Bile pigments in emergency and critical care medicine

  2022influential citation
• Commentary: Risk stratification in infective endocarditis: The emerging role of the liver-heart-kidney axis.

  2022cites this paper
• Photomedicine based on heme-derived compounds.

  2022cites this paper
• Effects of Mesobiliverdin IXα-Enriched Microalgae Feed on Gut Health and Microbiota of Broilers

  2021cites this paper
• NDT_A_300773 1165..1181

  2021cites this paper
• Heme oxygenase-1, carbon monoxide, and malaria – The interplay of chemistry and biology

  2021cites this paper
• Biliverdin Protects Against Cerebral Ischemia/Reperfusion Injury by Regulating the miR-27a-3p/Rgs1 Axis

  2021cites this paper
• Biliverdin and bilirubin sulfonate inhibit monosodium urate induced sterile inflammation in the rat.

  2020cites this paper
• The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19)

  2020cites this paper
• Hemin reduces postoperative ileus in a heme oxygenase 1‐dependent manner while dimethyl fumarate does without heme oxygenase 1‐induction

  2020cites this paper
• Microcins in Enterobacteriaceae: Peptide Antimicrobials in the Eco-Active Intestinal Chemosphere

  2019cites this paper
• HO-1 and CD39: It Takes Two to Protect the Realm

  2019cites this paper
• Heme oxygenase, bilirubin and vascular dysfunction. Studies in humans with the metabolic syndrome and type 2 diabetes mellitus

  2019cites this paper
• Effect of conjugated bilirubin on clinical outcomes in infective endocarditis

  2019cites this paper
• Heme‐Derived Bilins

  2019cites this paper
• Reporter Cell Assessment of TLR4-Induced NF-κB Responses to Cell-Free Hemoglobin and the Influence of Biliverdin

  2019cites this paper
• The Immune Functions of α1 Acid Glycoprotein.

  2019cites this paper
• Immune challenges decrease biliverdin concentration in the spleen of northern Bobwhite quail, Colinus virginianus

  2018cites this paper
• Host heme oxygenase‐1: Friend or foe in tackling pathogens?

  2018influential citation
• Bilirubin coating attenuates the inflammatory response to everolimus-coated stents.

  2018cites this paper
• Biliverdin administration ameliorates cerebral ischemia reperfusion injury in rats and is associated with proinflammatory factor downregulation

  2017cites this paper
• Die Fragmentierung der Extrazellulären Matrix als lokaler Trigger für den postoperativen Ileus

  2017influential citation
• Heme Oxygenases in Cardiovascular Health and Disease.

  2016cites this paper
• The antibacterial effects of bilirubin on gram-negative bacterial agents of sepsis.

  2016cites this paper
• Quantifying biliverdin in liver and spleen samples from multiple avian species

  2016cites this paper
• A Role for Heme oxygenase-1 in Embryonic Development

  2015cites this paper
• Scalable bio-production of high value products in bacteria

  2015cites this paper
• Effects of Achyranthoside C Dimethyl Ester on Heme Oxygenase-1 Expression and NO Production

  2015cites this paper
• Prevention of inflammatory cellular responses by ethanol and hemin interplay between inflammasomes and processes inhibiting inflammation

  2015influential citation
• Biliverdin reductase: a target for cancer therapy?

  2015cites this paper
• Preclinical Studies Suggest Complex Nutraceutical Strategies May Have Potential for Preventing and Managing Sepsis.

  2015cites this paper
• Crocin Suppresses LPS-Stimulated Expression of Inducible Nitric Oxide Synthase by Upregulation of Heme Oxygenase-1 via Calcium/Calmodulin-Dependent Protein Kinase 4

  2014cites this paper
• Endogenous Tetrapyrroles Influence Leukocyte Responses to Lipopolysaccharide in Human Blood: Pre-Clinical Evidence Demonstrating the Anti-Inflammatory Potential of Biliverdin

  2014influential citation
• Role of bile pigments in critical care medicine

  2014cites this paper
• CONNECTION BETWEEN MARKERS OF CHOLESTASIS AND INTENSITY OF OXIDATIVE MODIFICATION OF PROTEINS IN PATIENTS WITH CHOLEDOCHOLITHIASIS

  2014cites this paper
• Protective Effect of Adenoviral Transfer of Heme Oxygenase-1 Gene on Rats With Severe Acute Pancreatitis

  2014cites this paper
• Heme oxygenase system and hypertension: a comprehensive insight.

  2014cites this paper
• The Multifunctional Role and Therapeutic Potential of HO-1 in the Vascular Endothelium

  2014cites this paper
• Anti-Inflammatory and Cell Signalling Effects of Biliverdin and Biliverdin Reductase

  2014influential citation
• MiR-204/miR-211 downregulation contributes to candidemia-induced kidney injuries via derepression of Hmx1 expression.

  2014cites this paper
• Therapeutic efficacy of naringin on cyclosporine (A) induced nephrotoxicity in rats: Involvement of hemeoxygenase-1

  2013cites this paper
• Review article: carbon monoxide in gastrointestinal physiology and its potential in therapeutics

  2013cites this paper
• Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1

  2013cites this paper
• Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1.

  2013cites this paper
• Prolonged treatment with transcutaneous electrical nerve stimulation (TENS) modulates neuro-gastric motility and plasma levels of vasoactive intestinal peptide (VIP), motilin and interleukin-6 (IL-6) in systemic sclerosis.

  2013cites this paper
• Mesobiliverdin IXα Enhances Rat Pancreatic Islet Yield and Function

  2013cites this paper
• Intestinal Protective Effects of Herbal-Based Formulations in Rats against Neomycin Insult

  2013cites this paper
• Omega-3 Polyunsaturated Fatty Acids Delay the Progression of Endotoxic Shock-Induced Myocardial Dysfunction

  2013cites this paper
• Anti-inflammatory Effect of Achyranthoside E Dimethyl Ester in LPS-stimulated RAW 264.7 Cells

  2013cites this paper
• Scalable production of biliverdin IXα by Escherichia coli

  2012cites this paper
• Achyranthes japonica exhibits anti-inflammatory effect via NF-κB suppression and HO-1 induction in macrophages.

  2012cites this paper
• Iatrogenic extracellular matrix disruption as a local trigger for postoperative ileus.

  2012cites this paper
• Go Green: The Anti-Inflammatory Effects of Biliverdin Reductase

  2012cites this paper
• Heme Cytotoxicity and the Pathogenesis of Immune-Mediated Inflammatory Diseases

  2012cites this paper
• Transforming growth factor‐β1 suppression of endotoxin‐induced heme oxygenase‐1 in macrophages involves activation of Smad2 and downregulation of Ets‐2

  2012cites this paper
• The Activity of SV40 Promoter Can Be Inhibited by Overexpression of Heme Oxygenase-1 in Tumor Cells

  2012cites this paper
• Role of interleukin‐6 in hemopoietic and non‐hemopoietic synergy mediating TLR4‐triggered late murine ileus and endotoxic shock1

  2012cites this paper
• Hemin induction of HO-1 protects against LPS-induced septic ileus.

  2012influential citation
• Antioxidant potential of different melatonin-loaded nanomedicines in an experimental model of sepsis

  2012cites this paper
• A Cre‐reporter transgenic mouse expressing the far‐red fluorescent protein Katushka

  2011cites this paper
• Clinical potential of phycocyanobilin for induction of T regulatory cells in the management of inflammatory disorders.

  2011cites this paper
• Bile pigment pharmacokinetics and absorption in the rat: therapeutic potential for enteral administration

  2011cites this paper
• Pretreatment with bilirubin protects islet against oxidative injury during isolation and purification.

  2011cites this paper
• Nutritional stimulation of the autonomic nervous system.

  2011cites this paper
• Immune response and tissue cytoprotection: two sides of the same coin in immunopathology

  2011cites this paper
• Anti‐inflammatory role of glycine in reducing rodent postoperative inflammatory ileus

  2011cites this paper
• A new role for myeloid HO-1 in the innate to adaptive crosstalk and immune homeostasis.

  2011cites this paper
• Die Hemin-Induktion von HO-1 schützt gegen den Sepsis-induzierten Ileus

  2010cites this paper
• Metabolism of haem in Caco‐2 cells

  2010cites this paper
• Candida albicans heme oxygenase and its product CO contribute to pathogenesis of candidemia and alter systemic chemokine and cytokine expression.

  2010cites this paper
• Mechanisms of cell protection by heme oxygenase-1.

  2010cites this paper
• Bilirubin protects grafts against nonspecific inflammation-induced injury in syngeneic intraportal islet transplantation

  2010cites this paper
• A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders.

  2010cites this paper
• Heme oxygenase-1 in tumor biology and therapy.

  2010cites this paper
• Determinants of outcome in critically ill patients

  2010cites this paper
• Myocardial dysfunction in early state of endotoxemia role of heme-oxygenase-1.

  2010cites this paper
• Heme oxygenase-1: from biology to therapeutic potential.

  2009cites this paper
• Role of interleukin 10 in murine postoperative ileus

  2009cites this paper
• High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice.

  2009cites this paper
• INTERACTION OF HEMORRHAGIC SHOCK AND SUBSEQUENT POLYMICROBIAL SEPSIS ON GASTROINTESTINAL MOTILITY

  2009cites this paper
• Role of haem oxygenase‐1 in microbial host defence

  2009cites this paper
• Involvement of Heme Oxygenase-1 in Kaempferol-Induced Anti-Allergic Actions in RBL-2H3 Cells

  2009cites this paper
• Carbon monoxide is a poison... to microbes! CO as a bactericidal molecule.

  2009cites this paper
• Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells

  2009cites this paper
• BMP6 attenuates oxidant injury in HK-2 cells via Smad-dependent HO-1 induction.

  2009cites this paper
• The Role of Nrf2 in Cellular Innate Immune Response to Inflammatory Injury

  2009cites this paper
• Divergent Cardiopulmonary Actions of Heme Oxygenase Enzymatic Products in Chronic Hypoxia

  2009cites this paper
• Carbon Monoxide-releasing Antibacterial Molecules Target Respiration and Global Transcriptional Regulators*

  2009cites this paper
• Heme Oxygenase-1 Is a Critical Regulator of Nitric Oxide Production in Enterohemorrhagic Escherichia coli-Infected Human Enterocytes

  2008cites this paper
• The role of heme oxygenase-1 in T cell-mediated immunity: the all encompassing enzyme.

  2008cites this paper
• Heme Oxygenase-1 Is a Critical Regulator of Nitric Oxide Production in Enterohemorrhagic Escherichia coli-Infected Human Enterocytes1

  2008cites this paper