Transmural gradients of myocardial structure and mechanics: Implications for fiber stress and strain in pressure overload.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Progress in Biophysics and Molecular Biology

• Publication date

  2016-12-01

• Fields of study

  Medicine, Materials Science, Engineering

• Identifiers
  DOI 10.1016/j.pbiomolbio.2016.11.004PMID 27845176PMCID PMC5161628
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014influential reference
• Quantitative Study of the Effect of Tissue Microstructure on Contraction in a Computational Model of Rat Left Ventricle

  2014cited by this paper
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  2010influential reference
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• Changes in regional myocardial volume during the cardiac cycle: implications for transmural blood flow and cardiac structure.

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• Remodeling of Outward K+ Currents in Pressure‐Overload Heart Failure

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• GENE EXPRESSION OF STRETCH‐ACTIVATED CHANNELS AND MECHANOELECTRIC FEEDBACK IN THE HEART

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• The dynamic twisting of the left ventricle: A computer study

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• Transmural sheet strains in the lateral wall of the ovine left ventricle.

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  2004influential reference
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  1999influential reference
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