Novel TCR-Mediated Mechanisms of Notch Activation and Signaling

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Journal of Immunology

• Publication date

  2018-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.4049/jimmunol.1700070PMID 29288204PMCID PMC5854196
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Voltage-Gated Calcium Channel Regulates Lysosomal Fusion with Endosomes and Autophagosomes and Is Required for Neuronal Homeostasis

  2015cited by this paper
• In vivo TCR Signaling in CD4+ T Cells Imprints a Cell-Intrinsic, Transient Low-Motility Pattern Independent of Chemokine Receptor Expression Levels, or Microtubular Network, Integrin, and Protein Kinase C Activity

  2015cited by this paper
• Notch in T Cell Differentiation: All Things Considered.

  2015cited by this paper
• Activation of the Notch1 Stem Cell Signaling Pathway during Routine Cell Line Subculture

  2014cited by this paper
• Radiotherapy and the Tumor Stroma: The Importance of Dose and Fractionation

  2014cited by this paper
• NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma

  2014cited by this paper
• Faculty Opinions recommendation of Distinct TCR signaling pathways drive proliferation and cytokine production in T cells.

  2013cited by this paper
• Distinct T cell receptor signaling pathways drive proliferation and cytokine production in T cells

  2013cited by this paper
• Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals.

  2013cited by this paper
• Protein kinase C, an elusive therapeutic target?

  2012cited by this paper
• PKCα and PKCδ Regulate ADAM17-Mediated Ectodomain Shedding of Heparin Binding-EGF through Separate Pathways

  2011cited by this paper
• Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)*

  2011cited by this paper
• Notch signaling: simplicity in design, versatility in function

  2011cited by this paper
• Ion flux and the function of endosomes and lysosomes: pH is just the start

  2011cited by this paper
• Real-Time Imaging of Notch Activation with a Luciferase Complementation-Based Reporter

  2011cited by this paper
• The nuts and bolts of AGC protein kinases

  2010cited by this paper
• Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model

  2010cited by this paper
• Canonical and non-canonical Notch ligands.

  2010cited by this paper
• Protein kinase C: poised to signal.

  2010cited by this paper
• Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage*

  2009cited by this paper
• PKC inhibitors: potential in T cell-dependent immune diseases.

  2009cited by this paper
• T cell activation.

  2009cited by this paper
• The Potent Protein Kinase C-Selective Inhibitor AEB071 (Sotrastaurin) Represents a New Class of Immunosuppressive Agents Affecting Early T-Cell Activation

  2009cited by this paper
• Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling

  2009influential reference
• Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes

  2009cited by this paper
• Endosomal entry regulates Notch receptor activation in Drosophila melanogaster

  2008cited by this paper
• Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of notch in the endosomal trafficking pathway.

  2008cited by this paper
• Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways.

  2008cited by this paper
• Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.

  2008cited by this paper
• Ikaros Regulates Notch Target Gene Expression in Developing Thymocytes1

  2008cited by this paper
• Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo

  2007cited by this paper
• Notch directly regulates Gata3 expression during T helper 2 cell differentiation.

  2007cited by this paper
• c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.

  2006cited by this paper
• The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells.

  2006cited by this paper
• The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands

  2005cited by this paper
• Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21

  2005cited by this paper
• Notch ligands Delta‐like1, Delta‐like4 and Jagged1 differentially regulate activation of peripheral T helper cells

  2005cited by this paper
• The nervous system and innate immunity: the neuropeptide connection.

  2005cited by this paper
• Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor

  2004cited by this paper
• Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.

  2004cited by this paper
• Notch 1 signaling regulates peripheral T cell activation.

  2004cited by this paper
• Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

  2004cited by this paper
• Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development*

  2004cited by this paper
• Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.

  2004cited by this paper
• Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells.

  2003cited by this paper
• Notch Signaling Augments T Cell Responsiveness by Enhancing CD25 Expression 1

  2003influential reference
• TCR-Mediated Notch Signaling Regulates Proliferation and IFN-γ Production in Peripheral T Cells 1

  2003cited by this paper
• TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells.

  2003cited by this paper
• Ubiquitin Depletion as a Key Mediator of Toxicity by Translational Inhibitors

  2003cited by this paper
• Does artemis end the hunt for the hairpin-opening activity in V(D)J recombination?

  2002cited by this paper
• Intracellular cell-autonomous association of Notch and its ligands: a novel mechanism of Notch signal modification.

  2002cited by this paper
• The role of Notch signaling during hematopoietic lineage commitment

  2002cited by this paper
• Burnet oration. T-cell survival and the role of cytokines.

  2001cited by this paper
• SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation

  2001cited by this paper
• Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions

  2001influential reference
• T‐cell survival and the role of cytokines

  2001cited by this paper
• Calcium Depletion Dissociates and Activates Heterodimeric Notch Receptors

  2000cited by this paper
• Carboxyl-terminal Phosphorylation Regulates the Function and Subcellular Localization of Protein Kinase C βII*

  1999cited by this paper
• Deficient T cell fate specification in mice with an induced inactivation of Notch1.

  1999cited by this paper
• Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development.

  1999cited by this paper
• Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

  1999cited by this paper
• The Notch1 receptor is cleaved constitutively by a furin-like convertase.

  1998cited by this paper
• Activation of Protein Kinase C Triggers Its Ubiquitination and Degradation

  1998cited by this paper
• The sevenfold way of PKC regulation.

  1998cited by this paper
• A histone deacetylase corepressor complex regulates the Notch signal transduction pathway.

  1998cited by this paper
• Requirement for dynamin during Notch signaling in Drosophila neurogenesis.

  1997cited by this paper
• Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Calpha.

  1996cited by this paper
• Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

  1996cited by this paper
• Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin- coated pits, and altered endosomal sorting

  1993cited by this paper
• T-cell activation.

  1992cited by this paper
• TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.

  1991cited by this paper
• Endocytosis and the recycling of plasma membrane

  1983cited by this paper

• Synthetic Hybrid Receptors for Safer and Programmable T Cell Therapy

  2026cites this paper
• Tunable differentiation of human CD4+ and CD8+ T cells from pluripotent stem cells.

  2026cites this paper
• Biomedical engineering targeting cancer stem cells to reinforce cancer therapy

  2025cites this paper
• Canonical and noncanonical NOTCH signaling in the nongenetic resistance of cancer: distinct and concerted control

  2025cites this paper
• Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway

  2024cites this paper
• Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions

  2024cites this paper
• Updates on Inflammatory Molecular Pathways Mediated by ADAM17 in Autoimmunity

  2024cites this paper
• Engineered receptors for soluble cellular communication and disease sensing

  2024cites this paper
• Engineered Receptors for Soluble Cell-to-Cell Communication

  2024cites this paper
• A regulatory circuit controlled by extranuclear and nuclear retinoic acid receptor α determines T cell activation and function.

  2023cites this paper
• Astrogliosis in multiple sclerosis and neuro-inflammation: what role for the notch pathway?

  2023cites this paper
• Sulindac sulfide as a non-immune suppressive γ-secretase modulator to target triple-negative breast cancer

  2023cites this paper
• Notch signaling pathway: a new target for neuropathic pain therapy

  2023cites this paper
• Multiple Mechanisms of NOTCH1 Activation in Chronic Lymphocytic Leukemia: NOTCH1 Mutations and Beyond

  2022cites this paper
• Targeting Cblb-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cells responses

  2022cites this paper
• E3 Ubiquitin Ligase Regulators of Notch Receptor Endocytosis: From Flies to Humans

  2022cites this paper
• Njavara rice (Oryza sativa Linn.) bran oil exerts anti-inflammatory effects through regulation of Notch-mediated T-cell receptor (TCR) activation in experimentally induced atherosclerosis.

  2022cites this paper
• EGFL7 affects the migration of epidermal stem cells in refractory diabetic wounds by regulating Notch signaling pathway.

  2022cites this paper
• The role of Hedgehog and Notch signaling pathway in cancer

  2022cites this paper
• NOTCH1 Signalling: A key pathway for the development of high-risk chronic lymphocytic leukaemia

  2022cites this paper
• Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses

  2022cites this paper
• Notch signaling pathway: architecture, disease, and therapeutics

  2022cites this paper
• ADAM10 Site-Dependent Biology: Keeping Control of a Pervasive Protease

  2021cites this paper
• Notch Signaling in Embryology and Cancer: Notch Signaling in Cancer

  2021cites this paper
• Unravelling of Hidden Secrets: The Tumour Suppressor Lethal (2) Giant Discs (Lgd)/CC2D1, Notch Signalling and Cancer.

  2021cites this paper
• Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases

  2021cites this paper
• Cancer‐associated mutations in VAV1 trigger variegated signaling outputs and T‐cell lymphomagenesis

  2021cites this paper
• Targeting Notch to Maximize Chemotherapeutic Benefits: Rationale, Advanced Strategies, and Future Perspectives

  2021cites this paper
• To be more precise: the role of intracellular trafficking in development and pattern formation

  2020cites this paper
• Specific Targeting of Notch Ligand-Receptor Interactions to Modulate Immune Responses: A Review of Clinical and Preclinical Findings

  2020cites this paper
• CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells

  2020influential citation
• GCNT1-Mediated O-Glycosylation of the Sialomucin CD43 Is a Sensitive Indicator of Notch Signaling in Activated T Cells

  2020cites this paper
• Targeting Notch in oncology: the path forward

  2020cites this paper
• Intimate association of PRR- and NLR-mediated signaling in plant immunity.

  2020cites this paper
• Notch Pathway: A Journey from Notching Phenotypes to Cancer Immunotherapy.

  2020cites this paper
• Extra-Nuclear and Nuclear Rarα Reciprocally Control Tcr-Induced Proliferation and Differentiation

  2019cites this paper
• Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T cell immunity

  2019cites this paper
• Mechanisms of Notch signaling: a simple logic deployed in time and space

  2019cites this paper
• Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells

  2019influential citation
• Increased surface expression of NOTCH on memory T cells in peripheral blood from patients with asthma.

  2019cites this paper
• T Cell Reprogramming Against Cancer.

  2019cites this paper
• When encephalitogenic T cells collaborate with microglia in multiple sclerosis

  2019cites this paper
• Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter’s syndrome: therapeutic implications

  2019cites this paper
• Decoding the PTM-switchboard of Notch

  2019cites this paper
• Correction to: Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T-cell immunity

  2019cites this paper
• Immunometabolic phenotype of BV-2 microglia cells upon murine cytomegalovirus infection

  2019cites this paper
• Notch as an Immunologic Basis of Cancer Disparities.

  2019cites this paper
• A Review of Notch Processing With New Insights Into Ligand-Independent Notch Signaling in T-Cells

  2018influential citation
• Adhesive Interactions Delineate the Topography of the Immune Synapse

  2018cites this paper
• Dichotomy of Notch signalling in regulating tumour immune surveillance

  2018cites this paper