The role of Notch signaling during hematopoietic lineage commitment

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Immunological Reviews

• Publication date

  2002-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1034/j.1600-065X.2002.18706.xPMID 12366683
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Notch1 Perturbation of Hemopoiesis Involves Non-Cell- Autonomous Modifications

  2002cited by this paper
• Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome.

  2002cited by this paper
• Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.

  2002cited by this paper
• Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.

  2002cited by this paper
• γ-Secretase inhibitors repress thymocyte development

  2001cited by this paper
• A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer.

  2001cited by this paper
• Gamma -secretase inhibitors repress thymocyte development.

  2001cited by this paper
• Presenilin-dependent gamma-secretase activity modulates thymocyte development.

  2001cited by this paper
• Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus

  2001cited by this paper
• Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development

  2001cited by this paper
• Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1.

  2001cited by this paper
• Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation

  2001cited by this paper
• Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength.

  2001cited by this paper
• Presenilin-dependent γ-secretase activity modulates thymocyte development

  2001cited by this paper
• Evidence That γδ versus αβ T Cell Fate Determination Is Initiated Independently of T Cell Receptor Signaling

  2001cited by this paper
• The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells

  2000cited by this paper
• Notch signalling via RBP‐J promotes myeloid differentiation

  2000cited by this paper
• Notch1 Deficiency Dissociates the Intrathymic Development of Dendritic Cells and T Cells

  2000cited by this paper
• Lck activity controls CD4/CD8 T cell lineage commitment.

  2000cited by this paper
• Dll4, a novel Notch ligand expressed in arterial endothelium.

  2000cited by this paper
• Cutting Edge: An Essential Role for Notch-1 in the Development of Both Thymus-Independent and -Dependent T Cells in the Gut1

  2000cited by this paper
• Notch signal transduction: a real rip and more.

  2000cited by this paper
• Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells.

  2000cited by this paper
• The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

  2000cited by this paper
• Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes.

  2000cited by this paper
• Notch signaling in T cell development.

  2000cited by this paper
• Notch signaling: cell fate control and signal integration in development.

  1999cited by this paper
• Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development.

  1999cited by this paper
• Linked Suppression in Peripheral T Cell Tolerance to the House Dust Mite Derived Allergen Der p 1

  1999cited by this paper
• Contact-dependent inhibition of cortical neurite growth mediated by notch signaling.

  1999cited by this paper
• Notch Signaling : Cell Fate Control and Signal Integration in Development

  1999cited by this paper
• Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics.

  1999cited by this paper
• Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.

  1999cited by this paper
• Alpha beta/gamma delta lineage commitment in the thymus of normal and genetically manipulated mice.

  1999cited by this paper
• Deficient T cell fate specification in mice with an induced inactivation of Notch1.

  1999cited by this paper
• Notch‐1 inhibits apoptosis in murine erythroleukemia cells and is necessary for differentiation induced by hybrid polar compounds

  1999cited by this paper
• Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

  1999cited by this paper
• Notch1-Induced Delay of Human Hematopoietic Progenitor Cell Differentiation Is Associated With Altered Cell Cycle Kinetics

  1999cited by this paper
• The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1.

  1998cited by this paper
• The αβ versus γδ T-cell lineage choice

  1998cited by this paper
• The Notch1 receptor is cleaved constitutively by a furin-like convertase.

  1998cited by this paper
• Modulators of Notch signaling.

  1998cited by this paper
• The role of the T‐cell receptor (TCR) in αβ/γδ lineage commitment: clues from intracellular TCR staining

  1998cited by this paper
• The alpha beta versus gamma delta T-cell lineage choice.

  1998cited by this paper
• Events that regulate differentiation of αβ TCR+and γδ TCR+T cells from a common precursor

  1997cited by this paper
• Identification of clonogenic common lymphoid progenitors in mouse bone marrow.

  1997cited by this paper
• Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

  1997cited by this paper
• Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane.

  1997cited by this paper
• Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc.

  1997cited by this paper
• Notch activity influences the alphabeta versus gammadelta T cell lineage decision.

  1997cited by this paper
• Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina.

  1997cited by this paper
• Fringe modulates Notch–ligand interactions

  1997cited by this paper
• Events that regulate differentiation of alpha beta TCR+ and gamma delta TCR+ T cells from a common precursor.

  1997cited by this paper
• Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo.

  1997cited by this paper
• An activated form of Notch influences the choice between CD4 and CD8 T cell lineages.

  1996cited by this paper
• Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene.

  1996cited by this paper
• Inhibition of granulocytic differentiation by mNotch1.

  1996cited by this paper
• Jagged2: a serrate-like gene expressed during rat embryogenesis.

  1996cited by this paper
• Neurogenic genes and vertebrate neurogenesis.

  1996cited by this paper
• Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta.

  1995cited by this paper
• Notch signaling.

  1995cited by this paper
• Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta

  1995cited by this paper
• Jagged: a mammalian ligand that activates Notch1.

  1995cited by this paper
• A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors.

  1994cited by this paper
• fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development.

  1994cited by this paper
• The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium.

  1994cited by this paper
• Cloning, analysis, and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch.

  1993cited by this paper
• Motch A and motch B--two mouse Notch homologues coexpressed in a wide variety of tissues.

  1993cited by this paper
• Notch2: a second mammalian Notch gene.

  1992cited by this paper
• Expression analysis of a Notch homologue in the mouse embryo.

  1992cited by this paper
• The Drosophila RBP-J kappa gene encodes the binding protein for the immunoglobulin J kappa recombination signal sequence.

  1991cited by this paper
• A homolog of Drosophila Notch expressed during mammalian development.

  1991cited by this paper
• deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster.

  1990cited by this paper
• Character Changes Caused by Mutation of an Entire Region of a Chromosome in Drosophila.

  1919cited by this paper

• Notch Signaling as a Regulator of the Tumor Immune Response: To Target or Not To Target?

  2018cites this paper
• Novel TCR-Mediated Mechanisms of Notch Activation and Signaling

  2018cites this paper
• JAG2 signaling induces differentiation of CD14+ monocytes into Langerhans cell histiocytosis‐like cells

  2018cites this paper
• A Review of Notch Processing With New Insights Into Ligand-Independent Notch Signaling in T-Cells

  2018cites this paper
• Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesis.

  2015cites this paper
• Aanmaak van T-cellen tegen tumor-specifieke antigenen : Analyse van de autoreactiviteit van in vitro gematureerde T-cellen

  2014influential citation
• Technical Advance: Ascorbic acid induces development of double‐positive T cells from human hematopoietic stem cells in the absence of stromal cells

  2014cites this paper
• Determining Lineage Fate, Survival and Proliferation of Differentiating Thymocytes: Interplay between Notch, TCR, PI3K and MAPK Pathways

  2013cites this paper
• Notch signaling and its emerging role in autoimmunity

  2013cites this paper
• The Use of In Vitro Three-Dimensional System for Studying Breast Cancer and Preventing Agents

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• stem cells by Delta-like 1 in vitro Induction of T-cell development from human cord blood hematopoietic

  2013cites this paper
• NOTCH PRODUCES A DEREGULATION OF CXCR4/SDF-1A CHEMOKINE SIGNALING IN MULTIPLE MYELOMA CELLS

  2013cites this paper
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• Novel findings on the impact of HIV infection: Interplay between T cell development and peripheral T cell homeostasis

  2011influential citation
• Roles of O-fucose Molecules in Notch Signaling and Hematopoiesis

  2011cites this paper
• Die Rolle des Notch-Signalweges für die Modulation inflammatorischer T-Zell-Reaktionen

  2010cites this paper
• Estrogen-induced breast cancer is the result of disruption of asymmetric cell division of the stem cell

  2010cites this paper
• Dissecting Human NK Cell Development and Differentiation

  2010cites this paper
• The Pathophysiologic Role of the Bone Marrow Environment and its Niches in Multiple Myeloma

  2010cites this paper
• Activated notch supports development of cytokine producing NK cells which are hyporesponsive and fail to acquire NK cell effector functions.

  2009cites this paper
• Notch Increases T/NK Potential of Human Hematopoietic Progenitors and Inhibits B Cell Differentiation at a Pro‐B Stage

  2009cites this paper
• Bone marrow microenvironment and the identification of new targets for myeloma therapy

  2009cites this paper
• The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development

  2008cites this paper
• Generation of pro-T cells in vitro: potential for immune reconstitution.

  2007cites this paper
• In Vitro Models of Human T Cell Development: Dishing Out Progenitor T Cells

  2007cites this paper
• The role of Drosophila sumo conjugating enzyme lesswright in larval hematopoiesis : effects on cactus, dorsal and dorsal-related immunity factor (DIF).

  2007cites this paper
• Regulation of functional phenotypes of cord blood derived eosinophils by gamma-secretase inhibitor.

  2007cites this paper
• Regulation of Functional Phenotypes of Cord Blood–Derived Eosinophils by γ-Secretase Inhibitor

  2007cites this paper
• Jagged-1hi or Delta-1hi thymic stromal cell populations can trigger acquisition of Thy-1 and loss of B220.

  2006cites this paper
• Commitment issues: linking positive selection signals and lineage diversification in the thymus

  2006cites this paper
• Bone marrow versus thymic pathways of natural killer cell development

  2006cites this paper
• Progression of regulatory gene expression states in fetal and adult pro‐T‐cell development

  2006cites this paper
• Effects of Delta1 and Jagged1 on Early Human Hematopoiesis: Correlation with Expression of Notch Signaling‐Related Genes in CD34+ Cells

  2006cites this paper
• T Cells Develop Normally in the Absence of both Deltex1 and Deltex2

  2006cites this paper
• T Cells Develop Normally in the Absence of both Deltex1 and Deltex2 (cid:1) ‡

  2006cites this paper
• Autoreactive B cell development in the periphery

  2006cites this paper
• CHAPTER 10 – Developmental Signaling Networks: The Notch Pathway

  2006cites this paper
• A close developmental relationship between the lymphoid and myeloid lineages.

  2006cites this paper
• Enforced Expression of Spi-B Reverses T Lineage Commitment and Blocks β-Selection 1

  2005cites this paper
• Molecular signature of retinoic acid treatment in acute promyelocytic leukemia

  2005cites this paper
• Mind bomb 1 is essential for generating functional Notch ligands to activate Notch

  2005cites this paper
• Isolation of adult murine thymic stromal cells that naturally express Notch ligands

  2005cites this paper
• Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro.

  2005cites this paper
• Eosinophilic differentiation is promoted by blockage of Notch signaling with a gamma‐secretase inhibitor

  2005cites this paper
• Regulation of lymphoid development, differentiation, and function by the Notch pathway.

  2005cites this paper
• A novel role for Notch ligand Delta‐1 as a regulator of human Langerhans cell development from blood monocytes

  2005cites this paper
• Epstein-Barr virus latent proteins regulate expression of the anti-apoptotic cellular bfl-1 gene

  2005cites this paper
• The Zebrafish as a Model of Heart Regeneration

  2004cites this paper
• Direct regulation of the Nrarp gene promoter by the Notch signaling pathway.

  2004cites this paper
• Notch signaling in T- and B-cell development.

  2004cites this paper
• Notch1 expression on T cells is not required for CD4+ T helper differentiation

  2004cites this paper
• The Oncogene Nup98-HOXA9 Induces Gene Transcription in Myeloid Cells*

  2004cites this paper
• The Anti-apoptotic Effect of Notch-1 Requires p56lck-dependent, Akt/PKB-mediated Signaling in T Cells*

  2004cites this paper
• Viral interactions with the Notch pathway.

  2004cites this paper
• Notch regulation of lymphocyte development and function

  2004cites this paper
• Are genetic determinants of asymmetric stem cell division active in hematopoietic stem cells?

  2004cites this paper
• Biology of T lymphocytes.

  2004cites this paper
• The Central Role of the Thymus in the Development of Self-Tolerance and Autoimmunity in the Neuroendocrine System

  2004cites this paper
• Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism.

  2003cites this paper
• Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors.

  2003cites this paper
• Notch signalling in the regulation of peripheral T-cell function.

  2003cites this paper
• Notch1 enhances B-cell receptor-induced apoptosis in mature activated B cells without affecting cell cycle progression and surface IgM expression

  2003cites this paper
• Microenvironmental regulation of Notch signalling in T cell development.

  2003cites this paper
• Hematopoietic stem cells: generation and manipulation.

  2003cites this paper
• Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells.

  2003cites this paper
• Notch signaling in the immune system

  2003cites this paper
• Notch Signaling Augments T Cell Responsiveness by Enhancing CD25 Expression 1

  2003cites this paper
• HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures.

  2003cites this paper
• γ-Secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney

  2003cites this paper
• Future challenges for hematopoietic stem cell research.

  2003cites this paper
• Notch and the immune system.

  2003cites this paper
• Activation of Notch signaling pathway precedes heart regeneration in zebrafish

  2003cites this paper
• Aspects of early lymphoid commitment.

  2003cites this paper
• Targeting Presenilin-type Aspartic Protease Signal Peptide Peptidase with γ-Secretase Inhibitors*

  2003cites this paper
• Notch signaling in lymphopoiesis.

  2003cites this paper
• Expression Responsiveness by Enhancing CD 25 Notch Signaling Augments

  2003cites this paper
• Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8⁺ cell–dependent mechanism

  2003cites this paper
• Notch signaling in development and disease

  2003cites this paper
• T cell development in culture.

  2002cites this paper