Metastasis: new perspectives on an old problem

Many hypotheses have been postulated to explain the intricate nature of the metastatic process, but none of them completely accounted for the actual biological and clinical observations. Consequently, metastasis still remains an open issue with only few metastasis-inducing proteins experimentally validated so far. Recently proposed novel metastatic model, where serial and parallel metastatic processes are adequately integrated, might help to bridge the current gap between experimental results and clinical observations. In addition, the identification, isolation and molecular characterization of cancer stem cells, a population of the cells within the tumour mass able to proliferate, self-renew and induce tumorigenesis, will shed new light on the complex molecular events mediating metastasis, invasion and resistance to therapy. Understanding the molecular basis of these tumour characteristics will usher in a new age of individualized cancer therapy. In this review article, we will provide a current overview of molecular mechanisms underpinning metastasis, and discuss recent findings in this field obtained by global molecular profiling strategies such as proteomics.

• Publication year

  2011

• Venue

  Molecular Cancer

• Publication date

  2011-02-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/1476-4598-10-22PMID 21342498PMCID 3052211
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 1H-NMR-based metabolomics of tumor tissue for the metabolic characterization of rat hepatocellular carcinoma formation and metastasis

  2011cited by this paper
• Exploring disease through metabolomics.

  2010cited by this paper
• Quantitative proteomic profiling studies of pancreatic cancer stem cells.

  2010cited by this paper
• Activity-based protein profiling for biochemical pathway discovery in cancer

  2010cited by this paper
• Metabolomic Changes Accompanying Transformation and Acquisition of Metastatic Potential in a Syngeneic Mouse Mammary Tumor Model*

  2010cited by this paper
• Five serum proteins identified using SELDI-TOF-MS as potential biomarkers of gastric cancer.

  2010cited by this paper
• Identification of cell surface glycoprotein markers for glioblastoma-derived stem-like cells using a lectin microarray and LC-MS/MS approach.

  2010cited by this paper
• Profiling protein markers associated with lymph node metastasis in prostate cancer by DIGE-based proteomics analysis.

  2010cited by this paper
• Neoplastic stem cells: current concepts and clinical perspectives.

  2010cited by this paper
• Identification of metastasis associated proteins in human lung squamous carcinoma using two-dimensional difference gel electrophoresis and laser capture microdissection.

  2009cited by this paper
• Identification of metastasis-associated proteins involved in gallbladder carcinoma metastasis by proteomic analysis and functional exploration of chloride intracellular channel 1.

  2009cited by this paper
• Cancer stem cell: implications in cancer biology and therapy with special reference to lung cancer.

  2009influential reference
• Association of Breast Cancer Stem Cells Identified by Aldehyde Dehydrogenase 1 Expression with Resistance to Sequential Paclitaxel and Epirubicin-Based Chemotherapy for Breast Cancers

  2009cited by this paper
• Activity-based protein profiling of protein tyrosine phosphatases.

  2009cited by this paper
• Discovery of metastasis-associated biomarkers in ovarian cancer using SELDI-TOF: An in vitro and clinical study

  2009cited by this paper
• Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53‐Mediated Apoptosis and Acquiring a Stem‐Like Phenotype in Ovarian Cancer Cells

  2009cited by this paper
• Metabolic profiling reveals key metabolic features of renal cell carcinoma

  2009cited by this paper
• Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

  2009cited by this paper
• Latent bone metastasis in breast cancer tied to Src-dependent survival signals.

  2009cited by this paper
• Regulation of in situ to invasive breast carcinoma transition.

  2008cited by this paper
• The epithelial-mesenchymal transition generates cells with properties of stem cells.

  2008cited by this paper
• The premetastatic niche

  2008cited by this paper
• Systemic spread is an early step in breast cancer.

  2008cited by this paper
• SELDI-TOF MS profiling of serum for detection of laryngeal squamous cell carcinoma and the progression to lymph node metastasis

  2008cited by this paper
• Cancer-cell fusion with migratory bone-marrow-derived cells as an explanation for metastasis: new therapeutic paradigms.

  2008cited by this paper
• Application of activity-based probes to the study of enzymes involved in cancer progression.

  2008cited by this paper
• Does ionizing radiation stimulate cancer invasion and metastasis?

  2008cited by this paper
• Cancer stem cells: the seeds of metastasis?

  2008cited by this paper
• Colorectal cancer progression correlates with upregulation of S100A11 expression in tumor tissues

  2008cited by this paper
• Mechanisms of metastasis

  2008cited by this paper
• Surface-enhanced laser desorption/ionization time-of-flight proteomic profiling of breast carcinomas identifies clinicopathologically relevant groups of patients similar to previously defined clusters from cDNA expression

  2008cited by this paper
• Discovery and identification of Serum Amyloid A protein elevated in lung cancer serum

  2007cited by this paper
• Genetic determinants of cancer metastasis

  2007influential reference
• Mediators of vascular remodelling co-opted for sequential steps in lung metastasis

  2007cited by this paper
• Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

  2007cited by this paper
• Overexpression of CLIC1 in human gastric carcinoma and its clinicopathological significance

  2007influential reference
• Determination of metastasis‐associated proteins in non‐small cell lung cancer by comparative proteomic analysis

  2007influential reference
• Cancer stem cells: an old idea--a paradigm shift.

  2006cited by this paper
• Postoperative serum proteomic profiles may predict metastatic relapse in high-risk primary breast cancer patients receiving adjuvant chemotherapy

  2006cited by this paper
• Proteomic analysis on metastasis-associated proteins of human hepatocellular carcinoma tissues

  2006cited by this paper
• Cancer Transcriptomics: Modeling metastasis

  2006cited by this paper
• An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling.

  2006cited by this paper
• Preparing the "soil": the premetastatic niche.

  2006cited by this paper
• Potentiation of neuroblastoma metastasis by loss of caspase-8

  2006cited by this paper
• Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) for determining prognosis in advanced stage hormone relapsing prostate cancer

  2006cited by this paper
• Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

  2006cited by this paper
• Profiling cancer stem cells using protein array technology.

  2006cited by this paper
• Establishment of serum protein pattern for screening colorectal cancer using SELDI-TOF-MS.

  2006cited by this paper
• Genes that mediate breast cancer metastasis to lung

  2005cited by this paper
• Use of Reverse Phase Protein Microarrays and Reference Standard Development for Molecular Network Analysis of Metastatic Ovarian Carcinoma*

  2005cited by this paper
• Molecular requirements for epithelial-mesenchymal transition during tumor progression.

  2005cited by this paper
• Tumour stem cells and drug resistance

  2005cited by this paper
• Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF‐1–CXCR4 Axis

  2005cited by this paper
• Tumour-cell fusion as a source of myeloid traits in cancer.

  2005cited by this paper
• Opinion: the origin of the cancer stem cell: current controversies and new insights.

  2005influential reference
• The origin of the cancer stem cell: current controversies and new insights

  2005cited by this paper
• Proteomic analysis of human breast cancer tissue with laser-capture microdissection and reverse-phase protein microarrays.

  2004cited by this paper
• Use of proteomic analysis to monitor responses to biological therapies

  2004cited by this paper
• Identification of human brain tumour initiating cells

  2004cited by this paper
• Tumor-Associated Endothelial Cells with Cytogenetic Abnormalities

  2004cited by this paper
• Intravital imaging of cell movement in tumours

  2003cited by this paper
• Molecular markers in ductal carcinoma in situ of the breast.

  2003cited by this paper
• Gene expression profiles of human breast cancer progression

  2003cited by this paper
• Proteomic analysis of hematopoietic stem cell-like fractions in leukemic disorders

  2003cited by this paper
• Genome-wide analysis of organ-preferential metastasis of human small cell lung cancer in mice.

  2003cited by this paper
• High-level expression of cutaneous fatty acid-binding protein in prostatic carcinomas and its effect on tumorigenicity

  2003cited by this paper
• A multigenic program mediating breast cancer metastasis to bone.

  2003influential reference
• Stem cells in normal breast development and breast cancer

  2003cited by this paper
• Evidence emerges for early metastasis and parallel evolution of primary and metastatic tumors.

  2003cited by this paper
• From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression

  2003cited by this paper
• Genetic background is an important determinant of metastatic potential

  2003cited by this paper
• Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

  2003cited by this paper
• A molecular signature of metastasis in primary solid tumors

  2003cited by this paper
• MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis.

  2002cited by this paper
• Epithelial–mesenchymal transitions in tumour progression

  2002cited by this paper
• Molecular portraits and the family tree of cancer

  2002cited by this paper
• Gene expression profiling of lymphoid malignancies.

  2002cited by this paper
• A gene-expression signature as a predictor of survival in breast cancer.

  2002cited by this paper
• Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness

  2002cited by this paper
• Gene expression profiling predicts clinical outcome of breast cancer

  2002cited by this paper
• A progression puzzle.

  2002cited by this paper
• Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

  2001cited by this paper
• Human cutaneous fatty acid-binding protein induces metastasis by up-regulating the expression of vascular endothelial growth factor gene in rat Rama 37 model cells.

  2001cited by this paper
• Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front

  2001cited by this paper
• Early cancer cell dissemination and late metastatic relapse: clinical reflections and biological approaches to the dormancy problem in patients.

  2001cited by this paper
• Stem cells, cancer, and cancer stem cells

  2001cited by this paper
• Involvement of chemokine receptors in breast cancer metastasis

  2001cited by this paper
• Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

  2000cited by this paper
• A spontaneous murine melanoma lung metastasis comprised of host x tumor hybrids.

  2000cited by this paper
• Molecular portraits of human breast tumours

  2000cited by this paper
• Evaluation of the clonal relationship between primary and metastatic renal cell carcinoma by comparative genomic hybridization.

  1999cited by this paper
• Comparative genomic hybridization analysis of primary colorectal carcinomas and their synchronous metastases

  1999cited by this paper
• Genetic alterations in primary bladder cancers and their metastases.

  1998cited by this paper
• Cytogenetic comparison of primary tumors and lymph node metastases in breast cancer patients

  1998cited by this paper
• Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer.

  1997cited by this paper
• Sisters of mercy.

  1993cited by this paper
• Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice.

  1992cited by this paper
• Metastatic inefficiency.

  1990cited by this paper
• Production of a more aggressive tumor cell variant by spontaneous fusion of two mouse tumor subpopulations.

  1989cited by this paper
• Dynamic heterogeneity and metastasis

  1984cited by this paper

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• Optimizing rWTC-MBTA Vaccine Formulations, Dosing Regimens, and Cryopreservation Techniques to Enhance Anti-Metastatic Immunotherapy

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• Impact of hypoxia on the molecular content of glioblastoma-derived exosomes

  2024cites this paper
• Diagnostic Value and Molecular Function of MicroRNAs in Endometrial Diseases: A Systematic Review

  2024cites this paper
• Invasive FoxM1 phosphorylated by PLK1 induces the polarization of tumor-associated macrophages to promote immune escape and metastasis, amplified by IFITM1

  2023cites this paper
• Use of Arabidopsis thaliana as a model to understand specific carcinogenic events: Comparison of the molecular machinery associated with cancer-hallmarks in plants and humans.

  2023cites this paper
• Yulangsan polysaccharide inhibits epithelial-mesenchymal transition and invasion in NSCLC by attenuating the TGF-β1/ERK signaling pathway.

  2023cites this paper
• High expression of E2F transcription factors 7: An independent predictor of poor prognosis in patients with lung adenocarcinoma

  2022cites this paper
• Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis.

  2022cites this paper
• Antigen presentation and interferon signatures in B cells driven by localized ablative cancer immunotherapy correlate with extended survival

  2022cites this paper
• KPNA2 promotes renal cell carcinoma proliferation and metastasis via NPM

  2021cites this paper
• Oligometastases in head and neck carcinoma and their impact on management

  2021cites this paper
• The Anticancer Effects of Flavonoids through miRNAs Modulations in Triple-Negative Breast Cancer

  2021cites this paper
• Store Operated Calcium Entry in Cell Migration and Cancer Metastasis

  2021cites this paper
• Lovastatin Inhibits EMT and Metastasis of Triple-Negative Breast Cancer Stem Cells Through Dysregulation of Cytoskeleton-Associated Proteins

  2021cites this paper
• Recent Advances on Immune Targeted Therapy of Colorectal Cancer Using bi-Specific Antibodies and Therapeutic Vaccines

  2021cites this paper
• Long noncoding RNA lnc‐ABCA12‐3 promotes cell migration, invasion, and proliferation by regulating fibronectin 1 in esophageal squamous cell carcinoma

  2020cites this paper
• The Role of Bone Stem Cell Niches in Bone Metastasis

  2020cites this paper
• Nanomaterial-Based Tumor Photothermal Immunotherapy

  2020cites this paper
• Antineoplastic potential and chemical evaluation of essential oils from leaves and flowers of Tagetes ostenii Hicken.

  2020cites this paper
• Molecular mechanisms and clinical management of cancer bone metastasis

  2020cites this paper
• Nutraceuticals and Metastasis Development

  2020cites this paper
• Resveratrol inhibits ACHN cells via regulation of histone acetylation

  2020cites this paper
• Probing Cancer metastasis at a single-cell level by Raman-functionalized anionic probe.

  2020cites this paper
• Combination of Human Umbilical Vein Endothelial Cell Vaccine and Docetaxel Generates Synergistic Anti-Breast Cancer Effects

  2019cites this paper
• Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets

  2019cites this paper
• Amyloid β precursor protein silencing attenuates epithelial-mesenchymal transition of nasopharyngeal carcinoma cells via inhibition of the MAPK pathway

  2019cites this paper
• NETO2 promotes pancreatic cancer cell proliferation, invasion and migration via activation of the STAT3 signaling pathway

  2019cites this paper
• Upregulated RACK1 attenuates gastric cancer cell growth and epithelial–mesenchymal transition via suppressing Wnt/β-catenin signaling

  2019cites this paper
• LINC01503 promotes cell proliferation, invasion and EMT process in cholangio-carcinoma.

  2019cites this paper
• Novel 1,8-Naphthyridine Derivatives: Design, Synthesis and in vitro screening of their cytotoxic activity against MCF7 cell line

  2019cites this paper
• Upregulated RACK1 attenuates gastric cancer cell growth and epithelial – mesenchymal transition via suppressing Wnt/ β -catenin signaling

  2019cites this paper
• NETO2 promotes pancreatic cancer cell proliferation, invasion and migration via activation of the STAT3 signaling pathway

  2019cites this paper
• miRNA-205-5p functions as a tumor suppressor by negatively regulating VEGFA and PI3K/Akt/mTOR signaling in renal carcinoma cells

  2019cites this paper
• Nanotechnology-based photoimmunological therapies for cancer.

  2019cites this paper
• miR‑584‑5p regulates migration and invasion in non‑small cell lung cancer cell lines through regulation of MMP‑14.

  2019cites this paper
• GPER Mediates a Feedforward FGF2/FGFR1 Paracrine Activation Coupling CAFs to Cancer Cells toward Breast Tumor Progression

  2019cites this paper
• Hypoxia-Regulated miR-146a Targets Cell Adhesion Molecule 2 to Promote Proliferation, Migration, and Invasion of Clear Cell Renal Cell Carcinoma

  2018cites this paper
• Combination therapy of hepatocellular carcinoma by DNA shuffling-based VEGF vaccine and doxorubicin.

  2018cites this paper
• miR‐190 promotes HCC proliferation and metastasis by targeting PHLPP1

  2018cites this paper
• High NUCB2 expression level is associated with metastasis and may promote tumor progression in colorectal cancer

  2018cites this paper
• Up-regulated expression of CD147 gene in malignant bone tumor and the possible induction mechanism during osteoclast formation

  2018cites this paper
• Non-Coding RNAs in Endometrial Physiopathology

  2018cites this paper
• AP-2β inhibits hepatocellular carcinoma invasion and metastasis through Slug and Snail to suppress epithelial-mesenchymal transition

  2018cites this paper
• Novel Cancer Stem Marker and Its Applicability for Grading Primary Human Gliomas

  2018cites this paper
• Synthesis and molecular docking study of new benzofuran and furo[3,2-g]chromone-based cytotoxic agents against breast cancer and p38α MAP kinase inhibitors.

  2018cites this paper
• Long Noncoding RNA XIST Regulates miR-137–EZH2 Axis to Promote Tumor Metastasis in Colorectal Cancer

  2018cites this paper
• MicroRNA-30a-5p inhibits gallbladder cancer cell proliferation, migration and metastasis by targeting E2F7

  2018cites this paper
• Two tandem repeats of mHSP70407–426 enhance therapeutic antitumor effects of a recombined vascular endothelial growth factor (VEGF) protein vaccine

  2018cites this paper
• Functional SNP in microRNA‐491‐5p binding site of MMP9 3′‐UTR affects cancer susceptibility

  2018cites this paper
• Targeted inhibition of tumor survival, metastasis and angiogenesis by Acacia ferruginea mediated regulation of VEGF, inflammatory mediators, cytokine profile and inhibition of transcription factor activation

  2018cites this paper
• (EMT) phenotype of CTCs from the peripheral blood and distant metastasis in patients with non-small cell lung cancer (NSCLC). Expression of EMT markers in CTCs from a cohort

  2018cites this paper
• Knockdown of SNHG12 suppresses tumor metastasis and epithelial-mesenchymal transition via the Slug/ZEB2 signaling pathway by targeting miR-218 in NSCLC

  2018cites this paper
• Targeting tumour metastasis: the emerging role of nanotechnology.

  2018cites this paper
• Epithelial‑mesenchymal transition phenotype of circulating tumor cells is associated with distant metastasis in patients with NSCLC.

  2018cites this paper
• The Effect of LncRNA H19/miR-194-5p Axis on the Epithelial-Mesenchymal Transition of Colorectal Adenocarcinoma

  2018cites this paper
• Glycosylation and metastases

  2018cites this paper
• Gene expression profile analysis of the bone microenvironment in patients with spinal metastases

  2017cites this paper
• Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression

  2017cites this paper
• Overexpression of stromal interaction molecule 1 may promote epithelial-mesenchymal transition and indicate poor prognosis in gastric cancer

  2017cites this paper
• Downregulation of miR-218 contributes to epithelial–mesenchymal transition and tumor metastasis in lung cancer by targeting Slug/ZEB2 signaling

  2017cites this paper
• MiR-30b-5p functions as a tumor suppressor in cell proliferation, metastasis and epithelial-to-mesenchymal transition by targeting G-protein subunit α-13 in renal cell carcinoma.

  2017cites this paper
• Long noncoding RNA XIST expedites metastasis and modulates epithelial–mesenchymal transition in colorectal cancer

  2017cites this paper
• BMI-1 is a potential therapeutic target in diffuse intrinsic pontine glioma

  2017cites this paper
• miR-141 Inhibits Proliferation and Migration of Colorectal Cancer SW480 Cells.

  2017cites this paper
• MicroRNA-20a contributes to cisplatin-resistance and migration of OVCAR3 ovarian cancer cell line.

  2017cites this paper
• SSeCKS/AKAP12 scaffolding functions suppress B16F10-induced peritoneal metastasis by attenuating CXCL9/10 secretion by resident fibroblasts

  2017cites this paper
• The PIAS3-Smurf2 sumoylation pathway suppresses breast cancer organoid invasiveness

  2017cites this paper
• Cancer Bioinformatics for Updating Anticancer Drug Developments and Personalized Therapeutics.

  2017cites this paper
• NF-κB as the main node of resistance to receptor tyrosine kinase inhibitors in triple-negative breast cancer

  2017cites this paper
• Dp103 in Egyptian Patients with Breast Cancer: Prognosis to Lymph Node Metastasis

  2017cites this paper
• The Molecular Connections between Lung and Pancreatic Cancer Metastases: are we not seeing the Forest for the Trees?

  2017influential citation
• Benzofuran-2-acetic ester derivatives induce apoptosis in breast cancer cells by upregulating p21Cip/WAF1 gene expression in p53-independent manner.

  2017cites this paper
• Ellagic acid inhibits human glioblastoma growth in vitro and in vivo.

  2017influential citation
• MicroRNA-200c suppresses cell growth and metastasis by targeting Bmi-1 and E2F3 in renal cancer cells

  2017cites this paper
• Survival of breast cancer patients according to changes in expression of selected markers between primary tumor and lymph node metastases.

  2016cites this paper
• Multicolor Immunofluorescent Imaging of Complex Cellular Mixtures on Micropallet Arrays Enables the Identification of Single Cells of Defined Phenotype

  2016cites this paper
• Clinical significance of epithelial-mesenchymal transition and cancer stem cells.

  2016cites this paper
• A Combined Phagocytosis and Fluorescent Substrate Degradation Assay to Simultaneously Assess Cell Migration and Substrate Degradation.

  2016cites this paper
• miR-32 inhibits proliferation, epithelial–mesenchymal transition, and metastasis by targeting TWIST1 in non-small-cell lung cancer cells

  2016cites this paper
• Role of CD15 and CD15s in the cellular mechanisms of cancer cell metastasis from lung to the brain

  2016cites this paper
• Gene expression profiling of tumor-initiating stem cells from mouse Krebs-2 carcinoma using a novel marker of poorly differentiated cells

  2016cites this paper
• Anti-leukemic, anti-lung, and anti-breast cancer potential of the microbial polyketide 2, 4-diacetylphloroglucinol (DAPG) and its interaction with the metastatic proteins than the antiapoptotic Bcl-2 proteins

  2016cites this paper
• LncRNA MALAT1 exerts oncogenic functions in lung adenocarcinoma by targeting miR-204.

  2016cites this paper
• Anti-metastatic effect of the TM4SF5-specific peptide vaccine and humanized monoclonal antibody on colon cancer in a mouse lung metastasis model

  2016cites this paper
• Molecular Mechanisms of Bone Metastasis.

  2016cites this paper
• Ligand-activated PPARγ downregulates CXCR4 gene expression through a novel identified PPAR response element and inhibits breast cancer progression

  2016cites this paper
• InCVAX--a novel strategy for treatment of late-stage, metastatic cancers through photoimmunotherapy induced tumor-specific immunity.

  2015cites this paper
• The genetic basis of intradural spinal tumors and its impact on clinical treatment.

  2015cites this paper
• MiR-324-5p Suppresses Hepatocellular Carcinoma Cell Invasion by Counteracting ECM Degradation through Post-Transcriptionally Downregulating ETS1 and SP1

  2015cites this paper
• MicroRNA-429 suppresses cell proliferation, epithelial-mesenchymal transition, and metastasis by direct targeting of BMI1 and E2F3 in renal cell carcinoma.

  2015cites this paper
• Expression and Function of Phosphodiesterase Type 5 in Human Breast Cancer Cell Lines and Tissues: Implications for Targeted Therapy

  2015cites this paper
• Targeting FoxM1 inhibits proliferation, invasion and migration of nasopharyngeal carcinoma through the epithelial‑to-mesenchymal transition pathway.

  2015cites this paper
• High Expression of GRP78 Promotes Invasion and Metastases in Patients with Esophageal Squamous Cell Carcinoma

  2015cites this paper
• Phosphodiesterase Type 5 as a Candidate Therapeutic Target in Cancers

  2015cites this paper
• Mechanisms of Tumor Metastasis in the Orbit

  2015cites this paper
• The role of miRNAs in endometrial cancer.

  2015cites this paper
• miR-134 Functions as a Tumor Suppressor in Cell Proliferation and Epithelial-to-Mesenchymal Transition by Targeting KRAS in Renal Cell Carcinoma Cells

  2015cites this paper
• miR-4792 inhibits epithelial-mesenchymal transition and invasion in nasopharyngeal carcinoma by targeting FOXC1.

  2015cites this paper