Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Immunity

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/S1074-7613(01)00165-0PMID 11485737
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

  2003cited by this paper
• Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttling.

  2001cited by this paper
• Inflammation, a prototype for organogenesis of the lymphopoietic/hematopoietic system.

  2000cited by this paper
• The genome sequence of Drosophila melanogaster.

  2000cited by this paper
• Crystal structure of the lambda repressor C-terminal domain provides a model for cooperative operator binding.

  2000cited by this paper
• T cell life and death signalling via TNF-receptor family members.

  2000cited by this paper
• Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity.

  2000cited by this paper
• Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo.

  2000cited by this paper
• Signaling mechanisms in the antimicrobial host defense of Drosophila.

  2000cited by this paper
• Manipulating immune responses with immunosuppressive agents that target NFAT.

  2000cited by this paper
• The NFAT-Related Protein NFATL1 (TonEBP/NFAT5) Is Induced Upon T Cell Activation in a Calcineurin-Dependent Manner1

  2000cited by this paper
• Reciprocal Modulatory Interaction between Human Immunodeficiency Virus Type 1 Tat and Transcription Factor NFAT1

  1999cited by this paper
• NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun.

  1999cited by this paper
• Signal integration by transcription-factor assemblies: interactions of NF-AT1 and AP-1 on the IL-2 promoter.

  1999cited by this paper
• Characterization of the dimer interface of transcription factor NFkappaB p50 homodimer.

  1999cited by this paper
• NF-AT5: the NF-AT family of transcription factors expands in a new direction.

  1999cited by this paper
• Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-beta promoter.

  1999cited by this paper
• Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

  1999cited by this paper
• Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity.

  1999cited by this paper
• Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA

  1998cited by this paper
• Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA

  1998cited by this paper
• Solution structure of the core NFATC1/DNA complex.

  1998cited by this paper
• Involvement of interleukin-8 in dialysis-related arthritis.

  1998cited by this paper
• NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.

  1998cited by this paper
• HYPERTONIC SALINE RESUSCITATION: A TOOL TO MODULATE IMMUNE FUNCTION IN TRAUMA PATIENTS?

  1997cited by this paper
• IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.

  1997cited by this paper
• Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1-binding promoter element.

  1997cited by this paper
• Identification and Characterization of Multiple Osmotic Response Sequences in the Human Aldose Reductase Gene*

  1997cited by this paper
• The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells.

  1997cited by this paper
• Regulation of gene expression by hypertonicity.

  1997cited by this paper
• Transcription factors of the NFAT family: regulation and function.

  1997cited by this paper
• Hyperosmotic stress as a stimulant for proinflammatory cytokine production.

  1997cited by this paper
• Activation of Transcription Factor NF-κB and p38 Mitogen-activated Protein Kinase Is Mediated by Distinct and Separate Stress Effector Pathways*

  1997cited by this paper
• Role of CBP/P300 in nuclear receptor signalling

  1996cited by this paper
• The Rel family of eukaryotic transcription factors.

  1996cited by this paper
• Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-1 receptor antagonist in dialysate and serum from patients on continuous ambulatory peritoneal dialysis.

  1996cited by this paper
• The role of cellular hydration in the regulation of cell function.

  1996cited by this paper
• Functional analysis of the lymphotoxin-beta promoter. Sequence requirements for PMA activation.

  1996cited by this paper
• The role of T-lymphocytes and cytokines in rheumatoid arthritis.

  1996cited by this paper
• Osmotic regulation of cytokine synthesis in vitro.

  1995cited by this paper
• A metabolic complication of severe burns.

  1995cited by this paper
• Characterization of elements determining the dimerization properties of RelB and p50

  1995cited by this paper
• Balance between IL-1 beta, TNF-alpha, and their specific inhibitors in chronic renal failure and maintenance dialysis. Relationships with activation markers of T cells, B cells, and monocytes.

  1995cited by this paper
• Structure of the NF-kappa B p50 homodimer bound to DNA.

  1995cited by this paper
• Structure of NF-kappa B p50 homodimer bound to a kappa B site.

  1995cited by this paper
• Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins.

  1995cited by this paper
• Cell volume regulated transporters of compatible osmolytes.

  1995cited by this paper
• Plasma levels of IL-1 beta, TNF alpha and their specific inhibitors in undialyzed chronic renal failure, CAPD and hemodialysis patients.

  1994cited by this paper
• Hypertonic saline enhances cellular immune function.

  1994cited by this paper
• Interleukin-8 in chronic renal failure and dialysis patients.

  1994cited by this paper
• Fluid and electrolyte therapy for children

  1994cited by this paper
• Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter

  1993cited by this paper
• Chronic T-Lymphocyte Activation in Chronic Renal Failure: A Study of Hemodialysis, Capd and Pre-Dialysis Patients

  1992cited by this paper
• Chronic arthropathy in long-term hemodialysis.

  1985cited by this paper

• NFAT5: a stress-related transcription factor with multiple functions in health and disease

  2025cites this paper
• DEC1 deficiency promotes osteoclastic activity by augmenting NFATc1 signaling via transactivation and the Ca2+/calcineurin pathway.

  2025cites this paper
• NFAT5 exacerbates β-cell ferroptosis by suppressing the transcription of PRDX2 in obese type 2 diabetes mellitus

  2025cites this paper
• Direct ionic stress sensing and mitigation by the transcription factor NFAT5

  2025cites this paper
• Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

  2025cites this paper
• Hyperosmotic Stress Induces Inflammation and Excessive Th17 Response to Blunt T-Cell Immunity in Tilapia.

  2024cites this paper
• Nuclear factor of activated T cell cytoplasmic 1 (NFATc1) insertion gene polymorphism as a possible trigger in acute T cell-mediated rejection (aTCMR) after kidney transplantation.

  2024cites this paper
• Role of Osmotic Response Element-Binding Protein in High Glucose-Induced Cataractogenesis: Involvement of ERK and p38 MAPK Pathways

  2024cites this paper
• Prolonged extracellular low sodium concentrations and subsequent their rapid correction modulate nitric oxide production dependent on NFAT5 in microglia.

  2024cites this paper
• Effects of Hypernatremia on the Microglia.

  2024cites this paper
• The impact of high‐salt diet on asthma in humans and mice: Effect on specific T‐cell signatures and microbiome

  2024cites this paper
• NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer

  2024cites this paper
• Tissue Sodium Accumulation Induces Organ Inflammation and Injury in Chronic Kidney Disease

  2023cites this paper
• Temperature modulates the osmosensitivity of tilapia prolactin cells

  2023cites this paper
• NFAT5 Restricts Bovine Herpesvirus 1 Productive Infection in MDBK Cell Cultures

  2023cites this paper
• Temperature modulates the osmosensitivity of tilapia prolactin cells

  2023cites this paper
• Targeting CaN/NFAT in Alzheimer’s brain degeneration

  2023cites this paper
• Direct ionic stress sensing and mitigation by the transcription factor NFAT5

  2023cites this paper
• Inflammation of Dry Eye Syndrome: A Cellular Study of the Epithelial and Macrophagic Involvement of NFAT5 and RAGE

  2023cites this paper
• Serine protease 35 regulates the fibroblast matrisome in response to hyperosmotic stress

  2023cites this paper
• Role of Oxidative Stress in Vascular Low-Grade Inflammation Initiation Due to Acute Salt Loading in Young Healthy Individuals

  2022cites this paper
• Overexpression of miR-490-5p/miR-490-3p Potentially Induces IL-17-Producing T Cells in Patients With Breast Cancer.

  2022cites this paper
• Responses to Ang II (Angiotensin II), Salt Intake, and Lipopolysaccharide Reveal the Diverse Actions of TNF-α (Tumor Necrosis Factor-α) on Blood Pressure and Renal Function

  2022cites this paper
• Genetic deletion of the nuclear factor of activated T cells 5 in collecting duct principal cells causes nephrogenic diabetes insipidus

  2022cites this paper
• Inhibiting NFAT5 With KRN2 Mitigates Acute Allograft Rejection in a Murine Heart Transplantation Model

  2022cites this paper
• Rac1 deficiency impairs postnatal development of the renal papilla

  2022cites this paper
• Computational System Level Approaches for Discerning Reciprocal Regulation of IL10 and IL12 in Leishmaniasis

  2022cites this paper
• Calcicoptosis Induced by Purple Sweet Potato Anthocyanins through the Nonosmotic Regulation of the NFAT5/S100A4‐S100A9 Pathway in Acute Lymphoblastic Leukemia

  2022cites this paper
• NFAT5/TonEBP Limits Pulmonary Vascular Resistance in the Hypoxic Lung by Controlling Mitochondrial Reactive Oxygen Species Generation in Arterial Smooth Muscle Cells

  2021cites this paper
• NFAT5 Controls the Integrity of Epidermis

  2021cites this paper
• Potentially Detrimental Effects of Hyperosmolality in Patients Treated for Traumatic Brain Injury

  2021cites this paper
• Elevation of hypertonicity‑induced protein NFAT5 promotes apoptosis of human umbilical vein endothelial cells through the NF‑κB pathway.

  2021cites this paper
• The Role of Nuclear Factor of Activated T Cells 5 in Hyperosmotic Stress-Exposed Human Lens Epithelial Cells

  2021cites this paper
• Nuclear factor of activated T-cells (NFAT) regulation of IL-1β-induced retinal vascular inflammation.

  2021cites this paper
• NFAT5 Amplifies Antipathogen Responses by Enhancing Chromatin Accessibility, H3K27 Demethylation, and Transcription Factor Recruitment

  2021cites this paper
• Bavachin produces immunoadjuvant activity by targeting the NFAT signaling pathway.

  2021cites this paper
• Evaluation of an in vitro assay to screen for the immunotoxic potential of chemicals to fish

  2021cites this paper
• Multiscale Regulation of the Intervertebral Disc: Achievements in Experimental, In Silico, and Regenerative Research

  2021cites this paper
• Unconventional tonicity-regulated nuclear trafficking of NFAT5 mediated by KPNB1, XPOT and RUVBL2

  2021cites this paper
• The PKA-p38MAPK-NFAT5-Organic Osmolytes Pathway in Duchenne Muscular Dystrophy: From Essential Player in Osmotic Homeostasis, Inflammation and Skeletal Muscle Regeneration to Therapeutic Target

  2021cites this paper
• An intronic polymorphism of NFATC1 gene shows a risk association with biopsy-proven acute rejection in renal transplant recipients

  2020cites this paper
• Upregulation of Nfat5 mRNA and Fzd4 mRNA as a Marker of Poor Outcome in Neonatal Hypoxic-Ischemic Encephalopathy.

  2020cites this paper
• Hypotheses about sub-optimal hydration in the weeks before coronavirus disease (COVID-19) as a risk factor for dying from COVID-19

  2020cites this paper
• Titanium dioxide nanoparticles induced the apoptosis of RAW264.7 macrophages through miR-29b-3p/NFAT5 pathway

  2020cites this paper
• Salt generates anti-inflammatory Th17 cells but amplifies their pathogenicity in pro-inflammatory cytokine microenvironments.

  2020influential citation
• Does methylation of NFATC1 and C-FOS genes are associated with post-menopausal osteoporosis?

  2020cites this paper
• Correlation Profile of Suppression of Tumorigenicity 2 and/or Interleukin-33 with Biomarkers in the Adipose Tissue of Individuals with Different Metabolic States

  2020cites this paper
• An osmolality/salinity-responsive enhancer 1 (OSRE1) in intron 1 promotes salinity induction of tilapia glutamine synthetase

  2020cites this paper
• DMSO_A_251978 3839..3859

  2020cites this paper
• Medical Gas Plasma Jet Technology Targets Murine Melanoma in an Immunogenic Fashion

  2020cites this paper
• Do We Use Methylation of NFATC1 and FOS Genes As a Biomarker for Postmenopausal Osteoporosis?

  2020cites this paper
• Description of a Novel Mechanism Possibly Explaining the Antiproliferative Properties of Glucocorticoids in Duchenne Muscular Dystrophy Fibroblasts Based on Glucocorticoid Receptor GR and NFAT5

  2020cites this paper
• Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus

  2020cites this paper
• Serum sodium variability and acute kidney injury: a retrospective observational cohort study on a hospitalized population

  2020cites this paper
• NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis.

  2019cites this paper
• Increased mortality risk associated with serum sodium variations and borderline hypo- and hypernatremia in hospitalized adults

  2019cites this paper
• Hyperosmolar environment and intestinal epithelial cells: impact on mitochondrial oxygen consumption, proliferation, and barrier function in vitro

  2019cites this paper
• Amelioration of Lipopolysaccharide-Induced Nephrotic Proteinuria by NFAT5 Depletion Involves Suppressed NF-κB Activity

  2019cites this paper
• Protective effects of glycerol and xylitol in keratinocytes exposed to hyperosmotic stress

  2019cites this paper
• Role of NFAT5 in the Immune System and Pathogenesis of Autoimmune Diseases

  2019cites this paper
• NFAT5 and HIF-1α Coordinate to Regulate NKCC1 Expression in Hippocampal Neurons After Hypoxia-Ischemia

  2019cites this paper
• CCID_A_197946 323..331

  2019cites this paper
• Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment

  2019cites this paper
• The transcription factor NFAT5 limits infection-induced type I interferon responses

  2019influential citation
• Proteomic analysis of the psoriatic skin, and the effect of hyperosmotic stress on keratinocytes

  2019cites this paper
• Osmolarity and calcium regulate connective tissue growth factor (CTGF/CCN2) expression in nucleus pulposus cells.

  2019cites this paper
• Regulation of Inflammatory Functions of Macrophages and T Lymphocytes by NFAT5

  2019influential citation
• Osteoprotective action of low-salt diet requires myeloid cell-derived NFAT5.

  2019cites this paper
• Sodium chloride is an ionic checkpoint for human Th2 cell responses and shapes the atopic skin microenvironment

  2018cites this paper
• NFAT5 Has a Job in the Brain

  2018cites this paper
• Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5

  2018cites this paper
• How to reprogram microglia toward beneficial functions

  2018cites this paper
• NFAT5 promotes in vivo development of murine melanoma metastasis.

  2018cites this paper
• mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1

  2018cites this paper
• Ulipristal Acetate Mediates Decreased Proteoglycan Expression Through Regulation of Nuclear Factor of Activated T-Cells (NFAT5)

  2018cites this paper
• NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells

  2018cites this paper
• Localization and Expression of Nuclear Factor of Activated T-Cells 5 in Myoblasts Exposed to Pro-inflammatory Cytokines or Hyperosmolar Stress and in Biopsies from Myositis Patients

  2018cites this paper
• Revisiting the Concept of Targeting NFAT to Control T Cell Immunity and Autoimmune Diseases

  2018cites this paper
• Suppression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1-ETAR-NFAT5 Signaling in a Rat Model of Neuropathic Pain.

  2018cites this paper
• Investigation of NFATs regulatory potential and role in skeletal muscle during voluntary exercise

  2018cites this paper
• Transcription factor NFAT5 promotes macrophage survival in rheumatoid arthritis

  2017cites this paper
• Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors

  2017cites this paper
• Extracellular and cellular Hsp72 differ as biomarkers in acute exercise/environmental stress and recovery

  2017cites this paper
• Upregulation of DARS2 by HBV promotes hepatocarcinogenesis through the miR-30e-5p/MAPK/NFAT5 pathway

  2017cites this paper
• NFAT 5 genes are part of the osmotic regulatory system in Atlantic salmon ( Salmo salar )

  2017cites this paper
• NFAT5 genes are part of the osmotic regulatory system in Atlantic salmon (Salmo salar)

  2017cites this paper
• Expansion under Pathologic Hypernatremia Homeostasis and CD24-Dependent T Cell NFAT5 Regulates T Lymphocyte

  2017cites this paper
• Salinity stress, enhancing basal and induced immune responses in striped catfish Pangasianodon hypophthalmus (Sauvage).

  2017cites this paper
• A recipe for myositis: nuclear factor κB and nuclear factor of activated T-cells transcription factor pathways spiced up by cytokines

  2017influential citation
• Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5

  2016cites this paper
• Autocrine MCP-1/CCR2 signaling stimulates proliferation and migration of renal carcinoma cells.

  2016cites this paper
• Th17/Treg Imbalance Induced by Dietary Salt Variation Indicates Inflammation of Target Organs in Humans

  2016cites this paper
• NFATc2 is an intrinsic regulator of melanoma dedifferentiation

  2016cites this paper
• RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells

  2016cites this paper
• Mariner Transposons Contain a Silencer: Possible Role of the Polycomb Repressive Complex 2

  2016cites this paper
• The Roles of Dietary Nitrate in Bone and the Gut in an Ovarian Hormone-deficient Rodent Model

  2016cites this paper
• Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells

  2016cites this paper
• Pooled CRISPR screening with single-cell transcriptome read-out

  2016cites this paper
• Generation of a conditional knockout allele for the NFAT5 gene in mice

  2015cites this paper
• Spatial control of calcineurin in response to heat shock in fission yeast

  2015cites this paper